SQLite format 3@ ICF  ۍIC-ztnhb\VPJD>82,& ~xrlf`ZTNHB<60*$ |vpjd^X q  Q  ~ Mv 6n Іf ү^ zV %N ƊF Ã> ۆ6 ކ. &   T  ~ Jv n Of y^ CV ȅN F > 96 ~օ. {A& w t q  f  ZV~ VKv R`n N f JS^ F /M6 *5. '& $ "p 6 ) ҃~ v gn Xf ;^ V كN SF `> ԃ6 . ߔ&   %  ~ ȗv 8n nf ^ V N F > ɂ6 . & H  ނ y u~ rv nOn jf g^ dV aN ]UF Y> V:6 R_. M& I E B >W 9U~ 3v 0Yn , f ^ tV NIFA>9710.{ =Վ   0.0.0.1 kXN?&{cJ2%'time_cleanup1450550255.35-zorro_thresholds1.0-zorro_thresholds0.75-zorro_thresholds0.6-zorro_thresholds0.5-zorro_thresholds0.35-zorro_thresholds0.3-zorro_thresholds0.25-zorro_thresholds0.2-zorro_thresholds0.15-zorro_thresholds0.1-zorro_thresholds0.05 run_exe sh4 _mmfolder/home/ubuntu/repository/lazarus/paml/dat/8 %_fasttree_exe/home/ubuntu/repository/FastTree/FastTree zorro_exezorroD #yanccomp_exepython /home/ubuntu/repository/anccomp/compare_ancs.py?#olazarus_exepython /home/ubuntu/repository/lazarus/lazarus.pyphyml_exephyml!raxml_exeraxml -T 2!muscle_exemuscle%msaprobs_exemsaprobs'!Aergseqpathcmgc.erg.raw_dpf70HI.fasta'project_title cmgc geneidcmgcB*2{uoic]WQKE?93-'! (sP'F&=&C4$+$"##P #"v"0k!˄`!XU J ^?4)E}Mrg\QFc;0%*Ѓdyn"cȂXJMB7B,ׂ!x  ujF_ǁTdI>3(AŁh| qf:[ P pE : / E$    8zlWB8 Vu @ffffffA՝h\ @A՝h A՝hDNR@A՝>'C A՝>%@A՝ A՝(@Vkij?ffffffA՚피(  A՚S33 A՚#33!Gr}wqke_YSMGiB`8U.K$B80*|#si _TJ@7.؁$ρȁ~tjaXNEz;r2j(cVU ]\7qHomo.sapiens.MAPK6..sp.Q16659.MK06_HUMAN.Mitogen.a[Z7qHomo.sapiens.MAPK6..sp.Q16659.MK06_HUMAN.Mitogen.a o|AO( o/1AncestralCladogram AncestorsT 9SupportedMlPhylogenies 5BranchSupportMethods =UnsupportedMlPhylogenies  3ZorroThreshFasttree SiteSets  C AlignmentSiteScoringMethods -AlignedSequences ! TaxaGroups/OriginalSequencesI TaxaI-AlignmentMethods#PhyloModels)PhyloSoftwares+ TTXA`6MtableAboutAboutCREATE TABLE About(version TEXT)KktableSettingsSettingsCREATE TABLE Settings(keyword TEXT, value TEXT)}atableLogLogCREATE TABLE Log(id INTEGER primary key, time DATETIME DEFAULT CURRENT_TIMESTAMP, message TEXT, code INT) ktableErrorLogErrorLogCREATE TABLE ErrorLog(id INTEGER primary key, time DATETIME DEFAULT CURRENT_TIMESTAMP, message TEXT, code INT)X##ytableCheckPointsCheckPointsCREATE TABLE CheckPoints(checkpoint FLOAT, time FLOAT)yUtableTaxaTaxaCREATE TABLE Taxa(id INTEGER primary key autoincrement, fullname TEXT unique, shortname TEXT unique)';indexsqlite_autoindex_Taxa_1Taxa';indexsqlite_autoindex_Taxa_2Taxa P ++Ytablesqlite_sequencesqlite_sequence CREATE TABLE sqlite_sequence(name,seq) //itableOriginalSequencesOriginalSequences CREATE TABLE OriginalSequences(id INTEGER primary key autoincrement, taxonid INT, sequence TEXT, datatype INT) msaprobsmsaprobsmusclemuscle  msaprobs  muscle dd9T> --UtableAlignmentMethodsAlignmentMethods CREATE TABLE AlignmentMethods(id INTEGER primary key autoincrement, name TEXT unique, exe_path TEXT)? S-indexsqlite_autoindex_AlignmentMethods_1AlignmentMethods* --tableAlignedSequencesAlignedSequencesCREATE TABLE AlignedSequences(id INTEGER primary key autoincrement, taxonid INT, alsequence TEXT, almethod INT, datatype INT)l/tableSiteMapSiteMapCREATE TABLE SiteMap(taxonid INT, almethod1 INT, site1 INT, almethod2, site2 INT)g??]tableSequenceSimilarityNetworkSequenceSimilarityNetworkCREATE TABLE SequenceSimilarityNetwork(id INTEGER primary key autoincrement, label TEXT unique, xgmml TEXT, filter_name TEXT, filter_direction TEXT, filter_value FLOAT)Qe?indexsqlite_autoindex_SequenceSimilarityNetwork_1SequenceSimilarityNetworkm-tableSiteSetsSiteSetsCREATE TABLE SiteSets(id INTEGER primary key autoincrement, setname TEXT unique) Y .Oł`IpH=W$#}vohaZSLE>70)" zsle^W#!#Yp"D"M")!Ē!`' o  1̐ig%~8HӏQox @.@@ۍvGOV}_fNh銧2#iU#W&4{\5-CɆ<c_x5 Є_k6[ ?333333>6C- ?? *sqT ?ffffff?$ u?333333?01nF??=}H˒?ə?K:WG?333333?_ ??H?@ w+E((=(((\(' '|'{ w`I2zcL5?޹"]@ilnr":1J@Z-"r]jKy/'t 9L~օrzTRY.Y-8 pzx++#tableAncestralStatesAncestralStates8CREATE TABLE AncestralStates(ancid INTEGER, site INT, state CHAR, pp FLOAT) 211ktableAncestralCladogramAncestralCladogram:CREATE TABLE AncestralCladogram(id INTEGER primary key autoincrement, unsupportedmltreeid INTEGER, newick TEXT)|377tableAncestorsAcrossModelsAncestorsAcrossModels;CREATE TABLE AncestorsAcrossModels(ancid INTEGER, same_ancid INTEGER) 4))MtableAncestorsAliasAncestorsAliasCREATE TABLE MutationIndex(ancid1 INTEGER, ancid2 INTEGER, mlstate1 TEXT, mlstate2 TEXT, state1pp FLOAT, state2pp FLOAT)c7--{tableCompareAncestorsCompareAncestors?CREATE TABLE CompareAncestors(alias1 TEXT, alias2 TEXT)  Y*  = C   Im Ё U      <<KV>8%%wtableFScore_TestsFScore_Tests@CREATE TABLE FScore_Tests(id INTEGER primary key autoincrement, almethod INT, phylomodel INT, ancid1 INT, ancid2 INT)p9%%#tableFScore_SitesFScore_SitesBCREATE TABLE FScore_Sites(testid INT, site INT, df FLOAT, k FLOAT, p FLOAT)^:##tableDNDS_ModelsDNDS_ModelsCCREATE TABLE DNDS_Models(id INTEGER primary key, name TEXT)(;!!tableDNDS_TestsDNDS_TestsDCREATE TABLE DNDS_Tests(id INTEGER primary key autoincrement, almethod INT, phylomodel INT, anc1 INTEGER, anc2 INTEGER, dnds_model INT)<99QtableLabeledDnDsPhylogeniesLabeledDnDsPhylogeniesECREATE TABLE LabeledDnDsPhylogenies(id INTEGER primary key autoincrement, testid INT, newick TEXT)H=etableDNDS_lnLDNDS_lnLFCREATE TABLE DNDS_lnL(testid INT, lnl FLOAT)?>##EtableDNDS_paramsDNDS_paramsGCREATE TABLE DNDS_params(testid INT, pclass1 FLOAT, pclass2 FLOAT, pclass3 FLOAT, pclass4 FLOAT, wclass1 FLOAT, wclass2 FLOAT, wclass3 FLOAT, wclass4 FLOAT)        44~$0"?!!tableNEB_scoresNEB_scoresHCREATE TABLE NEB_scores(testid INT, site INT, ppcat1 FLOAT, ppcat2 FLOAT, ppcat3 FLOAT, ppcat4 FLOAT, ancmu INT, significant INT)"@!!tableBEB_scoresBEB_scoresJCREATE TABLE BEB_scores(testid INT, site INT, ppcat1 FLOAT, ppcat2 FLOAT, ppcat3 FLOAT, ppcat4 FLOAT, ancmu INT, significant INT)zA55tableCompare_DNDS_FscoresCompare_DNDS_FscoresKCREATE TABLE Compare_DNDS_Fscores(dnds_testid INT, fscore_testid INT)B!!StableHtmlPiecesHtmlPiecesLCREATE TABLE HtmlPieces(id INTEGER primary key autoincrement, keyword TEXT unique, htmlstring TEXT)3CG!indexsqlite_autoindex_HtmlPieces_1HtmlPiecesMlD--tableAncestralStates1AncestralStates1 CREATE TABLE AncestralStates1(site INT, state CHAR, pp FLOAT)lE--tableAncestralStates2AncestralStates2 _CREATE TABLE AncestralStates2(site INT, state CHAR, pp FLOAT)lF--tableAncestralStates3AncestralStates3 CREATE TABLE AncestralStates3(site INT, state CHAR, pp FLOAT)     ll # MKKYLWRTPSMANQNGRSLKEVIKCTAIYDVFSVVQKVGDGTFGSVHLATRKGSMKVVAIKSMKKKLMKISDAARLREVHSLLHLSEHDNIVNIFDLYIDQSFCLHIVMEFLEFNLFQLINSRRDKPFSYNSVRDIMSQIFKGIGHIHANGFFHRDMKPENILVSPIENSDVYKVKIADFGLAREINSSPPYTEYVSTRWYRAPELLLRDSYYSCPVDIYAAGCMAFEIATLQPIFPGMDDLDQLYKICEILGSPDDESQKMGFGGGGTWKQAEKLTKDLGIILPKSAPLNLRELFSPPWNGAFASMLTELLQWNPDARPSAQACLELDFFVAKEEKVQKPRKEKETKANQVGKVGETQVSLPTFSLQNIFTKVTLPYVEDKTGKRSSTLYQKFHKGITGFKRTFQKANKSKKSTKMSQTISTPMYRPPSPFFPILPQIRPSTPLNLKLRNYMLSTAEYNATNKSMPMFMETSQTEGPNQLRDKENTQFRRKSTNASTPSYFTSSARNSILSYFDAETSSPTTLNDRSATLRSSKFSGLSNDSSRSTAQTYSVLLEPSDCEKTLLWKKSSLKGDSNAQVTKRSLKNFKGEEADEEKNDSHQHLDSEKPSIFSSDILEHDFPDFCVTSLADTLGVPGLTLKSDSHVTSETIS 2f21a MESFQKVEKIGEGTYGVVYKAKNKVTGETVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLRDVIHTENKLYLVFEFLHQDLKRFMDSTSVSGISLPLVKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINAQGEIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMITRRALFPGDSEIDQLFRIFRTLGTPDESIWPGVTSMPDYKPSFPKWARQDLSKVVPPLDEDGRDLLGQMLTYDPNKRISAKNALVHRFFRDVTMPVPPLRL- MSDIQQDSTSTTLGGTSLGGTSLGGTSLGGTSLGGTSLGGTSLGGTSLGGSTTTSTTTPKSTNSKNKKKKQTSSNNNNNNNNNNNNNNENNRDNDAGSSNKSFMPLNNNEDEGTKDYKQGGYHPVRRNDVYGNRYQVVDKLGWGHFSTVWLCNDKDTPITTSSSSSSTTTTTTSSSSNGNGNGNGGNVIGYKQVALKIVRSARTYSETAEDEIKILNAISKYNAQDKCVARLLDHFTHRGPNGRHYCMVFELLGNNLLDLIKHHRYRGMPITLVKTLMKQTLIALDYIHTKCKIIHTDLKPENVLLEKSFDFFTSNDYIWSEKYGYFKNRTSSSNKQSQQQQQPQQQQSQQNINDYSDDSDDSHSDYSDSEDELKNKGNKKSSNRDRDNNKNKNIKKDDNKSSVNEINNISKENTDNKDLNSSEENKKEEEQQQNKKEEPTTTTTTATATATTTTTTGTEEFKFVNGISYKFKKNNELFNENHYPRAQLVDLGNACWTDKHFTDDIQTRQYRAPEAIVKAKWGTPVDIWSAACMAFELATGDHLFKPKSGKGFEKSDDHLALMIELLGKPPRFIFAGGDESRVYFTHKGDLRKIPDLSDQWPLFSVLTEKYKFSIQEAKDFEAFLLPMLNYLPEKRATAKDCLNHTWLKDVPPFLN EsE+U MQKYEKLEKIGEGTYGTVFKAKNRDTHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFMYQLLKGLAFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPAMTKLPDYKPYPMYPATMSLVNVVPKLNATGRDLLQNLLKCNPVQRICADEALQHPYFADFCPP  MEGGGAPPADTVMSDAAPAPPQMGIENIPAVLSHGGRFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAHNSETNEHVAVKKIANAFDNKIDAKRTLREIKLLRHMDHENVVAIRDIVPPPQREVFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSETDFMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEDDLGFLNENAKRYIRQLPPYRRQSFQEKFPHVHPEAIDLVEKMLTFDPRKRITVEDALAHPYLTSLHDISDEPVCMTPFSFDFEQHALTEEQMKELIYREALAFNPEYQQ %I MVAKNYVGLSLLTNALEQVIVLFMFSHTAMGITEMWKPSKMLPQRSNLHDKTPPDVNKPPPTIPLKSLENDYKMISRLGDGGFGIVRLAKYRHDKSNLLQSAKRGTLTDVGDGSNVNLSPLVAIKTMNARLPKLEHYTRVKEVQFIQAMPAHINLLHIYEVFIDTSQYCLHFSMECMDQTLYGLMRSRGGKRFTASTVRSILWQLLSAISHIHDHGYFHRDIKPQNILISSMSQYYGGIDSVPPGSRDQKYMVKLADYGLARHVENCKDFTTYISTRWYRAPEMLLRRKWHSTPVDIWAFGTVAAEVAKVTPLFPGANEIDQIWRIFKVLGNPAPPKNIQARPFPVGGYWVEGQLLAGKCGYSFPEGTGIPIDEFIPHSYPFLCDMIRICLRWNPETRPIASELYDQSYFMYTPEKKAMETSLFKRSGNVSLLSATAKESVDHSNISPIETYDFYKVPPDLEADMDNYGYMDSGNNKENLGPYDIEVDESQIACQSPRTDHTNNLEIDEAMNPLNPNQLKGASSEGTFSFSGSCVSLAQLMG5i MENRNSSKVGRYEKLEKIGEGTYGTVFRGRDRDGSEVALKRIKLDDDEEGVPSSALREICLLRELRHKNVVRLLDVLHTDKKLTLVFEYCSVDLKRYFEIKGKLHAPEVSALFYQLLKGLSYCHAKSVLHRDLKPQNLLIHEGVLKLADFGLARAVGLPVRQYSNEVVTLWYRPPDVLLGARVYTFTVDSWSAGCIFAEIANSGTPLFPGQDIEDQLRIIFRLIGTPNDNEWPTMRRLPDYRPFPRFPAETNWSEQVPTLSETGIDLLKKMLMPNPQSRLTADQALMHQYFTMLNGNSRTLL ""[5 MDHVVGGKFKLGKKIGSGSFGELFLAVNVQTGEEVAVKLENVKTKHPQLHYESKLYMLLQGGTGIPHLKWFGVEGEYNVMVIDLLGPSLEDLFNYCSRKFSLKTVLMLADQMINRVEYMHQKGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKYRDLQTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQGLKAGTKKQKYDKISEKKMLTPVEVLCKSYPSEFISYFHYCRSLRFEDKPDYSYLKRLFRDLFIREGYQFDYVFDWTILKYPQIGSNPRMRAGERTSGAAGPSMDKIEKATGEAGGRRNLSGPVNQTDSYAQRPRETVSMSLKEIMHSTDRSGERTMERPRTSSRTGSASRRAVASSSRQASSVEPSEQQYSRASRLFSSNSGSRPSSTQRVNPSPGEARATSLSRAAVARGARDEPLHRSLELLSLGGGGKRK k U MHKYRLVAKKGEGTFSEVLKAQCIKNGKYVAIKCMKNHFDSLDQVNNLREIQALRRLSPHANIIKLLEVLYDQPTGRLALVFELMDMNIYELIRGRRHYVAEERIKNYMYQLMKSMDHMHRNGIFHRDIKPENILIMDDCLKLADFGSCRGIYSKQPYTEYISTRWYRAPECLLTDGYYNYKMDMWGVGCVFFEIVSLFPLFPGTNELDQITKIHNILGTPPPDLLAKMKKRSAHMDFNFPPKEGSGVAKLIPHVNPECVDLIVKLLMYNPDERLSARQALRHPYFRDLREAEKRQKALLAPDVSNHFTAMEADKARQQQTVSSTGSDHEHPTSAGGDGGAGTGAVGTHDGSAAAAAAAAALPSISGARGHAGPEGGHDNDMGGMDASGGGGGGGYGRLPGLAAQSSMASVDGDEASLPPIANLSLGKANMTGSTVGGAAHASTRRSTLNTYYEPGAGGGGGTGGAGGGGGGAGPGPAGYGKVAKAAAVGGAGSVAGGGGVVGGAGVGGGGAVGSGTVGRRQSVGVVVGKYGSVNKQASQGHGGGGPGVAGAAGMAVTGGHAGGGVGGGGGGAVGVGGVGVNKYKANVGKTNSKYISPYSLRQLAGQNAGQG yX / MDKMRILKESRPEIIVGGKYRVIRKIGSGSFGDIYLGMSIQSGEEVAIKMESAHARHPQLLYEAKLYRILSGGVGFPRIRHHGKEKNFNTLVMDLLGPSLEDLFNFCTRHFTIKTVLMLVDQMIGRLEYIHLKCFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKFRDPHTRHHIVYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVMMYFNRGVLPWQGMKANTKQQKYEKISEKKMSTPIEVLCKGSPAEFSMYLNYCRSLRFEEQPDYMYLRQLFRILFRTLNHQYDYIYDWTMLKQKTHQGQPNPAILLEQLDKDKEKQNGKPLIAD  MSDDSHLETKVVTDGTTGEKKTISYEPCRVLGSGSFGVVIQAKLVGTPGFIAVKRVLQDKRYKNRELQIMRAISHPNIIKLIAFFHTHNPSKDETHLCLLLEYMPETVFDDMRWYTRRRKSIPNLSIKLYAFQLFRALAYLHSTGVCHRDIKPQNLLVDYKTGILKLCDFGSAKVLVPSEPNVSYICSRYYRAPELVFGATHYTTKIDVWSAACVIAELFIGRPLFPGDSSVEQLVEIIRVLGTPSYHEISVMNPNYVNHSLPNVRPHTLESVMPHNCTKNAMDLLHKMLTYVPSKRISAIEVLTHPFFDELRDPNCMYHCSRDEGTIERHLPPLFNFNLAELSIRPNLNKAILPPHVYESLDVDINNFEPIVVKQADADS ,J$P@,h qqDrosophila.melanogaster.CK1c...gi.7292798.gb.AAF48Drosophila.melanogaster.CK1c...gi.7292798.gb.AAF48h qqSchizosaccharomyces.pombe.GSK3.1..Protein.kinase.gSchizosaccharomyces.pombe.GSK3.1..Protein.kinase.g> GGChlamydomonas.reinhardtii.LF4Chlamydomonas.reinhardtii.LF4hqqZea.mays.CK1a..gi.413939414.gb.AFW73965.1..putativZea.mays.CK1a..gi.413939414.gb.AFW73965.1..putativ:CCCandida.guilliermondii.IME2Candida.guilliermondii.IME2hqqOikopleura.dioica.CDK5..tr.J9JF51.J9JF51_OIKDI.CDKOikopleura.dioica.CDK5..tr.J9JF51.J9JF51_OIKDI.CDKhqqXenopus.laevis.CDK5..sp.P51166.CDK5_XENLA.Cyclin.dXenopus.laevis.CDK5..sp.P51166.CDK5_XENLA.Cyclin.dhqqMedicago.sativa.MAPK3..sp.Q07176.MMK1_MEDSA.MitogeMedicago.sativa.MAPK3..sp.Q07176.MMK1_MEDSA.Mitoge$--Danio.rerio.CDK1Danio.rerio.CDK1hqqDictyostelium.discoideum.SKY1..sp.Q86A12.SKY1_DICDDictyostelium.discoideum.SKY1..sp.Q86A12.SKY1_DICDJSSSchizosaccharomyces.octosporus.IME2Schizosaccharomyces.octosporus.IME2 6,r46hqqMus.musculus.CLK1..sp.P22518.CLK1_MOUSE.Dual.speciMus.musculus.CLK1..sp.P22518.CLK1_MOUSE.Dual.speci(11Aedes.aegypti.CDK1Aedes.aegypti.CDK1hqqHomo.sapiens.CLK3..Dual.specificity.protein.kinaseHomo.sapiens.CLK3..Dual.specificity.protein.kinasehqqSuberites.domuncula.JNK..Stress.activated.protein.Suberites.domuncula.JNK..Stress.activated.protein.hqqGaldieria.suphuraria.CK1..gi.545709990.ref.XP_0057Galdieria.suphuraria.CK1..gi.545709990.ref.XP_0057hqqArabidopsis.thaliana.CK2a2..sp.Q08466.CSK22_ARATH.Arabidopsis.thaliana.CK2a2..sp.Q08466.CSK22_ARATH.hqqCandida.albicans.MAPK3..Extracellular.signal.regulCandida.albicans.MAPK3..Extracellular.signal.regulNWWSchizosaccharomyces.octosporus.b.IME2Schizosaccharomyces.octosporus.b.IME2h qqHomo.sapiens.CDK8..Cyclin.dependent.kinase.8.OS.HoHomo.sapiens.CDK8..Cyclin.dependent.kinase.8.OS.Hoh qqSaccharmomyces.cerevisiae.CK1..gi.433622.emb.CAA42Saccharmomyces.cerevisiae.CK1..gi.433622.emb.CAA42 ) Q MSQVQSPLTATNSGLAVNNNTMNSQMPNRSNVRLVNGTLPPSLHVSSNLNHNTGNSSASYSGSQSRDDSTIVGLHYKIGKKIGEGSFGVLFEGTNMINGLPVAIKFEPRKTEAPQLKDEYRTYKILAGTPGIPQEYYFGQEGLHNILVIDLLGPSLEDLFDWCGRRFSVKTVVQVAVQMITLIEDLHAHDLIYRDIKPDNFLIGRPGQPDANKVHLIDFGMAKQYRDPKTKQHIPYREKKSLSGTARYMSINTHLGREQSRRDDMEAMGHVFFYFLRGQLPWQGLKAPNNKQKYEKIGEKKRLTNVYDLAQGLPIQFGRYLEIVRNLSFEETPDYEGYRMLLLSVLDDLGETADGQYDWMKLNGGRGWDLSINKKPNLHGYGHPNPPNEKSKRHRSKNHQYSSPDHHHHYNQQQQQQQAQAQAQAQAQAKVQQQQLQQAQAQQQANRYQLQPDDSHYDEEREASKLDPTSYEAYQQQTQQKYAQQQQKQMQQKSKQFANTGANGQTNKYPYNAQPTANDEQNAKNAAQDRNSNKSSKGFFSKLGCC &&W - MDYDFKVKLSSERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDKDYALKQIEGTGISMSACREIALLRELKHPNVISLQKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKANKKPVQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLLQKLLTMDPIKRITSEQAMQDPYFLEDPLPTSDVFAGCQIPYPKREFLTEEEPDDKGDKKNQQQQQGNNHTNGTGHPGNQDSSHTQGPPLKKVRVVPPTTTSGGLIMTSDYQRSNPHAAYPNPGPSTSQPQSSMGYSATSQQPPQYSHQTHRY J MSKEIPFSSLNLKEFRFEDRYYVKHKLGDGSFGTVYLAKCKGKQGHDQVVLRQISKHPSLIDLLETFMDPNRNIYLVMECMEANLYQILKRRQGKPFTKYTACHILNQIVRGIEHIHTHGFMHRDVKPENILVKKVTDRPVFSRYSVKIADFGLARSSTSDDSLTEYVSTRWYRAPELLLRAKNYGKAVDMYAFGCITFEVFTLKPLFPGRNETDQLNRICEILGNPLLNVKDKLHYWPTAKELAVKLGFSFSATRPYPLRKLLPANCDDMYTEMIAQLLAWDPFIRPSAVSCKEKYFPKPPESPNGQQGTKLGSTKVNNIGSSKNDATVKPNNEKRQEKRVSWFKKNLNSLTNAVKMALPEAPPPHLPRKSVKLVSDEKDSQMCNFLMSETMNSNESPAKIKQPETISCELVESRLLPVYEQQSSHLMSKTDQSILQVNPEISIESLPAEPKKCVNHVPNRDENKACEEVNWSRATFFHDNKLYKPPISLNLKTDSCLKLPSDYDTAVGTPKDAMGQGLKIIGINHSLIPRPVRRNHGAPDFQASRSISCQAYPNFMVYNPSSPVRINRSTSEGFSKG W3 MHLIFFFSYFLRRYLLLLCAILILRAPLAHSLIPPLTCVNTGTVESDVTGIRFDRCLDTDSLAKISLSTVMSKARVYTDVNVIRPKDYWDYESLNVQWGEQDDYEVVRKVGRGKYSEVFEGINMNNNEKCIIKILKPVKKKKIRREIKILQNLCGGPNIVKLLDVVRDQHSKTPSLIFEYVNSTDFKVLYPTLTDYDIRYYIYELLKALDFCHSQGIMHRDVKPHNVMIDHELRKLRLIDWGLAEFYHPGKEYNVRVASRYFKGPELLVDLQDYDYSLDMWSLGCMFAGMIFRKEPFFYGHDNQDQLVKIAKVLGTDELNAYLNKYQLELDTQLEALVGRHSRKPWSKFINADNRHLVSPEAIDYLDKLLRYDHQDRLTAKEAMAHPYFAQVRAAESSRMRTQ&K MNIDQHHQLQQQHQQQMLQQQAQAQAQAQAQAQQQQQAAAAAAAANAAATTSSSPRQVSFNVSDHYQILEIVGEGAYGIVCSAIHKPSQQKVAIKKIEPFERSMLCLRTLRELKLLKHFNHENIISILAIQRPINYESFNEIYLIQELMETDLHRVIRTQNLSDDHIQYFIYQTLRALKAMHSANVLHRDLKPSNLLLNSNCDLKICDFGLARSIASQEDNYGFMTEYVATRWYRAPEIMLTFQEYTTAIDVWSVGCILAEMLSGRPLFPGRDYHNQLWLIMEVLGTPNMEDYYNIKSKRAREYIRSLPFCKKIPFSELFANTNNNTSTSNTGGRTNINPLALDLLEKLLIFNPAKRITVEDALKHPYLQLYHDPNDEPISDKIPEDFFDFDKMKDQLTIEDLKKLLYEEIMKPL cc3 MCNGFLSCVAVLAAFFVLGNRQAKEPSGSTNRERFLFTSENKGRRFAHTDFRNKHSRENSTSFATSPSLKHPSQQQERKTELELSSSVEAFSSSLAVSRDRKASQVENVLEETEQFRKEQSGQPSRSLGRIEGTCVETTAETKKLESYSRTPLEGTLEYPLCLNREQAVPTISASRQGISKEEELETRPVAEQETLEKITAQKRNNGFFDKTAELQGSTNFISSSENRENLDRKLFRMGEKSSRSDRVVAGKWRLGRKIGSGSFGEIYLGTNIYTMEEVALKFETAKTKHPQLLYESKIYRYLAISPCGQPVVGFPTVKWYGQEGDFNVMAMELLGPSLEDLFNFCHRKFSLKTVLMIAIQTITRIEYIHSRSFIHRDIKPDNFLMGLGKHSETIYLIDFGLSKRYRDPKTHVHIPYREGKNLTGTARYASINTHLGLEQSRRDDLESLGYVLMYFNRGSLPWQGLKAATKKQKYQKISDKKANTPIEVLCKGYPAEFAIYLNYCRSLKFEEKPDYDYLRSIFQALYRKKGFPDDYVFDWTALTRNASSSLRANATAVHRETKNRDDSLAVALDQQQEERILDHTERLESSGIGTAPILSSPLVKEEETSRRMLGEGGVDTLKDSKQNVVSNSPNASHVLNAGIGGKDISLFSNSRNRR p_ MSSSDYYSQRVGDTVFTVQKRYTNLTNIGSGAQGVVCSAFDTVTQEKIAIKKLVKPFQNETYAKRAFRELRLMKMVDHKNIIGLKNLFTPAKSLDDFQDVYIVMELMDANLCRVIGIELDHDRMSYLLYQLLCGIKHLHSAGIIHRDLKPSNIVVKEDCSLKILDFGLARTADQTFNMTPYVVTRYYRAPEVIVGMKYKENVDIWSVGCIFAEMIRGDILLPGKDYIDQWNKVTQVLGTPPSVFFKQLSSSVRLYCESQPRYAGKSWKDLFPDDVFPNDTPEDKAKTRHGRDLLSKMLQIDPQNRITVEQALAHPYVSIWYDPAEVHAPPPKRYDHALDEQSIPLDQWKTRIYEEVKTYNS OxO&K MEDFQKIEKIGEGTYGVVYKGRNKLTGQIVAMKKIRLESEDEGIPSTAIREISLLKELKHPNIVSLEDVLMEENRLYLIFEFLSMDLKKYMDTLPPEKMMDSDLVKSYMYQITAALLFCHKRRVLHRDLKPQNLLINKEGLIKVADFGLGRSFNIPVRNYTHEIVTLWYRAPEVLLGSPRYACPVDIWSIGCIFAEMTTRKPLFQGDSEIDQLFRMFRILKTPTEEIWPGVTSLPDYKPTFPCWTQNNLTSQVKNLDSAGLDLLQKCLIYDPVHRISAKKILEHKYF MPVLSARRRELADHAGSGRRSGPSPTARSGPHLSALRAQPARAAHLSGRGTYVRRDTAGGGPGQARPLGPPGTSLLGRGARRSGEGWCPGAFESGARAARPPSRVEPRLATAASREGAGLPRAEVAAGSGRGARSGEWGLAAAGAWETMHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR ;^:r8To=Acyrthosiphon.pisum.CDK11Aedes.aegypti.CDK17qAedes.aegypti.CDK8..Cyclin.dependent.kinase.8.OS.A CAjellomyces.capsulatus.CDK1"GAmphimedon.queenslandica.CDK1&6qAncylostoma.caninum.MAPK8.sp.Q9U6D2.JNK1_ANCCA.Stro6qArabidopsis.thaliana.CK1..gi.332659757.gb.AEE8515736qArabidopsis.thaliana.CK2a..sp.Q08467.CSK21_ARATH.C56qArabidopsis.thaliana.CK2a2..sp.Q08466.CSK22_ARATH.7qArabidopsis.thaliana.CSK2a1..gi.30698301.ref.NP_206qArabidopsis.thaliana.SRPK1..tr.Q9FYB4.Q9FYB4_ARATH"5Ashbya.gossypii.IME206qAshbya.gossypii.SSN3..Serine.threonine.protein.kinrAAspergillus.fumigatus.IME2?Aspergillus.nidulans.IME2I9Aspergillus.niger.IME29Bombus.terrestris.CDK1*7qBos.taurus.CDK10..sp.Q2TBL8.CDK10_BOVIN.Cyclin.dep7qBos.taurus.MAPK7..sp.A5PKJ4.MK07_BOVIN.Mitogen.act CBranchiostoma.floridae.CDK1 wVVw2j7qCaenorhabditis.elegans.MBK1..Dual.specificity.tyroF6qCaenorhabditis.briggsae.CDK2..tr.A8XL31.A8XL31_CAEs7qCaenorhabditis.briggsae.CDK4..tr.Q8MUK2.Q8MUK2_CAE 7qCaenorhabditis.briggsae.DYRK1..Dual.specificity.ty7qCaenorhabditis.briggsae.GSK3..sp.A8X5H5.GSK3_CAEBR7qCaenorhabditis.briggsae.NLK..sp.A8XSC1.NLK_CAEBR.S CCaenorhabditis.elegans.CDK16qCaenorhabditis.elegans.CSK2a..sp.P18334.CSK2A_CAEEj7qCaenorhabditis.elegans.GSK3..sp.Q9U2Q9.GSK3_CAEEL. 7qCaenorhabditis.elegans.MAPK8.sp.Q8WQG9.JNK1_CAEEL.6qCaenorhabditis.elegans.NLK..sp.Q9U9Y8.NLK_CAEEL.SeK7Candida.albicans.CDK17Candida.albicans.IME26qCandida.albicans.MAPK3..Extracellular.signal.regul7qCandida.albicans.SSN3..Serine.threonine.protein.ki?Candida.dubliniensis.IME27Candida.glabrata.IME2CCandida.guilliermondii.IME2;Candida.lusitaniae.IME2ACandida.orthopsilosis.IME2m ;^:r8To=Acyrthosiphon.pisum.CDK11Aedes.aegypti.CDK17qAedes.aegypti.CDK8..Cyclin.dependent.kinase.8.OS.A CAjellomyces.capsulatus.CDK1"GAmphimedon.queenslandica.CDK1&6qAncylostoma.caninum.MAPK8.sp.Q9U6D2.JNK1_ANCCA.Stro6qArabidopsis.thaliana.CK1..gi.332659757.gb.AEE8515736qArabidopsis.thaliana.CK2a..sp.Q08467.CSK21_ARATH.C56qArabidopsis.thaliana.CK2a2..sp.Q08466.CSK22_ARATH.7qArabidopsis.thaliana.CSK2a1..gi.30698301.ref.NP_206qArabidopsis.thaliana.SRPK1..tr.Q9FYB4.Q9FYB4_ARATH"5Ashbya.gossypii.IME206qAshbya.gossypii.SSN3..Serine.threonine.protein.kinrAAspergillus.fumigatus.IME2?Aspergillus.nidulans.IME2I9Aspergillus.niger.IME29Bombus.terrestris.CDK1*7qBos.taurus.CDK10..sp.Q2TBL8.CDK10_BOVIN.Cyclin.dep7qBos.taurus.MAPK7..sp.A5PKJ4.MK07_BOVIN.Mitogen.act CBranchiostoma.floridae.CDK1 wVVw2j7qCaenorhabditis.elegans.MBK1..Dual.specificity.tyroF6qCaenorhabditis.briggsae.CDK2..tr.A8XL31.A8XL31_CAEs7qCaenorhabditis.briggsae.CDK4..tr.Q8MUK2.Q8MUK2_CAE 7qCaenorhabditis.briggsae.DYRK1..Dual.specificity.ty7qCaenorhabditis.briggsae.GSK3..sp.A8X5H5.GSK3_CAEBR7qCaenorhabditis.briggsae.NLK..sp.A8XSC1.NLK_CAEBR.S CCaenorhabditis.elegans.CDK16qCaenorhabditis.elegans.CSK2a..sp.P18334.CSK2A_CAEEj7qCaenorhabditis.elegans.GSK3..sp.Q9U2Q9.GSK3_CAEEL. 7qCaenorhabditis.elegans.MAPK8.sp.Q8WQG9.JNK1_CAEEL.6qCaenorhabditis.elegans.NLK..sp.Q9U9Y8.NLK_CAEEL.SeK7Candida.albicans.CDK17Candida.albicans.IME26qCandida.albicans.MAPK3..Extracellular.signal.regul7qCandida.albicans.SSN3..Serine.threonine.protein.ki?Candida.dubliniensis.IME27Candida.glabrata.IME2CCandida.guilliermondii.IME2;Candida.lusitaniae.IME2ACandida.orthopsilosis.IME2m zs MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISRjS MRHSKRTYCPDWDERDWDYGTWRSSSSHKRKKRSHSSAREQKRCRYDHSKTTDSYYLESRSINEKAYHSRRYVDEYRNDYMGYEPGHPYGEPGSRYQMHSSKSSGRSGRSSYKSKHRSRHHTSQHHSHGKSHRRKRSRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKVGGRRVAVKIVKNVDRYCEAAQSEIQVLEHLNTTDPHSTFRCVQMLEWFEHRGHICIVFELLGLSTYDFIKENSFLPFRMDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVKSDYTEAYNPKMKRDERTIVNPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSREHLAMMERILGPLPKHMIQKTRKRRYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDAEHELLFDLIGKMLEYDPAKRITLKEALKHPFFYPLKKHT f,X,Xf<EEDrosophila.melanogaster.CDK1Drosophila.melanogaster.CDK1hqqZea.mays.CK1b..gi.226502995.ref.NP_001148106.1..caZea.mays.CK1b..gi.226502995.ref.NP_001148106.1..caHQQStrongylocentrotus.purpuratus.CDK1Strongylocentrotus.purpuratus.CDK1hqqDrosophila.melanogaster.MAPK3..sp.P40417.ERKA_DROMDrosophila.melanogaster.MAPK3..sp.P40417.ERKA_DROMhqqHomo.sapiens.CSK2a2..sp.P19784.CSK22_HUMAN.Casein.Homo.sapiens.CSK2a2..sp.P19784.CSK22_HUMAN.Casein.*33Nosema.ceranae.CDK1Nosema.ceranae.CDK1hqqGallus.gallus.CDKL1..tr.E1C5K5.E1C5K5_CHICK.UncharGallus.gallus.CDKL1..tr.E1C5K5.E1C5K5_CHICK.UncharhqqHomo.sapiens.HIPK1..Homeodomain.interacting.proteiHomo.sapiens.HIPK1..Homeodomain.interacting.proteihqqHomo.sapiens.DYRK4..Dual.specificity.tyrosine.phosHomo.sapiens.DYRK4..Dual.specificity.tyrosine.phoshqqHomo.sapiens.CLK2..Dual.specificity.protein.kinaseHomo.sapiens.CLK2..Dual.specificity.protein.kinase ""A MASQLQVFSPPSVSSSAFCSAKKLKIEPSGWDVSGQSSNDKYYTHSKTLPATQGQANSSHQVANFNIPAYDQGLLLPAPAVEHIVVTAADSSGSAATSTFQSSQTLTHRSNVSLLEPYQKCGLKRKSEEVDSNGSVQIIEEHPPLMLQNRTVVGAAATTTTVTTKSSSSSGEGDYQLVQHEILCSMTNSYe MPASELKASEIPFHPSIKTQDPKAEEKSPKKQKVTLTAAEALKLFKNQLSPYEQSEILGYAELWFLGLEAKKLDTAPEKFSKTSFDDEHGFYLKVLHDHIAYRYEVLETIGKGSFGQVAKCLDHKNNELVALKIIRNKKRFHQQALMELKILEALRKKDKDNTYNVVHMKDFFYFRNHFCITFELLGINLYELMKNNNFQGFSLSIVRRFTLSVLKCLQMLSVEKIIHCDLKPENIVLYQKGQASVKVIDFGSSCYEHQKVYTYIQSRFYRSPEVILGHPYDVAIDMWSLGCITAELYTGYPLFPGENEVEQLACIMEVLGLPPAGFIQTASRRQTFFDSKGFPKNITNNRGKKRYPDSKDLTMVLKTYDTSFLDFLRRCLVWEPSLRMTPDQALKHAWIHQSRNLKPQPRPQTLRKSNSFFPSETRKDKVQGCHHSSRKADEITKETTEKTKDSPTKHVQHSGDQQDCLQHGADTVQLPQLVDAPKKSEAAVGAEVSMTSPGQSKNFSLKNTNVLPPIVEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQIEVSILSRLSSENADEYNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILQQVATALMKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDPNLGYPLWRLKTPEEHELETGIKSKEARKYIFNCLDDMAQVNMSTDLEGTDMLAEKADRREYIDLLKKMLTIDADKRITPLKTLNHQFVTMTHLLDFPHSNHVKSCFQNMEICKRRVHMYDTVSQIKSPFTTHVAPNTSTNLTMSFSNQLNTVHNQASVLASSSTAAAATLSLANSDVSLLNYQSALYPSSAAPVPGVAQQGVSLQPGTTQICTQTDPFQQTFIVCPPAFQTGLQATTKHSGFPVRMDNAVPIVPQAPAAQPLQIQSGVLTQGSCTPLMVATLHPQVATITPQYAVPFTLSCAAGRPALVEQTAAVLQAWPGGTQQILLPSTWQQLPGVALHNSVQPTAMIPEAMGSGQQLADWRNAHSHGNQYSTIMQQPSLLTNHVTLATAQPLNVGVAHVVRQQQSSSLPSKKNKQSAPVSSKSSLDVLPSQVYSLVGSSPLRTTSSYNSLVPVQDQHQPIIIPDTPSPPVSVITIRSDTDEEEDNKYKPSSSGLKPRSNVISYVTVNDSPDSDSSLSSPYSTDTLSALRGNSGSVLEGPGRVVADGTGTRTIIVPPLKTQLGDCTVATQASGLLSNKTKPVASVSGQSSGCCITPTGYRAQRGGTSAAQPLNLSQNQQSSAAPTSQERSSNPAPRRQQAFVAPLSQAPYTFQHGSPLHSTGHPHLAPAPAHLPSQAHLYTYAAPTSAAALGSTSSIAHLFSPQGSSRHAAAYTTHPSTLVHQVPVSVGPSLLTSASVAPAQYQHQFATQSYIGSSRGSTIYTGYPLSPTKISQYSYL ]]6k MSFICIPMSDSFQKIEKIGEGTYGVVYKAKERKTGKIVALKKIRLENESEGIPPTTIREILLLKNLKHPTIVSLDDVIYNINKMYLVFEYIDMDLRQYLDNLYREEKLMDLNILKKMVYQLITAIHFCHSKNIFHRDLKPQNLLIDTYGNLKLADFGLARLASIPLRTYTTEVVTLWYRPPDLLLGSKHYDSSVDVWSAACIIAEMILLRPLFSGDSEIEQLLKIFKILGTPSNVNWKNVESLPNYQASFPKYKAIPLGEILTIDEDLINLLENMFIYDPIIRISAQQALNHKFFEDFVAFNNgM MERYEKLGKVGEGSYGVVFKCRNRETGQIVAIKKFLESEEDPVIRKIALREVRMLKQLKHPNLVNLLEVFRRKRKLHLVFEYCDHTVLHELDKHPRGVPEQLVRSITWQTLQAVNFCHKHNCIHRDVKPENILITKHSVIKLCDFGFARMLTGPGDYYTDYVATRWYRSPELLVGDTQYGPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRRTLGDLIPRHQQVFSTNQFFSGVTIPDPESMEPLEMKFPSISYPALALMKGCLHMDPAERQTCEQLLQHPYFDSVREAGDVGKEHEKAARRPAKLTRKHVPGFQYLPQLSSSNVLPALDSKKYFCKTRKSNYHFPNI } MEEFNSSGSVVNGTGSTEVPQSNAEVIRGQIFEVGPRYIKLAYIGEGAYGMVVSADDTLTNQRVAIKKISPFEHQTYCQRTLREITILTRFKHENIIDIRDILRVDSIDQMRDVYIVQCLMETDLYKLLKTQRLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNKTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGVLGSPSRDDLECIINEKARNYLESLPFKPNVPWAKLFPNADALALDLLGKMLTFNPHKRIPVEEALAHPYLEQYYDPGDEPVAEVPFRINMENDDISRDALKSLIFEETLKFKERQPDNAPeI MPGPAAGSRARVYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYPVVKEQSQPCADNAVLSSGLTAAR ##%I MDRIVGSKYKLGRKIGSGSFGEIYLATHVDTYEIVAVKIESSKTNHPQLLYEAKLYNALQGGTGIANIKWCGIDGDENILVIDLLGPSLEDLFVYCGRRFSLKTVLMLADQMITRIEFMHSKGYLHRDIKPDNFLMGLGRKANQVYVIDFGLAKRYRDSATNRHIPYRENKNLTGTARYASRNTHLGIEQSRRDDLESIGYVLLYFLRGSLPWQGLKAATKKQKYDKISEKKLSTPIEALCKSHPVEFASYFHYCHSLTFDQRPDYSFLRHVFRELFEREGYQFDYVYDWTLLKCKQSQKAKVQQGCSHDAGVSSRPVATNVDKHQVGVARPINASGLLEAEQRPAIRMQLNSRSNNLHPERLGVSASHNNVLLQSTSLDNADAPMDHATHSKAQGSIDPHTRGSYSPGPSNRT2c MNNFEKIEKIGEGTYGVVYKARDLKSGKTVALKKIRLDTESEGVPSTAIREIALLKELDHKNIVKLHDVVHSDKKLYLVFEFMNQDLKKYMDVAPPSGLPPGLVKSYLHQLLQGIAFCHAHRVLHRDLKPQNLLIDADGRIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCRYYSTAVDIWSLGCIFVEMITRRALFPGDSEIDQLFRIFRTMGTPDEKLWPGVTSLPDYKTSFPRWTPQDFTKIVPMLNKDGKDLLKSMLCYEPDKRISAKTGLSHPYFKDVKMVPPPRLPT y q MIKKVGSGAFGEIYKGINLKTGEECAIKLEPAKTKYPQLYYEAKLYKIFDGAVGLPKLYYYSQEGDYNVMVIDLLGPSLEELFEYCRRKFTLKTVLMIAIQMLQRIEFVHQNGFLHRDIKPDNYLIGSGKNQHIIYIIDFGLAKRYKDPKTGRHISFKDNKSLTGTARYASLNTHLGIEQARRDDLEQIGIVLMYFLRGNLPWQGLPAKTKEEKYEQIKIKKAVTSIEDLTAGYPKEFQQYLNYSRKLKFEEKPDYQQVISMFRELFVREGFDFDFMYDWILKKQAMKQRLAASTRNTQRVEEEKKNTIDQANRANNTQQNQHRDLQNNSSLVQGLQTITGNFQYNNDYQPVQQQPIIQSKLRESASMIRNPNDIMMKYNSNGRQPSVENTNMLQSLTQGQSTSNQFYLQQNKMSNDQQMKNRQMRNEFKSSAQHILDGQAGAVPLPNIAKQNSNSNTRVNSQLNNKRLESNASQMLSQPFSMGLQSQNMMNSYYQNR0_ MEDFEKIEKIGEGTYGVVYKGRNRLTGQIVAMKKIRLESDDEGVPSTAIREISLLKELKHENIVCLEDVLMEENRIYLIFEFLSMDLKKYMDSLPVDKHMESELVRSYLYQITSAILFCHRRRVLHRDLKPQNLLIDKSGLIKVADFGLGRSFGIPVRIYTHEIVTLWYRAPEVLLGSPRYSCPVDIWSIGCIFAEMATRKPLFQGDSEIDQLFRMFRILKTPTEDIWPGVTSLPDYKNTFPCWSTNQLTNQLKNLDANGIDLIQKMLIYDPVHRISAKDILEHPYFNGFQSGLVRN F,XFh(qqHomo.sapiens.MAPK13..sp.O15264.MK13_HUMAN.Mitogen.Homo.sapiens.MAPK13..sp.O15264.MK13_HUMAN.Mitogen.h'qqTakifugu.rubripes.MAPK10..tr.H2U861.H2U861_TAKRU.UTakifugu.rubripes.MAPK10..tr.H2U861.H2U861_TAKRU.Uh&qqHomo.sapiens.CDKL2..Cyclin.dependent.kinase.like.2Homo.sapiens.CDKL2..Cyclin.dependent.kinase.like.2h%qqTetradon.nigroviridis.MAPK10..tr.H3CCC1.H3CCC1_TETTetradon.nigroviridis.MAPK10..tr.H3CCC1.H3CCC1_TETh$qqCrassostrea.gigas.PFTAIRE..tr.K1Q2C8.K1Q2C8_CRAGI.Crassostrea.gigas.PFTAIRE..tr.K1Q2C8.K1Q2C8_CRAGI.h#qqHomo.sapiens.CDK18..sp.Q07002.CDK18_HUMAN.Cyclin.dHomo.sapiens.CDK18..sp.Q07002.CDK18_HUMAN.Cyclin.dh"qqArabidopsis.thaliana.SRPK1..tr.Q9FYB4.Q9FYB4_ARATHArabidopsis.thaliana.SRPK1..tr.Q9FYB4.Q9FYB4_ARATHh!qqDictyostelium.discoideum.CK1..sp.Q556Y4.KC1_DICDI.Dictyostelium.discoideum.CK1..sp.Q556Y4.KC1_DICDI.h qqOxytricha.trifallax.CK..gi.403365855.gb.EJY82718.1Oxytricha.trifallax.CK..gi.403365855.gb.EJY82718.1 L="y "MSCSSSSGSEGEEEGFDAYRKGGYHAVRVGDPFSGGRYIAQRKLGWGQFSTVWLAYDTLTSTYVALKIQKSAQQFAQAALHEIEFLSAAADGDLDKTKCVVRLIDHFKHSGPNGQHLCMVLEFLGDSLLRLIRYNQYKGLKLNKVREICRCILTGLDYLHRELGMIHSDLKPENILLCSTIDPAKDPVRSGLTPLLEKPEGNANGGASTMNLIEKKLKRRAKRAVAKISERRVSMVTGEEASSKTEKSLDGIDMRCKVVDFGNACWADKQFAEEIQTRQYRAPEVILKSGYSFSVDMWSFGCTAFELVTGDMLFAPKDGNGYGEDEDHLALMMELLGKMPRKIAIGGAKSKDYFDRHGDLKRIRRLKYWPLDRLLIDKYKLPEAEAKEFAEFLIPTLEFAPEKRPTAQQCLDHPWMNVTTQNDAENVDDQMNNLHIKG1!a !MDLRIGGKYRISRKIGGGSFGEIYLGTNISTNEEVAIKLEPAKAIHPQLLFESKLYKIFQGGIGIPAVKWFGFDGDYNIMVMDLLGPSLEDLFNYCGRKFSLKTVLMLGDQMLRRIEFIHSNNFIHRDIKPDNFLMGIGKRGHVVNLIDFGLAKRYRDPKTHQHIPYREHKNLTGTARYASLNTHQGIEQSRRDDLESLGYVLMYFNRGSLPWQGLKAYTKRDKYEKICDKKAQTKIDTLCQGFPSEFATFLNYTRFLKFEDKPDFLYLRKLLREMFVREGYRYDYMFDWVIVRKLREKPPLERPLSNDNKQIQQQIQQQQQAQQQLQQQAQQQQQQTTTTTTTSSSQPSNVKNISTVSNIATTTTDEQFRQLLSTPSYNNVDSDQSPQQTTTTTSSSNPNQTTFYRQNKVVVPQSSSTTTKPPAK _#= #MNKMKNFKRRFSLSVPRTETIEESLAEFTEQFNQLHNRRNENLQLGPLGRDPPQECSTFSPTDSGEEPGQLSPGVQFQRRQNQRRFSMEDVSKRLSLPMDIRLPQEFLQKLQMESPDLPKPLSRMSRRASLSDIGFGKLETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHEEGAPCTAIREVSLLKNLKHANIVTLHDLIHTDRSLTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMFQLLRGLAYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEYSTPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSEFRTYSFPCYLPQPLINHAPRLDTDGIHLLSSLLLYESKSRMSAEAALSHSYFRSLGERVHQLEDTASIFSLKEIQLQKDPGYRGLAFQQPGRGKNRRQSIF ^$; 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(MSLIRKKGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDPEEETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVNFSPIARKDSRRRSGMKLW'- 'MSRHFLYNCSQPILDVKIAFCQGFGQQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAGYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKSLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPSPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDCLFPADSEHNKLKASQARDLLSKMLIIDPAKRISVDEALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHSIDEWKELIYKEVMNFEERTKNGVVKGQPSPSGAAVNSSESPPPSSSINDISSMSTDQTLASDTDSSLETSAGPLGCCR %%Bz Ce!Y;Candida.tropicalis.CDK17qCarassius.auratus.CDK2..sp.P43450.CDK2_CARAU.CycliB7qCarassius.auratus.CDK7..sp.P51953.CDK7_CARAU.Cycli!GChlamydomonas.reinhardtii.LF4 7qCordyceps.militaris.GSK3..tr.G3JGQ8.G3JGQ8_CORMM.P 6qCrassostrea.gigas.PFTAIRE..tr.K1Q2C8.K1Q2C8_CRAGI.$!ECryptococcus.neoformans.IME27qCryptococcus.neoformans.SSN3..Serine.threonine.pro-Danio.rerio.CDK17qDanio.rerio.CDK20.sp.A8WIP6.CDK20_DANRE.Cyclin.dep6qDanio.rerio.CDK7..tr.Q6NWC5.Q6NWC5_DANRE.Cdk7.protn7qDanio.rerio.CDK8..Cyclin.dependent.kinase.8.OS.Dan7qDanio.rerio.CDKL1..sp.Q6AXJ9.CDKL1_DANRE.Cyclin.de6qDanio.rerio.CDKL5..tr.B9X2H6.B9X2H6_DANRE.Cyclin.d:7qDanio.rerio.CK2a1..gi.40538752.ref.NP_571327.1..ca %%Bz Ce!Y;Candida.tropicalis.CDK17qCarassius.auratus.CDK2..sp.P43450.CDK2_CARAU.CycliB7qCarassius.auratus.CDK7..sp.P51953.CDK7_CARAU.Cycli!GChlamydomonas.reinhardtii.LF4 7qCordyceps.militaris.GSK3..tr.G3JGQ8.G3JGQ8_CORMM.P 6qCrassostrea.gigas.PFTAIRE..tr.K1Q2C8.K1Q2C8_CRAGI.$!ECryptococcus.neoformans.IME27qCryptococcus.neoformans.SSN3..Serine.threonine.pro-Danio.rerio.CDK17qDanio.rerio.CDK20.sp.A8WIP6.CDK20_DANRE.Cyclin.dep6qDanio.rerio.CDK7..tr.Q6NWC5.Q6NWC5_DANRE.Cdk7.protn7qDanio.rerio.CDK8..Cyclin.dependent.kinase.8.OS.Dan7qDanio.rerio.CDKL1..sp.Q6AXJ9.CDKL1_DANRE.Cyclin.de6qDanio.rerio.CDKL5..tr.B9X2H6.B9X2H6_DANRE.Cyclin.d:7qDanio.rerio.CK2a1..gi.40538752.ref.NP_571327.1..ca 0dBn0h2qqDrosophila.melanogaster.CK1a...gi.22832152.gb.AAN0Drosophila.melanogaster.CK1a...gi.22832152.gb.AAN0h1qqLeishmania.infantum.GSK3..tr.A4HXQ3.A4HXQ3_LEIIN.GLeishmania.infantum.GSK3..tr.A4HXQ3.A4HXQ3_LEIIN.Gh0qqTrypanosoma.brucei.GSK3..Glycogen.synthase.kinase.Trypanosoma.brucei.GSK3..Glycogen.synthase.kinase.h/qqMus.musculus.MOK..MAPK.MAK.MRK.overlapping.kinase.Mus.musculus.MOK..MAPK.MAK.MRK.overlapping.kinase.h.qqHomo.sapiens.CDK12..sp.Q9NYV4.CDK12_HUMAN.Cyclin.dHomo.sapiens.CDK12..sp.Q9NYV4.CDK12_HUMAN.Cyclin.dh-qqXenopus.laevis.MAPK8.sp.Q8QHK8.MK08_XENLA.Mitogen.Xenopus.laevis.MAPK8.sp.Q8QHK8.MK08_XENLA.Mitogen.h,qqGallus.gallus.CDKL2..tr.E1C431.E1C431_CHICK.UncharGallus.gallus.CDKL2..tr.E1C431.E1C431_CHICK.UncharL+UUHomo.sapiens.SRSF.GN.SRPK1.PE.1.SV.2Homo.sapiens.SRSF.GN.SRPK1.PE.1.SV.20*99Bombus.terrestris.CDK1Bombus.terrestris.CDK1h)qqHomo.sapiens.NLK..sp.Q9UBE8.NLK_HUMAN.Serine.threoHomo.sapiens.NLK..sp.Q9UBE8.NLK_HUMAN.Serine.threo 2*c *MDNFVKIEKIGEGTYGVVYKAKDKLTGKLVALKKIRLETESEGVPSTAIREISLLRELTHPNIVQLFDVVDGDNHLYLVFEFLQQDLKKLLDSVKGGLDQALVKSYLYQLLKAISFCHLHCILHRDLKPQNLLIDREGHIKLADFGLARTFGVPVRTYTHEIVTLWYRAPEILLGTKLYSNAVDVWSLGCIFAEMATRRALFPGDSEIDQLFRIFRTLGTPDENIWPGVSQLRDYTSMFPRWEPRPLDEVVPSFDSDAKDLLLKLLTYDPNQRITAKKGLSHPYFTGVTLVPPPLPKKT)+ )MSLCGARANAKMMAAYNGGTSAAAAGHHHHHHHHLPHLPPPHLHHHHHPQHHLHPGSAAAVHPVQQHTSSAAAAAAAAAAAAAMLNPGQQQPYFPSPAPGQAPGPAAAAPAQVQAAAAATVKAHHHQHSHHPQQQLDIEPDRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQPPHIDYFEEIYVVTELMQSDLHKIIVSPQPLSSDHVKVFLYQILRGLKYLHSAGILHRDIKPGNLLVNSNCVLKICDFGLARVEELDESRHMTQEVVTQYYRAPEILMGSRHYSNAIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPSLEAMRTACEGAKAHILRGPHKQPSLPVLYTLSSQATHEAVHLLCRMLVFDPSKRISAKDALAHPYLDEGRLRYHTCMCKCCFSTSTGRVYTSDFEPVTNPKFDDTFEKNLSSVRQVKEIIHQFILEQQKGNRVPLCINPQSAAFKSFISSTVAQPSEMPPSPLVWE gg++ +MERKVLALQARKKRTKAKKDKAQRKSETQHRGSAPHSESDLPEQEEEILGSDDDEQEDPNDYCKGGYHLVKIGDLFNGRYHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTETALDEIRLLKSVRNSDPNDPNREMVVQLLDDFKISGVNGTHICMVFEVLGHHLLKWIIKSNYQGLPLPCVKKIIQQVLQGLDYLHTKCRIIHTDIKPENILLSVNEQYIRRLAAEATEWQRSGAPPPSGSAVSTAPQPKPADKMSKNKKKKLKKKQKRQAELLEKRMQEIEEMEKESGPGQKRPNKQEESESPVERPLKENPPNKMTQEKLEESSTIGQDQTLMERDTEGGAAEINCNGVIEVINYTQNSNNETLRHKEDLHNANDCDVQNLNQESSFLSSQNGDSSTSQETDSCTPITSEVSDTMVCQSSSTVGQSFSEQHISQLQESIRAEIPCEDEQEQEHNGPLDNKGKSTAGNFLVNPLEPKNAEKLKVKIADLGNACWVHKHFTEDIQTRQYRSLEVLIGSGYNTPADIWSTACMAFELATGDYLFEPHSGEEYTRDEDHIALIIELLGKVPRKLIVAGKYSKEFFTKKGDLKHITKLKPWGLFEVLVEKYEWSQEEAAGFTDFLLPMLELIPEKRATAAECLRHPWLNS 1-a -MSRSKRDSNFSVFEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAFDAVLERHVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDLYIVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCILGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCTEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDDALQHPYINVWYDPLEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVLDWEERAKNGVIRGQPAPLGAAVTDGSQAHTSSSSGDASSMSTDPTLPSDTDSSLETSAGTLGCCR+,U ,MKVMEKYQVLGLIGEGSYGVVSRCRNKESGQVVAVKKFLESEDNAAVRKIAVREIKLLKQLRHENLVSLLEVYKKKKRWYLVFEFVDHTVLDDLEAFPNGLDYSRVRKYLFQILRGIAFCHSQNIIHRDIKPENILVSQSGVVKLCDFGFARTLAASGEAYTDYVATRWYRAPELLVGDTKYGRAVDVWAIGCLVTEMLTGEPLFPGDSDIDQLYHITKCLGNLIPRHQELFCKNPLFAGMRLPEVKEAESLDRRYPKLSASVLDLAKKCLQIDPDKRPSCAELLQSDFFNKDGFAERFAQELKLRIHKEARDHQSQKKSKINRKDKDDAVEERKMLGVQDFNTDPKSRDAKVFKVKCSKADGEKAERSSDLSSLYDSAINPFKICSQTNLKDSSSNLHYIKNADIVIPPINQNVSPTMSSMVPVPGNCNYRVDERSKNYLKPFLKQMKHSPAGHYSVSLTSVSNEKNILQANKKKREFSKTDVHLPELNHLPELKGVEGWHPRYLKKENKTVSESRVPSLAAIDLHNTSLASQQKTTNNGTRGGPRREVKNSSDTGKVKLDENSEKHLVKDLKAQGTRDSKPIALKEEIVTPKETETSEKETPPPLPTIASPPPPLPTTTPPPQTPPLPPLPPIPALPQQPPLPPSQPAFSQVPASSTSTLPPSTHSKTSAVSSQANSQPPVQVSVKTQVSVTAAIPHLKTSTLPPLPLPPLLPGDDDMDSPKETLPSKPVKKEKEQRTRHLLTDLPLPPELPGGDLSPPDSPEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNIHSNPEMQQQLEALNQSISALTEATSQQQDSETMAPEESLKEAPSAPVILPSAEQTTLEASSTPADMQNILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAACPPHILPPEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPHEHQALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERNSGPALTESLVQTLVKNRTFSGSLSHLGESSSYQGTGSVQFPGDQDLRFARVPLALHPVVGQPFLKAEGSSNSVVHAETKLQNYGELGPGTTGASSSGAGLHWGGPTQSSAYGKLYRGPTRVPPRGGRGRGVPY nn+/U /MKNYKAIGKIGEGTFSEVMKMQSLRDGNYYACKQMKQHFESIEQVNSLREIQALRRLNPHPNILALHEVVFDRKSGSLALICELMDMNIYELIRGRRHPLSEKKIMLYMYQLCKSLDHMHRNGIFHRDVKPENILVKQDVLKLGDFGSCRSVYSKQPYTEYISTRWYRAPECLLTDGFYTYKMDLWSAGCVFYEIASLQPLFPGVNELDQISKIHDVIGTPCQKTLTKFKQSRAMSFDFPFKKGSGIPLLTANLSPQCLSLLHAMVAYDPDERIAAHQALQHPYFQVQRAAETQTLAKHRRAFCPKFSMVPESSSHNWSFSQEGRKQKQSLRHEEGHARRQGPTSLMELPKLRLSGMTKLSSCSSPALRSVLGTGANGKVPVLRPLKCAAVNKKTDTQKDIKPHLKHYHLPTINRKGGEYY.1 .MPNSERHGGKKDGSGGASGTLQPSSGGGSSNSRERHRLVSKHKRHKSKHSKDMGLVTPEAASLGTVIKPLVEYDDISSDSDTFSDDMAFKLDRRENDERRGSDRSDRLHKHRHHQHRRSRDLLKAKQTEKEKSQEVSSKSGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLHKEKTRKERELKSGHKDRSKSHRKRETPKSYKTVDSPKRRSRSPHRKWSDSSKQDDSPSGASYGQDYDLSPSRSHTSSNYDSYKKSPGSTSRRQSVSPPYKEPSAYQSSTRSPSPYSRRQRSVSPYSRRRSSSYERSGSYSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSRSPAYSRHSSSHSKKKRSSSRSRHSSISPVRLPLNSSLGAELSRKKKERAAAAAAAKMDGKESKGSPVFLPRKENSSVEAKDSGLESKKLPRSVKLEKSAPDTELVNVTHLNTv ))j1S 1MSLNAADAADERSRKEMDRFQVERMAGQGTFGTVQLGKEKSTGMSVAIKKVIQDPRFRNRELQIMQDLAVLHHPNIVQLQSYFYTLGERDRRDIYLNVVMEYVPDTLHRCCRNYYRRQVAPPPILIKVFLFQLIRSIGCLHLPSVNVCHRDIKPHNVLVNEADGTLKLCDFGSAKKLSPSEPNVAYICSRYYRAPELIFGNQHYTTSVDIWSVGCIFAEMMLGEPIFRGDNSAGQLHEIVRVLGCPSREVLRKLNPSHTDVDLYNSKGIPWSSVFCDHSLKDAKEAYDLLSALLQYLPEDRMKPYEALCHPYFDELHDSATKLPNNKDLPEDLFRFLPSEIEVMSEAQKAKLVRKg0M 0MSLNLTDAADDRSYKEMEKYTVERVAGQGTFGTVQLARDKSTGSLVAIKKVIQDPRFKNRELQIMQHLARLRHPNIVMLKNYFYTVGGEGRRNDVYLNVVMEFVPETLHRTCRNYYRRMTNPPLILVKVFMFQLLRSIACLHIPVINICHRDIKPHNVLVDEQTGELKLCDFGSAKRLAADEPNVAYICSRYYRAPELIFGNQFYTTAVDIWSVGCIFAEMLLGEPIFCGENTSGQLREIVKILGKPTKEELHKLNGSSTEINANAKATPWENVFKQPLPAEVYDLCGKIFKYVPDQRITPLDALCHPFFNELREPTTKLPSGNPLPAHLYQFTPDEVEAMTEAQREYLLKK I3 3MEPRVGNKFRLGRKIGSGSFGEIYLGTNIHTNEELAIKLENVKTKHPQLLYESKLYRILQGGTGVPNVKWFGVEGDYNVLVMDLLGPSLEDLFNFCSRKLSLKSVLMLADQMINRVEFFHSKSFLHRDLKPDNFLMGLGRRANQVYIIDFGLAKKYRDSTTHQHIPYRENKNLTGTARYASMNTHLGIEQSRRDDLESLGYILMYFLKGSLPWQGLKAGTKKQKYERISEKKVSTSIEALCRGYPSEFASYFHYCRSLRFDDKPDYAYLKRIFRDLFIREGFQFDYVFDWTILKYQQSQLTAPPSRALNPAVGTSAALPPGISNIDRYTGEEEGRPHMESSRRRVSGALDNSGNISNQPTSSSARDSMIPSSSLFAQSAGSSRRVTAVSGSRDNFPGSEELLQRSRTGDVSRGVIPRNSPGEAGKSTRRHYESVVKGIDNLQVSDEHHPHX2/ 2MDKMRILKESRPEIIVGGKYRVIRKIGSGSFGDIYLGMSIQSGEEVAIKMESAHARHPQLLYEAKLYRILSGGVGFPRIRHHGKEKNFNTLVMDLLGPSLEDLFNFCTRHFTIKTVLMLVDQMIGRLEYIHLKCFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKFRDPHTRHHIVYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVMMYFNRGVLPWQGMKANTKQQKYEKISEKKMSTPIEVLCKGSPAEFSMYLNYCRSLRFEEQPDYMYLRQLFRILFRTLNHQYDYIYDWTMLKQKTHQGQPNPAILLEQLDKDKEKQNGKPLIAD F,XFh;qqMus.musculus.CLK2..sp.O35491.CLK2_MOUSE.Dual.speciMus.musculus.CLK2..sp.O35491.CLK2_MOUSE.Dual.specih:qqDanio.rerio.CDKL5..tr.B9X2H6.B9X2H6_DANRE.Cyclin.dDanio.rerio.CDKL5..tr.B9X2H6.B9X2H6_DANRE.Cyclin.dh9qqHomo.sapiens.CDK11A..Cyclin.dependent.kinase.11A.OHomo.sapiens.CDK11A..Cyclin.dependent.kinase.11A.Oh8qqHomo.sapiens.HIPK3..Homeodomain.interacting.proteiHomo.sapiens.HIPK3..Homeodomain.interacting.proteih7qqHomo.sapiens.CDKL1..Cyclin.dependent.kinase.like.1Homo.sapiens.CDKL1..Cyclin.dependent.kinase.like.1h6qqXenopus.tropicalis.NLK1..tr.B0JZD9.B0JZD9_XENTR.NlXenopus.tropicalis.NLK1..tr.B0JZD9.B0JZD9_XENTR.Nlh5qqArabidopsis.thaliana.CK2a..sp.Q08467.CSK21_ARATH.CArabidopsis.thaliana.CK2a..sp.Q08467.CSK21_ARATH.Ch4qqDrosophila.melanogaster.HIPK..tr.M9PDR2.M9PDR2_DRODrosophila.melanogaster.HIPK..tr.M9PDR2.M9PDR2_DROh3qqArabidopsis.thaliana.CK1..gi.332659757.gb.AEE85157Arabidopsis.thaliana.CK1..gi.332659757.gb.AEE85157ENIMLVDPVRQPYRVKVIDFGSASHVSKTVCNTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVVAELFLGWPLYPGSSEFDQIRYISQTQGLPTEHMLNSASKTSKFFYRDVDSTYPFWRLKTTEEHEAETNTKSKEARKYIFNCLDDIGQVNVPTDLEGGQLLAEKTDRREFIDLLKRMLTIDQERRLTPAEALNHSFTRLTHLVDYVYCNNVKASVQMMEVCRRGDFHTVQPASTLVTNFVPSSTENMTFTINNQLTSQVQRLVRDGRPLAYEGLYQIYNGRSVARQYPQTRTDSFQHQLVSNILCPPSYQTMPSPTKHVVVGSATMQPPLQVPPQQYVNVPVPVSMVEPTSGQRMLLTNRVQASGVAWPQTGRQMALVPSWPQQAPAHSLIVDSTPLFNVEEIYPKHHLNLPRNDLKKESPAHHIAKGNSYRVPRHEKKEHQQLSPVKKRVKESSPPHQQRYQRAAHVSPQYHAHHNCNYGNGSGYSASAGSVVASSAASSSNIVNGSSSSSHHHHVPVAHAQPYSSSSGHHIVSNCNANGGAGGAVVYQQPPAHAHQQHGQQPHPQSSQHPQHVKQPTITIHDTPSPTAVITISDSEDEGGEAGGAQVPVLKQRAHAQSQTSGSLLQHAPSSSCSRSSAHQQPHPHPQQQQQQQINYGDHDPEDARRRHHAAAAAAVGSPKHHHHQQQQQPAPPPQQQQQQYQPQPPPQQVLPQPQPSIKYEPGQSQKKRILAMAQSECGYQPQVPSQPSSSASLPHIPTKQEPAEFYPEYAAAPPQQLDTKRSSWAPTSSGSGVSALPLAHPKREAPSVAPISYVAPSVAPPLAHSKSSSASSSSSISAATAAAAAAAAAAAASVGPPSWGPPQVYRQPSQPPPGSVGLPGSTQPPPSSVAPHPHHHSHGHHHHQAGTPLGGSPSSTAAAALLQPDIYAQGDIYRRPTVFVSQAAPSYAYANRAVVAPPPAHNSSSRQVIPSHPLPAHIQIPTQYSQFGPLSPAQVAASKHAAHFAPTNIWYGAE cc 5? 5MIDTLFFLFFLFFDSPLRRLLLLCAVLALRAPTAHSPILRSSIVTPTARAVSEVSGCTTIDPDFLVEISDSNQTRAMSKARVYTEVNVIRPKDYWDYESLIVQWGEQDDYEVVRKVGRGKYSEVFEGINVNSKEKCIIKILKPVKKKKIRREIKILQNLCGGPNIVKLLDVVRDQHSKTPSLIFEYVNSTDFKVLYPTLTDYDIRYYIYELLKALDFCHSQGIMHRDVKPHNVMIDHELRKLRLIDWGLAEFYHPGKEYNVRVASRYFKGPELLVDLQDYDYSLDMWSLGCMFAGMIFRKEPFFYGHDNQDQLVKIAKVLGTDELNAYLNKYQLELDPQLEALVGRHSRKPWSKFINADNQHLVSPEAIDFLDKLLRYDHQDRLTAKEAMAHAYFAQVRAAETSRMRSQo4] 4MISLVIRRLFRKDCDCGCVDSYNSSHGPPVQQDSSAAAGAGSVGSKAGSGPGPDGIGPISSLKTAHTKVATSGGHANTQPPSKRSSSGADGDYQLVQHEVLYSLSAEYEVLEFLGRGTFGQVVKCWKRGTSEIVAIKILKNHPSYARQGQIEVSILSRLSQENADEFNFVRAFECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILEQVLTALLKLKQLGLIHADLKP{ qql7W 7MEKYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLKHPNLVNLLEVFRRKRRLHLVFEYCDHTVLHELDRYQRGVPEHLVKSITWQTLQAVNFCHKHNCIHRDVKPENILITKHSVIKLCDFGFARLLAGPSDYYTDYVATRWYRSPELLVGDTQYGPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSTNQYFSGVKIPDPEDMEPLELKFPNISYPALGLLKGCLHMDPTQRLTCEQLLHHPYFENIREIEDLAKEHNKPTRKTLRKSRKHHCFTETSKLQYLPQLTGSSILPALDNKKYYCDTKKLNYRFPNI69 6MSLCGTSSNANMMAAYNGGTSTAAGGHHHHHHHHLAHLPPPHLHHHHHLHPQHHLHPGSAAAVHPVQQHVSSSSASTSSSAAAAAAAAAAAAAMLNPGQAQSYFPSPAPGQAPGPAAAVAPAQVQAAAVKAHHHQHSHHAQQLDIEPDRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQPPHIDYFEEIYVVTELMQSDLHKIIVSPQPLSSDHVKVFLYQILRGLKYLHSAGILHRDIKPGNLLVNSNCVLKICDFGLARVEELDESRHMTQEVVTQYYRAPEILMGSRHYTNAIDVWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPSLEAMRTACEGAKAHILRGPHKQPSLPVLYTLSSQATHEAVHLLCRMLVFDPSKRISAKDALAHPYLDEGRLRYHTCMCKCCFSTSSGRVYTSDFEPITNPKFDDTFEKNLSSVRQVKEIIHQFILEQQKGNRVPLCINPQSAAFKSFISSTVAQPSEMPPSPLVWETYEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTENADEYNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIRPILQQVATALKKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGEQLLNVGTKSTRFFCKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSLDDVAHVNTVMDLEGSDLLAEKADRREFVSLLKKMLLIDADLRITPAETLNHPFVNMKHLLDFPHSNHVKSCFHIMDICKSHLNSCDTNNHNKTSLLRPVASSSTATLTANFTKIGTLRSQALTTSAHSVVHHGIPLQAGTAQFGCGDAFQQTLIICPPAIQGIPATHGKPTSYSIRVDNTVPLVTQAPAVQPLQIRPGVLSQTWSGRTQQMLVPAWQQVTPLAPATTTLTSESVAGSHRLGDWGKMISCSNHYNSVMPQPLLTNQITLSAPQPVSVGIAHVVWPQPATTKKNKQCQNRGILVKLMEWEPGREEINAFSWSNSLQNTNIPHSAFISPKIINGKDVEEVSCIETQDNQNSEGEARNCCETSIRQDSDSSVSDKQRQTIIIADSPSPAVSVITISSDTDEEETSQRHSLRECKGSLDCEACQSTLNIDRMCSLSSPDSTLSTSSSGQSSPSPCKRPNSMSDEEQESSCDTVDGSPTSDSSGHDSPFAESTFVEDTHENTELVSSADTETKPAVCSVVVPPVELENGLNADEHMANTDSICQPLIKGRSAPGRLNQPSAVGTRQQKLTSAFQQQHLNFSQVQHFGSGHQEWNGNFGHRRQQAYIPTSVTSNPFTLSHGSPNHTAVHAHLAGNTHLGGQPTLLPYPSSATLSSAAPVAHLLASPCTSRPMLQHPTYNISHPSGIVHQVPVGLNPRLLPSPTIHQTQYKPIFPPHSYIAASPAYTGFPLSPTKLSQYPYM /9+ 9MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKWKHARVKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPGEARPAPAQKPAQLKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALLPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTQWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKVFKELGTPSEKIWPGYSELPVVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKFF8 8MASQVLVYPPYVYQTQSSAFCSVKKLKVEPSSCVFQERNYPRTYVNGRNFGNSHPPTKGSAFQTKIPFNRPRGHNFSLQTSAVVLKNTAGATKVIAAQAQQAHVQAPQIGAWRNRLHFLEGPQRCGLKRKSEELDNHSSAMQIVDELSILPAMLQTNMGNPVTVVTATTGSKQNCTTGEGDYQLVQHEVLCSMKN~LELLEELPNGALPDKVRSYIFQLIKAIHWCHKNEIVHRDIKPENLLISANDILKLCDFGFARNLSEGSDANYTEYVATRWYRSPELLLGAPYGKAVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPPEQMKLFYSNPRFAGLRFPSVSHPQTLDRRYLGIINGLMLDLMKNLLCLNPTERFLTEQCLNHPVFQGLRGPEQPAVPSPTPPRSSKRKPYHGDNTIPSRSHGSKSSSHRRANSKDCSSLPRHEDLHRSTDSFLNGTNMPTSSTLSPTLHPKSYQAQTLSRSASSNKDLANNNLPHLLSPKDAKGKTEFDFNLGPKVGVASVGMDTSTGKYLKSSKQGRHSSFLEGKTSTLQSGDKHSRHNYMESSHGSMPSTSSSKSSSSFLSLSKSHGALNDAKSVSNLAETRLHLDDPMAGSGSGSRYFPSSCLDLNAAPGSPRGERHAGTERQGHSPSGRGSNRLEGGTLDSRRSSGRKKTPDEPKPTDTLDPSRAAGGHAHNLPSPHESYPYGLGYTSPFSSQQRPHRHSMYVRRERHRPHGQENNLVVGQGVPTRASSLQLLSPQLQHRTLPRHNTSSSREELTPELSRNDQSPKEKPHSRPLIKDSTRDNTATFHTQRPKNEAGMYHDAHMEDGTSSKENRIIYSDSMPRRVGSFYRVPSPRPDNTFLETTGQSRVQAVAAENPTMTNHSKRQTNFDPWNNSEAMVMNPPEVPKQKEKQGFFRAIKKKKKKSQPTDGNAGRNPSIKKSLFPLFNSKNSLKHNSSVKVLPVVPQPMVPSETQQDQLVLQRPVKSSSHHSSRHRNRDRERERDMERDRERERDRNRDRDRERDRDNTWPPEKQPEVQPQNQPLKSLRKLLHLSSPATSNQPPPPDRSAELRFQPLPNPPSKANLNEVRGHPAGSVTPNTKSRKPHNYPLPGQIESSWHVSALNRAEGAPYPDQLANKGGQNGIGFTRAARTRMPNLNDLKETAL z;s ;MPHPRRYHSSERGSRGSYHEHYQSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDHSSDRRLYDRRYCGSYRRNDYSRDRGEAYYDTDFRQSYEYHRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGTQVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPVPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEDHHQLFDLIENMLEYEPAKRLTLGEALQHPFFACLRTEPPNTKLWDSSRDISR?:} :MKIPDIGNVMNKFEVLGIVGEGAYGVVLKCRHKETKELVAIKKFKDSEENEEVKETTLRELKMLRTLKQDNIVELKEAFRRRGKLYLVFEYVEKNM ff Cz!X!Y7qDictyostelium.discoideum.CDK11..Cyclin.dependent.k6qDictyostelium.discoideum.CDK7..Cyclin.dependent.kiA6qDictyostelium.discoideum.CDK8..Probable.cyclin.depW6qDictyostelium.discoideum.CK1..sp.Q556Y4.KC1_DICDI.!6qDictyostelium.discoideum.DYRK1..Probable.serine.thB7qDictyostelium.discoideum.DYRK2..Probable.serine.th,6qDictyostelium.discoideum.GSK3..sp.P51136.GSK3_DICDl7qDictyostelium.discoideum.MAPK1.sp.Q54QB1.ERK2_DICD6qDictyostelium.discoideum.SKY1..sp.Q86A12.SKY1_DICD7qDictystelium.discoideum.MAPK3..Extracellular.signa EDrosophila.melanogaster.CDK17qDrosophila.melanogaster.CDK11.sp.Q9VPC0.KP58_DROME)7qDrosophila.melanogaster.CDK4..tr.Q94877.Q94877_DRO7qDrosophila.melanogaster.CDK5..sp.P48609.CDK5_DROME+7qDrosophila.melanogaster.CDK8..Cyclin.dependent.kin6qDrosophila.melanogaster.CK1a...gi.22832152.gb.AAN027qDrosophila.melanogaster.CK1b...gi.7292799.gb.AAF48$ ff Cz!X!Y7qDictyostelium.discoideum.CDK11..Cyclin.dependent.k6qDictyostelium.discoideum.CDK7..Cyclin.dependent.kiA6qDictyostelium.discoideum.CDK8..Probable.cyclin.depW6qDictyostelium.discoideum.CK1..sp.Q556Y4.KC1_DICDI.!6qDictyostelium.discoideum.DYRK1..Probable.serine.thB7qDictyostelium.discoideum.DYRK2..Probable.serine.th,6qDictyostelium.discoideum.GSK3..sp.P51136.GSK3_DICDl7qDictyostelium.discoideum.MAPK1.sp.Q54QB1.ERK2_DICD6qDictyostelium.discoideum.SKY1..sp.Q86A12.SKY1_DICD7qDictystelium.discoideum.MAPK3..Extracellular.signa EDrosophila.melanogaster.CDK17qDrosophila.melanogaster.CDK11.sp.Q9VPC0.KP58_DROME)7qDrosophila.melanogaster.CDK4..tr.Q94877.Q94877_DRO7qDrosophila.melanogaster.CDK5..sp.P48609.CDK5_DROME+7qDrosophila.melanogaster.CDK8..Cyclin.dependent.kin6qDrosophila.melanogaster.CK1a...gi.22832152.gb.AAN027qDrosophila.melanogaster.CK1b...gi.7292799.gb.AAF48$ Ff,XFhEqqMus.musculus.CDKL5..sp.Q3UTQ8.CDKL5_MOUSE.Cyclin.dMus.musculus.CDKL5..sp.Q3UTQ8.CDKL5_MOUSE.Cyclin.dhDqqHomo.sapiens.DYRK2..Dual.specificity.tyrosine.phosHomo.sapiens.DYRK2..Dual.specificity.tyrosine.phoshCqqMus.musculus.DYR1B..Dual.specificity.tyrosine.phosMus.musculus.DYR1B..Dual.specificity.tyrosine.phoshBqqDictyostelium.discoideum.DYRK1..Probable.serine.thDictyostelium.discoideum.DYRK1..Probable.serine.thhAqqDictyostelium.discoideum.CDK7..Cyclin.dependent.kiDictyostelium.discoideum.CDK7..Cyclin.dependent.kih@qqDanio.rerio.MAPK12..sp.O42376.MK12_DANRE.Mitogen.aDanio.rerio.MAPK12..sp.O42376.MK12_DANRE.Mitogen.ah?qqMus.musculus.CSK2a2..sp.O54833.CSK22_MOUSE.Casein.Mus.musculus.CSK2a2..sp.O54833.CSK22_MOUSE.Casein.8>AASaccharomyces.bayanus.IME2Saccharomyces.bayanus.IME2.=77Naegleria.gruberi.LF4Naegleria.gruberi.LF4h<qqHomo.sapiens.CDK11B..Cyclin.dependent.kinase.11B.OHomo.sapiens.CDK11B..Cyclin.dependent.kinase.11B.O "<C  >MVEKRCRQSSSSGSEFSIPPDVDNPPLSIPLKTLSDRYQLIEKLGAGSFGCVTLAKAQFSLSNILGRQQQDLRGTLMDQPKNGHQNYITKTQGVVAIKTMMTKLHTLQDYTRVREIKFILAIPANDHLIQIFEVFIDSENYQLHIVMECMEQNLYQMMKHRRRRVFSIPSLKSILSQILAGLRHIHQENFFHRDLKPENILITPSTQYFEKEYMNQIGYQDNYVIKLADFGLARHVENKNPYTAYVSTRWYRSPEILLRSGYYSKPLDIWAFGCVAVEVTVFRALFPGANEIDQIWKILEVLGTPIKNSDFANTNHIITPPPGGFWDDASKLVHKLNLKLPDVEGSSLDHLLSSSQLSDLSDVVKKCLRWDPNERATAQELCEMPFFENTVASQVETKTDVTNTEQALIFAGINPLAAKNTKPLCFNSSDKLPVETESHGFDINQNDNNSQTVCSPTLNQEKLTLVEFLNEFVEEDNDDHSIPDVDTDSTISDSIDETDLSKEIRNNLALCQLPDEEVLDHSLSNIRQLTNDIEIINKDEADNMEQLFFDLEIPEQDEFHKKQPFNEHEDFDEDIVLPFVNDSNYTHTEKPYHKGSNFLGDASLGDSFNSMPDFTPRNFLIPTLEKSQEKFETHLSNQNQHFGNVTF ##r@c @MTARSRPGYFRQEINKTIWEVPDRYKDLKQVGTGAYGTVCYALDRRTGAKVAIKKLHRPFQSDLFAKRAYRELRLLKHMKHDNVIGLVDVFTADLSLDRFHDFYLVMPFMGTDLGKLMKMERLSEERVQYLVYQMLKGLKYIHAAGIIHRDLKPGNLAINEECELKILDFGLARQTDSEMTGYVVTRWYRAPEVILSWMHYTQTVDIWSVGCIMAEMLLGKPLFKGHDHLDQLMEIMKVTGTPSKEFTAKLQSEDARNYVTKLPRFRKKDLRILLPNVNPQAIKVLDGMLLLDPESRITAAEALAFPFFSEFREPEEETEAPPYDHSLDEADQSLEQWKRLTFTEILTFQPAPAVAESKETALe?I ?MPGPAAGSRARVYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGQDNYDQLVRIAKVLGTDELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYPVVKEQSQPCAENTVLSSGLTAAR oA] AMDKYNIEALIGEGTYGVVSRATVKATGQIVAIKKIRKILIQNQTDDGINFSAIREIKILQELKHDNVVNLLDIFAHKSNVYLVFELMQWDLQEVIEDKSIILKPADIKSYMKMLLQGIEACHRNWVLHRDLKPNNLLMSINGDLKLADFGLARQYGSPNKVFSPQAVTIFYRAPELLFGAKSYGPSVDIWSIGCIFAELMLRTPYLPGTGEIDQLRKICSALGTPNESNWPGVTCLPNYIKFTDHPATPFKQLFTAASDEAIDLISKMLLFNPSNRISAADALNHPYFTSGVKHTNPADLPVPFAKKASLLQQRQVLAQVQQQLLQKQQQQQQQQQQQIQSQPEPIQVDNVEQTQQAQQV KB BMDSDAKSRNDAPIIKLSIDLIKTYKHINQVYYTAKAKKKQQAQQQAQQQAQQLQQQAQQQQHQLQQQQQLLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQYQQQHNNNINNNNNNSNINNKNNNNNNTNFNTSNNNNNTNNNSNNNSNNNNSNNNNNNNNINNINNININNKNNNNNNNNNNNINNINNNNNKNNNNNNNNNNNDDNNNINNNNSNNNNNNNNNNNNNNNNNNNNNNNNNSNNNNNNNNLNNNNSNNNYNNNTTTTSSSNNNNNNKQSKYNDGYDDENADYIVRIGEVFVDRFEIISSLGKGSFGQVVKAFDSVLKEYVAIKIIKNKVPFYNQALIEIRLLELMNNKDPEDQYKIIKLKHHFKFRNHLCIVTELLSYNLYDLLRNTHFHGVSLNLIKKFAHQILTALFFMSTPEVDVIHCDLKPENILLRNPKRSAIKIIDFGSSCHSNERMYKYIQSRFYRSPEILLELEYSFSIDMWSLGCILVEMHVGEPLFSGQNEQDQLTKIIEVLDLPPSHMIDSSPKAKKFFTKDPINSTYQLKKNEKLKTNVEFCKKKLSEIIGVETGGPQSRRKNEPGHALVDYLKFLDLIEKMLIYDPQKRITPLEALQHSFFLTDETSQPPQQQSQQQSQQQSQQQSQQQSQQQSQQRRQSNTDNNFSNNNPINNYNSPSSKSPHQQLQQQQQQQQQQQQQQQQQQQQQQQQQQQTYSPTTQQSNHKLVDQMKKASMKDKSPHSNISNILNDSEEDNSKVHINSNTSDNMQARINFQVENQSNIYNNNNNNNNNNNNNNNNNNSNNYNNSNELSPNPPILPNLKDLLPHNNNNI |Cw CMAVPPGHGPFSGFPGPQEHTQVLPDVRLLPRRLPLAFRDAASAPLRKLSVDLIKTYKHINEVYYAKKKRRAQQAPPQDSSTKKEKKVLNHGYDDDNHDYIVRSGERWLERYEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMSRIVEVLGIPPAPMLEQAPKARKYFERLPGGGWTLRRTKELRKDYQGPGTRRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARISPLGALQHGFFRRTADEATNTGPAGSSASTSPAPLDTCPSSSTASSISSSGGSSGSSNDNRAYRYSNRYCGGPGPPITDCEMNSPQVLPSQPLRPWAGGDVPHKTHQAPISASTLPGTGAQLPPLPRCLGRPPSPTSPPPPELMDVSLVGSPPDCSPPPPAPAPQHPAASALRTRMTGGRPPLPPPDDPATLGPRLGLHGVPQSTAASS `D? DMLTRKPSAAAPAAYPTGRGGDSAVRQLQASPGLGAGATRSGVGTGPPSPIALPPLRASNAAAAAHTIGGSKHTMNDHLHVGSHAHGQIQVQQLFEDNSNKRTVLTTQPNGLTTVGKTGLPVVPERQLDSIHRRQGSSTSLKSMEGMGKVKATPMTPEQAMKQYMQKLTAFEHHEIFSYPEIYFLGLNAKKRQGMTGGPNNGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLRRRLPKPPTGEKTSVKRITESTGAITSISKLPPPSSSASKLRTNLAQMTDANGNIQQRTVLPKLVS LL1Ea EMKIPNIGNVMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQRLLDRSPSRSTKRKPYHVESSTLSNRNQSTKGAALQTHHRSNSKDIQNLSVGLPRAEEGLPANESFLNGNLAGATLSPMHTKTYQASTQPGSSSKDLTNNNIPHLLSPKEAKSKTEFDFNIDTKPSEGPGTKYLKSSTRSQQNRHSFMESSQSKAGTLQPSEKQSRHSYIDTIPQSSRSPSYRTKAKSHGALSDSKSVSNLSEARAQITETNTSRYFPSSCLDLNSPTSPTPTRHTDTRTLLSPSGRNNRNEGTLDSRRTTTRHSKTMEELKLPEHMDSSHSHSLSAPHESFSYGLGYTSPFSSQQRPHRHSMYVTRDKVRAKGLDGSLSIGQGMAARANSLQLLSPQPGEQLPPEMTVARPSVKESSREGASSFHTRQKSEGGVYHDPHSDDGTAPKENRHLYNDPVPRRVGSFYRVPSPRPDNSFHENNVSTRVSSLPSDSSSGTNHSKRQPGFDPWKSPENISHADQLKEKEKQGFFRSMKKKKKKTQTVPNTDGPDLLTLQKAIHSSSTASSRPKEWRPEKLSDLQTQSQPLKSLRKLLHLSSSTNHPASSDPRFQPLTAQQAKNSFSEIRIHPLSQATGGSSNIRQEPTPKGRPALQLPGSSLLRYNGWKHSRSRSSQPDEVIFLASHEKWKQ x, LxhNqqXenopus.tropicalis.MAPK10..tr.F7CYE3.F7CYE3_XENTR.Xenopus.tropicalis.MAPK10..tr.F7CYE3.F7CYE3_XENTR.hMqqHomo.sapiens.CDK2..sp.P24941.CDK2_HUMAN.Cyclin.depHomo.sapiens.CDK2..sp.P24941.CDK2_HUMAN.Cyclin.dephLqqMus.musculus.MAK..Serine.threonine.protein.kinase.Mus.musculus.MAK..Serine.threonine.protein.kinase.hKqqCaenorhabditis.elegans.NLK..sp.Q9U9Y8.NLK_CAEEL.SeCaenorhabditis.elegans.NLK..sp.Q9U9Y8.NLK_CAEEL.SehJqqMus.musculus.CDC7...sp.Q9Z0H0.CDC7_MOUSE.Cell.diviMus.musculus.CDC7...sp.Q9Z0H0.CDC7_MOUSE.Cell.divi6I??Aspergillus.nidulans.IME2Aspergillus.nidulans.IME2hHqqMus.musculus.DYRK4..Dual.specificity.tyrosine.phosMus.musculus.DYRK4..Dual.specificity.tyrosine.phoshGqqDanio.rerio.TTK..sp.Q8AYG3.TTK_DANRE.Dual.specificDanio.rerio.TTK..sp.Q8AYG3.TTK_DANRE.Dual.specifichFqqMus.musculus.MAPK15.sp.Q80Y86.MK15_MOUSE.Mitogen.aMus.musculus.MAPK15.sp.Q80Y86.MK15_MOUSE.Mitogen.a ,FW FMCAAEVDRHVAQRYLIKRRLGKGAYGIVWKAMDRRTGEVVAIKKIFDAFRDQIDAQRTFREIMLLKEFGGHPNIIRLLDVIPAKNDRDIYLVFESMDTDLNAVIQKGRLLKDIHKRCIFYQLLRATKFIHSGRVIHRDQKPANVLLDSACRVKLCDFGLARSLGDLPEGPGGQALTEYVATRWYRAPEVLLSSRWYTPGVDMWSLGCILGEMLRGQPLFPGTSTFHQLELILKTIPLPSMEELQDLGSDYSALILQNLGSRPQQTLDALLPPDTPPEALDLLKRLLAFAPDKRLSAEQALQHPYVQRFHCPDREWARESDVRLPVHEGDQLSAPEYRKRLYQIILEQSGNSRSPREEGLGVVASRAELRASPARTQSLKSGVLPQVPAETPARKRGPKPPRSPGHDPEHVEVRRQSSDPLFQLPPPGRGERPPGATGQPPSAPSGVKTQVRAMAPSLTSQAEAQAANQALIRSDPARGGGPRAVGARRVPSRLPREAPEPRPGRRMFGISVSQGAQGAARAALGGYSQAYGTVCRSALGRLPLLPGPRA  ]G9 GMDEEESTERQMQIAMLCQKLAMMKQLFNEDDTDYINQAISSNSPDTCRTFLSNLEKKGNPQADPSLLSKLMDSYTRVFSSMPLGKYSQNESYAKMLVRFAELKAIQDVNDAQTSFDIARSHCKDFAFVHVAYAQFELLQGNMKKCTMILQKAFEMNAKPRHVLEAAVRNLKTGKRQLLSHEDKENLSVSALDHTQGSRRSDGTCELKPSNTFLHSDQKFSPQEENGPVWRTGSQHRRTAMAERVPMVPLSIPENETSDSDCAQKAEAPFTHSSGFSRQTSGSSVRSAFSLCSSKKGTPDGDSYSLNIKPPVISPDYLREDIEEGHTITALLNRAEKRETARTEETTDINQIISTNSTEGCQAFLKNLEKRADPHSDAAFLSKLLDCYSKVFARFPLAEHCKTESYARMLVRYAELKGIEDPEDAADDFSIARSHCKAFAFVHIAHAQFELSRGNSRKSVSILQKALSSNARPIELLQTAIRNLKSGKTLLLPAEHQESSEAENVEAQNGMKREENPVKAPEDHQKPFSKETSSEWKIPALITKHTSPEDRKAPVEPVSSSSSHHAVRTPAPLRLNPSLSCQTPNYRQPNPNSFVTPVVKQRPVIVSVPATAQKMCPTALPCTPQSGVSYIQPPTQTPSSAFSNESITIKGKQFFIFKMIGRGGSSKVYQVFDHKKHVYAVKYVNLEEADAQAVESYKNEIEHLNHLQQYSDQIIKLYDYEITSSYIYMLMECGHLDLNTWLRNRKTVKPLDRKAYWRNMLEAVHTIHKHGIVHSDLKPANFLIVDGSLKLIDFGIANQIQPDVTSIMKDSQVGTLNYMPPEAIKDTSSNGKPGSKISAKGDVWSLGCILYCMTYGKTPFQNITNQISKIHAIIDPSHEIDFPDIPEKDLLDVLKKCLVRNPRERISIAELLDHPYLQLQPQPAPEPAETSSSDFKRILNELVALQSPNSIARAASNLAMMCNSGRKLDVSECVKSSSQTLWK ~~H} HMQLLRLPALTRTETSMDTNKARKRSLTTFPILKARKKQSFTSVKVESKPLGHLQKPSSKNKKLRVNRCPQKIPSNTAFPFVDTKGKRNTVNFPQIGNKVPSKGPMQYQENQIHNQVLSSELKTSEIPFNINTKAQDTKPHPELQKKHKVPLTVAEALKFFKNQLSPYEQSEILGYSELWFLGLEAKKLNVVPEKFSKTSFDDEHGSYMKVLHDHIAYRYEVLEMIGKGSFGQVAKCLDHKNNELVALKIIRNKKRFHHQALVELKILEALRRKDKDNNHNVVHMKDFFYFRNHLCITFELLGINLYELMKNNSFHGFNLSIVRRFTFSILKCLHMLYVEKIIHCDLKPENIVLYQRGQVTVKVIDFGSSCYEHQKVYTYIQSRFYRSPEVILGHPYNMAIDMWSLGCIMAELYTGYPLFPGENEVEQLACIMEVLGLPPAHFTQTASRRQVFFDSKGLPKNINNNRGGKRYPDSKDLTMVVKTYDSSFLDFLRRCLVWEPSLRMTPEQALKHAWIHEPRKFKPRPKPQILRKPGASISSEISTEKAEEQQASKGKKDEATKETTDKLKDEAEKHLENSGKQQSSVEHTADTIQLPHLTEASGKSETVAGSEMSAEQQSTSSPKSTNILPPIV I' IMTVCYEHPSRGLTPTSMATLSDRFELMKEVGDGSFGSVAVARVRTAGSNIARRGTLVAIKTMKKTFDSLAPCLELREVIFLRTLPPHPHLVPALDIFLDPLTRKLHIAMEYMDGNLYQLMKARDHKYLDGKHVKSILYQILCGLDHIHAHHFFHRDIKPENILVSTSAPNDSTFSRYSNLVTPPSTPTTYTVKIADFGLARETHSKLPYTTYVSTRWYRAPEVLLRAGEYSAPVDMWAVGAMAVEIATLKPLFPGGNEVDQVWRVCEIMGSPGNWYSKSGAKLGGGEWKDGSRLAQKLGFTFPKMAPHSMESILPAPQWPAALSNFVTWCLMWDPKNRPTSSQAMQHEYFADAVDPLSVRPRSSTARLLGRKQSEKSVKSPTKDTYESPTLSSKPSWFRRSLIGRSESPALVEPEQPSKPTLPALDSNVDPQLLKPKHSTSKRATWAHGAPMPILPSIRPVSPLSNAVTAQANPPAQESNTNAAKSSKKIGRQLSVNSHGNHYGDVHRQEAERALNGLGNNSTSTISQKESFFSHLRKRARRLSGRNQNAMNDDIEANAGCMPWSNRSSLALDSVNVSEAKQNSDFSELDKAVQNVRYSMDSAALGNVPVSITTPVEASKRQSMPQGSIRSMGDSPASMNGNGGPISSRTRRAMQMTNHPVHRYETPEEEDELLDEVLHSASSAAMRLAQAQMSDTSSNYSRPLCNEQSHNLPSPYPTPSPSAKCDGVSFGNEDAAPNRRLPLSDEKSATSATRQWPTPPYDDGDWMNPASTKFLTGSTYR ;Ju JMEEPMAFSSLRGSDRCPADDSLKKYEQSVKLSGIKRDIEELCEAVPQLVNVFKIKDKIGEGTFSSVYLATAQLQEGHEEKIALKHLIPTSHPMRIAAELQCLTVAGGQDNVMGLKYCFRKNDHVVIAMPYLEHESFLDILNSLSFQEVREYMYNLFVALKRIHQFGIVHRDVKPSNFLYNRRLKKYALVDFGLAQGTRDTKIELLKFVQSEAQQEDCSRNKYHGVVGHKGLLSRPAPKTVDQQCTPKTSVKRSYTQVHIKQGKDGKERSVGLSVQRSVFGERNFNIHSSISHESPAEKLIKQSKTVDIISRKLATKKTAISTKAMNSVMRETARSCPAVLTCDCYGSDRVCSVCLSRRQQVAPRAGTPGFRAPEVLTKCPDQTTAIDMWSAGVIFLSLLSGRYPFYKASDDLTALAQIMTIRGSRETIQAAKAFGKSVLCSKEVPAQDLRALCERLRGLDSTTPRSASGPPGNASYDPAASKNTDHKASRVQAAQAQHSEDSLYKRDNDGYWSHPKDCTSNSEGWDSVPDEAYDLLDKLLDLNPASRITAEAALLHAFFKDMCS E|"Zz*ay7qGallus.gallus.CDK10..tr.F1NCQ0.F1NCQ0_CHICK.Unchar/6qDrosophila.melanogaster.CK1d..gi.272506076.gb.ACZ9]6qDrosophila.melanogaster.CSK2a..sp.P08181.CSK2A_DROu6qDrosophila.melanogaster.GSK3..Protein.kinase.shagg}7qDrosophila.melanogaster.GSK3H..Putative.glycogen.s6qDrosophila.melanogaster.HIPK..tr.M9PDR2.M9PDR2_DRO47qDrosophila.melanogaster.JNK..sp.P92208.JNK_DROME.SCDrosophila.melanogaster.MAKS7qDrosophila.melanogaster.MAPK15..tr.Q9W354.Q9W354_D6qDrosophila.melanogaster.MAPK3..sp.P40417.ERKA_DROM=Emericella.nidulans.CDK1"GEncephalitozoon.cuniculi.CDK16qGaldieria.suphuraria.CK1..gi.545709990.ref.XP_00571Gallus.gallus.CDK1 1Gallus.gallus.CDK27qGallus.gallus.CDK3..tr.F1NA68.F1NA68_CHICK.Unchara6qGallus.gallus.CDK6..tr.Q90771.Q90771_CHICK.Cyclin.x E|"Zz*ay7qGallus.gallus.CDK10..tr.F1NCQ0.F1NCQ0_CHICK.Unchar/6qDrosophila.melanogaster.CK1d..gi.272506076.gb.ACZ9]6qDrosophila.melanogaster.CSK2a..sp.P08181.CSK2A_DROu6qDrosophila.melanogaster.GSK3..Protein.kinase.shagg}7qDrosophila.melanogaster.GSK3H..Putative.glycogen.s6qDrosophila.melanogaster.HIPK..tr.M9PDR2.M9PDR2_DRO47qDrosophila.melanogaster.JNK..sp.P92208.JNK_DROME.SCDrosophila.melanogaster.MAKS7qDrosophila.melanogaster.MAPK15..tr.Q9W354.Q9W354_D6qDrosophila.melanogaster.MAPK3..sp.P40417.ERKA_DROM=Emericella.nidulans.CDK1"GEncephalitozoon.cuniculi.CDK16qGaldieria.suphuraria.CK1..gi.545709990.ref.XP_00571Gallus.gallus.CDK1 1Gallus.gallus.CDK27qGallus.gallus.CDK3..tr.F1NA68.F1NA68_CHICK.Unchara6qGallus.gallus.CDK6..tr.Q90771.Q90771_CHICK.Cyclin.x ||K KMVSWGRGKDAYYLYISREQEEDDDDSLSFYSSQKDTEDEFCGCLFPDPEIPGSSSSSGCSSSSTELYDLAAAHAALISRQQQILSQAIPIIPEHQLAAVAAHHQHHQQLHPSVQYQLVAAATHHNHHQPQAAQPHYSAVVPRSDVIQQPPHFALHHHLQNLVQQQQQQQAHHHHQQLVGEMALVSHTHPAAVGSTTCYEKNQQKQQQVQQIPTQPQVAHVSSNAILAAAQPFYPPPVQDSQPDRPIGYGAFGVVWSVTDPRSGKRVALKKMPNVFQNLASCKRVFREIKMLSSFRHDNVLSLLDILQPANPSFFQELYVLTELMQSDLHKIIVSPQALTPDHVKVFVYQILRGLKYLHTANILHRDIKPGNLLVNSNCILKICDFGLARTWDQRDRLNMTHEVVTQYYRAPELLMGARRYTGAVDIWSVGCIFAELLQRKILFQAAGPIEQLQMIIDLLGTPSQEAMKYACEGAKNHVLRAGLRAPDTQRLYKIASPDDKNHEAVDLLQKLLHFDPDKRISVEEALQHRYLEEGRLRFHSCMCSCCYTKPNMPSRLFAQDLDPRHESPFDPKWEKDMSRLSMFELREKMYQFVMDRPALYGVALCINPQSAAYKNFASSSVAQASELPPSPQAW TT1Ma MMENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRLuLi LMNRYTTMKQLGDGTYGSVLMGKSNESGELVAIKRMKRKFYSWDECMNLREVKSLKKLNHANVIKLKEVIRENDHLYFVFEYMKENLYQLMKDRNKLFPESVIRNIMYQILQGLAFIHKHGFFHRDMKPENLLCMGPELVKIADFGLARELRSQPPYTDYVSTRWYRAPEVLLRSSVYSSPIDVWAVGSIMAELYTFRPLFPGTSEVDEIFKICQVLGTPKKSDWPEGYQLASSMNFRFPQCIPINLKTLIPNASSEAIQLMTEMLNWDPKKRPTASQALKHPYFQVGQVLGSSAHHLDTKQTLHKQLQPLEPKPSSSERDPKPLPNILDQPAGQPQPKQGHQPLQTIQPPQNTVTHPPPKQQGHQKPPQTMFPSIIKTIPVNSVSTLGHKGARRRWGQTVFKSGDSCDDIEDDLGASHSKKPSMEACKEKKKESPFRFPDSGLPVSNHFKGENRNLHASVSLKSDPNLSTASTAKQYYLKQSRYLPGVNPKNVSLVAGGKDINSHSWNNQLFPKSLGSMGADLSFKRSNAAGNLGSYTTYNQTGYMPSFLKKEVGSAGQRIQLAPLGASASDYTWSTKTGRGQFSGRTYNPTAKNLNIVNRTQPVPSVHGRTDWVAKYGGHR &!OA OMTSVGVAPTSGLREASGHGAAGVDRLPEEMNDMKIRDDREMEATVVDGNGTETGHIIVTTIGGRNGQPKQTISYMAERVVGHGSFGVVFQAKCLETGETVAIKKVLQDKRYKNRELQTMRLLDHPNVVCLKHCFFSTTEKDELYLNLVLEYVPETVNRVIKHYNKLNQRMPLIYVKLYTYQIFRALSYIHRCIGVCHRDIKPQNLLVNPHTHQVKLCDFGSAKVLVKGEPNISYICSRYYRAPELIFGATEYTTAIDVWSVGCVLAELLLGQPLFPGESGVDQLVEIIKVLGTPTREEIKCMNPNYTEFKFPQIKAHPWHKIFHKRMPPEAVDLVSRLLQYSPNLRCTALDALTHPFFDELRDPNSRLPNGRFLPPLFNFKSHELKGVPAEILVKLVPEHARKQCPFLGLWN- NMSRHFLYNCSEPTLDVKIAFCQGFGNQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKSLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDEALQHPYINVWYDPSEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNFEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR :\Lx:hXqqMus.musculus.CDK10..sp.Q3UMM4.CDK10_MOUSE.Cyclin.dMus.musculus.CDK10..sp.Q3UMM4.CDK10_MOUSE.Cyclin.dhWqqDictyostelium.discoideum.CDK8..Probable.cyclin.depDictyostelium.discoideum.CDK8..Probable.cyclin.dephVqqMus.musculus.CDK12.sp.Q14AX6.CDK12_MOUSE.Cyclin.deMus.musculus.CDK12.sp.Q14AX6.CDK12_MOUSE.Cyclin.dehUqqMus.muculus.PRP4..sp.Q61136.PRP4B_MOUSE.Serine.thrMus.muculus.PRP4..sp.Q61136.PRP4B_MOUSE.Serine.thrhTqqSchizosaccharomyces.pombe.PRP4..sp.Q07538.PRP4_SCHSchizosaccharomyces.pombe.PRP4..sp.Q07538.PRP4_SCH:SCCDrosophila.melanogaster.MAKDrosophila.melanogaster.MAKhRqqHomo.sapiens.MAPK4..sp.P31152.MK04_HUMAN.Mitogen.aHomo.sapiens.MAPK4..sp.P31152.MK04_HUMAN.Mitogen.ahQqqDanio.rerio.MAPK14b..sp.Q9DGE1.MK14B_DANRE.MitogenDanio.rerio.MAPK14b..sp.Q9DGE1.MK14B_DANRE.Mitogen8PAAPenicillium.marneffei.IME2Penicillium.marneffei.IME2hOqqGlycine.max.GSK3..tr.C7AE95.C7AE95_SOYBN.Glycogen.Glycine.max.GSK3..tr.C7AE95.C7AE95_SOYBN.Glycogen. P7 PMAISHEYSLKGTSHSAMTLEDRFEVIKEVGDGSFGSVVLARTRTAGSNVARRGTMVAIKTMKKTFESFAPCLELREVIFLRTLPHHTHIVPALDIFLDPLSKKLHICMEYMDGNLYQLMKARDHKYLEAKHVKSILYQIMSGLDHIHAHNFFHRDIKPENILVSTSAPNDSSAFSRYSNLVTPPSTPPTYTVKIADFGLARETHSKSPYTTYVSTRWYRAPEVLLRAGEYSAPVDIWAVGAMAVEIATLKPLFPGVNEVDQVWRICEIMGSPGNWYTKSGAKVGGGEWREGTKLAQKLGFTFPKMAPHSMSSILQGPHWPQSLANFVTWCLMWDPRNRPTSTQALNHEYFADAVDPLRPKSSASRLLGRKMSEKSFKPAPTKETTELPALSSKPSWFRRSLVLRTDSPTPLLEPETAVRPPAISYNTVPEVQASKGRSIKRATWANGAPMPILPSIRPVSPLSNAVTAQANSSVAHNGDQTLAVPVEDIGKSKKIGRQLSVNSHGNHYADIHRQEAERALNGLSGGANTSTQKEGFFSHLRKRARRLSGRNQVAAVAPTSNYDIEANAGCSPWPNRSSVVLDSGVIDTKTGDFTELDKTLQNVKYGLSSAANPPPQITSIPNQSPSKRQSVPQVPMRSMTESPTPSVGGPIYGRTRRALQMTSHPVHRYETPEEEDELLDEVLHSADRAARHLAQHYDSESASLYKEDHRLAHLVNDSTRTLNPYPTPSPSAKRDGVSFGDIDNTPVRQRDVTKIPEDTSSRQWPTPPYGEQEWASSVANSILSGSTYR EERR# RMAEKGDCIASVYGYDLGGRFVDFQPLGFGVNGLVLSAVDSRACRKVAVKKIALSDARSMKHALREIKIIRRLDHDNIVKVYEVLGPKGTDLQGELFKFSVAYIVQEYMETDLARLLEQGTLAEEHAKLFMYQLLRGLKYIHSANVLHRDLKPANIFISTEDLVLKIGDFGLARIVDQHYSHKGYLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCILAEMLTGRMLFAGAHELEQMQLILETIPVIREEDKDELLRVMPSFVSSTWEVKRPLRKLLPEVNSEAIDFLEKILTFNPMDRLTAEMGLQHPYMSPYSCPEDEPTSQHPFRIEDEIDDIVLMAANQSQLSNWDTCSSRYPVSLSSDLEWRPDRCQDASEVQRDPRAGSAPLAEDVQVDPRKDSHSSSERFLEQSHSSMERAFEADYGRSCDYKVGSPSYLDKLLWRDNKPHHYSEPKLILDLSHWKQAAGAPPTATGLADTGAREDEPASLFLEIAQWVKSTQGGPEHASPPADDPERRLSASPPGRPAPVDGGASPQFDLDVFISRALKLCTKPEDLPDNKLGDLNGACIPEHPGDLVQTEAFSKERWcQE QMSQKARPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVMSAFDGKAGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFSPATSLEGFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRALKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARLTDDEMTGYVATRWYRAPEIMLNWMHYNMTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTGTPPASLISRMPSHEARNYISSLPHMPKRNFADVFIGANPLAVDLLEKMLVLDTDKRITASQALAHPYFAQYHDPDDEPEADPYDQSFESRDLEIEEWKSKIYIQNRN 44IS SMNRYITLTQLGDGTYGTVVLGQRKDTGEKVAIKRMKRKYYSWEEAMNLREVKSLKKLSHPNIVKLKEVIRENDTLYFVFEYMKENLYQMIKDRDTHLPEPELKSILFQVLTGLAFMHRHGFFHRDLKPENLLCSGPDLIKIADFGLAREIRSRPPFTDYVSTRWYRAPEVLLHSTNYGSTIDLWAMGCIMAELYTFRPLFPGSSEVDQLFKICSVLGTPDKDDWPDGYRLASMIHFRYPDCIKVPLSSVVSRCSQNGLDLLEDMLAYDPDKRPTAQQSLKYPYFHALKRISPTAATKANVRLNSKYAASNGHPVQSVSNNVLPVQEKLQAVTELLHQTNNNMNSHSNLGKNNNLAPKNGGVPRKYQPKLSFLTTSEMGAGSHADSSSLVGGATVDGVPVPQHQNGGESINDIYLNRNISQLFGLPAGPQHQQQQQVHHPNVSFSTTSSRNAGAIYVNGSHLSYDTANMNAKNNAKFVVGASNGGYYVPVARPSLLGPDAKVYNVFSKVSASQAPPSLIVRQPQLQPEVAPAPMRLSGRSRAAAAVQDPKMGALKSDDLDLILGSKLKTSAKRQRNAKANILLEDLFGQLSMDSDSDGKYPHTVPPTQQAKSGKTSTGGHGAGARERDLFGESYLPRPGLRKKATQSSLEVNNGSHADSLAPNAQKEKPAVASSFPWDESNRTEDEKLTAWMVAENGNLILDNHQQA vUk UMAATEPPSLREQAEMDDADNSEKSVNEENGEVSEDQSQNKHSRHKKKKHKHRSKHKKHKHSSEEDRDKKHKHKHKHKKHKRKEVIEASDKEGLSPAdTG TMSDDRFAEDEIIQQRRKRRLEILKKYQQTGNGHSDLSIPEKKLKEDVDQVSTTKPIEAVPKMKTNASKIEINKEGSNSNTKLDVTNSTTSDSPSIKSSVQIEDTEDDMFADSPSPSVKRQNTGKGISTLTRSFADMQDNWDDIEGYYKVVLMEELDSRYIVQSNLGKGMFSTVVSALDRNRNQTFAIKIIRNNEVMYKEGLKEVSILERLQAADREGKQHIIHYERHFMHKNHLCMVFEMLSLNLRDILKKFGRNVGLSIKAVRLYAYQMFMALDLLKQCNVIHSDIKPDNMLVNEKRNILKICDLGSASDASENEITPYLVSRFYRAPEIILGFPYSCPIDTWSVGCSLYELYTGQILFPGRTNNQMLRYMMECKGKFSHKMLKRSQFLNDHFDADFNFIQIDHDPITNQETRKPVKFSKPTKDIRSRLKEVPTSTDEEFIIRQELMDLLEKCLELNPEKRVPPEVALKHPFFIKKKRTKLDDLALLEDLEKQRALIKAELDNELMEGKVQSGMGLILQGYESGSEEEGEIHEKARNGNRSSTRSSSTRGKLEITDNKNSAKKRSKSRSKERTRHRSDKRKSKGAGEMLREKANRSKSKERRKSKSPSKRSKSQDQARKSKSPPLRRRSQEKVGKARSPAEEKMKSEEKGKIKDRKKSPIVNERSRDRSKKSKSPVDLRDKSKDRRSRSKERKSKRSEIDKEKKPIKSPSKDASSGKENRSPSRRPGRSPKRRSLSPKLRDKSRRSRSPLLNDRRSKQSKSPSRTLSPGRRAKSRSLERKRREPERRRLSSPRTRPRDDILGRCERSKDASPINRWSPTRRRSRSPIRRRSRSPLRRSRSPRRRSRSPRRRDRSRRSRSRLRRRSRSRGGHRRRSRSKVKEDKFKGSLSEGMKVEQESSSDDNLEDFDVEEEDEEALIEQRRIQRQAIVQKYKYLAEDSNISVPSEPSSPQSSTRSRSPSPDDILERVAADVKEYERENVDTFEASVKAKHNLMTVEQNNGSSQKKILAPDMFTESDDMFAAYFDSARLRAAGIGKDFKENPNLRDNWTDAEGYYRVNIGEVLDKRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIRNNELMQKTGLKELEFLKKLNDADPDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLREVLKKYGKDVGLHIKAVRSYSQQLFLALKLLKRCNILHADIKPDNILVNESKTILKLCDFGSASHVADNDITPYLVSRFYRAPEIIIGKSYDYGIDMWSVGCTLYELYTGKILFPGKTNNHMLKLAMDLKGKMPNKMIRKGVFKDQHFDQNLNFMYIEVDKVTEREKVTVMSTINPTKDLLADLIGCQRLPEDQRKKVHQLKDLLDQILMLDPAKRISINQALQHAFIQEKISNPEVKHCLDTGKVRLDENLQKHPAKDLKAQGTKDVKPVAPKEVIVTSKETETSEKETLPPLPTITSPPPLPATTPPPQTPPLPPLPPLPAIPLQPPLPPPQPPFSQVPVSSTSILPSSPHPRTSTLSSQTNSQPPVQVSMKTQVSITAAIPHLKTSTLPPLPLPPLLPGDDDMDSPKETLPSKPAKKEKEQRTRHLLTDLPLPPELPGGDPSPPDSPEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLVHQSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLDYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGIVIEDPPPSKASRKETTSGTTAEPVKNNSPAPPQPAPVKAEPGPGDAVGLGDITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNIHSNPEMQQQLEALNQSISALTEASSQQQDSESIAPEESLKEVPSVPVVLPPAEQTTPEASNTPADMQNVLAVLLSQLMKTQEPAGNLEENTNDKNSGPQGPRRTPTMPQEEAAACPPHILPPEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPHEHQALRPMEYSTRSHPNRTYGNTDGPETGFSSADTDERSSGPALTESLVQTPVKNRTFSGSVSHLGESNSYQGTGSVQFPGDQDLRFTRVPLALHSVVGQPFLKSEGNSNSVVHAETKLQNYGELGPGTTGANSSGTTLQWGGPAQSYGKPYRGAARVLPRGGRGRGVPY "W WMNTHNQSSNQNGGGSGGGGGGGGSSTFSPIVLTSTYRLDVQEKYTFSYEIGSGTYGMVYKADDKKRPNNKVAVKKFRSTKEGEGLSLTAYREIGLLKELSNENIVKLLDVCLNPKDKLLYLIFDYAEFDLFGIIKYHRENGSHFSDATIKSLIWQVLNGIHYLHSNWVIHRDLKPSNILVMGEGKECGTVKIGDFGLARIFQSPLKPLNENGVVVTIWYRSPELLLGSKHYTRAVDIWAIGCIFAELITTKPLFPGKEKDPKIPSLFQDDQVEKIIRVLGKPTLDMWPDIKHLPEWKRLSSMEAFPNSLAKCVGIDENSQAYDLLSKMILYDPSKRITASEALDHPYFKELPLPLPNAFSKPIPYPPRLPINKKKREFDDSV% VMPNSERHGGKKDGSGGASGTSQPSSGGGSSNSRERHRLVSKHKRHKSKHSKDVGLVTPEAASLGTIIKPLVEYDDISSDSDTFSDDTAFKSDRRENEERRGTDRSDRLHRHRHHQHRRSRDLLKTKQTEKEKNQEVSKSGSMKDRVSGSSKRSVEGSDDYGKAQLSKSGSKESRSSKMHKEKTRKERELKSGYKDRSKSHRKRETPKSYKTVASPKRRSRSPHRKWSDSSKQDDSPSGASYGQDYDLSPPRSHTSSNYDSYKKSPGSTSRRQSISPPYKEPSAYQSSTRSPSPYSRRQRSVSPYSRRRSSSYERSGSYSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSRSPAYSRHSSSHSKKKRSGSRSRHSSISPVRLPLNSSLGAELSRKKKERAAAAAAAKMDGKESKSSPIILPKKEKLEVKESGLESKKLPRSIKSEKSTPDTELVTVAH WY- YMSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCRoX] XMAEVDLESDQIRLKCIRKEGFFTVPPEHRLGRCRSVKEFEKLNRIGEGTYGIVYRARDTQTDEIVALKKVRMDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENMPTPFSEAQVKCIMLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVPVKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHKPLLPGTSEIHQIDLIVQLLGTPSENIWPGFSKLPLAGQYSLRKQPYNNLKHKFPWLSEAGLRLLNFLFMYDPKKRATSGDCLESSYFKEKPLPCEPELMPTFPHHRNKRAAPAAAEGQSKRCRP x,XLxhaqqGallus.gallus.MAPK9..sp.P79996.MK09_CHICK.Mitogen.Gallus.gallus.MAPK9..sp.P79996.MK09_CHICK.Mitogen.h`qqHomo.sapiens.GSK3a..sp.P49840.GSK3A_HUMAN.GlycogenHomo.sapiens.GSK3a..sp.P49840.GSK3A_HUMAN.Glycogenh_qqSchizosaccharomyces.pombe.SSN3..Serine.threonine.pSchizosaccharomyces.pombe.SSN3..Serine.threonine.p6^??Candida.parapsilosis.IME2Candida.parapsilosis.IME2h]qqDrosophila.melanogaster.CK1d..gi.272506076.gb.ACZ9Drosophila.melanogaster.CK1d..gi.272506076.gb.ACZ9h\qqHomo.sapiens.CDC7..sp.O00311.CDC7_HUMAN.Cell.divisHomo.sapiens.CDC7..sp.O00311.CDC7_HUMAN.Cell.divish[qqHomo.sapiens.CLK1..Dual.specificity.protein.kinaseHomo.sapiens.CLK1..Dual.specificity.protein.kinasehZqqHomo.sapiens.MAPK9..sp.P45984.MK09_HUMAN.Mitogen.aHomo.sapiens.MAPK9..sp.P45984.MK09_HUMAN.Mitogen.ahYqqHomo.sapiens.MAPK10..Mitogen.activated.protein.kinHomo.sapiens.MAPK10..Mitogen.activated.protein.kin `N`k[U [MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI/Z] ZMSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEVMDWEERSKNGVVKDQPSDAAVSSNATPSQSSSINDISSMSTEQTLASDTDSSLDASTGPLEGCR ]]X]/ ]MDKMRILKESRPEIIVGGKYRVIRKIGSGSFGDIYLGMSIQSGEEVAIKMESAHARHPQLLYEAKLYRILSGGVGFPRIRHHGKEKNFNTLVMDLLGPSLEDLFNFCTRHFTIKTVLMLVDQMIGRLEYIHLKCFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKFRDPHTRHHIVYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVMMYFNRGVLPWQGMKANTKQQKYEKISEKKMSTPIEVLCKGSPAEFSMYLNYCRSLRFEEQPDYMYLRQLFRILFRTLNHQYDYIYDWTMLKQKTHQGQPNPAILLEQLDKDKEKQNGKPLIADE\ \MEASLGIQMDEPMAFSPQRDRFQAEGSLKKNEQNFKLAGVKKDIEKLYEAVPQLSNVFKIEDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHPIRIAAELQCLTVAGGQDNVMGVKYCFRKNDHVVIAMPYLEHESFLDILNSLSFQEVREYMLNLFKALKRIHQFGIVHRDVKPSNFLYNRRLKKYALVDFGLAQGTHDTKIELLKFVQSEAQQERCSQNKSHIITGNKIPLSGPVPKELDQQSTTKASVKRPYTNAQIQIKQGKDGKEGSVGLSVQRSVFGERNFNIHSSISHESPAVKLMKQSKTVDVLSRKLATKKKAISTKVMNSAVMRKTASSCPASLTCDCYATDKVCSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFYKASDDLTALAQIMTIRGSRETIQAAKTFGKSILCSKEVPAQDLRKLCERLRGMDSSTPKLTSDIQGHASHQPAISEKTDHKASCLVQTPPGQYSGNSFKKGDSNSCEHCFDEYNTNLEGWNEVPDEAYDLLDKLLDLNPASRITAEEALLHPFFKDMSL   x_o _MKDGYKIIGFISSGTYGKVYKAVSSNSNDKRLFAIKKFKAESKQVSSNAQQTGVSQSAIREMMLCREIQHENIVSLVQVLLKDGTISMVFEYAEHDLLQIIHFHSRSRTRQIPPSILKSILWQIINGVAYLHENWIMHRDLKPANIMITATGKVKIGDLGLGRLIRDPILPFYSSDRVVVTIWYRAPELLLGAHDYTPAIDVWAIGCIYGEMLALSPLFKGDEIKMEDKKVVPFQSTQMLRIMELLGTPTEERWPGLKNYPEYYQLSSFEVRYWNNLLPQWYQTVKNRDPQGLDLLMKMLQYDPKSRITAKQALEHVFFTSDKLWTTSPFLNQPIHYPERRISEDDSEVSSKRVLSTSLRSESKRFKGNx^o ^MPNMALSYYNDSPPKHVTVHSYQQRYQIISSLGNGSFGTVELARIKFPKEELLHAHMHKSGTMLYPLEDSKRNTSNLVAIKTMKKKLPSLHDYAKVKEIKFISSVPSHPNLVQIFEIFIDDLDHHLHITMEALNQNLYQLIKSRKGTRFSSMTLRSILSQLLQAIKHIHHHQYFHRDVKPENILVIPTSHYYGSKDSVPSYRRNDNFIIKLGDYGLARHVNTMRPYTGYVSTRWYRSPEILLRQSKYDCGIDIWAYGAVAAEIINFAPLFPGANEVDMLCKIIQTLGSPTIPGNLAQEYWVPVGGCWPQAATLSHALGHSLPFDRGLTRTQILPDAGRELCEVVMSCLQWSPEQRPTAQDLACSKYFSE a aMSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKSLEEFQDVYLVMELMDANLCQVIHMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESDRDKLKTSQARDLLSKMLVVDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEVMDWEERSKNGVVKDQPSAQMQQj`S `MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS ppO.f#Z6qGallus.gallus.CDKL2..tr.E1C431.E1C431_CHICK.Unchar,7qGallus.gallus.CDKL5..tr.E1BTX0.E1BTX0_CHICK.Unchar7qGallus.gallus.CLK2..tr.Q5ZJ82.Q5ZJ82_CHICK.Unchara7qGallus.gallus.CSK2a..sp.P21868.CSK21_CHICK.Casein.7qGallus.gallus.CSK2a2..sp.P21869.CSK22_CHICK.Casein7qGallus.gallus.MAPK10..tr.E1C8C5.E1C8C5_CHICK.Uncha7qGallus.gallus.MAPK13..tr.E1C7W3.E1C7W3_CHICK.Uncha6qGallus.gallus.MAPK9..sp.P79996.MK09_CHICK.Mitogen.a7qGlossina.morsitans.CDK5..sp.Q2PQN9.CDK5_GLOMM.Cycl6qGlycine.max.GSK3..tr.C7AE95.C7AE95_SOYBN.Glycogen.O6qHomo.sapiens.CDC7..sp.O00311.CDC7_HUMAN.Cell.divis\/Homo.sapiens.CDK17qHomo.sapiens.CDK10..Cyclin.dependent.kinase.10.OS.6qHomo.sapiens.CDK11A..Cyclin.dependent.kinase.11A.O96qHomo.sapiens.CDK11B..Cyclin.dependent.kinase.11B.O<6qHomo.sapiens.CDK12..sp.Q9NYV4.CDK12_HUMAN.Cyclin.d.7qHomo.sapiens.CDK14..Cyclin.dependent.kinase.14.OS. ppO.f#Z6qGallus.gallus.CDKL2..tr.E1C431.E1C431_CHICK.Unchar,7qGallus.gallus.CDKL5..tr.E1BTX0.E1BTX0_CHICK.Unchar7qGallus.gallus.CLK2..tr.Q5ZJ82.Q5ZJ82_CHICK.Unchara7qGallus.gallus.CSK2a..sp.P21868.CSK21_CHICK.Casein.7qGallus.gallus.CSK2a2..sp.P21869.CSK22_CHICK.Casein7qGallus.gallus.MAPK10..tr.E1C8C5.E1C8C5_CHICK.Uncha7qGallus.gallus.MAPK13..tr.E1C7W3.E1C7W3_CHICK.Uncha6qGallus.gallus.MAPK9..sp.P79996.MK09_CHICK.Mitogen.a7qGlossina.morsitans.CDK5..sp.Q2PQN9.CDK5_GLOMM.Cycl6qGlycine.max.GSK3..tr.C7AE95.C7AE95_SOYBN.Glycogen.O6qHomo.sapiens.CDC7..sp.O00311.CDC7_HUMAN.Cell.divis\/Homo.sapiens.CDK17qHomo.sapiens.CDK10..Cyclin.dependent.kinase.10.OS.6qHomo.sapiens.CDK11A..Cyclin.dependent.kinase.11A.O96qHomo.sapiens.CDK11B..Cyclin.dependent.kinase.11B.O<6qHomo.sapiens.CDK12..sp.Q9NYV4.CDK12_HUMAN.Cyclin.d.7qHomo.sapiens.CDK14..Cyclin.dependent.kinase.14.OS. F,XFhjqqCaenorhabditis.elegans.CSK2a..sp.P18334.CSK2A_CAEECaenorhabditis.elegans.CSK2a..sp.P18334.CSK2A_CAEEhiqqHomo.sapiens.DYR1B..Dual.specificity.tyrosine.phosHomo.sapiens.DYR1B..Dual.specificity.tyrosine.phoshhqqXenopus.tropicalis.MAPK13..tr.B1WBJ0.B1WBJ0_XENTR.Xenopus.tropicalis.MAPK13..tr.B1WBJ0.B1WBJ0_XENTR.hgqqYarrowia.lipolytica.SSN3..Serine.threonine.proteinYarrowia.lipolytica.SSN3..Serine.threonine.proteinhfqqHomo.sapiens.CSK2a1..sp.P68400.CSK21_HUMAN.Casein.Homo.sapiens.CSK2a1..sp.P68400.CSK21_HUMAN.Casein.heqqMus.musculus.CDK16..sp.Q04735.CDK16_MOUSE.Cyclin.dMus.musculus.CDK16..sp.Q04735.CDK16_MOUSE.Cyclin.dhdqqMus.musculus.MAPK4..sp.Q6P5G0.MK04_MOUSE.Mitogen.aMus.musculus.MAPK4..sp.Q6P5G0.MK04_MOUSE.Mitogen.ahcqqTaeniopygia.guttata.CLK4..tr.H0YSC9.H0YSC9_TAEGU.UTaeniopygia.guttata.CLK4..tr.H0YSC9.H0YSC9_TAEGU.UhbqqHomo.sapiens.CK2a..sp.P68400.CSK21_HUMAN.Casein.kiHomo.sapiens.CK2a..sp.P68400.CSK21_HUMAN.Casein.ki ohcO cMRHSKQSHCPEWDDRRSWDQRKHSSSRKRRKRSHSSGQESKHYKPSRISERPDSHYLDDRAINERDHHDRRYVEEYRNDFCEVYDHRHYHRDYEKSHHHHYSKSSGRSRKSSHKRKHKRHHCSSHQSHSKSHRRKRSRSVEDDEEGHLICESGDVLRARYEIVATLGEGAFGKVVECIDHDMRGMHVAVKIVKNVGRYREAARSEIQVLEHLNNMDPSSNFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFHINDIRNMAYQICQSINFLHHNKLTHTDLKPENILFVESDYIVKYNAKMKRDERTLKNTDIKVVDFGSATFDDEHHSTLVSTRHYRAPEVILALGWSQGTLPILIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPLPTHMIKKSRYRSFKTHNVLFGLDEHSSAGRYRRRCKPLKERQHFYCSARLHLFDLVRRMLEYDPAKRITLDEALQHPFFDPLNKb bMSGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMGSSSMPGGSTPVSSANMMSGISSVPTPSPLGPLAGSPVIAAANPLGMPVPAAAGAQQ Nd dMAEKGDCIASVYGYDLGGRFIDFQPLGFGVNGLVLSATDSRACRKVAVKKIVLSDARSMKHALREIKIIRRLDHDNIVKVYEVLGPKGSDLQGELFKFSVAYIVQEYMETDLACLLEQGTLTEDHAKLFMYQLLRGLKYIHSANVLHRDLKPANIFISTEDLVLKIGDFGLARIVDQHYSHKGYLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCILAEMLTGKMLFAGAHELEQMQLILDTIPVVREEDKEELLRVMPSFVSSTWEVKRPLRKLLPDVNSEAIDFLEKILTFNPMDRLTAEMGLQHPYMSPYSCPEDEPTSQHPFRIEDEIDDIVLMAASQSQLSNWDRYPVSLSSDLEWRPDRCQDASEVQRDPRAGSTPLAEDVQVDPRKDSQSSSERFLEQSHSSMERAFEADYGRSCDYKVGSPSYLDKLLWRDNKPHHYSEPKLILDLSHWKQAASAPPRAAVAADPVSREDEPASLFLEIAQWVKSTQSGSERASPPPDAPEPRLSASPPGHPTPIDGGASPQFDLDVFISRALKLCTKPEDLPENKLGDLNGACISEHPGDLVQTEAFSKERW uuf fMSGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMGSSSMPGGSTPVSSANMMSGISSVPTPSPLGPLAGSPVIAAANPLGMPVPAAAGAQQwem eMDRMKKIKRQLSMTLRGGRGIDKTNGVPEQIGLDESGGGGGSDLGEAPTRIAPGELRSVRGPLSSAPEIVHEDMKMGSDGESDQASATSSDEVQSPVRVRMRNHPPRKISTEDINKRLSLPADIRLPEGYLEKLTLNSPIFDKPLSRRLRRVSLSEIGFGKLETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDCGNVINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFRTYNYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDARKHPFFLSLGERIHKLPDTTSIFALKEVQLQKEANIRSTSMPDSGRPAFRVVDTEF a~h{ hMSSSVKCKFRKEEVNKTLWEIPLRYASLCLVGSGAYGSVCSAIDLKTGEKVAIKKLSRPFQSEIFAKRAFRELTLLKHMNHENVIGLLDVFTSATSFNDFHNFYLVMPYMQIDLQKIMGHHLSEDKVQYLVYQMLCGLKYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYVVTRWYRAPEVILNWMHYNKTVDIWSVGCIMGEMLTGKTLFKGKDYLDQLTQILKVTGVPGPEFIQKLEDMAAKKYIQSLPKIPKKEFSLLFPNASDLAVDLLEKMLELDVEKRLTATEALEHPYFDEFHDADEETEAPPYDDSLEGEKLSVEEWRKYTYEEVINYTPILRKDSKRKSGMSIKDEFEGTCPLPg7 gMSNYRRGVGSYSRMLGGGTNPFAAYTARKAKTKKRVLDKYEIIGYIAAGTYGRVYKARSKDPGDTNQYAIKKFKADKEGEMVHYAGISQSACREVALCAELDNRNITKLVETILEDTCIYMVFEYAEHDLLQIIHYHSHPERKPIPEYTLKSILWQLLNGVSYLHQNWVLHRDLKPANTMVTSDGVLKIGDLGLARLFSNPLQSLYSGDKVVVTIWYRAPELLLGARHYSPAVDLWAVGCIFAELLALRPIFKGEEAKMDNKTNVPFQRNQMQKIIEILGSPQEDDWPSLSKFPEYESLKQMKTFPPNLEAWYQSIGGTNQKGFQLLSRLLEYDPAKRLTANDALLHPYFTEAPKVSQNVFERQEYKYPPRRISCEDSDIKTMTYQGTKRGSQGGDNLHPRKKQK oj] jMPPIPSRARVYAEVNPSRPREYWDYEAHMIEWGQIDDYQLVRKLGRGKYSEVFEGFKMSTDEKVVVKILKPVKKKKIKREIKILENLRGGTNIITLLDVVKDPISRTPALIFEHVNNSDFKQLYQTLSDYDIRYYLYELLKALDFCHSQGIMHRDVKPHNVMIDAEKRELRLIDWGLAEFYHPRQDYNVRVASRYFKGPELLVDYQCYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTDELYEYIARYHIDLDPRFNDILGRHSRKRWERFIHAENQHLVTPEALDFLDKLLRYDHAERLTAQEAMGHEYFRPVVEAHARANGTEQADGQGASNSASSQSSDAKIDGA|iw iMAVPPGHGPFSGFPGPQEHTQVLPDVRLLPRRLPLAFRDATSAPLRKLSVDLIKTYKHINEVYYAKKKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHDYIVRSGERWLERYEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRTKELRKDYQGPGTRRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARISPLGALQHGFFRRTADEATNTGPAGSSASTSPAPLDTCPSSSTASSISSSGGSSGSSSDNRTYRYSNRYCGGPGPPITDCEMNSPQVPPSQPLRPWAGGDVPHKTHQAPASASSLPGTGAQLPPQPRYLGRPPSPTSPPPPELMDVSLVGGPADCSPPHPAPAPQHPAASALRTRMTGGRPPLPPPDDPATLGPHLGLRGVPQSTAASS h,zhn{ nMALDVKSRAKRYEKLDFLGEGQFATVYKARDKTTNTIVAIKKLLDAFGHKSNISLVFDYMETDLEVIIKDTSLVLTPANIKAYILMTLQGLEYMHNHWILHRDLKPNNLLLDENGVLKLADFGLAKAFGSPNRVYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLAGDSDLDQLTKIFEALGTPTDEIWPGMSSLPDYVSFKPFPGTPLEHIFSAAGDDLLELLRGLFTYNPCSRTTAMQALKMKYFSNRPGPTPGPQLPRPNSSTEALKEKENLLIGIKRKRDSIEQGTLKKKLVFxmo mMSNIALSYYNDSPPKHVTVHSYQQRYQIISNLGNGSFGTVELARIKFPKEELLCTHIHKSGTLLYPLDDSKRNTSNLVAIKTMKKKLPSLHDYAKVKEIKFISSVPSHPNLVQIFEIFIDDLDHQLHITMEALNQNLYQLIKSRKGTRFSSMTLRSILTQLLQAIKHIHHHQYFHRDVKPENILVIPTAHYYGSKESVPAYRRNDNFLIKLGDYGLARHVNTMRPYTGYVSTRWYRSPEILLRQNKYGCEIDIWAYGTVAAEIVNFAPLFPGANEMDMLCKVIQTLGSPTLPGKVDQEYCVPIGGYWPQAAILSHALGHSLPFDRGFTRAQILPDAGRELCDAIMSCLQWDPISRPTAQELACFEYFSK ~~o} oMASTSVPENYYVVPIGETQMVILKRYENLRLIGSGAQGIVCAATDMVTNKPVAIKKLSRPFQNVTHAKRAYREFILMNLVNHKNIIGLLNAFSPQREVEEFNDLYIVMELMDANLCQVIQMDLDHERLSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAVEAFMMTPYVVTRYYRAPEVILGMGYGENVDVWSVGCIFGELIRGRVLFPGADHIDQWTRIIELLGTPEPQFLARLQTTVRNYVENRQKYQPVPFETLFADNMFPPGADNARLTAAKARDLLSRMLVIDPEKRISVDDALAHEYVNVWYDASRGSCSSAGPSTILLVDGEHTVEEWRAMLFAELQNYYRTHDVYGVGQRR ~~p} pMMEKVTISVPVVKKRVVPPDINNPPSGIPLKSFGDHYQAISSLGNGSFGSVVLAKYKKDEKNLLKVDLRKRGTLIDPLEESDAHLSCLVAIKTMKTPLCTLNEATTVKEVKFILRIPSHPSLVQIYDMFIDNKEFHLHIVMETMNQNLYQLMRARKRIKFSPATLKSVLTQLLEGIRHIHKYDYFHRDVKPENILIMPTSQYYGSRENIPPNRRGDNYVLKLADYGLARHIGNLGKYTSYVATRWYRSPEILLRRMWYSKPVDMWAFGTIAVEVANFIPLFPGASEVDQIWRILEVLGSPTLPSFGTHMHKGHYYPPLGGYWKEAQLLSSRMGFSLPYTDGVQICNLIPDSVSELGEVVKACLTWNPDVRADVETVCAMSYFKNTSVSKAYKEPERPSNKMTRPSPLKEVNGSFQMFSGIQPYKMSLNEFNNKKRMRNSSSFESQNSYIPQYNNENYLSNSFNQMKSNAISKTEFQIHDDFDDGYEKEFMKEYIGKQAGNSISQGRDSFDFENKCIKNIGDDSNITPRGINNTPPELAEEYCNESFNFYDLNYSNNEGDAIITEYDSENTYSKNDHDYSWEGFNNLDITNNDSVNNTEQYIPNNLAALKEPLEDEFGIIADISFGSSHGIKC ^Lr rMGIRLQSSDSMNNQHQTQQNKYFNVSNQASTRSLWSQQQQQQLLDTKGSASTSKSPMLMANNNVFSIGPYRQRKDAGRVSVLEKYEIIGYIAAGTYGKVYKAKAKETQEEQENSIHTHNQTLGSVSVAGIDGGMASREVENGGDDPLRLDGHGGIAVAPAAGGGLSSAAAHRARSNGAVKALPKKSAFTPFYAIKKFKTEREGVEQLHYTGISQSACREMSLCRELDNKHLTKLVEIFLERKSIYMVSEFAEHDLLQIIHFHSHPEKRLIAPRMLKSIMWQILDGVSYLHQNWILHRDLKPANIMVTVDGCVKIGDLGLARKFYNLVQTLYTGDKVVVTIWYRAPELLLGARHYSPAIDLWAVGCIFAELIGLRPIFKGEEAKMDSKKSVPFQGNQLQRILEVLGTPTHHTWPNIHKYPEYEQLSKFSKYRDNLSVWYHSSGGRDKAALSLLYSLLKYDPITRIDAIDALEHEYFTNNDPPVSSDVFEGLSYKYPPRRIHTSDNDIMNVGANKNKSGFNHHPPQQQTVNNNGVTNSSIGGLGVNRRILAAAAAAAAAVQVNGTNIVSGSSSSNGPIRKKKRq= qMSASVGNAAQQPSVSGNDLQQSMKELTIKDEEAGSSNKPLQNPATAEIFEGRLIEGDLKSGGHVLSASAGTGASRQTYNYSTDRVVGNGSFGVVFQATCLETGETVAIKKVLQDKRFKNRELQIMKLVDHPNIVKLKHCFYSHTDKDETYLHLVLEFVPDTVYRISKHYAKNNQRMPNLFVKLYAYQMCRALNSIHKMGICHRDIKPQNLLVNTETHQLKLCDFGSAKVLIKGEPNISYICSRYYRAPELIFGATDYTSGIDVWSVGCVLAELLLGQPLFPGESGVDQLVEIIKVLGTPTREEINSMNPNYTEFKFPQIKAHPWTKVFSKRMPPDAVDLVSKLLQYAPQKRMTAIQAMTHPFFDELRDPNTRLPNGRSLPPLFNWLPGELDEVPADIVRKLQPAVKTT ,c C{!X7qHomo.sapiens.CDK16.sp.Q00536.CDK16_HUMAN.Cyclin.de7qHomo.sapiens.CDK17..sp.Q00537.CDK17_HUMAN.Cyclin.d6qHomo.sapiens.CDK18..sp.Q07002.CDK18_HUMAN.Cyclin.d#6qHomo.sapiens.CDK2..sp.P24941.CDK2_HUMAN.Cyclin.depM7qHomo.sapiens.CDK20..sp.Q8IZL9.CDK20_HUMAN.Cyclin.d7qHomo.sapiens.CDK3..sp.Q00526.CDK3_HUMAN.Cyclin.dep?7qHomo.sapiens.CDK4..sp.P11802.CDK4_HUMAN.Cyclin.dep7qHomo.sapiens.CDK5..sp.Q00535.CDK5_HUMAN.Cyclin.dep 7qHomo.sapiens.CDK6..sp.Q00534.CDK6_HUMAN.Cyclin.dep6qHomo.sapiens.CDK8..Cyclin.dependent.kinase.8.OS.Ho 7qHomo.sapiens.CDK9..Cyclin.dependent.kinase.9.OS.Ho6qHomo.sapiens.CDKL1..Cyclin.dependent.kinase.like.176qHomo.sapiens.CDKL2..Cyclin.dependent.kinase.like.2&7qHomo.sapiens.CDKL3..sp.Q8IVW4.CDKL3_HUMAN.Cyclin.d7qHomo.sapiens.CDKL4..sp.Q5MAI5.CDKL4_HUMAN.Cyclin.d'7qHomo.sapiens.CDKL5..sp.O76039.CDKL5_HUMAN.Cyclin.d ,c C{!X7qHomo.sapiens.CDK16.sp.Q00536.CDK16_HUMAN.Cyclin.de7qHomo.sapiens.CDK17..sp.Q00537.CDK17_HUMAN.Cyclin.d6qHomo.sapiens.CDK18..sp.Q07002.CDK18_HUMAN.Cyclin.d#6qHomo.sapiens.CDK2..sp.P24941.CDK2_HUMAN.Cyclin.depM7qHomo.sapiens.CDK20..sp.Q8IZL9.CDK20_HUMAN.Cyclin.d7qHomo.sapiens.CDK3..sp.Q00526.CDK3_HUMAN.Cyclin.dep?7qHomo.sapiens.CDK4..sp.P11802.CDK4_HUMAN.Cyclin.dep7qHomo.sapiens.CDK5..sp.Q00535.CDK5_HUMAN.Cyclin.dep 7qHomo.sapiens.CDK6..sp.Q00534.CDK6_HUMAN.Cyclin.dep6qHomo.sapiens.CDK8..Cyclin.dependent.kinase.8.OS.Ho 7qHomo.sapiens.CDK9..Cyclin.dependent.kinase.9.OS.Ho6qHomo.sapiens.CDKL1..Cyclin.dependent.kinase.like.176qHomo.sapiens.CDKL2..Cyclin.dependent.kinase.like.2&7qHomo.sapiens.CDKL3..sp.Q8IVW4.CDKL3_HUMAN.Cyclin.d7qHomo.sapiens.CDKL4..sp.Q5MAI5.CDKL4_HUMAN.Cyclin.d'7qHomo.sapiens.CDKL5..sp.O76039.CDKL5_HUMAN.Cyclin.d RRMt tMTAIRKNDMNYTLDDFTKLEKIGEGTYGVVYKGRNRRTQAMVAMKKIRLESEDEGVPSTAVREISLLKELQHPNVVGLEAVIMQENRLYLIFEFLSYDLKRYMDTLSKEEYLPSETLKSYTFQILQAMCFCHQRRVIHRDLKPQNLLVDEKGAIKLADFGLARAIGIPIRVYTHEVVTLWYRAPEILMGAQRYSMGVDMWSIGCIFAEMATKKPLFQGDSEIDELFRIFRILGTPTELEWNGVESLPDYKATFPKWRENFLRDKFYDKKSGNYLMDEDAFSLLEGLLIYDPALRISSKKALHHPYFNDIDTSKLPAGNYRGELQLE[s5 sMPTDISPERDLSGRFRAFRKIGEGTYGVVYKAVHVRDNVQCALKMIRTDRDEEGIPSTCLREISCIKDLQHDNIVTLFDIIYANSKLYMVFEFIDQDLKNLMDMLDPVDMMLPQEYVKSFMWQLLSALSYCHLRRIVHRDLKPQNILVSNSGIVKIADFGLARNFSFPSRNYTHEVVTLWYRPPEILLGSQRYSTSLDMWSLGCIFSEIASTKPLFPGECEISQLFKIFEIIGTPNTRNWPGVAEYPHFKTVFPQWSFNLNKLAELSCLTGHGLDILREILRYPPEHRLTAKGALCHRYFLHNEFTQNRPSVAKLKEEIDQRMRSRRRTNRAASPNDHIF 8,X v 8h~qqPlasmodium.falciparum.CK1..sp.Q8IHZ9.KC1_PLAF7.CasPlasmodium.falciparum.CK1..sp.Q8IHZ9.KC1_PLAF7.Cash}qqDrosophila.melanogaster.GSK3..Protein.kinase.shaggDrosophila.melanogaster.GSK3..Protein.kinase.shaggh|qqPetromyzon.marinus.CDKL3..tr.S4RCQ7.S4RCQ7_PETMA.UPetromyzon.marinus.CDKL3..tr.S4RCQ7.S4RCQ7_PETMA.Uh{qqKomagataella.pastoris.MAPK3..tr.F2QYY4.F2QYY4_PICPKomagataella.pastoris.MAPK3..tr.F2QYY4.F2QYY4_PICP>zGGSaccharomyces.cerevisiae.SKY1Saccharomyces.cerevisiae.SKY16y??Monosiga.brevicollis.CDK1Monosiga.brevicollis.CDK1hxqqGallus.gallus.CDK6..tr.Q90771.Q90771_CHICK.Cyclin.Gallus.gallus.CDK6..tr.Q90771.Q90771_CHICK.Cyclin.hwqqMus.musculus.DYRK3..Dual.specificity.tyrosine.phosMus.musculus.DYRK3..Dual.specificity.tyrosine.phoshvqqMus.musculus.CDK20.sp.Q9JHU3.CDK20_MOUSE.Cyclin.deMus.musculus.CDK20.sp.Q9JHU3.CDK20_MOUSE.Cyclin.dehuqqDrosophila.melanogaster.CSK2a..sp.P08181.CSK2A_DRODrosophila.melanogaster.CSK2a..sp.P08181.CSK2A_DRO BBavA vMDQYCILGRIGEGAHGIVFKAKHVETGEIVALKKVALRRLEDGIPNQALREIKALQEIEDSQYVVQLKAVFPHGAGFVLAFEFMLSDLAEVVRHAQRPLAPAQVKSYLQMLLKGVAFCHANNIVHRDLKPANLLISASGQLKIADFGLARVFSPDGGRLYTHQVATRWYRAPELLYGARQYDQGVDLWAVGCIMGELLNGSPLFPGENDIEQLCCVLRILGTPSPRVWPEITELPDYNKISFKEQAPVPLEEVLPDASPQALDLLGQFLLYPPRQRIAASQALLHQYFFTAPLPAHPSELPIPQRPGGPAPKAHPGPPHVHDFHVDRPLEESLLNPELIRPFIPEGWu- uMTLPSAARVYTDVNAHKPDEYWDYENYVVDWGNQDDYQLVRKLGRGKYSEVFEAINITTTEKCVVKILKPVKKKKIKREIKILENLRGGTNIITLLAVVKDPVSRTPALIFEHVNNTDFKQLYQTLTDYEIRYYLFELLKALDYCHSMGIMHRDVKPHNVMIDHENRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEELYAYLDKYNIDLDPRFHDILQRHSRKRWERFVHSDNQHLVSPEALDFLDKLLRYDHVDRLTAREAMAHPYFLPIVNGQMNPNNQQ \\Mx xMDKDGTNLADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTSEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMLQLFRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGNSDVDQLGKIFDVIGLPEEEDWPNDVALPRNAFASRPAQPIEKFVPDIDDMGKDLLLKCLAFNPAKRISAYAALSHPYFHDLEKCKENLDSHMSSSQNSSEVNASQw! wMGGAARDRGRKDAALPGAGLPPQQRRLGDGVYDTFMMIDETKGPPYSDTFSNPSEAPVSRRLNITTEPLTRGHTQHFVNGSEMKVEQLFQEFGNRRSNTLQSDGISNSEKSSPASQGKSSESLSAVKCNLSSRPSKVLPLTPEQALKQYKHHLTAYEKLEIVSYPEIYFVGPNAKKRQGVIGGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSATKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGCRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMIELLGMPPQKLLEQSKRAKYFINSKGLPRYCSVSTQTDGRVVLLGGRSRRGKKRGPPGSKDWATALKGCGDYLFIEFLKRCLQWDPSARLTPAQALRHPWISKSTPKPLTMDKVPGKRVVNPTNAFQGLGSKLPPVVGIASKLKANLMSETSGSIPLCSVLPKLIS >y{ yMALHDDYVKIEKIGEGTYGVVYKGRNKKTNQIVALKKIRLESEEEGVPSTAIREISILKELQHPNIVSLQDVVLQESNLFLVFEFLQMDLKKYMDTIGSGKYMDKDLVKSYTYQILQGITYCHSRRVLHRDMKPQNLLIDRNGIIKLADFGLARAFGIPVRVYTHEVVTLWYRAPEVLLGSSRYSTPVDVWSIGTIFAEMATKRPLFHGDSEIDQLFRIFRVLGTPTDDIWPGVTQLKDYKQTFPKWKKGCLNDSVKNLDEDGIDLLTKCLVYNPAKRISAKVALCHPYFDDIDKKALPGTHVPLVPRIAG mzY zMGSSINYPGFVTKSAHLADTSTDASISCEEATSSQEAKKNFFQRDYNMMKKAPAPTKSKLSLALQTSKSSSSANGTVQEDTSSKTEDFSTKSIKKKPDSGVESHVSIQSDSGPQSDSDLDSDSSISSCDERNEESLKDYRPGGYHPAFKGEPYKDARYILVRKLGWGHFSTVWLAKDMVNNTHVAMKIVRGDKVYTEAAEDEIKLLQRVNDADNTKEDSMGANHILKLLDHFNHKGPNGVHVVMVFEVLGENLLALIKKYEHRGIPLIYVKQISKQLLLGLDYMHRRCGIIHTDIKPENVLMEIGDVEGIVQMVEALDKQKREAKRLQRHVSRSSDITANDSSDEKWAECQTSMPCGSSSNSKSRSIEKDLSKRCFRRPRRHTIITGSQPLPSPISSSNFFEMRAHFCGSSHNSFSSVSGNRNIPSSINNNSINNGIGIKNSNNSFLNSVPHSVTRMFINEDSNDNNNNDNSKNKNNNNNNSNNNNNEDIMNTPLHEEQLADSLSTFDISNISQSSDTNGPYISNTMDSNSNVSTDINSPENLIQIKIADLGNACWYDEHYTNSIQTREYRSPEVLLGAPWGCGADIWSTACLIFELITGDFLFEPDEGHSYTKDDDHIAQIIELLGELPSYLLRNGKYTRTFFNSRGLLRNISKLKFWPLEDVLTEKYKFSKDEAKEISDFLSPMLQLDPRKRADAGGLVNHPWLKDTLGMEEIRVPDRELYGSGSDIPGWFEEVRDHKRH LLH| |MEKYENLGLVGEGSYGIVLKCRHRDTGQIVAIKKFLDSEDHKSVRKIAAREIKMLKQLRHENLVNLLEVFRRKRRLYLVFEFVDHTVLDELERYPRGLPTARVRPCLLQVLRAVGFCNSNNVVHRWTTPVNVFLRIVDPCYFCIFLFQEASQHPFKCHSDIRLNEYKQSPLMFACVCVCERYRAVDVWAVGCVAVEIQTGEPVFPGDSDIDQLYQIVKCFGNLMPRHRELFYKNPVFTGLKVPEVHAVEPLEKRLPRLPPLLLDLIKQCLYMDADTRPPCSRLLQHDYFTADGFADKRFSQHLELCNGAQSGPYHSIKPSAf{K {MASGQRSISFNVSHHYQILDIVGEGAYGVVCSAIHLPSQQKVAIKKIVPFSKPMFCLRTLRELKLLKHFNHENIISILDIQVPYDFSSFHEVYLIQELMETDLHRVIRTQQLSDDHCQYFVYQTLRALKALHSANVLHRDLKPSNLLLNANCDLKVCDFGLARSVAKTEDNYGFMTEYVATRWYRAPEIMLTFQEYTAAIDVWSVGCILAEMLSGTPLFPGKDYHHQLSLIFDVLGTPGKEDLAAIKSPRPREYVGSMTPRPGVDFKTLFPGANPLGLDLLSRLLTFSPARRICVDDALRHPYLQLYHDPNDEPVAAPLEDDFFDFDRRKEELTMLDLKELLYEEIIKPLQ J~ ~MEIRVANKYALGKKLGSGSFGDIYVAKDIVTMEEFAVKLESTRSKHPQLLYESKLYKILGGGIGVPKVYWYGIEGDFTIMVLDLLGPSLEDLFTLCNRKFSLKTVLMTADQMLNRIEYVHSKNFIHRDIKPDNFLIGRGKKVTLIHIIDFGLAKKYRDSRSHTHIPYKEGKNLTGTARYASINTHLGIEQSRRDDIEALGYVLMYFLRGSLPWQGLKAISKKDKYDKIMEKKISTSVEVLCRNASFEFVTYLNYCRSLRFEDRPDYTYLRRLLKDLFIREGFTYDFLFDWTCVYASEKDKKKMLENKNRFDQTADQEGRVKQN } }MSGRPRTSSFAEGNKQSPSLVLGGVKTCSRDGSKITTVVATPGQGTDRVQEVSYTDTKVIGNGSFGVVFQAKLCDTGELVAIKKVLQDRRFKNRELQIMRKLEHCNIVKLLYFFYSSGEKRDEVFLNLVLEYIPETVYKVARQYAKTKQTIPINFIRLYMYQLFRSLAYIHSLGICHRDIKPQNLLLDPETAVLKLCDFGSAKQLLHGEPNVSYICSRYYRAPELIFGAINYTTKIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEVIKVLGTPTREQIREMNPNYTEFKFPQIKSHPWQKVFRIRTPTEAINLVSLLLEYTPSARITPLKACAHPFFDELRMEGNHTLPNGRDMPPLFNFTEHELSIQPSLVPQLLPKHLQNASGPGGNRPSAGGAASIAASGSTSVSSTGSGASVEGSAQPQSQGTAAAAGSGSGGATAGTGGASAGGPGSGNNSSSGGASGAPSAVAAGGANAAVAGGAGGGGGAGAATAAATATGAIGATNAGGANVTDS l+UBlhqqHomo.sapiens.MAPK8.sp.P45983.MK08_HUMAN.Mitogen.acHomo.sapiens.MAPK8.sp.P45983.MK08_HUMAN.Mitogen.achqqBos.taurus.CDK10..sp.Q2TBL8.CDK10_BOVIN.Cyclin.depBos.taurus.CDK10..sp.Q2TBL8.CDK10_BOVIN.Cyclin.dephqqHomo.sapiens.CDK6..sp.Q00534.CDK6_HUMAN.Cyclin.depHomo.sapiens.CDK6..sp.Q00534.CDK6_HUMAN.Cyclin.dephqqDictystelium.discoideum.MAPK3..Extracellular.signaDictystelium.discoideum.MAPK3..Extracellular.signa:CCAjellomyces.capsulatus.CDK1Ajellomyces.capsulatus.CDK1hqqHomo.sapiens.CDKL5..sp.O76039.CDKL5_HUMAN.Cyclin.dHomo.sapiens.CDKL5..sp.O76039.CDKL5_HUMAN.Cyclin.dhqqDictyostelium.discoideum.CDK10..Probable.cyclin.deDictyostelium.discoideum.CDK10..Probable.cyclin.dehqqMus.musculus.CDKL2..sp.Q9QUK0.CDKL2_MOUSE.Cyclin.dMus.musculus.CDKL2..sp.Q9QUK0.CDKL2_MOUSE.Cyclin.dhqqHomo.sapiens.MAPK15..sp.Q8TD08.MK15_HUMAN.Mitogen.Homo.sapiens.MAPK15..sp.Q8TD08.MK15_HUMAN.Mitogen. 'M MCTVVDPRIVRRYLLRRQLGQGAYGIVWKAVDRRTGEVVAIKKIFDAFRDKTDAQRTFREITLLQEFGDHPNIISLLDVIRAENDRDIYLVFEFMDTDLNAVIRKGGLLQDVHVRSIFYQLLRATRFLHSGHVVHRDQKPSNVLLDANCTVKLCDFGLARSLGDLPEGPEDQAVTEYVATRWYRAPEVLLSSHRYTLGVDMWSLGCILGEMLRGRPLFPGTSTLHQLELILETIPPPSEEDLLALGSGCRASVLHQLGSRPRQTLDALLPPDTSPEALDLLRRLLVFAPDKRLSATQALQHPYVQRFHCPSDEWAREADVRPRAHEGVQLSVPEYRSRVYQMILECGGSSGTSREKGPEGVSPSQAHLHKPRADPQLPSRTPVQGPRPRPQSSPGHDPAEHESPRAAKNVPRQNSAPLLQTALLGNGERPPGAKEAPPLTLSLVKPSGRGAAPSLTSQAAAQVANQALIRGDWNRGGGVRVASVQQVPPRLPPEARPGRRMFSTSALQGAQGGARALLGGYSQAYGTVCHSALGHLPLLEGHHV BBvi MRSVLSFEKLDSIGEGTYGIVSKGRDKETGRIVALKKVKIGQQDKDGIPLTSLREIQILKEIKHPNIVSLLEVVIGSTGDKIYLVFEYLEHDVASLIDNINKPFKLSEIKCFLLQLLRAVEYLHSHWIIHRDLKCSNLLYGNNGNLKLADFGLARKFGYPIESITPCMVTLWYRSPELLLGCQKYSTAVDLWSIGSIFGELLIGRPLITGNNEVDQIMRIFNLLGEPNEQIWPGFSSLPNFKRLNNIPHQPYNNLRELVPTISDTAFDLLNQLLTYDPTKRITASDAIKHPFFYENPFPQSIEMMPKFPTISKSFKNQNKKQNNNFNNFVQNNQTNQNNQTNQNNQTNQNNKTSQNNNMDSYKYSK@} MEKYENLGLVGEGSYGMVMKCRNKDSGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRHENLVNLLEVCKKKKRWYLVFEFVDHTILDDLKLFPNGLDYQVVQKYLFQIINGIGFCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYTDYVATRWYRAPELLVGDVKYGKAVDIWAIGCLVIEMLMGQPLFPGESDIDQLHHIMTCLGNLIPRHQELFYKNPVFAGVRLPEVKDAEAEPLESRYPKLPEAVISLAKKCLHIDPDKRPFCADLLRHDFFQMDGFAERFSQELQLKIEKDARNNSLPKKSQNRKKEKDDALGEERKTLVVQDTNADPKIKDSKVFKVKGSKIDVEKMEKGSRASNANCLHDNGTNHKGLASTSLRDCSNVNIDHSRNPGTAIPPLTHNLSAVAPGINAGMGTIPGVQNYRVDEKTKKYCNPFVKPNQPPPAGIYNMNVSTSVSGEKYLLQANKKRKEYPKADVRLPELNYNHLPELRALEGIARNSRLIKKENKCLSESRIPSLAAIDLHVSSVASHQGAGSPLSDDSEADLPRMEHQHMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQRLLDRSPSRSAKRKPYHVESSTLSNRNQAGKSTALQSHHRSNSKDIQNLSVGLPRADEGLPANESFLNGNLAGASLSPLHTKTYQASSQPGSTSKDLTNNNIPHLLSPKEAKSKTEFDFNIDPKPSEGPGTKYLKSNSRSQQNRHSFMESSQSKAGTLQPNEKQSRHSYIDTIPQSSRSPSYRTKAKSHGALSDSKSVSNLSEARAQIAEPSTSRYFPSSCLDLNSPTSPTPTRHSDTRTLLSPSGRNNRNEGTLDSRRTTTRHSKTMEELKLPEHMDSSHSHSLSAPHESFSYGLGYTSPFSSQQRPHRHSMYVTRDKVRAKGLDGSLSIGQGMAARANSLQLLSPQPGEQLPPEMTVARSSVKETSREGTSSFHTRQKSEGGVYHDPHSDDGTAPKENRHLYNDPVPRRVGSFYRVPSPRPDNSFHENNVSTRVSSLPSESSSGTNHSKRQPAFDPWKSPENISHSEQLKEKEKQGFFRSMKKKKKKSQTVPNSDSPDLLTLQKSIHSASTPSSRPKEWRPEKISDLQTQSQPLKSLRKLLHLSSASNHPASSDPRFQPLTAQQTKNSFSEIRIHPLSQASGGSSNIRQEPAPKGRPALQLPDGGCDGRRQRHHSGPQDRRFMLRTTEQQGEYFCCGDPKKPHTPCVPNRALHRPISSPAPYPVLQVRGTSMCPTLQVRGTDAFSCPTQQSGFSFFVRHVMREALIHRAQVNQAALLTYHENAALTGK $A$/ MEPEFDHFQSQMDSDNTHQSTMFNVQDNNAILMSGMENVLQSPRQLQAAAQAQQQAAAQAQQQQVQAQQVQAQQAQQQQQQQQNQQQQQQQQNQQNQQQQQNQQQQSQQMTQQQLQQLMPPPPTSDTSNFNDNISYFVYGSQFTVPRRYSIVKCIGHGAYGVVCSAKDNLTGEKVAIKKISKAFDNLKDTKRTLREIHLLRHFKHENLISIKDILKPNSKEQFEDVYIVSELMDTDLHQIITSPQPLSDDHCQYFVYQMLRGLKHIHSANVLHRDLKPSNLLINEDCLLKICDLGLARVEDATHQGFMTEYVATRWYRAPEVILSWNKYTKAIDIWSVGCIFAELLGRKPLFQGKDYIHQITLIIETIGSPSEEDICNIANEQARQFIRNMGNQPKVNFANMFPKANPDAIDLLERMLYFDPSKRLTVEEALAHPYFQSLHDPSDEPICLHKFSLNFEAWDLNRDLLKELIYNEMLAYHPEDPQAPYYTDLNNPNFNLSRIQSSSELFNLLQQQKQQIHQQVNQQSIKNL MENYQKIEKIGEGTYGVVYKARDLTHPNRIVALKKIRLEAEDEGVPSTAIREISLLKEMHDPNIVRLLNIVHADGHKLYLVFEFLDLDLKKYMEALPVSEGGRGKALPDGSTLDMNRLGLGEAMVKKFMAQLVEGIRYCHSHRVLHRDLKPQNLLIDREGNLKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLGGRQYSTGVDMWSVGAIFAEMCTRKPLFPGDSEIDEIFKIFKLLGTPDENTWPGVTSFPDFKASFPKWKREDTRKLVPGLERNGLDLLDAMLEYDPARRISAKQACMHPYFQAGSSAYSGRERLQPYP MKIPNIGNVMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKN I(_*0On7qKluyveromyces.lactis.CDC7.tr.Q6CUJ8.Q6CUJ8_KLULA.KC?Hydra.magnipapillata.CDK1.7qHomo.sapiens.MAPK7..Mitogen.activated.protein.kina!7qHomo.sapiens.MAPK8.sp.P45983.MK08_HUMAN.Mitogen.ac6qHomo.sapiens.MAPK9..sp.P45984.MK09_HUMAN.Mitogen.aZ7qHomo.sapiens.MOK..MAPK.MAK.MRK.overlapping.kinase.6qHomo.sapiens.NLK..sp.Q9UBE8.NLK_HUMAN.Serine.threo)7qHomo.sapiens.SGK71..sp.Q8NE28.SGK71_HUMAN.Probable(UHomo.sapiens.SRSF.GN.SRPK1.PE.1.SV.2+7qHomo.sapiens.TTK..sp.P33981.TTK_HUMAN.Dual.specifi7qKluyveromyces.lactis.GSK3..tr.O60042.O60042_KLULC.?Kluyveromyces.lactis.IME2 ?Kluyveromyces.waltii.IME26qKomagataella.pastoris.MAPK3..tr.F2QYY4.F2QYY4_PICP{"GLachancea.thermotolerans.SKY17qLatimeria.chalumnae.CDKL1..tr.H3BGX9.H3BGX9_LATCH. I(_*0On7qKluyveromyces.lactis.CDC7.tr.Q6CUJ8.Q6CUJ8_KLULA.KC?Hydra.magnipapillata.CDK1.7qHomo.sapiens.MAPK7..Mitogen.activated.protein.kina!7qHomo.sapiens.MAPK8.sp.P45983.MK08_HUMAN.Mitogen.ac6qHomo.sapiens.MAPK9..sp.P45984.MK09_HUMAN.Mitogen.aZ7qHomo.sapiens.MOK..MAPK.MAK.MRK.overlapping.kinase.6qHomo.sapiens.NLK..sp.Q9UBE8.NLK_HUMAN.Serine.threo)7qHomo.sapiens.SGK71..sp.Q8NE28.SGK71_HUMAN.Probable(UHomo.sapiens.SRSF.GN.SRPK1.PE.1.SV.2+7qHomo.sapiens.TTK..sp.P33981.TTK_HUMAN.Dual.specifi7qKluyveromyces.lactis.GSK3..tr.O60042.O60042_KLULC.?Kluyveromyces.lactis.IME2 ?Kluyveromyces.waltii.IME26qKomagataella.pastoris.MAPK3..tr.F2QYY4.F2QYY4_PICP{"GLachancea.thermotolerans.SKY17qLatimeria.chalumnae.CDKL1..tr.H3BGX9.H3BGX9_LATCH. 99q_ MGEPEPEQIRLKCVRKEGFFTVPPEHRLGRCRSVKEFEKLNRIGEGTYGIVYRARDTHTDEIVALKKVRMDKEKDGVPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENMPTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGIPVKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHKPLLPGTSEIHQVDLIVQLLGTPSENIWPGFSQLPLASQYSLRKQPYNNLKHKFPWLSEAGLRLMNLLFMYDPKKRATAGDCLESSYFKEKPLPCEPELMPTFPHHRNKRATPATSLGTESQSRRGRPN MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA Ivi MSLTRKRGFYKQDINKTAWELPKTYLAPAHVGSGAYGAVCSAIDKRTGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMHHENVIGLLDVFTPASSLRSFHDFYLVMPFMQTDLQKIMGMEFSEDKVQYLVYQMLKGLKYIHSAGIVHRDLKPGNLAVNEDCELKILDFGLARHTDTEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGAEFVQKLKDKAAKSYIQSLPQSPKKDFTQLFPRASPQAADLLDKMLELDVDKRLTAAQALAHPFFEPFRDPEEETEAQQPFDDALEHEKLSVDEWKQHIYKEISNFSPIARKDSRRRSGMKLQ3c MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVMDLEERTKNGVIRGQPSPLGAAVINGSQHPSSSSSVNDVSSMSTDPTLASDTDSSLEAAAGPLGCCR $*Te$hqqKluyveromyces.lactis.GSK3..tr.O60042.O60042_KLULC.Kluyveromyces.lactis.GSK3..tr.O60042.O60042_KLULC.hqqGallus.gallus.CDKL5..tr.E1BTX0.E1BTX0_CHICK.UncharGallus.gallus.CDKL5..tr.E1BTX0.E1BTX0_CHICK.UncharhqqXenopus.tropicalis.CLK2..tr.F7C0E3.F7C0E3_XENTR.UnXenopus.tropicalis.CLK2..tr.F7C0E3.F7C0E3_XENTR.UnhqqDanio.rerio.MAPK14a..sp.Q9DGE2.MK14A_DANRE.MitogenDanio.rerio.MAPK14a..sp.Q9DGE2.MK14A_DANRE.Mitogen@ IILodderomyces.elongisporus.IME2Lodderomyces.elongisporus.IME2> GGSaccharomyces.cerevisiae.CDK1Saccharomyces.cerevisiae.CDK1h qqGallus.gallus.MAPK10..tr.E1C8C5.E1C8C5_CHICK.UnchaGallus.gallus.MAPK10..tr.E1C8C5.E1C8C5_CHICK.Unchah qqXenopus.tropicalis.NLK2..sp.B1H3E1.NLK2_XENTR.SeriXenopus.tropicalis.NLK2..sp.B1H3E1.NLK2_XENTR.Serih qqDrosophila.melanogaster.CDK4..tr.Q94877.Q94877_DRODrosophila.melanogaster.CDK4..tr.Q94877.Q94877_DROhqqMus.musculus.MAPK13..sp.Q9Z1B7.MK13_MOUSE.Mitogen.Mus.musculus.MAPK13..sp.Q9Z1B7.MK13_MOUSE.Mitogen. N  MAFQGPGRSLPGQLCAGVFGGLIQPPLGQKFYCPNGGSGGGGVPAVPSPLPQALSAPQCNGDGRGEPEPDRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQPPQIDCFEEIYVITELMQTDLHKVIVSPQPLSSDHIKVFLYQILRGLKYLHSAGILHRDIKPGNLLVNSNCVLKICDFGLARVEELDESQHMTQEVVTQYYRAPEILMGSRHYRSAIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPPLTAMRSACEGARAHILRGPHKPPSLSVLYMLSGEATHEAVHLLCRMLLFDPLKRISAKDALAHPYLEEGRLRYHTCMCHCCYSVSSGRVYTADFEPTATNRFDDSYEKSLTSVWQVKELVHRFITDQQQGKRPPLCINPHSAAFKTFIRSTAWHSSKVSKKEERE  MSYVRQLKRQKMSQAKKFGDGDPFNYQELNIIGEGAYGTVYRARDVITGNIVALKKVRISLNENGVPMSTLREISLLKQLNASNHANIVKLYEVCQFLERDGQLLILLAFEHVEQDLSDLIDRLPKSGMSPPTIQRLSRELLTGVDFLHSHRIIHRDLKPQNLLVSSQGHLKIADFGLAKTYGSEMKLTSVVVTLWYRAPEVLLAQPYNSTVDIWSAACIIFEMFNRRALFPGTSEKNQLDRIFELTGRPTEQQWPQTISVALEHFPQRHPKRPKDFCPHLCKYADDLLNKMLSYDLHLRPSALACLEHDYFQQEPL $2 a MSGELANYKRLEKVGEGTYGVVYKALDLRPGQGQRVVALKKIRLESEDEGVPSTAIREISLLKELKDDNIVRLYDIVHSDAHKLYLVFEFLDLDLKRYMEGIPKDQPLGADIVKKFMMQLCKGIAYCHSHRILHRDLKPQNLLINKDGNLKLGDFGLARAFGVPLRAYTHEIVTLWYRAPEVLLGGKQYSTGVDTWSIGCIFAEMCNRKPIFSGDSEIDQIFKIFRVLGTPNEAIWPDIVYLPDFKPSFPQWRRKDLSQVVPSLDPRGIDLLDKLLAYDPINRISARRAAIHPYFQESX - MSRHLLYYCGEPTLDVKIAFCQGFGKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKSLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDMWSVGCIMGEMVKGAVLFPGTDHIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDEALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSANDISSMSTDQTLASDTDSSLEASAGPLGCCR !!q_ MSQKERPTFYRQEVNKTIWEVPVQYQNLSPVGSGAYGSVCSAFDAKTGFKVAVKKLSRPFQSIIHAKRTYRELRLLKHMRHENVIGLLDVFTPATSLKEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNVTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTGTPPSSLISRMPSHEARTYISSLPQMPKRNFADVFIGANPQAVDLLEKMLVLDTDKRITAAEALAHPYFAQYHDPDDEPEAEPFDQSFESRELDIEEWKRQTYEEMISFEPPVFDVDEMESf I MSIYKPLPLKIGSPQPPQSPKNLTVHSYNNHYQTISNLGNGSFGSVELAKIRFSKLDLLNSHYSEAGTLLYPLEDSKFNTSNLVAIKTMKKKLPLLQDYSKVKEVKFILSVPSHPCLVQVFEVFIDDLNHQLHISMEALNQNLYQLIRSRKNMRFSQTTLKSILSQLLCAIKHIHNNQYFHRDVKPENILILPTLQYYGSKERVPPHRKNDNFIVKLGDYGLARHISNMRTYTAYVSTRWYRLPEILLRQQWYSRPIDIWAFGAVAAEVINFAPLFPGSNEFDQIWKILQILGSPTMPELFVHNNNNNNNNNIKSSISGIGSRSNPHGNQNCIIPFGGFWNEAKPLASNLGIELPNEPGTNIHEIVPCIKDNSLRQVIQSCLLWDPLARPDANQLSKMSYFKESVHAIDKYHEISSSMGMIKGIVSSSSSSSSSFSILPSSTSSTITTITTTPAKLLNSLSNSLSSTVLSPSLPFRYHCNKPAQLPTLPIEKPLLPSPLVQPINLEHTNGTSTTNIAGQGFPNIENSYENYFSDYLSQVADCSSQQKLENGCYTLYNNYGEKFKSDKSKEPRSINEFKRDYAQSPAGKNNSISTVSFDSEDILNLH } MPHSRRYRSSERGSRGSYHERYRSRKHRRRRSRSRSSSSDRGRDRRHKHGDSYHERSRSLGLCERSSNRRAYDRRYCDGYRRNEYSRDRGDVYYEADYRHSYEYKHSREDSYRSCKSARRKQKRRKRRTRSYSQSSSRSRQSSRRAKSVEDDVEGHLIYHSGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPENKHLCVQMYDWFDYHGHMCISFELLGLSTFDFLKENNYFPYPIHQVRHMALQVCQAVKFLHDNKLTHTDLKPENILFVSSDYELTYNMEKRDERCVKNTDIRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWNQPCDVWSVGCIIFEYYVGFTLFQTHDNREHLAMMERILGPVPSRMVRKTRKQKYFYHGRLDWDDNTSAGRYVRENCKPLRRYMMMETEEHHQLFSLIEGMLEYEPSKRMTLAAALKHPFFSPFKGEPALKHWDTGRDISR ll MKIPNIGNVMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGSNANYTEYVATRWYRSPELLLGAPYGKAVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPAEQMKLFYSNPRFHGLRFPAVNHPQSLERRYLGILSGVLLDLMKNLLKLDPADRYLTEQCLNHPSFQTQRLLDRCGSSPSRSAKRKPYHVDSNTLSNRNQASKSSALQSHHRSNSKDIQTLGIGGPREEGLPANESFLNGNLSGAAHSPMHAKKSSNQPGSGNKDLANNNMPHLLSPKETKAKTEFDFNVDPKSSDGPGTKYLKSNTRSQQNRHSFMETSQSKTGTLQPGDKHSRHSYIDTIPQSSKSPSYRTKSKSHGVLTDSKSVGNLSEARAQAAEPNSSRYFPSSCMDLNSPTSPTAPRHSDNRTLLSPSGRNNRSEGTLDTRRPSTRHSKTMEELKLPDHMDGSHSHSLSAPHESFSYGLGYTSPFSSQQRPHRHSMYVSRDRVRSKGSEGGLSVGQGMAARANSLQLLSPQQSDQIPSETNLTRPPVKDSSRDVTAAFHSRRKSEGGAYHDPHTEDGASTKENRILYNEAVPRRVGSFYRVPSPRPDSTYIENNVSNRASVLPADSSTVANHSKRQTTFDTWKSPENLNSHSEQLKEKEKQGFFRAIKKKKKKSQTMPGTDGQDLLALQKAIHSSNHQSSRQKDWHPEKMTEIQPHSQPLKSLRKLLHLSSNHPIPAEPRFQPLPSQPAKPAFSEVRIHPMSQSSSSGSSNARQEPQPKSRPTLQIP UU'K MKVGELLESSGAGGSRSIIAYTNDKNAGFETEMDSILPSDDLKQGSLHSKNSHGNDVKIVPDEDEVITRRTVVKGHSNPRSQLLFHAVTPEIVGNGSFGVVFRTKVKETGRMLSLRRFYRIRRFKNRELEIMKLISHPNLIDLKYYFLEQSDQELYLNLIVDYMPMSLYQRLKEFISLHQPMDRYEIKIYMFQLFKSLNYLHQVVNVCHRDIKPQNILVDPDTLLLKICDLGSAKQLKPNEPNVSYICSRYYRAPELIFGATNYTTKIDIWSAGCVMAELLLGQPIFPGESKIDQLVEIIKVLGTPTREEICSMNENYSEHKFPQIRPIPLNRIFKKETQETIDLLYHIMKYDPNIRYSALQCMFNSTYFTDIVSNTGSDSNLSLIDSLPLLHFEESELQGLSSNDIYRLTGKLI D*TADhqqXenopus.Laevis.CDK7..sp.P20911.CDK7_XENLA.Cyclin.dXenopus.Laevis.CDK7..sp.P20911.CDK7_XENLA.Cyclin.d$--Salmo.salar.CDK1Salmo.salar.CDK1hqqCryptococcus.neoformans.SSN3..Serine.threonine.proCryptococcus.neoformans.SSN3..Serine.threonine.prohqqHomo.sapiens.CDK4..sp.P11802.CDK4_HUMAN.Cyclin.depHomo.sapiens.CDK4..sp.P11802.CDK4_HUMAN.Cyclin.dep:CCCaenorhabditis.elegans.CDK1Caenorhabditis.elegans.CDK1hqqMus.musculus.GSK3a..sp.Q2NL51.GSK3A_MOUSE.GlycogenMus.musculus.GSK3a..sp.Q2NL51.GSK3A_MOUSE.GlycogenhqqMus.musculus.CDKL1..sp.Q8CEQ0.CDKL1_MOUSE.Cyclin.dMus.musculus.CDKL1..sp.Q8CEQ0.CDKL1_MOUSE.Cyclin.dhqqXenopus.tropicalis.HIPK2..tr.F7A386.F7A386_XENTR.UXenopus.tropicalis.HIPK2..tr.F7A386.F7A386_XENTR.UhqqHomo.sapiens.CLK4..Dual.specificity.protein.kinaseHomo.sapiens.CLK4..Dual.specificity.protein.kinasehqqDrosophila.melanogaster.MAPK15..tr.Q9W354.Q9W354_DDrosophila.melanogaster.MAPK15..tr.Q9W354.Q9W354_D ``5 MANYQTAHAQERRIQELDQTVESIFDVRKRMGKGAYGIVWKATDRRTKNTVALKKVFDAFRDETDAQRTYREVIFLRAFRCHPNIVRLVDIFKASNNLDFYLVFEFMESDLHNVIKRGNVLKDVHKRFVMYQLINAIKFIHSGNVIHRDLKPSNILIDSKCRLKVADFGLARTLSSRRIYDDLEQDGMLTDYVATRWYRAPEILVASRNYTKGIDMWGLGCILGEMIRQKPLFQGTSTVNQIEKIVTSLPNVTKLDIASIGPSFGSVLLSRNIQRDRRYSLDEMMKNCCDDGISLVKALLVLNPHNRLTAKEAIRHPYVSRFQYASAEMDLHMDVVPPLKDHVRYDVDQYRNSLYELIDRETSCSNRTVSNSTPSSNRDELPKPVRVTKQARTTSAKQPTTSPAERKKEPSSVEVTQSRKNIKLLGSAHKAQSKEINHMESAITQVSIASAPPAAAPPAPAATAPAVPRKSGDKSVPKCQHNNAAVQRELAAVAAAAAVARRKKSSWQSQAQSQGKFHTEAKAHVQTAIQTQKDNIKDSPPRMIQESQSLTEAKAPIPKNRYSNKMCQEKKYKKKHHSMSCITRDTFPSETEHRQQREERAYQRQMKRELQLKESYRRRIEAESEPLKETTEQESKTIKVIEQKVCEHTEKKADESLSKDQQKDSITFGTCVRERIHHLELEMEKCTEELVDFVELNADVLNYANVSTHLKKLQRSKESDEKDEDDRRALPEGIGGPGSQNYEIFRQEQEKERQRQVQEFLARDETNEYDNLDLDHAYRAKYYTAYKEIGKELNPAPDSGGRDSGSEHSPGRDNYTTYADYFLKYTTPQQNWNDLERANGLQREHDRIYGLFWLNDRRQEEKYRRKLAQNDQEELPVHHHKACRHRHHKPNHHAPYDHMRPTEDDIQEADSLPESN 88hM MEKYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKRFLETEDDPVIKKIALREIRMLKQLKHPNLVNLLEVFRRKRRLHLVFEYCDHTVLHELDRYQRGVPEPLVKNITWQTLQAVNFCHKHNCIHRDVKPENILITKQSAIKLCDFGFARLLTGPGDYYTDYVATRWYRSPELLVGDTQYGPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSMNQYFSGVKIPDPEDMETLELKFPNISYSALGFLKGCLHMDPAERLTCEQLLQHPYFDSIREVGELTRQHDKPARKTLRQSRKHLTGLQYLPQLTSSRILPALDNKKYHCSTKRFNYHFPNI; SLSLSAGMASHLQIFSSHGLPLRTFCKVKKPKLELSPGWDMTGYGCHSKVYNSGKNSSTSGQPVLSHASLLQSYEQTVIFPTSAGHIVVTSSSNG҃iO MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKKSSAATGQALGGPQTNLMRRSTVSLLDTYQKCGLKRKCEELENNSSVQIVDEHPPVTQNNASGATAATTSTATSKNSGSNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVGTALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSSGTKTTRFFNRDGDSPYPLWRLKTPEDHENETGIKSKEARKYIFNCLDDMAQVNMASDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPFVTMTHLLDFPHSSHVKSCFQNMEICKRRVNMYDTVNHSKTPFITHVAPSTSTNLTMTFSNQLNTVHSQVGVWLPGTSLTMYQPLPAQRFTPIRNTHAHGTHYNPIMQQPALLTGHVTLPSAQPLNVGVAHVMRQQPTSSSSSSRKKHHSLASRNISAYEVTSSQSVNSPQRSKRVKENTPPRCAVPQNTTACVPSITCGWGDSAVGGSHNRQRQTIIIPDTPSPAVSVITISSDTDEEEEQKHVAPRCSLPKQRRNVISCVTVHDSPISDSSSNTSPYAASGHRRGNNTSAAESKCQTGNPCPANPRTIIVPPLKTQPSEGRLECERKQPDTTSHHMYKAKLLSSVASASHSSASSAGTAYRHSRAPGHSFQQQPLNLSQVSQHISTERTGSHRRQHAYIAPTLAQAPYSFPHSSPSHGAVHPHLAAAAHLPSQPHLYTYTAPAALGSSGTVAHLVASQGSARHAAYPASIVPVSMAQRLLPSPSLHPSQYQAQFAHQTYIPASPTSTVYTGYPLTPPKVNQYPYI  T% MDPIREGEVAHEGDSVYTLNDFTKLEKIGEGTYGVVYKGKNRRTNAMVAMKKIRLESEDEGVPSTAVREISLLKELQHPNVVGLEAVIMQENRLFLIFEFLSFDLKRYMDQLGKDEYLPLETLKSYTFQILQAMCFCHQRRVIHRDLKPQNLLVDNNGAIKLADFGLARAIGIPIRVYTHEVVTLWYRAPEILMGAQRYSMGVDMWSIGCIFAEMATKKPLFQGDSEIDELFRIFRVLGTPTELEWNGVESLPDYKATFPKWRENFLRDKFYDKKTGKHLLDDTAFSLLEGLLIYDPSLRLNAKKALVHPYFDNMDTSKLPAGNYRGELELFra MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPSGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATVGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLITPIIYIKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSSKTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRRLGAQLPNDRPLPPLFNFSPGELSIQPSLNAILIPPHLRSPAGPASPLTTSYNPSSQALTEAQTGQDWQPSDATTATLASSS G D{!Y#ILodderomyces.elongisporus.IME27qLytechinus.variegatus.GSK3..tr.Q6IUG5.Q6IUG5_LYTVA6qMedicago.sativa.MAPK3..sp.Q07176.MMK1_MEDSA.Mitoge7qMeleagris.gallopavo.MAPK13..tr.G1MQ62.G1MQ62_MELGA7qMicromonas.RCC299.GSK3..tr.C1ED07.C1ED07_MICSR.Gly7qMicromonas.sp.RCC299.LF4..long.flagella.protein.LF?Monosiga.brevicollis.CDK1y6qMus.muculus.PRP4..sp.Q61136.PRP4B_MOUSE.Serine.thrU6qMus.musculus.CDC7...sp.Q9Z0H0.CDC7_MOUSE.Cell.diviJ6qMus.musculus.CDK10..sp.Q3UMM4.CDK10_MOUSE.Cyclin.dX7qMus.musculus.CDK11B.sp.P24788.CD11B_MOUSE.Cyclin.d6qMus.musculus.CDK12.sp.Q14AX6.CDK12_MOUSE.Cyclin.deV7qMus.musculus.CDK14..Cyclin.dependent.kinase.14.OS.7qMus.musculus.CDK15..Cyclin.dependent.kinase.15.OS.6qMus.musculus.CDK16..sp.Q04735.CDK16_MOUSE.Cyclin.de7qMus.musculus.CDK17..sp.Q8K0D0.CDK17_MOUSE.Cyclin.d G D{!Y#ILodderomyces.elongisporus.IME27qLytechinus.variegatus.GSK3..tr.Q6IUG5.Q6IUG5_LYTVA6qMedicago.sativa.MAPK3..sp.Q07176.MMK1_MEDSA.Mitoge7qMeleagris.gallopavo.MAPK13..tr.G1MQ62.G1MQ62_MELGA7qMicromonas.RCC299.GSK3..tr.C1ED07.C1ED07_MICSR.Gly7qMicromonas.sp.RCC299.LF4..long.flagella.protein.LF?Monosiga.brevicollis.CDK1y6qMus.muculus.PRP4..sp.Q61136.PRP4B_MOUSE.Serine.thrU6qMus.musculus.CDC7...sp.Q9Z0H0.CDC7_MOUSE.Cell.diviJ6qMus.musculus.CDK10..sp.Q3UMM4.CDK10_MOUSE.Cyclin.dX7qMus.musculus.CDK11B.sp.P24788.CD11B_MOUSE.Cyclin.d6qMus.musculus.CDK12.sp.Q14AX6.CDK12_MOUSE.Cyclin.deV7qMus.musculus.CDK14..Cyclin.dependent.kinase.14.OS.7qMus.musculus.CDK15..Cyclin.dependent.kinase.15.OS.6qMus.musculus.CDK16..sp.Q04735.CDK16_MOUSE.Cyclin.de7qMus.musculus.CDK17..sp.Q8K0D0.CDK17_MOUSE.Cyclin.d Z1 MATIPGGGTIMDPMHLYRARRDKERRGVLKTYKILGFISSGTYGRVYKAVLLPPPKTASAKSALPSSTRAALSLPKDKLPSPSFTEDSDPLNNPEMCMRPGDRPAKRGDVFAIKKFKPDKEGDVLTYAGISQSGAREIMLNRELHHRNLVSLREVILEDKSIYMVFEYAEHDFLQIIHYHSQTARASIPPSTLRRLLHQLLCGVHFLHSNFVLHRDLKPANILVTSQGVVKIGDLGLARLWHKPLAQQGLYGGDKVVVTIWYRAPELILGAKHYTAAVDIWAVGCIYAELLSLRPIFKGDEAKMDGKKSLPFQRDQMGKICEVLGPVKPEQWPGIVHMPEYRTYQATGPYPHSNPLAPWYHARSNSSEGYDILVKMFEWDPARRITARDALRHPWFQEEGGVDTKSVFEGSSITYPTRRVTHEDNGDAKMGSLPQSMAGGRLPSSSNFRPASGNIVQPAARKKARI7k MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNPE ^^hM MEGIAARGVDVRSRAKQYEKLDFLGEGQFATVYKARDKNTDRIVAIKKIKLGHRAEANDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDTSLVLTPAHIKSYMLMTLQGLEYLHHLWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRIYTHQVVTRWYRSPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPGMSSLPDYVAFKSFPGTPLHLIFIAAGDDLLELLQGLFTFNPCARCTASQALRKRYFSNRPAPTPGNLLPRPNCSIEALKEQQNLNLGIKRKRTEGMDQKDIAKKLSF2a MESFQKVEKIGEGTYGVVYKAKNKVTGETVALKKIRLDTETEGVPSTAIREISLLKELSHPNIVELRDVIHTENKLYLVFEFLHQDLKKFMDSSSVSGIALPLVKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINAQGEIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMITRRALFPGDSEIDQLFRIFRTLGTPDEVAWPGVTSMPDYKPSFPKWARQELSKVVPPLDDDGRELLGQMLAYDPNKRISAKNALVHRFFRDVTMPMPHLRL m*TCmh$qqCaenorhabditis.briggsae.NLK..sp.A8XSC1.NLK_CAEBR.SCaenorhabditis.briggsae.NLK..sp.A8XSC1.NLK_CAEBR.Sh#qqGallus.gallus.MAPK13..tr.E1C7W3.E1C7W3_CHICK.UnchaGallus.gallus.MAPK13..tr.E1C7W3.E1C7W3_CHICK.Unchah"qqOryzias.latipes.CLK2b.tr.H2M4E3.H2M4E3_ORYLA.UnchaOryzias.latipes.CLK2b.tr.H2M4E3.H2M4E3_ORYLA.Unchah!qqDanio.rerio.CDK8..Cyclin.dependent.kinase.8.OS.DanDanio.rerio.CDK8..Cyclin.dependent.kinase.8.OS.Dan8 AAAspergillus.fumigatus.IME2Aspergillus.fumigatus.IME2hqqHomo.sapiens.SGK71..sp.Q8NE28.SGK71_HUMAN.ProbableHomo.sapiens.SGK71..sp.Q8NE28.SGK71_HUMAN.ProbablehqqMus.musculus.GSK3b..sp.Q9WV60.GSK3B_MOUSE.GlycogenMus.musculus.GSK3b..sp.Q9WV60.GSK3B_MOUSE.GlycogenhqqHomo.sapiens.TTK..sp.P33981.TTK_HUMAN.Dual.specifiHomo.sapiens.TTK..sp.P33981.TTK_HUMAN.Dual.specifihqqHomo.sapiens.CDK20..sp.Q8IZL9.CDK20_HUMAN.Cyclin.dHomo.sapiens.CDK20..sp.Q8IZL9.CDK20_HUMAN.Cyclin.d bA MDQYCILGRIGEGAHGIVFKAKHVETGEIVALKKVALRRLEDGFPNQALREIKALQEMEDNQYVVQLKAVFPHGGGFVLAFEFMLSDLAEVVRHAQRPLAQAQVKSYLQMLLKGVAFCHANNIVHRDLKPANLLISASGQLKIADFGLARVFSPDGSRLYTHQVATRWYRAPELLYGARQYDQGVDLWSVGCIMGELLNGSPLFPGKNDIEQLCYVLRILGTPNPQVWPELTELPDYNKISFKEQVPMPLEEVLPDVSPQALDLLGQFLLYPPHQRIAASKALLHQYFFTAPLPAHPSELPIPQRLGGPAPKAHPGPPHIHDFHVDRPLEESLLNPELIRPFILEG a? MESEDLSGRELTIDSIMNKVRDIKNKFKNEDLTDELSLNKISADTTDNSGTVNQIMMMANNPEDWLSLLLKLEKNSVPLSDALLNKLIGRYSQAIEALPPDKYGQNESFARIQVRFAELKAIQEPDDARDYFQMARANCKKFAFVHISFAQFELSQGNVKKSKQLLQKAVERGAVPLEMLEIALRNLNLQKKQLLSEEEKKNLSASTVLTAQESFSGSLGHLQNRNNSCDSRGQTTKARFLYGENMPPQDAEIGYRNSLRQTNKTKQSCPFGRVPVNLLNSPDCDVKTDDSVVPCFMKRQTSRSECRDLVVPGSKPSGNDSCELRNLKSVQNSHFKEPLVSDEKSSELIITDSITLKNKTESSLLAKLEETKEYQEPEVPESNQKQWQSKRKSECINQNPAASSNHWQIPELARKVNTEQKHTTFEQPVFSVSKQSPPISTSKWFDPKSICKTPSSNTLDDYMSCFRTPVVKNDFPPACQLSTPYGQPACFQQQQHQILATPLQNLQVLASSSANECISVKGRIYSILKQIGSGGSSKVFQVLNEKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSDKIIRLYDYEITDQYIYMVMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLIVDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIIDPNHEIEFPDIPEKDLQDVLKCCLKRDPKQRISIPELLAHPYVQIQTHPVNQMAKGTTEEMKYVLGQLVGLNSPNSILKAAKTLYEHYSGGESHNSSSSKTFEKKRGKK PP,U MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASPPANATAASDTNAGDRGQTNNAASASASNST LL0] MLGPGSNRRRPTQGERGPGSPGEPMEKYQVLYQLNPGALGVNLVVEEMETKVKHVIKQVECMDDHYASQALEELMPLLKLRHAHISVYQELFITWNGEISSLYLCLVMEFNELSFQEVIEDKRKAKKIIDSEWMQNVLGQVLDALEYLHHLDIIHRNLKPSNIILISSDHCKLQDLSSNVLMTDKAKWNIRAEEDPFRKSWMAPEALNFSFSQKSDIWSLGCIILDMTSCSFMDGTEAMHLRKSLRQSPGSLKAVLKTMEEKQIPDVETFRNLLPLMLQIDPSDRITIKDVVHITFLRGSFKSSCVSLTLHRQMVPASITDMLLEGNVASILEVMQKFSGWPEVQLRAMKRLLKMPADQLGLPWPPELVEVVVTTMELHDRVLDVQLCACSLLLHLLGQALVHHPEAKAPCNQAITSTLLSALQSHPEEEPLLVMVYSLLAITTTQESESLSEELQNAGLLEHILEHLNSSLKSRDVCASGLGLLWALLLDGIIVNKAPLEKVPDLISQVLATYPADGEMAEASCGVFWLLSLLGCIKEQQFEQVVALLLQSIRLCQDRALLVNNAYRGLASLVKVSELAAFKVVVQEEGGSGLSLIKETYQLHRDDPEVVENVGMLLVHLASYEEILPELVSSSMKALLQEIKERFTSSLVSDSSAFSKPGLPPGGSPQLGCTTSGGLE  - MTISYDYPSRVPATTSMATLEDRFEVIKEVGDGSFGSVAVARVRTAGSNVARRGTMVAIKTMKKTFDSLAPCLELREVIFLRTLPAHPHLVPALDIFLDPLSRKLHICMEYMDGNLYQLMKSRDHKYLEGKHVKSILYQILSGLDHIHAHHFFHRDIKPENILVSTSAPNDSAFSRYSNLVTPPSTPPTYTVKIADFGLARETHSKSPYTTYVSTRWYRAPEVLLRAGEYSAPVDMWAVGAMAVEIATLKPLFPGGNEVDQVWRICEIMGSPGNWYSKSGTKLGGGEWREGSRLAQKLGFTFPKVRRFVLVTELERIANVGRTDGASFYGEHPAASSLACIFEPFRDLVPDALNHEYFADAVDPLRPKSSTSRLLGRKQSDRSFRSPTPQSSDSPSVSSKPSWFRRSLIGRSESPAPALETDQAVRPSVVSYNTTPDLQANKTRPAAAKRATWANGAPMPILPSIRPVSPLSNAVTAQASSTLAHGGDNAQSGAAKASKKIGRQLSLNSHGNHYADVHRQEAERTLNGAGTTNATLNQKESFFSHLRKRARRLSGRNQANLATDDIEANAGCMPWSNRSSLALDSVNAGDAKQNSDLNDLDRALQNVKYSLDSAALGNVPVQITSTGDVSKRQSMPQGSIRAMTDSPVSTSGTPGPISSRTRRALQMSSHPVHRYETPEEEDELLDEVLHSASKAARRLAQGETLSDASSNYSRQAPGNDGSRPLPSPYPTPSPSAKCDGVSFGQQDSTPCRRDEKIDHASSNRQWPTPPYEERDWMNTTSSNF $X"- EIINTLGEGTFGKVVQCLDHGRGGRQIALKIIKNQEKYRNTAKLEINVLEKISEKDPLHKYHCVQMLEWFNYNGHICISFQLLSLSTFDFLKSNNFLPYPLQQIRLMAGQICRAVSFLHDNKLTHTDLKPENILFVNSNYSLVYNAEKKCNEKRINDTTVRLIDFGTATFDYEHHSVVISTRHYRAPEVILELGWSHPCDVWSIGCILFEYYEGFTLFQTHDNKEHLAMMERTHGPLPQRMIQSSRKQKYFCSGHLDWNESSKAGRFVKSKCKPLRQYLLSHGREHHHFFDLMERMLEYEPSKRISLHSALEHPFFLPLNPQMANTVTGNKKTGNKX!- MGYDFKVKLTGERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDRDYALKQIEGTGISMSACREIALLRELKHPNVISLQKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKANKKPLQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLSNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLLQKLLTMDPIRRITSEQAMQDPYFLEEPLPTSDVFAGCQIPYPKREFLTEEEPEDKADKKNQQQQQGNNHTNGAGHTGNPDNSHAQGPPLKKVRVVPPTATSSGLIMTSDYQRSNPHAAYQNPGPSTSLPQSSMGYSSTSQQPPQYSHQTHRY u#g MNFTRRRGFYRQELNRTIWELPRRYTSLHPVGSGAYGSVCSAIDKKTGEKVAIKKLCRPFQSEIFAKRAYRELTLLKQMQHENVIGLLDVFTSAPSYHGFQDFYLVMPYMRTDLQKIMGHEFSDEKIQYLVYQMLKGLKYIHSAGIIHRDLKPGNLAVNEDCQLKILDFGLARHADAEMTGYVVTRWYRAPEVILNWMHYNQTVDIWSIGCIMAEMLTGKTLFKGKDYVDQLTQILKVTGHPGDDFVEKLEDKAAKSYIKSLPKMPKKDLSVLFPTANPQAVDLLDKMLQLDVEKRLTATEALAHPYFDQFRDIEEETEAQQSYDDSLEREKLSIEEWKKHIYKEILSFSPIAQKDSKKRSGMSL c4%e MAPVYEGMASHVQVFSPHTLQSSAFCSVKKLKVEPSSNWDMTGYGSHSKVYSQSKNIPPSQPASTTVSTSLPIPNPSLPYEQTIIFPGSTGHIVVTSASSTSVTGQVLGGPHNLMRRSTVSLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNS$/ MPSSTLLELAPNTHSKCKFETRNRSSSSSSGCSSSSTELYDLAAAHAALISRQQQILNQGIPIIPEHQLAAAAVAHHHHQLHPSVQHQLVAGHHHHHLPQVAHHPAILPRSDVIQQPSHFALHQHLQNLVQQQQQQQALHHHQQLVGDMALVSHTHPAAVGSTTCYEKNPQKQQQVPQIPTQPQVAHVSSNAILAAAQPFYQPPVQDSQPDRPIGYGAFGVVWSVTDPRSGKRVALKKMPNVFQNLASCKRVFREIKMLSSFRHDNVLSLLDILQPANPSFFQEFTSWHLTPSIHHQRLISHIKPICLFFVLPLVSLLCAHMYVCMWWHGTALLEGRKETITYVLTELMQSDLHKIIVSPQTLTIDHVKVFVYQILRGLKYLHTANILHRDIKPGNLLVNSNCILKICDFGLARTWDSRDRLNMTHEVVTQYYRAPELLMGARRYTGAVDIWSVGCIFAELLQRKILFQAAGPIEQLQMIIDLLGTPSQEAMKYACEGAKNHVLRAGPRAPNLQSLYRLSQQTTDDAVDLLVKLLKFNPDERISVEEALSHPYLEEGRLRFHSCMCSCCYTKANVPSRIFSQELDPKHESPFDPKWEKDMSRLSMFELREKMYQFVMDRPALYGVALCINPQSAAYKNFASSSVAQASELPPSPQAW 4*T~w4@.IISchizosaccharomyces.pombe.IME2Schizosaccharomyces.pombe.IME2h-qqHomo.sapiens.MAK..Serine.threonine.protein.kinase.Homo.sapiens.MAK..Serine.threonine.protein.kinase..,77Candida.glabrata.IME2Candida.glabrata.IME2h+qqPetromyzon.marinus.MAPK13..tr.S4RVM7.S4RVM7_PETMA.Petromyzon.marinus.MAPK13..tr.S4RVM7.S4RVM7_PETMA.h*qqDrosophila.melanogaster.JNK..sp.P92208.JNK_DROME.SDrosophila.melanogaster.JNK..sp.P92208.JNK_DROME.Sh)qqDanio.rerio.CDKL1..sp.Q6AXJ9.CDKL1_DANRE.Cyclin.deDanio.rerio.CDKL1..sp.Q6AXJ9.CDKL1_DANRE.Cyclin.deh(qqHomo.sapiens.CDK10..Cyclin.dependent.kinase.10.OS.Homo.sapiens.CDK10..Cyclin.dependent.kinase.10.OS.h'qqMus.musculus.CDK17..sp.Q8K0D0.CDK17_MOUSE.Cyclin.dMus.musculus.CDK17..sp.Q8K0D0.CDK17_MOUSE.Cyclin.dh&qqHomo.sapiens.MAPK3..Mitogen.activated.protein.kinaHomo.sapiens.MAPK3..Mitogen.activated.protein.kinah%qqMus.musculus.HIPK2.sp.Q9QZR5.HIPK2_MOUSE.HomeodomaMus.musculus.HIPK2.sp.Q9QZR5.HIPK2_MOUSE.HomeodomaGSNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRVTPIETLNHPFVTMTHLLDFPHSAHVKSCFQNMEICKRRVNMYDTVNQSKTPFITHVAPSTSTNLTMTFNNQLTTVHNQAPTTSSATLSLANPEVSILNYQSALYQPSAASMAAVAPRSMPLQTGTAQICARPDPFQQALIVCPPGFQGLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGLLAQQAWPGGAQQILLPPAWQQLTGVATHTSVQHAAVIPETMAGTQQLADWRNTHAHGSHYNPIMQQPALLTGHVTLPAAQPLNVGVAHVMRQQPTSTTSSRKSKQHQSSVRNVSTCEVTSSQAISSPQRSKRVKENTPPRCAMVHSSPACSTSVTCGWGDVASSTTRERQRQTIVIPDTPSPTVSVITISSDTDEEEEQKHAPTSTVSKQRKNVISCVTVHDSPYSDSSSNTSPYSVQQRTGHNGTNTLDTKGGLENHCTGNPRTIIVPPLKTQASEVLVECDSLGPAISASHHSSSFKSKSSSTVTSTSGHSSGSSSGAIAYRQQRPGPHFQQQQPLNLSQAQQHMAADRTGSHRRQQAYITPTMAQAPYTFPHNSPSHGTVHPHLAAAAHLPTQPHLYTYTAPTALGSTGTVAHLVASQGSARHTVQHTAYPASIVHQVPVSMGPRVLPSPTIHPSQYPAQFAHQTYISASPASTVYTGYPLSPAKVNQYPYI byb'# MKKFKRRLSLTLRGSQTIDESLSELAEQMTIEESSSKDNEPIVKNGRPPTSHSVHSFLHQYTGSFKKPPLRRPHSVIGGSLGSFMAMPRNGSRLDIVHENLKMGSDGESDQASGTSSDEVQSPTGVCLRNRIHRRISMEDLNKRLSLPADIRIPDGYLEKLQISSPPFDQPMSRRSRRASLSEIGFGKMETYIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIVHTDKSLTLVFEYLDKDLKQYMDDCGNIMSMHNVKLFLYQILRGLAYCHRRKVLHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSSEYSTQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLLGTPSQETWPGVSSNDEFKNYNFPKYKPQPLINHAPRLDSEGIELITKFLQYESKKRVPAEEAMKHVYFRSLGPRIHALPESVSIFSLKEIQLQKDPGFRNSSYPETGHGKNRRQSMLF& MAAAAAQGGGGGEPRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPKERLKELIFQETARFQPGVLEAP ""f)I MEKYEKISKIGEGSYGVVFKCRNKDTGQIVAIKKFVESEDDPIIKKIALREIRMLKQLKHPNLVNLMEVFRRKRKLHLVFEYCDHTVLNELDRYPRGVPEHMVKSIIWQTLQAVNFCHKQNCIHRDVKPENILITKHQVIKLCDFGFARILTGPCDYYTDCVATRWYRAPELLVGDTQYGPPVDVWAVGCVFAELLSGAPLWPGKSDVDQLYLIRKTLGELIPRHQQVFSTNQFFSGVCVPEPQEMEPLELKYPNLSYQALSLMKGCLRMDPAERLSCEQLLEQPYFDSLREESESVTRELDRKKRTRQPRKHLPPGYLPQLASSTVFPAVENRRNYNNLRKFNYHLPNIp(] MAEPDLECEQIRLKCIRKEGFFTVPPEHRLGRCRSVKEFEKLNRIGEGTYGIVYRARDTQTDEIVALKKVRMDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENMPTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVPVKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLIVQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWLSEAGLRLLHFLFMYDPKKRATAGDCLESSYFKEKPLPCEPELMPTFPHHRNKRAAPATSEGQSKRCKP LL)a Ay X7qMus.musculus.DYR1A..Dual.specificity.tyrosine.phos6qMus.musculus.DYR1B..Dual.specificity.tyrosine.phosC6qMus.musculus.DYRK3..Dual.specificity.tyrosine.phosw6qMus.musculus.DYRK4..Dual.specificity.tyrosine.phosH7qMus.musculus.GSK3a..sp.Q2NL51.GSK3A_MOUSE.Glycogen7qMus.musculus.GSK3b..sp.Q9WV60.GSK3B_MOUSE.Glycogen7qMus.musculus.HIPK1..sp.O88904.HIPK1_MOUSE.Homeodom7qMus.musculus.HIPK2.sp.Q9QZR5.HIPK2_MOUSE.Homeodoma7qMus.musculus.HIPK3..sp.Q9ERH7.HIPK3_MOUSE.Homeodom77qMus.musculus.HIPK4..sp.Q3V016.HIPK4_MOUSE.Homeodom7qMus.musculus.ICK..Serine.threonine.protein.kinase.6qMus.musculus.MAK..Serine.threonine.protein.kinase.L7qMus.musculus.MAPK1..sp.P63085.MK01_MOUSE.Mitogen.a67qMus.musculus.MAPK10..sp.Q61831.MK10_MOUSE.Mitogen."7qMus.musculus.MAPK11..sp.Q9WUI1.MK11_MOUSE.Mitogen.%7qMus.musculus.MAPK12..sp.O08911.MK12_MOUSE.Mitogen.7qMus.musculus.MAPK13..sp.Q9Z1B7.MK13_MOUSE.Mitogen. LL)a Ay X7qMus.musculus.DYR1A..Dual.specificity.tyrosine.phos6qMus.musculus.DYR1B..Dual.specificity.tyrosine.phosC6qMus.musculus.DYRK3..Dual.specificity.tyrosine.phosw6qMus.musculus.DYRK4..Dual.specificity.tyrosine.phosH7qMus.musculus.GSK3a..sp.Q2NL51.GSK3A_MOUSE.Glycogen7qMus.musculus.GSK3b..sp.Q9WV60.GSK3B_MOUSE.Glycogen7qMus.musculus.HIPK1..sp.O88904.HIPK1_MOUSE.Homeodom7qMus.musculus.HIPK2.sp.Q9QZR5.HIPK2_MOUSE.Homeodoma7qMus.musculus.HIPK3..sp.Q9ERH7.HIPK3_MOUSE.Homeodom77qMus.musculus.HIPK4..sp.Q3V016.HIPK4_MOUSE.Homeodom7qMus.musculus.ICK..Serine.threonine.protein.kinase.6qMus.musculus.MAK..Serine.threonine.protein.kinase.L7qMus.musculus.MAPK1..sp.P63085.MK01_MOUSE.Mitogen.a67qMus.musculus.MAPK10..sp.Q61831.MK10_MOUSE.Mitogen."7qMus.musculus.MAPK11..sp.Q9WUI1.MK11_MOUSE.Mitogen.%7qMus.musculus.MAPK12..sp.O08911.MK12_MOUSE.Mitogen.7qMus.musculus.MAPK13..sp.Q9Z1B7.MK13_MOUSE.Mitogen. w+k EMAHASSRKGFYRIEINKMVWEVPKRYSQLFAVGSGAYGTVCSSMDLVTGSKVAVKKLYRPFQSRVFAKRAYRELRLLKHMKHENVIGLVDVFTPNDTLDQFQDFYLVMPFMGTDLSKIMKHGKQSDDKVQYLIYQILKGLKYIHSSGIIHRDLKPGNLAVNEDCELKILDFGLARHADQEMTGYVVTRWYRAPEVILNWMHYTQTVDIWSVGCIMAEMITGKPLFPGNDHMDQLMLILKLTGTPPQYLVDRMDENEAAKYIKTLPKMEKRRISTVFPNANPIAIDLLEKMLALDPEQRPTASEALQHPFFSETREPLEETEAEPYDQTFEGVELETSEWKSNDFSLVPFSLSPLLPFASPPLPAPL|*u MTTAQHQHYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHEYINVWYDAEEVDAPAPEPYDHSVDEREHTVEQWKELIYEEVMDYEAHNTNNRTR w,k MFQNKARNSDTEMRSGNQMESSIEDIQELEPPPDLDSPPSTIPLKSMHENYEILEELGNGSFGSVTLAKYKINDCFSKDQDRKRMTMMDPKYNNRPENISNSRKQGLVAIKTMLTRLPTLHDYTRVREVKFILSMTANKHLIQVYEIFVDSEKYQLHIAMEYMEQNLYQMMRRRKKRVFSIPSLKSILAQVLAGLRHIHDQNFFHRDLKPENILITPSTRYFDSSWLEKGNYPDNYVVKLADFGLARHVENKNPYTAYVSTRWYRSPEILLRSGYYSKPLDIWAFGCVAMEVTVFKPLFPGSNEIDQIWKILEVLGTPHTLEESKNSNYTPHGGLWELSKAYAAKLNLKFPYVEGSSLEKLLCSNQLTDLLAVIKLCLKWDPNERASVEQLSSMPFFTNTVADNSIYEKENNTNKNTLRSIAEQALLFAGLPSSLSLKSLRGNIKLRDTEELVTDEQPNDREKDTNFENVPLDDRSESLSIRREDRVPLTTSTNKKESQCSAKDICRDSSFMLRSISQSKKRKKLDNNKLQIDSSANSNNNESNKIIGCSTYRFPNFQGNFASKQDQNIELGNCNGSEITKTDFMKSGQLHQCNRINEEIQNELSKPITFEEQNANNIEKEPFSTVPERCPTDYTAFTFNNITGNDYTFGCQFFKTKKETGRLPHESSHSVNELLDNMSIEDLPLKSNQMTELEPRTIPISLVDQFGSDNLNYNIFENNSELRSPNTNEAKASTYEFAFSNPCHAIGNITF w-k MNRYTTMRQLGDGTYGSVLMGKSNESGELVAIKRMKRKFYSWDECMNLREVKSLKKLNHANVIKLKEVIRENDHLYFIFEYMKENLYQLMKDRNKLFPESVIRNIMYQILQGLAFIHKHGFFHRDMKPENLLCMGPELVKIADFGLARELRSQPPYTDYVSTRWYRAPEVLLRSSVYSSPIDVWAVGSIMAELYMLRPLFPGTSEVDEIFKICQVLGTPKKSDWPEGYQLASSMNFRFPQCVPINLKTLIPNASNEAIQLMTEMLNWDPKKRPTASQALKHPYFQVGQVLGPSSNHLESKQSLNKQLQPLESKPSLVEVEPKPLPDIIDQVVGQPQPKTSQQPLQPIQPPQNLSVQQPPKQQSQEKPPQTLFPSIVKNMPTKPNGTLSHKSGRRRWGQTIFKSGDSWEELEDYDFGASHSKKPSMGVFKEKRKKDSPFRLPEPVPSGSNHSTGENKSLPAVTSLKSDSELSTAPTSKQYYLKQSRYLPGVNPKKVSLIASGKEINPHTWSNQLFPKSLGPVGAELAFKRSNAGNLGSYATYNQSGYIPSFLKKEVQSAGQRIHLAPLNATASEYTWNTKTGRGQFSGRTYNPTAKNLNIVNRAQPIPSVHGRTDWVAKYGGHR jj.! MKKYLWGTPTTNTVFTGKQPKYTKEVRKCISIDEVYNVVRKVGDGTFGSVYLATTKTPSKEVVAIKSMKKKLAKVSDATRLREVHSLLRLSENENIVNIFDLYIDQFRCLHIVMEFLDCNLYQLISTRKNDPLTLEQVQDIMRQIFKGLNHIHTNGFFHRDMKPENILISSNSDSSSFNVKIADFGLAREINSRPPYTEYVSTRWYRAPELLLRDSYYSFPVDIYAAGCMAFEIATLQPIFPGNDDFDQLYKMCEILGSPDEQSQNTGDKGGGIWDRAELLANKLGISLPKMAPLDFGDLFSPPWNLAFASMLSQLLKWDPAKRPTAEMCLDLEFCRVSAPADAVASKEEVNKNTDFRVSISYFPSSSSIPDECNTEEESRINPSTSKFLKQLNKGFNGFTKPFRKSRKQSKNRKNKSSVATQFSEESEDIADSITSSTFFPVLPQIRPSTPLNLKLRNFIISSSEDSTSPKAKEFDRPLPSTEFLVAINKSQEALLNNSPNSKSGSTQLSASTCLSDLISPQLSILSHEDKRENQSVNSESSKYSPRSSNHSPTLHSKDLHRDMATVNNYAKSPPSFHATQDLLRKTLAYTNSSGTSTVLSNDSSAISSTFLDRDFPDFGITSLAGSLTLPDSKIIDRSKTHVSTQLLP k*T~Akh7qqSchizosaccharomyces.pombe.GSK3..sp.Q10452.GSK3_SCHSchizosaccharomyces.pombe.GSK3..sp.Q10452.GSK3_SCHh6qqGallus.gallus.CLK2..tr.Q5ZJ82.Q5ZJ82_CHICK.UncharaGallus.gallus.CLK2..tr.Q5ZJ82.Q5ZJ82_CHICK.Unchara:5CCBranchiostoma.floridae.CDK1Branchiostoma.floridae.CDK1h4qqMus.musculus.CDKL4..sp.Q3TZA2.CDKL4_MOUSE.Cyclin.dMus.musculus.CDKL4..sp.Q3TZA2.CDKL4_MOUSE.Cyclin.dh3qqMus.musculus.CDK18..sp.Q04899.CDK18_MOUSE.Cyclin.dMus.musculus.CDK18..sp.Q04899.CDK18_MOUSE.Cyclin.dh2qqHomo.sapiens.CK1..gi.68303575.ref.NP_001020276.1..Homo.sapiens.CK1..gi.68303575.ref.NP_001020276.1..h1qqMus.musculus.HIPK4..sp.Q3V016.HIPK4_MOUSE.HomeodomMus.musculus.HIPK4..sp.Q3V016.HIPK4_MOUSE.Homeodomh0qqGlossina.morsitans.CDK5..sp.Q2PQN9.CDK5_GLOMM.CyclGlossina.morsitans.CDK5..sp.Q2PQN9.CDK5_GLOMM.Cyclh/qqScheffersomyces.stipitis.MAPK3..tr.A3GF15.A3GF15_PScheffersomyces.stipitis.MAPK3..tr.A3GF15.A3GF15_P ZZ,0U MQKYEKLEKIGEGTYGTVFKGRNRETLEIVALKRVRLDEDDEGVPSSALREICLLKELKHKNIVRLYDVLHSEKKLTLVFEHCDQDLKKYFDSLNGDIDMAVCRSFMLQLLRGLAFCHSHNVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVKCYSAEVVTLWYRPPDVLFGAKLYTTSIDMWSAGCIFAELADAGRPLFPGSDVLDQLMKIFRVLGTPTEESWPGVTHLSDYVALPHFPAITSWSQIVPRLSSKGRDLLQKLLVCRPNQRVSAEQAMQHPYFTDSSNHr/a MNIEQPEQAPARQISFNVSSHYQILEIVGEGAYGIVCSAIHKPSNQKVAIKKIEPFERSMLCLRTLRELKLLKHFNHENIISILAIQRPVSYEFFNEIYLIQELMETDLHRVIRTQKLTDDHIQYFIYQTLRALKAMHSANVLHRDLKPSNLLLNSNCDLKVCDFGLARSIASSEDNFGYMTEYVATRWYRAPEIMLTFQEYTTAIDVWSVGCILAEMLSGRPLFPGRDYHNQLWLIMEVLGTPNMEDYYNIKSKRAREYIRSLPFCKKIPFQDLFGNINPNVQINPLAIDLLENLLIFNPAKRITVDDALKHPYLKLYHDPNDEPVSEKIPEDFFDFDKRKDELSIDDLKKMLYEEIMKPL 66mL+c !Y6qMus.musculus.MAPK15.sp.Q80Y86.MK15_MOUSE.Mitogen.aF6qMus.musculus.MAPK4..sp.Q6P5G0.MK04_MOUSE.Mitogen.ad7qMus.musculus.MAPK6..sp.Q61532.MK06_MOUSE.Mitogen.a7qMus.musculus.MAPK7..sp.Q9WVS8.MK07_MOUSE.Mitogen.a7qMus.musculus.MAPK8.sp.Q91Y86.MK08_MOUSE.Mitogen.ac<7qMus.musculus.MAPK9..sp.Q9WTU6.MK09_MOUSE.Mitogen.a6qMus.musculus.MOK..MAPK.MAK.MRK.overlapping.kinase./7qMus.musculus.NLK..sp.O54949.NLK_MOUSE.Serine.threoG7qMus.musculus.SGK71..sp.Q80YS9.SGK71_MOUSE.Probable>7qMus.musculus.SRSF.sp.O70551.SRPK1_MOUSE.SRSF.prote7qMus.musculus.TTK..sp.P35761.TTK_MOUSE.Dual.specifi17Naegleria.gruberi.LF4=7qNeurospora.crassa.GSK3..tr.Q9HE92.Q9HE92_NEUCS.GlyD9Neurospora.crassa.IME2*3Nosema.ceranae.CDK17qOikopleura.dioica.CDK10..tr.J7PN91.J7PN91_OIKDI.CD6qOikopleura.dioica.CDK5..tr.J9JF51.J9JF51_OIKDI.CDK7qOikopleura.dioica.CDKL2..tr.E4XDC6.E4XDC6_OIKDI.CD7qOryzias.latipes.CLK2a..tr.H2LBC0.H2LBC0_ORYLA.Unch9 66mL+c !Y6qMus.musculus.MAPK15.sp.Q80Y86.MK15_MOUSE.Mitogen.aF6qMus.musculus.MAPK4..sp.Q6P5G0.MK04_MOUSE.Mitogen.ad7qMus.musculus.MAPK6..sp.Q61532.MK06_MOUSE.Mitogen.a7qMus.musculus.MAPK7..sp.Q9WVS8.MK07_MOUSE.Mitogen.a7qMus.musculus.MAPK8.sp.Q91Y86.MK08_MOUSE.Mitogen.ac<7qMus.musculus.MAPK9..sp.Q9WTU6.MK09_MOUSE.Mitogen.a6qMus.musculus.MOK..MAPK.MAK.MRK.overlapping.kinase./7qMus.musculus.NLK..sp.O54949.NLK_MOUSE.Serine.threoG7qMus.musculus.SGK71..sp.Q80YS9.SGK71_MOUSE.Probable>7qMus.musculus.SRSF.sp.O70551.SRPK1_MOUSE.SRSF.prote7qMus.musculus.TTK..sp.P35761.TTK_MOUSE.Dual.specifi17Naegleria.gruberi.LF4=7qNeurospora.crassa.GSK3..tr.Q9HE92.Q9HE92_NEUCS.GlyD9Neurospora.crassa.IME2*3Nosema.ceranae.CDK17qOikopleura.dioica.CDK10..tr.J7PN91.J7PN91_OIKDI.CD6qOikopleura.dioica.CDK5..tr.J9JF51.J9JF51_OIKDI.CDK7qOikopleura.dioica.CDKL2..tr.E4XDC6.E4XDC6_OIKDI.CD7qOryzias.latipes.CLK2a..tr.H2LBC0.H2LBC0_ORYLA.Unch9 u2g MASSSGSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKCLESPVGKRKRSMTVSTSQDPSFSGLNQLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQLFRILFRTLNHQYDYTFDWTMLKQKAAQQAASSSGQGQQAQTPTGKQTDKTKSNMKGFp1] MATIQSETDCYDIIEVLGKGTFGEVAKGWRRSTGEMVAIKILKNDAYRSRIIKNELKLLRCVRGLDPDEAHVIRFLEFFHDALKFYLVFELLEQNLFEFQKENNFAPLPARHIRTVTLQVLRALARLKELAIIHADLKPENIMLVDQTRCPFRVKVIDFGSASIFSEVRYVKEPYIQSRFYRAPEILLGLPFCEKVDVWSLGCVMAELHLGWPLYPGNNEYDQVRYICETQGLPKPHLLHAARKAHHFFKRNPHPDATNPWQLKSSADYLAETKVRPLERRKYMLKSLDQIETVNGGGAVSRLSFPDREALAEHADLKSMVELIKRMLTWESHERISPSAALRHPFVSMQQLRSAHEATRYYQLSLRGCRLSLQVDGKPPPPVIASAEDGPPYYRLAEEEETAGLGGVTGSGSFFREDKAPGMQRAIDQLDDLSLQEARRGLWSDTRADMVSDMLVPLKVASTSHRVPDSGPEPILAFYGSRLTGRHKARKAPAGSKSDSNFSNLIRLSQASPEDAGPCRGSGWEEGEGRTTSTEPSVIPQREGDGPGIKDRPMDAERPGPELFDPSSCPGEWLSEPEWTLEGIRGSRAQGLPAHHPHPHGPPRTTSFLQHVGGHH 1^49 MEKYEKLAKIGEGSYGVVFKCRNKSSGQVVAIKKFVESEDDRVVRKIALREIRMLKQLKHPNLVNLIEVFRRKRKMHLVFEYCDHTLLNELERNPNGVSDGVIKSVLWQTLQALNFCHKHNCIHRDVKPENILITKQGMIKICDFGFARILIPGDAYTDYVATRWYRAPELLVGDTKYGSSVDVWAVGCVFAELLTGQPLWPGKSDVDQLYLIIRTLGKLIPRHQSIFRSNQFFRGISIPEPEDMETLEEKFSNVQPVALSFMKGCLKMNPDERLTCAQLLDSAYFESFQEDQMKRKARSEGRSRRRQQNQLLPLIPGSHISPTPDGRKQVVQLKFDHLPNIK3 MNKMKNFKRRLSLSVPRPETIEESLAEFTEQFNQLHTQTNEDGTDEPEQLSPGMQYQQRQNQRRFSMEDLNKRLSLPMDIRLPQEFLQKLQLENPGLPKPLTRMSRRASLSDIGFGKLETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDLIHTDRSLTLVFEYLDSDLKQYLDHCGNLMNMHNVKIFMFQLLRGLAYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEYSTPIDMWGVGCILYEMATGKPLFPGSTVKEELHLIFRLLGTPTEESWPGVTSISEFRAYNFPRYLPQPLLSHAPRLDTEGINLLSSLLLYESKSRMSAEAALNHPYFQSLGDRVHQLHDTASIFSLKEIQLQKDPGYRGLAFQHPGRGKSRRQSIF }6w MPHSRRYRSSERSSRGSFHERYRSRKHKRRRSRSSSSERERRHRREGSYHVRSRSYDDHSADRRAYDRRYCDSYRRNDYSRERGEPYYDPEYRHSYEYRRSRDRDGSYRSCKSSRRKHRRRRRRSRSFSRSSSRSRQSSRRAKSVEDDDEGHLIYRVGDWLQERYEILSTLGEGTFGRVVQCMDHRRGGVRVALKIIKNVEKYKEAARLEINVLEKINEKDPENKNLCVRMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQVCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAIRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYHGRLDWDENTSAGRYVRDNCKPLRRYLTSEAEDHHRLFDLIESMLEYEPSKRISLAEALKHPFFDVLEMEPSTKMWDSSRDISR35c MDNFQKIEKIGEGTYGVVYKAKDKVTGRMVALKKIRLDTESEGVPSTAIREISLLKELNHPNIVRLLDVVHSEKKLYLVFEYLNLDLKKYMDSAPPSGLPTELVKSYVHQILKGIAYCHSHRVLHRDLKPQNLLIDAEGNIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGSKFYSTPVDVWSIGCIFAEMITRRALFPGDSEIDQLFRVFRTLGTPDETTWPGVSQLPDYKPTFPRWPRQDVTKLFASLEPEGTELFAQMLLYEPNKRISAKAAINHVYFHDVRKIEVPNLKG q+8S MARVGRPAREDVLEKYEMMGVVGEGSYGTVHKARNKESGQIVAIKKFLEEDSNSFKIARRELRALRQLRHENLVNMLEHARRRRRLFIIFEYVDGTVLDYIEAQSSKRISGEKCREITWQVLRGLEFIHRNRMIHRDVKPENILYSKEGVAKLCDFGFARPNSIINGEVFTDYVATRWYRAPELIVKESTYDQSIDIWAVGCLLPEMLSGDALFPGESDVDQLYQVMSVCGPLPRDLHDSLRLRPEFYGFRFPEKQTMLEDHFRILRNLPVELEFIRKCLNLSPCARETACSLLTNSEYFLNDDFTRNKPDLLEKIHRFNAPVRHIIPKQSKSDLKFPTSTSKIPLTNPQSKRNKHQKVNAANSNHRLEQLDAHNSGFSSMPVTLSMPEIKSNAKQRKQKQKWSKAGTQKQSQTKLPKL 7 MNHGTKIPVDPFRIIKETARDGSTGEVKQLSYTSSKVVGSGSFGVVMQVHLIESDSKAAIKRVLQDKRFKNRELQIMRIMKHPNIVDLIAYYYTTGDNSDEVYLNLVLEFMPETIYRASRLYTRQKLSMPMLEVKLYIYQLLRSLAYIHASGICHRDIKPQNLLLDPENGILKLCDFGSAKILVAGEPNVSYICSRYYRAPELIFGATDYTHAIDIWSTGCVMAELMLGHPLFPGESGIDQLVEIIKILGTPSREQIKTMNPNYMEHRFPQIRPQPLSRVFSRSVPLDALDLLSKMLQYTPTDRLTAAEAMCHPFFDELRDPNTKLHNSRNPDASPRHLPELFNFSPFELSIRPDLNQKLIPSHARDALPVKLDDFVPIPIHRARID =*T~=h@qqHomo.sapiens.MAPK14..sp.Q16539.MK14_HUMAN.Mitogen.Homo.sapiens.MAPK14..sp.Q16539.MK14_HUMAN.Mitogen.h?qqBos.taurus.MAPK7..sp.A5PKJ4.MK07_BOVIN.Mitogen.actBos.taurus.MAPK7..sp.A5PKJ4.MK07_BOVIN.Mitogen.acth>qqMus.musculus.CDK2..sp.P97377.CDK2_MOUSE.Cyclin.depMus.musculus.CDK2..sp.P97377.CDK2_MOUSE.Cyclin.deph=qqMus.musculus.DYR1A..Dual.specificity.tyrosine.phosMus.musculus.DYR1A..Dual.specificity.tyrosine.phosh<qqMus.musculus.CLK3..sp.O35492.CLK3_MOUSE.Dual.speciMus.musculus.CLK3..sp.O35492.CLK3_MOUSE.Dual.specih;qqHomo.sapiens.ICK..Serine.threonine.protein.kinase.Homo.sapiens.ICK..Serine.threonine.protein.kinase.h:qqTaeniopygia.guttata.CDK10..tr.H0ZC86.H0ZC86_TAEGU.Taeniopygia.guttata.CDK10..tr.H0ZC86.H0ZC86_TAEGU.h9qqCaenorhabditis.briggsae.GSK3..sp.A8X5H5.GSK3_CAEBRCaenorhabditis.briggsae.GSK3..sp.A8X5H5.GSK3_CAEBRh8qqOikopleura.dioica.CDKL2..tr.E4XDC6.E4XDC6_OIKDI.CDOikopleura.dioica.CDKL2..tr.E4XDC6.E4XDC6_OIKDI.CD m:W APAEPELEPLRLRRLRGDGFFEVPAADRLGRCRSVKEFEKLNRIGEGTYGIVYRARDTLTDETVALKKVRMDNEKDGMPISSLREITLLLQLQHPNIVELKDVVVGNHLESIFLVMGYCEQDLASLLENMQTPFSEAQVKCIILQVLKGLQYLHENYIIHRDLKVSNLLMTDKGCVKIADFGLARTYGMPPKPMTPKVVTLWYRAPELLLGMTTQTTSIDMWAAGCILAo9[ MNKQLLSCSLKSGKQVTMVVASVATDGVDQQVEISYYDQKVIGNGSFGVVFLAKLSTTNEMVAIKKVLQDKRFKNRELQIMRKLNHPNIVKLKYFFYSSGDKKDELYLNLILEYVPETVYRVARHYSKQRQSIPMIYVKLYMYQLLRSLAYIHSIGICHRDIKPQNLLIDPETGILKLCDFGSAKYLVRNEPNVSYICSRYYRAPELIFGATNYTNSIDVWSAGTVIAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIQSMNPNYKEFKFPQIKAHPWNKVFRVHTPAEAIDLISKIIEYTPTSRPTPQAACQHAFFDELRSPDARLPSGRALPQLEMDGPNEVSATGGDMAGPSA ||;} MNRYTTIRQLGDGTYGSVLLGRSIESGELIAIKKMKRKFYSWEECMNLREVKSLKKLNHANVVKLKEVIRENDHLYFIFEYMKENLYQLIKERNKLFPESAIRNIMYQILQGLAFIHKHGFFHRDLKPENLLCMGPELVKIADFGLAREIRSKPPYTDYVSTRWYRAPEVLLRSTNYSSPIDVWAVGCIMAEVYTLRPLFPGASEIDTIFKICQVLGTPKKTDWPEGYQLSSAMNFRWPQCVPNNLKTLIPNASSEAVQLLRDMLQWDPKKRPTASQALRYPYFQVGHPLGSTTQNLQDSEKPQKGILEKAGPPPYIKPVPPAQPPAKPHTRISSRQHQASQPPLHLTYPYKAEVSRTDHPSHLQEDKPSPLLFPSLHNKHPQSKITAGLEHKNGEIKPKSRRRWGLISRSTKDSDDWADLDDLDFSPSLSRIDLKNKKRQSDDTLCRFESVLDLKPSEPVGTGNSAPTQTSYQRRDTPTLRSAAKQHYLKHSRYLPGISIRNGILSNPGKEFIPPNPWSSSGLSGKSSGTMSVISKVNSVGSSSTSSSGLTGNYVPSFLKKEIGSAMQRVHLAPIPDPSPGYSSLKAMRPHPGRPFFHTQPRSTPGLIPRPPAAQPVHGRTDWASKYASRR vv< MPVLSARRKRLASTAGPRRGSGPSLAVRWVPPLGPEPSSDRGRAPMRPRGPTCSTTRRGAGRGPRLLPGPPGRDLHRCRPDPGGAGQSPRVCEFGARAVRPLGRVEPGPPTAASREGAVLPRAEARAGSGRGARSGEWGLAAAGAWETMHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRIPYQRRYREHRDSDTYRCEERSPSFGEDCYGSSRSRHRRRSRERAPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHSSRNPSR = MHTGGETSACKPSSVRLAPSFSFHAAGLQMAAQMPHSHQYSDRRQPSISDQQVSALPYSDQIQQPLTNQVMPDIVMLQRRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQQGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWSLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKTADEGTNTSNSVSTSPAMEQSQSSGTTSSTSSSSGGSSGTSNSGRARSDPTHQHRHSGGHFAAAVQAMDCETHSPQVRQQFPAPLGWSGTEAPTQVTVETHPVQETTFHVAPQQNALHHHHGNSSHHHHHHHHHHHHHGQQALGNRTRPRVYNSPTNSSSTQDSMEVGHSHHSMTSLSSSTTSSSTSSSSTGNQGNQAYQNRPVAANTLDFGQNGAMDVNLTVYSNPRQETGIAGHPTYQFSANTGPAHYMTEGHLAMRQGADREESPMTGVCVQQSPVASS b>A MENFQKVEKIGEGTYGVVYKAKNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINAEGSIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMHLVCTQHHAKCCGEHRRNGRHSLCPLCSYLEVAASQGGGMTAVSAPHPVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL ?' MAEPLKEDDGEDGSGEPPGPVKAEPAGTAASVAAKNLALLKARSFDVTFDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMTVLGTPSPAVIQAVGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARVSAAAALRHPFLAKYHDPDDEPDCAPPFDFAFDREALTRERIKEAIVAEIEDFHARREGIRQQIRFQPSLQPVASEPGCPDVEMPSPWAPSGDCAMESPPPAPLPCPGPAPDTIDLTLQPPPPASEPAPPKKEGAISDNTKAALKAALLKSLRSRLRDGPSAPLEAPEPRKPVTAQERQREREEKRRRRQERAKEREKRRQERERKERGAGVSGGPSADPLAGLVLSDNDRSLLERWTRMAQPPAPAPATARPPSPPAGPATQPTGPLPQPACPPPAPAAGPAAPQTTAASGLLAPQPLVPPPGLPGPSALSVLPYFPSGPPPPDPGGAPQPSTSESPDVTLVTQQLSKSQVEDPLPPVFSGTPKGSGAGYGVGFDLEEFLNQSFDMGVADGPQDGQADSASLSASLLADWLEGHGMNPADIESLQREIQMDSPMLLADLPDLQEP 00XA- MGSSINYPGFVSKPNQRATSNPFFQRESVPGTQGTAKSKLSLALQIQKDGNNDCGDGKDKSDPEEQESDSEYSSCDEKNEESLRDYKPGGYHPAFRGETYNEGRYMVVRKLGWGHFSTVWLAKDTATNAHVAMKIVRSDKVYTEAALDEIKLLRQVSAPVSSTESLYDSSKHILSLLDSFNHNGPNGKHVVMVFEVLGENLLALIKKYEHRGIPVMYVKQIAKQLLLGLDYMHRKCGVIHTDIKPENVLMDVGDVEAIVRMVEVLDKKKRDQKRSQRRATKTSMDLPAAPNSLSRGSASASLERSSSDRRMRRHTIITGSQPLPSPISSTNFFEMKAQMIGNSLPRPTACSSRSNANLSGGDDEQVANSLSSLELTTTADERPEDESQREHDIIQIKIADLGNACWYDEHYTNSIQTREYRSPEVLLGCQWGCSADIWSAACLIFELLTGDFLFEPDEGHSYSKDDDHIAQIIELLGEIPARLLSTGRHARTFFNSRGQLRNISKLKFWPLKDVLMEKYRFAAEDAETISDFLMPMLRLDPQERADAGGMVNHPWLRDTVGLEGVALSERKLYQSGADIPGWSQEVTGHPRHp@] MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES \Ts2\hJqqMus.musculus.CDK15..Cyclin.dependent.kinase.15.OS.Mus.musculus.CDK15..Cyclin.dependent.kinase.15.OS.hIqqGallus.gallus.CDK3..tr.F1NA68.F1NA68_CHICK.UncharaGallus.gallus.CDK3..tr.F1NA68.F1NA68_CHICK.UncharahHqqXenopus.laevis.CDK2..sp.P23437.CDK2_XENLA.Cyclin.dXenopus.laevis.CDK2..sp.P23437.CDK2_XENLA.Cyclin.dhGqqGallus.gallus.CSK2a..sp.P21868.CSK21_CHICK.Casein.Gallus.gallus.CSK2a..sp.P21868.CSK21_CHICK.Casein.hFqqXenopus.tropicalis.HIPK1..tr.F6T404.F6T404_XENTR.UXenopus.tropicalis.HIPK1..tr.F6T404.F6T404_XENTR.U2E;;Xenopus.tropicalis.IME2Xenopus.tropicalis.IME2hDqqMus.musculus.MAPK12..sp.O08911.MK12_MOUSE.Mitogen.Mus.musculus.MAPK12..sp.O08911.MK12_MOUSE.Mitogen.>CGGDictyostelium.discoideum.CDK1Dictyostelium.discoideum.CDK1hBqqMus.musculus.MAPK6..sp.Q61532.MK06_MOUSE.Mitogen.aMus.musculus.MAPK6..sp.Q61532.MK06_MOUSE.Mitogen.a>AGGLachancea.thermotolerans.SKY1Lachancea.thermotolerans.SKY1 $$XB- MAEKFESLMNIHGFDLGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDPQSVKHALREIKIIRRLDHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGPLLEEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILDSIPVVHEEDRQELLSVIPVYIRNDMTEPHRPLTQLLPGISREALDFLEQILTFSPMDRLTAEEALSHPYMSIYSFPTDEPISSHPFHIEDEVDDILLMDETHSHIYNWERYHDCQFSEHDWPIHNNFDIDEVQLDPRALSDVTDEEEVQVDPRKYLDGDREKYLEDPAFDTSYSAEPCWQYPDHHENKYCDLECSHTCNYKTRSSPYLDNLVWRESEVNHYYEPKLIIDLSNWKEQSKEKSDKRGKSKCERNGLVKAQIALEEASQQLAERERGQGFDFDSFIAGTIQLSAQHQSADVVDKLNDLNSSVSQLELKSLISKSVSREKQEKGRANLAQLGALYQSSWDSQFVSGGEECFLISQFCCEVRKDEHAEKENTYTSYLDKFFSRKEDSEMLETEPVEEGKRGERGREAGLLSGGGEFLLSKQLESIGTPQFHSPVGSPLKSIQATLTPSAMKSSPQIPHKTYSSILKHLN Q1E_ MENFQKVEKIGEGTYGVVYKARNRETGEIVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLNQDLKKFMDGSNISGISLALVKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINSEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKFYSTAVDIWSLGCIFAEMITRRALFPGDSEIDQLFRIFRTLGTPDEVSWPGVTTMPDYKSTFPKWVRQDFSKVVPPLDDDGRDLLAQMLQYDSNKRISAKAALTHAFFRDVSRPTPHLIwDk MSSPPPARKGFYRQEVTKTAWEVRAVYQDLQPVGSGAYGAVCSAVDSRTGNKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDESLDDFTDFYLVMPFMGTDLGKLMKHETLSEDRIQFLVYQMLKGLKYIHAAGVIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKILFKGNDHLDQLKEIMKITGTPPPEFVQKLQSAEAKNYMEGLPELEKKDFASVLTNASPQAVNLLERMLVLDAEQRVTAAEALTHPYFESLRDTEDEPKAQKYDDSFDDVDRTLEEWKRVTYKEVLSFKPPRQLGARVPKETAL0C] MESDGGLSRYQKLEKLGEGTYGKVYKAKEKATGRMVALKKIRLEDDGVPSTALREISLLKEVPHPNVVSLFDVLHCQNRLYLVFEYLDQDLKKYMDSVPALCPQLIKSYLYQLLKGLAYSHGHRILHRDLKPQNLLIDRQGALKLADFGLARAVSIPVRVYTHEIVTLWYRAPEVLLGSKSYSVPVDMWSVGCIFGEMLNKKPLFSGDCEIDQIFRIFRVLGTPDDSIWPGVTKLPEYVSTFPNWPGQPYNKIFPRCEPLALDLIAKMLQYEPSKRISAKEALLHPYFGDLDTSFFGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQIEVSILSRLSSENADEYNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILQQVATALMKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTSRFFNRDPDLGYPLWRLKAPDEHEMETGIKSKEARKYIFNCLDDMAQVNMSTDLEGTDMLAEKADRREYIDLLKKMLTIDADKRITPLKTLNHPFVTMTHLLDFPHSNHVKSCFQNMEICKRRSNMYDTVNQIKSPFTTHVAPNTSTNLTMSFNNQLNSVHNQASVLASSSTAAATLSLANSDVSLLNYQSALYPPAAGPVTGVTQQSVSLQPGTTQLCTQTDPFQQTFIVCPPAFQAAGLQATTKHSGFPVRMDNSVPIVPQAPAAQPLQIQSGVLTQGSCTPLMVATLHPHVATITPQYAVPFTLNCAAGRPALVEQTAAVLQAWPGGTQQILLPSTWQQLPGVALHNSVQPTAMIPETIGNNQQLTDWRNAHSHGNQYSTLMQQPSLLANHVTLAAAQPLNVGVAHVVRQQQNSNTSTKKNKQQASQSSSKALSSLDVIPSQVYSLVGSSPLQASSSYNPLLPLQEQRQPIVIPDTPSPPVSVITIRSDTDEEEDSKYKPTNSGMKLRSNVISYVTVNDSPDSDSSVSSPYLADRHTSVNGVTGVFDMSNSRTAHSQSLNSRTIIVPPLKSQMNDCPLDTQLTGVLSGAAKITKSCTATNGQSSSCITQTGCRSHRMLNGVQPLNLSQNQQSAMMGTQERSMNPGSRRQQAYVAPLPSISQAPFTFQHSSPLHSTVHPHLAAAATATSHLTSQPHMYTYAPTTAASLGSTTSIAHLFSPQGSSRHTTFATHPSTLVHQVPVSVGPSLLTSANVASAQYPHQFAAQSYIGASRGSAIYTGYPLSPTNINQYSYL Z"Z1H_ MENFQKVEKIGEGTYGVVYKARNRETGEIVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLNQDLKKFMDGSNISGISLALVKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINSDGAIKLADFGLARAFGVPVRTFTHEVVTLWYRAPEILLGCKFYSTAVDIWSLGCIFAEMITRRALFPGDSEIDQLFRIFRTLGTPDEVSWPGVTTMPDYKSTFPKWIRQDFSKVVPPLDEDGRDLLAQMLQYDSNKRISAKVALTHPFFRDVSRPTPHLIG MSGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYPIVKDQARMGSSNMPGGSTPVSSASMMSGISSVPTPSPLGPLAGSPVISATTTLGMPVPAAAGAQQRF! LKIIFLIGMASQLQVFSPSSVSSSAFCSAKKLKVEPSGWDVTGQGSSNKYYTHTKNLPVAQGHASSSHQVAGFSLPAYEPNLLIPAAAAEHIVVTAADSTDSGPTTSFQNSQILTHRSNVPLLDPYQKCGLKRKSEEVDSNGSVQIIDERPPLMLQNRTVVGAAATTTTVTTKSSSSNGEGDYQLVQHEILCSMTNSYEVLEFLGR 9Jo MGQELCAKRLQPGCSCYHRSEGGEAHSCQRSQPGSTEPAVFELTEASSSTASFHPRGLEAASAQKLKSKRPRSNSDSFQEENLRQGLPWKKSLPFGAASSYLNLEKLGEGSYAKVYKGISRINGQLVALKVISMNAEEGVPFTAIREASLLKGLKHANIVLLHDIVHTKETLTFVFEYMHTDLAQYMSQHPGGLHPHNVRLFMFQLLRGLAYIHHQRVLHRDLKPQNLLLSHLGELKLADFGLARAKSIPSQTYSSEVVTLWYRPPDALLGATEYSSELDIWGAGCIFIEMFQGQPLFPGVSNILEQLEKIWEVLGVPTEDTWPGVSKLPNYNPEWFPPPKPQSLQIVWDRLGGVPEAEDLASQMLKGFPRDRVSAQEALVHDYFSVLPSQLYQLPDEESLFAVSGVKLKPEMCDLSASYRKRHHLVGVNKCW=Iw MEAFQQVFQKVEKIGEGTYGVVYKARNKRTGQLVALKKIRLDAETEGVPSTAIREISLLKELKHPNIVRLLDVVHSQKKLYLVFEYLNQDLKKYIDSSQTGEFPLSLVKNYLFQLLQGVSFCHSHRVIHRDLKPQNLLINEAGAIKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSIGCIFAEMVTRKALFQGDSEIDQLFRIFRTLGTPTEATWPGVSQLPDYKGDFPQWARKEMKEIVPNLDRHGRDLLAQLLLYDPSKRISAKAALSHQYFFRKSPQSTEEQHVQQRHCR **Tk*hTqqHomo.sapiens.CDK15..Cyclin.dependent.kinase.15.OS.Homo.sapiens.CDK15..Cyclin.dependent.kinase.15.OS.hSqqHomo.sapiens.MAPK1..sp.P28482.MK01_HUMAN.Mitogen.aHomo.sapiens.MAPK1..sp.P28482.MK01_HUMAN.Mitogen.ahRqqMus.musculus.CLK4..sp.O35493.CLK4_MOUSE.Dual.speciMus.musculus.CLK4..sp.O35493.CLK4_MOUSE.Dual.speci:QCCSaccharomyces.kluyveri.IME2Saccharomyces.kluyveri.IME2>PGGEncephalitozoon.cuniculi.CDK1Encephalitozoon.cuniculi.CDK1hOqqOikopleura.dioica.CDK10..tr.J7PN91.J7PN91_OIKDI.CDOikopleura.dioica.CDK10..tr.J7PN91.J7PN91_OIKDI.CDhNqqDrosophila.melanogaster.GSK3H..Putative.glycogen.sDrosophila.melanogaster.GSK3H..Putative.glycogen.shMqqHomo.sapiens.GSK3b..sp.P49841.GSK3B_HUMAN.GlycogenHomo.sapiens.GSK3b..sp.P49841.GSK3B_HUMAN.GlycogenhLqqHomo.sapiens.DYR1A..Dual.specificity.tyrosine.phosHomo.sapiens.DYR1A..Dual.specificity.tyrosine.phoshKqqDictyostelium.discoideum.MAPK1.sp.Q54QB1.ERK2_DICDDictyostelium.discoideum.MAPK1.sp.Q54QB1.ERK2_DICD yKo MSSEDIDKHVLRKYEVLQKIGKGAYGIVWKAIDKKTKQTVALKKIFDAFQNATDAQRTFREIMFLQELHGHENIIKLLNVIKADNDRDIYLVFEHMETDLHAVIRAKILEEIHKQYTIYQLLKALKYMHSANVLHRDIKPSNLLLNSECLVKVADFGLARSITSLESIAEANPVLTEYVATRWYRAPEILLGSTKYTKGVDMWSIGCILGELLGEKAMFPGNSTMNQLDLIIEVTGRPSAEDIEAIKSPFAGTMLESLPPSNPRSLSDMYPSASVDALDLLKKLLQFNPDKRITAEEALAHPFVTQFHNPAEEPHFDRIIKISIDDGQKFPIAEYRNRLYNDIIKKKKEERKKQTNPTKPDTTAPTLST L MHTGGETSACKPSSVRLAPSFSFHAAGLQMAGQMPHSHQYSDRRQPNISDQQVSALSYSDQIQQPLTNQVMPDIVMLQRRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQQGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKTADEGTNTSNSVSTSPAMEQSQSSGTTSSTSSSSGGSSGTSNSGRARSDPTHQHRHSGGHFTAAVQAMDCETHSPQVRQQFPAPLGWSGTEAPTQVTVETHPVQETTFHVAPQQNALHHHHGNSSHHHHHHHHHHHHHGQQALGNRTRPRVYNSPTNSSSTQDSMEVGHSHHSMTSLSSSTTSSSTSSSSTGNQGNQAYQNRPVAANTLDFGQNGAMDVNLTVYSNPRQETGIAGHPTYQFSANTGPAHYMTEGHLTMRQGADREESPMTGVCVQQSPVASS OPO}Nw MASQSKNSGLTNKVTTVVATNAFGADVMSEISYTDAKVVGNGSFGVVFQAKMVPSNEMVAIKKVLQDRRFKNRELQIMRKLRHDNIITLKWFFFSSGEKRDEVYLNLVMEFLPETLYKVERQYARAKQTLPVNFVRLYMYQLLRSMGYLHSLGFCHRDIKPQNMLLDSETGVLKLCDFGSAKQLISGEPNVSYICSRYYRAPELIFGSTDYTTKIDMWSAGCVMSELLLGQLIFPGDSGVDQIVEIVKVMGTPTSEQLHDMNPHYKQFKLPELKPHPWSKVFRIRTPAEAIDLVSKMLIYSPNARVSPLMGCAHPFFDELRQDPHQQLPNGRSLPPLFNFTDYEKTIEPDTMPLLLPRAQGSSTTKEPSAAHRNRNTAGEESPRKTEDSQKPATAALSKSPGPSGKALESPPGFLQHDLGNGDHVAVGTMPMEPLTLEQNHFAAESYAVGEDAEDNLEEDVGDENDYDYDDGGQCNSTYISDDMDEASESDDDDFEEEDEN,MU MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST 0P] MTESFQKLEKIGEGTYGVVYKARERNTNRVVALKKIRLENENEGIPATTIREILLLKNLKHSTIVELSDVIYNNNKMYLVFEYVELDLRRYLDRMSDEGRLVEEGFVRKMSQQLLTAMEYCHSRNIFHRDLKPQNILVDPKENIKLADFGLGRAAGIPLRTYTTEVVTLWYRPPELLLGCKYYDASVDVWSAACIMAEVVLMRPFFPGDSEIDQLFRIFKVLGTPNNSRWSNVENFPNYKVEFPVWDPVDLKTIFRGDPDFVDLISKMLEYDPKMRMTAKNGLSHKYFEGMPLIMEjOQ MMRGNDNYVPVAQFPKREKKVPVSENCAPPNSTSTISSSSSTTARTAHGIRAFQKDARATFSVDSSRQKRSNHKKEERRKSVNKDRKRNISHEDSQETRGSSQIRKKSEEEGTRYPKPAKKLPPVVDVKTLEQNEIPERLKMGRCRPVTEFEKLNRIGEGTYGIVYRARDTADDRIVALKKVRMEKERDGIPVSSIREISLLFSLHHENIVKLESVAVGQQLESLFLVMGYCQYDLAGLLDHMSKPFLEEQVKCLMLQVLKGLEFMHSKYIAHRDLKVSNLLLTDEGVLKIADFGLARSFGTPRKPSTPKVVTLWYRAPEVLFGDRIHTTAMDLWSAGCVLSELLLHDPLFPARTELELIDKIIDTIGSPNETIWPGYSDLPLVKGRSLRQQPYNNLKSKFPWWNSDAGFRLLNNMLAYCPEKRITAAAALKHQYFKEAPLPSLNSEMPDFPNYKSRQNQTDRKKPEKKAENQRKTSTITLS L+Lc C{"Y7qMus.musculus.CDK5..sp.P49615.CDK5_MOUSE.Cyclin.depI7qMus.musculus.CDK3..sp.Q80YP0.CDK3_MOUSE.Cyclin.dep=7qMus.musculus.CDK2..sp.P97377.CDK2_MOUSE.Cyclin.dep6qMus.musculus.CDK20.sp.Q9JHU3.CDK20_MOUSE.Cyclin.dev7qMus.musculus.CDK4..sp.P30285.CDK4_MOUSE.Cyclin.dep-7qMus.musculus.CDK6..sp.Q64261.CDK6_MOUSE.Cyclin.dep7qMus.musculus.CDK7..sp.Q03147.CDK7_MOUSE.Cyclin.dep7qMus.musculus.CDKL1..sp.Q8CEQ0.CDKL1_MOUSE.Cyclin.d7qMus.musculus.CDKL2..sp.Q9QUK0.CDKL2_MOUSE.Cyclin.d7qMus.musculus.CDKL3.sp.Q8BLF2.CDKL3_MOUSE.Cyclin.de7qMus.musculus.CDKL4..sp.Q3TZA2.CDKL4_MOUSE.Cyclin.d6qMus.musculus.CDKL5..sp.Q3UTQ8.CDKL5_MOUSE.Cyclin.dE7qMus.musculus.CK1..gi.20544149.ref.NP_620690.1..cas;6qMus.musculus.CLK1..sp.P22518.CLK1_MOUSE.Dual.speci6qMus.musculus.CLK2..sp.O35491.CLK2_MOUSE.Dual.speci;7qMus.musculus.CLK3..sp.O35492.CLK3_MOUSE.Dual.speci7qMus.musculus.CLK4..sp.O35493.CLK4_MOUSE.Dual.speci L+Lc C{"Y7qMus.musculus.CDK5..sp.P49615.CDK5_MOUSE.Cyclin.depI7qMus.musculus.CDK3..sp.Q80YP0.CDK3_MOUSE.Cyclin.dep=7qMus.musculus.CDK2..sp.P97377.CDK2_MOUSE.Cyclin.dep6qMus.musculus.CDK20.sp.Q9JHU3.CDK20_MOUSE.Cyclin.dev7qMus.musculus.CDK4..sp.P30285.CDK4_MOUSE.Cyclin.dep-7qMus.musculus.CDK6..sp.Q64261.CDK6_MOUSE.Cyclin.dep7qMus.musculus.CDK7..sp.Q03147.CDK7_MOUSE.Cyclin.dep7qMus.musculus.CDKL1..sp.Q8CEQ0.CDKL1_MOUSE.Cyclin.d7qMus.musculus.CDKL2..sp.Q9QUK0.CDKL2_MOUSE.Cyclin.d7qMus.musculus.CDKL3.sp.Q8BLF2.CDKL3_MOUSE.Cyclin.de7qMus.musculus.CDKL4..sp.Q3TZA2.CDKL4_MOUSE.Cyclin.d6qMus.musculus.CDKL5..sp.Q3UTQ8.CDKL5_MOUSE.Cyclin.dE7qMus.musculus.CK1..gi.20544149.ref.NP_620690.1..cas;6qMus.musculus.CLK1..sp.P22518.CLK1_MOUSE.Dual.speci6qMus.musculus.CLK2..sp.O35491.CLK2_MOUSE.Dual.speci;7qMus.musculus.CLK3..sp.O35492.CLK3_MOUSE.Dual.speci7qMus.musculus.CLK4..sp.O35493.CLK4_MOUSE.Dual.speci II3Qc MVFVRYKYRSNSSPLQYRISVNYTAYFFPELMKLPHNSSNEMSPEKNKIIVPPDLDNPPFYIPLKNISDRYELVQELGNGSFGSVTLAKAKFNINMINGYQNTLMDQRLIPNVSEENFYNKENGVVAIKTMMTRLPTLNDYTRVREIKFILAMPAHKHLVQIYELFIDNAQYQLHIVMECLEQNLYQLMRQRKRNVFSLPTLKSILSQILAGIRHIHQHNFFHRDIKPENILISPANRYYSKSWLQEGHFRENYVVKIADYGLARHVTNKNPYTAYVSTRWYRSPEILLRQSSYARPVDVWAFGCVALEVATFRPLFPGSDEMDQIWKILEVLGTPFITSEMKNTGYTPHGGIWQNAPSLAARLNLKFPYVEGVNIEVLLSNPLLRKLCEVIKVCLTWDPDKRANVNQVCCMPYFKETIVDDNYMLNNSTDSTNAERALMFAGIKPNGLQRPILFHENDENALTMKATQPILIKEPVQGKVDTSSLMPNIINFNHGGKLQKSSKEEVSLQEFLKETEVKDEEQDSESTLSGAEDDFAISREIQDNVHLYSLSRDPEFSSEPQLNDEGYKYLKIQNIGGRNIDEDNEEDEEDSLVDFYTNLCGAERPLLAGSNENDIPNYIHYPEPELAQRCHILDDMSMDSGGSQIPRGFMVPLISDNDTTTSTNTTVQEQHHSFTHVNGLTF pS] MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRSiRO MRHSKRTHCPDWDSRESWGHESYSGSHKRKRRSHSSTQENRHCKPHHQFKDSDCHYLEARCLNERDYRDRRYIDEYRNDYCEGYVPRHYHRDVESTYRIHCSKSSVRSRRSSPKRKRNRPCASHQSHSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGLHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPAHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPARRITLDEALQHPFFDLLKRK AjUQ MTSALLPTGQTLKGSAIMSQDFSIYREPADYHHSRLRDNISTGGSHYARSASHAYSEPASSQNFANSSPSPYPAQYRTPEEYIATPDSTVPIQQQQQAVYSR ;Ts MGQELCAKTVQPGCSCYHCSEGGEAHSCRRSQPETTEAAFKLTDLKEASCSMTSFHPRGLQAARAQKFKSKRPRSNSDCFQEEDLRQGFQWRKSLPFGAASSYLNLEKLGEGSYATVYKGISRINGQLVALKVISMNAEEGVPFTAIREASLLKGLKHANIVLLHDIIHTKETLTFVFEYMHTDLAQYMSQHPGGLHPHNVRLFMFQLLRGLAYIHHQHVLHRDLKPQNLLISHLGELKLADFGLARAKSIPSQTYSSEVVTLWYRPPDALLGATEYSSELDIWGAGCIFIEMFQGQPLFPGVSNILEQLEKIWEVLGVPTEDTWPGVSKLPNYNPEWFPLPTPRSLHVVWNRLGRVPEAEDLASQMLKGFPRDRVSAQEALVHDYFSALPSQLYQLPDEESLFTVSGVRLKPEMCDLLASYQKGHHPAQFSKCW =VKu =h_qqHomo.sapiens.MOK..MAPK.MAK.MRK.overlapping.kinase.Homo.sapiens.MOK..MAPK.MAK.MRK.overlapping.kinase.4^==Emericella.nidulans.CDK1Emericella.nidulans.CDK1(]11Gallus.gallus.CDK2Gallus.gallus.CDK2h\qqLatimeria.chalumnae.CDKL1..tr.H3BGX9.H3BGX9_LATCH.Latimeria.chalumnae.CDKL1..tr.H3BGX9.H3BGX9_LATCH.h[qqDanio.rerio.CDK20.sp.A8WIP6.CDK20_DANRE.Cyclin.depDanio.rerio.CDK20.sp.A8WIP6.CDK20_DANRE.Cyclin.dephZqqAedes.aegypti.CDK8..Cyclin.dependent.kinase.8.OS.AAedes.aegypti.CDK8..Cyclin.dependent.kinase.8.OS.AhYqqMus.musculus.HIPK1..sp.O88904.HIPK1_MOUSE.HomeodomMus.musculus.HIPK1..sp.O88904.HIPK1_MOUSE.Homeodom2X;;Candida.lusitaniae.IME2Candida.lusitaniae.IME2hWqqMus.musculus.SRSF.sp.O70551.SRPK1_MOUSE.SRSF.proteMus.musculus.SRSF.sp.O70551.SRPK1_MOUSE.SRSF.protehVqqHomo.sapiens.HIPK4..Homeodomain.interacting.proteiHomo.sapiens.HIPK4..Homeodomain.interacting.proteiCHMRW\afkpuz $).38=BGLQV[`ejpv|NOPQRS T W X YZ[\]bdfghi k"l#m$n&o(s*t+u-w/x1y3|5}79;<=>@ABCDEFGHIJKMOPRSUWY[]_acdfhjlnoprtvxyz|~ÁƁǁɁ ʁ ˁ́́΁ЁсӁցׁفځہ܁݁ ށ"߁#%')aw &,28>DJPV\bhntz "(.4:@FLRX^djpv|vGuF,-.02468:;<=>?ABEHJKLNPQ S U VWY[^`bcdeg"i$k%n'p(r)t+v,w-y.{/}2~345679: ; > ?@ACDEFGJLMNO R!S#T%V(W)X*Y+^,_.a/b0c1d3e4f6h8j:k<l>m?n@oBsDtE |;e(R|hiqqMicromonas.RCC299.GSK3..tr.C1ED07.C1ED07_MICSR.GlyMicromonas.RCC299.GSK3..tr.C1ED07.C1ED07_MICSR.GlyhhqqMus.musculus.CDK14..Cyclin.dependent.kinase.14.OS.Mus.musculus.CDK14..Cyclin.dependent.kinase.14.OS.hgqqMus.musculus.CDK7..sp.Q03147.CDK7_MOUSE.Cyclin.depMus.musculus.CDK7..sp.Q03147.CDK7_MOUSE.Cyclin.dephfqqSalmo.salar.CLK4..tr.B5X280.B5X280_SALSA.Dual.specSalmo.salar.CLK4..tr.B5X280.B5X280_SALSA.Dual.spec:eCCSaccharomyces.castelli.IME2Saccharomyces.castelli.IME2hdqqMus.musculus.ICK..Serine.threonine.protein.kinase.Mus.musculus.ICK..Serine.threonine.protein.kinase.hcqqMus.musculus.MAPK7..sp.Q9WVS8.MK07_MOUSE.Mitogen.aMus.musculus.MAPK7..sp.Q9WVS8.MK07_MOUSE.Mitogen.ahbqqDanio.rerio.CK2a1..gi.40538752.ref.NP_571327.1..caDanio.rerio.CK2a1..gi.40538752.ref.NP_571327.1..ca.a77Candida.albicans.CDK1Candida.albicans.CDK1&`//Homo.sapiens.CDK1Homo.sapiens.CDK1   b# MSGPVPSRSRVYPDVNTQRPREYWDYESHVVDWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLLDIIKDPVSRTPALVFEHVNNTDFKQLYQTLSDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPNQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSTEALDFLDKLLRYDHQARLTAREAMDHSYFYPIVKDQGRGAPAAGMAASSTPVSSSSLMAGIASMTPSTQPNIANISAGSPVIPAPNTMATQVPTAAGAQPEa MVELSDYQRQEKVGEGTYGVVYKALDTKHNNRVVALKKIRLESEDEGVPSTAIREISLLKEMKDDNIVRLYDIIHSDSHKLYLVFEFLDLDLKKYMESIPQGVGLGANMIKRFMNQLIRGIKHCHSHRVLHRDLKPQNLLIDKEGNLKLADFGLARAFGVPLRAYTHEVVTLWYRAPEILLGGKQYSTGVDMWSVGCIFAEMCNRKPLFPGDSEIDEIFRIFRILGTPNEEIWPDVNYLPDFKSSFPQWKKKPLSEAVPSLDANGIDLLDQMLVYDPSRRISAKRALIHPYFNDNDDRDHNNYNEDNIGIDKHQNMQ -d D{"Z7qHomo.sapiens.HIPK2..Homeodomain.interacting.protei6qHomo.sapiens.HIPK3..Homeodomain.interacting.protei87qHomo.sapiens.HIPK4..Homeodomain.interacting.protei7qHomo.sapiens.ICK..Serine.threonine.protein.kinase.7qHomo.sapiens.MAK..Serine.threonine.protein.kinase.7qHomo.sapiens.MAPK1..sp.P28482.MK01_HUMAN.Mitogen.a6qHomo.sapiens.MAPK10..Mitogen.activated.protein.kinY7qHomo.sapiens.MAPK11..sp.Q15759.MK11_HUMAN.Mitogen.#7qHomo.sapiens.MAPK12..sp.P53778.MK12_HUMAN.Mitogen.6qHomo.sapiens.MAPK13..sp.O15264.MK13_HUMAN.Mitogen.(7qHomo.sapiens.MAPK14..sp.Q16539.MK14_HUMAN.Mitogen.6qHomo.sapiens.MAPK15..sp.Q8TD08.MK15_HUMAN.Mitogen.7qHomo.sapiens.MAPK3..Mitogen.activated.protein.kina6qHomo.sapiens.MAPK4..sp.P31152.MK04_HUMAN.Mitogen.aR -d D{"Z7qHomo.sapiens.HIPK2..Homeodomain.interacting.protei6qHomo.sapiens.HIPK3..Homeodomain.interacting.protei87qHomo.sapiens.HIPK4..Homeodomain.interacting.protei7qHomo.sapiens.ICK..Serine.threonine.protein.kinase.7qHomo.sapiens.MAK..Serine.threonine.protein.kinase.7qHomo.sapiens.MAPK1..sp.P28482.MK01_HUMAN.Mitogen.a6qHomo.sapiens.MAPK10..Mitogen.activated.protein.kinY7qHomo.sapiens.MAPK11..sp.Q15759.MK11_HUMAN.Mitogen.#7qHomo.sapiens.MAPK12..sp.P53778.MK12_HUMAN.Mitogen.6qHomo.sapiens.MAPK13..sp.O15264.MK13_HUMAN.Mitogen.(7qHomo.sapiens.MAPK14..sp.Q16539.MK14_HUMAN.Mitogen.6qHomo.sapiens.MAPK15..sp.Q8TD08.MK15_HUMAN.Mitogen.7qHomo.sapiens.MAPK3..Mitogen.activated.protein.kina6qHomo.sapiens.MAPK4..sp.P31152.MK04_HUMAN.Mitogen.aR .cY MAEPLKEEDGEDGSGEPPGRVKAEPVHTAASVVAKNLALLKARSFDVTFDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDNIIAIKDILKPTVPYGEFRSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLAKYHDPDDEPDCAPPFDFAFDREALTRERIKEAIVAEIEDFHARREGIRQQIRFQPSLQPVASEPVCPDVEMPSPWAPSGDCAMESPPPALPPCSDPAPDTVDLTLQPAPPASELAPPKREGAISDNTKAALKAALLKSLRSRLRDGPSAPLEAPEPRKPVTAQERQREREEKRRRRQERAKEREKRRQERERKERGAGTLGGPSTDPLAGLVLSDNDRSLLERWTRMARPPAPAPAPAPAPAPAPSSAQPTSTPTGPVSQSTGPLQPAGSIPGPASQPVCPPPGPVPQPAGPIPAPLQTAPSTSLLASQSLVPPSGLPGSGAPEVLPYFPSGPPPPDPGLTPQPSTSESPDVNLVTQQLSKSQVEDPLPPVFSGTPKGSGAGYGVGFDLEEFLNQSFDMGVADGPQDGQADSASLSASLLADWLEGHGMNPADIESLQREIQMDSPMLLSDLPDLQEP }dw MNRYTTIKQLGDGTYGSVLLGRSIESGELIAIKKMKRKFYSWEECMNLREVKSLKKLNHANIVKLKEVIRENDHLYFIFEYMKENLYQLIKERNKLFPESAIRNIMYQILQGLAFIHKHGFFHRDLKPENLLCMGPELVKIADFGLAREIRSRPPYTDYVSTRWYRAPEVLLRSTNYSSPIDIWAVGCIMAEVYTLRPLFPGASEIDTIFKICQVLGTPKKTDWPEGYQLSSAMNFLWPQCIPNNLKTLIPNASSEAIQLLRDLLQWDPKKRPTASQALRYPYFQIGHPLGIISKDSGKPQREVQDKTGPPPYIKPAPPAQAPAKAYTLISSRPSQASQPPQHSVHPYKGDVSRTEQLSHVQEGKPSPPFFPSLHNKNLQPKILASLEQKNGEIKPKSRRRWGLISRSTKGSDDWADLDDLDFSPSLTRIDVKNKKRQSDDTLCRFESVLDLKPSESVGTGTTVSTQASSQRRDTPTLQSSAKQHYLKHSRYLPGINIRNGVLPNPGKDFLPSNSWSSSGLSGKSSGTVSVVSKITSVGSGSASSSGLTGSYIPSFLKKEIGSVMQRVQLAPLAAPPPGYSSLKAVRPHPGRPFFHTQPRSTPGLIPRPPAAQPVHGRIDWSSKYPSRR _e; MLDINERENSSRSSVCKIPPDLNDPPKNIPLKSLYDRYQLIEELGNGSFGCVTLAKAKFDLINLSSNVHQCKGTLLDQTNTEYQNFIAKSQRLVAIKTMLTKLYTLHDYTRVREVKFILALPTNKHLIQIFEIFADTSNYQLHIVMECMEQNLYQMMLHRKKRVFSIPSLKSILAQILAGIKHIHDHNFFHRDIKPENILVSPNKRYFDKERLELGFYPDNYVVKLADFGLARHVENKNTYTAYVSTRWYRSPEILLRNGYYSTPLDIWAFGCVAVEATIFKPLFPGSNELDQIWRILEVLGTPYNNKNDSTVPNNFKPYGGTWNHVAELASKLNLEFPFVEGISLDRFIPLPELYDLLDVIKKCLRWNPLERASANDLCLMEYFKDTVASESMKNSNTKGESRKDVTVKNNRVTTNTEQALIFAGINSDPSKTSQLVFSSTKNSNIDHNMEEDSIQINDENQRSPKHNGHMLSIPETKNNGKFFGDVLPLNPKNITNAIKPFDHSKLPMKGFAPEFNFIEKINYLSDDNDPPIPDMEKDDENDDENGIFSDTDSTEEDEINMTRELQRETHIKIPNELDQNVSLYFGNNLENLDNGDNKEESESFNQYISEMGFNIDDYEQEADNDDIITEGEPYESENGRNCDEDKSDFFYVFSHKEQTNNPFTRRTFPMNHEQEQEEVEAGNTSLPFPDVAPRTFEIPHLGPSEEVTNNCSLMNPNSFFGNLTF bgA MAVDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGVPLQHIFIAAGDDLLELIQGLFLFNPCTRTTASQALKTKYFSNRPGPTPGCQLPRPNCPVEALKEPANPTVATKRKRAEALEQGILPKKLIFwfk MRQAKRIRSPGVWLSEFSWVESRKRQKRDDSNSSVRENKSRRRQQPLKTHEGHYLETHSLNQQRIESKDRRAREASLEMGYGEDNRAAATRDRDREREKDKEWHHYSKSSGRSGKSGRSSRRGRRRSPSHQRSSYSRSHHRRSRKRSRSVEDDDEGHLIYHRRDMLRARYEIVSTLGEGAFGKVVECIDHSKIGSRVALKIIKNIDRYREAAMAEVEVLEQMNSLDCDRRYGCVRMLDWFDHHGHVCISFELLGLSTYDYLKENNFQPFPIEHIRIMAYQIIRAVRFLHKNKLTHTDLKPENILFVDSEYDIEYNAKMKRDERTLKNPDVKVVDFGNATYEHNHHTSVVSTRHYRAPEVILDLGWDHACDVWSLGCILIEYYLGSTLFQTHDSKEHLAMMERVLGPIPVHLLQKTKKRRYVHRYQLDWDALSSSGRYVRKHCKPLKQYMMVQSLDHDQLFDLIQKMLEYDPAKRLSLDQALRHPFFTCLRKATRK {{@w&^6n6qOxytricha.trifallax.CK..gi.403365855.gb.EJY82718.1 APenicillium.marneffei.IME2P6qPetromyzon.marinus.CDKL3..tr.S4RCQ7.S4RCQ7_PETMA.U|7qPetromyzon.marinus.MAPK13..tr.S4RVM7.S4RVM7_PETMA.6qPlasmodium.falciparum.CK1..sp.Q8IHZ9.KC1_PLAF7.Cas~6qSaccharmomyces.cerevisiae.CK1..gi.433622.emb.CAA42 7qSaccharmomyces.cerevisiase.CK2a2..sp.P19454.CSK22_ASaccharomyces.bayanus.IME2> CSaccharomyces.castelli.IME27qSaccharomyces.cerevisiae.CDC7..sp.P06243.CDC7_YEAS"GSaccharomyces.cerevisiae.CDK1"GSaccharomyces.cerevisiae.IME27qSaccharomyces.cerevisiae.MRK1.sp.P50873.MRK1_YEAST7qSaccharomyces.cerevisiae.RIM11..Serine.threonine.p3!GSaccharomyces.cerevisiae.SKY1z7qSaccharomyces.cerevisiae.SSN3..Meiotic.mRNA.stabilA CSaccharomyces.kluyveri.IME2"GSaccoglossus.kowalevskii.CDK1:-Salmo.salar.CDK17qSalmo.salar.CLK4..tr.B5X280.B5X280_SALSA.Dual.spec {{@w&^6n6qOxytricha.trifallax.CK..gi.403365855.gb.EJY82718.1 APenicillium.marneffei.IME2P6qPetromyzon.marinus.CDKL3..tr.S4RCQ7.S4RCQ7_PETMA.U|7qPetromyzon.marinus.MAPK13..tr.S4RVM7.S4RVM7_PETMA.6qPlasmodium.falciparum.CK1..sp.Q8IHZ9.KC1_PLAF7.Cas~6qSaccharmomyces.cerevisiae.CK1..gi.433622.emb.CAA42 7qSaccharmomyces.cerevisiase.CK2a2..sp.P19454.CSK22_ASaccharomyces.bayanus.IME2> CSaccharomyces.castelli.IME27qSaccharomyces.cerevisiae.CDC7..sp.P06243.CDC7_YEAS"GSaccharomyces.cerevisiae.CDK1"GSaccharomyces.cerevisiae.IME27qSaccharomyces.cerevisiae.MRK1.sp.P50873.MRK1_YEAST7qSaccharomyces.cerevisiae.RIM11..Serine.threonine.p3!GSaccharomyces.cerevisiae.SKY1z7qSaccharomyces.cerevisiae.SSN3..Meiotic.mRNA.stabilA CSaccharomyces.kluyveri.IME2"GSaccoglossus.kowalevskii.CDK1:-Salmo.salar.CDK17qSalmo.salar.CLK4..tr.B5X280.B5X280_SALSA.Dual.spec i MADKAAQDMQAMKLRDRSEESAREEVYEAIHIDGNPNESGHTVTTGVPSNASAPRKSYETVKVVGNGSFGVVFQATCVETGDVVAIKKVLQDKRFKNRELQIMRVLDHPNIVRLKHCFYSTNEKEEVYLNLVLEFVPDTVYRLSKMYSKSAQRMPDVLVKLYTYQMARALANIHSGGVCHRDIKPQNLLVDTRTHQLKLCDFGSAKILVRTEPNISYICSRYYRAPELIFGATEYTTAIDIWSLGCVMAELLLGQPLFPGESGVDQLVEIIKVLGTPTREEIHSMNPNYTEFKFPQIKAHPWSKVFHKRLKDEALDLISHLLVYSPDVRFGGLEICCHRYFDDLRDPAARTPDGKPLPPLFDFTEDELRACTPEMRARLVPEWYRGEGAGAA]h7 MCDLIEPQPAEKIGKMKKLRRTLSESFSRIALKKEDTTFDEICVTKMSTRNCQGTDSVIKHLDTIPEDKKVRVQRTQSTFDPFEKPANQVKRVHSENNACINFKSSSAGKESPKVRRHSSPSSPTSPKFGKADSYEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQEEEGTPFTAIREASLLKGLKHANIVLLHDIIHTKETLTLVFEYVHTDLCQYMDKHPGGLHPDNVKLFLFQLLRGLSYIHQRYILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTEYSTCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKPERFTVYSSKSLRQAWNKLSYVNHAEDLASKLLQCSPKNRLSAQAALSHEYFSDLPPRLWELTDMSSIFTVPNVRLQPEAGESMRAFGKNNSYGKSLSNSKH <*T}<hsqqHomo.sapiens.CDK16.sp.Q00536.CDK16_HUMAN.Cyclin.deHomo.sapiens.CDK16.sp.Q00536.CDK16_HUMAN.Cyclin.dehrqqSpodoptera.frugiperda.CSK2a..sp.O76484.CSK2A_SPOFRSpodoptera.frugiperda.CSK2a..sp.O76484.CSK2A_SPOFRhqqqSuberites.domuncula.GSK3..tr.Q4H118.Q4H118_SUBDO.GSuberites.domuncula.GSK3..tr.Q4H118.Q4H118_SUBDO.GhpqqDrosophila.melanogaster.CDK8..Cyclin.dependent.kinDrosophila.melanogaster.CDK8..Cyclin.dependent.kin2o;;Candida.tropicalis.CDK1Candida.tropicalis.CDK14n==Acyrthosiphon.pisum.CDK1Acyrthosiphon.pisum.CDK1hmqqHomo.sapiens.HIPK2..Homeodomain.interacting.proteiHomo.sapiens.HIPK2..Homeodomain.interacting.proteihlqqHomo.sapiens.CDK9..Cyclin.dependent.kinase.9.OS.HoHomo.sapiens.CDK9..Cyclin.dependent.kinase.9.OS.HohkqqCarassius.auratus.CDK7..sp.P51953.CDK7_CARAU.CycliCarassius.auratus.CDK7..sp.P51953.CDK7_CARAU.CyclihjqqSaccharomyces.cerevisiae.CDC7..sp.P06243.CDC7_YEASSaccharomyces.cerevisiae.CDC7..sp.P06243.CDC7_YEAS `k= MALDVKSRAKLYEKLDFLGEGQFATVYKARDKTTNTIVAIKKIKVGHRTEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLLCFMETDLEVIIKDTSLVLTPANIKAYILMSLQGLEYMHNHWILHRDLKPNNLLLDENGVLKLADFGLAKAFGSPNRVYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGSILAELLLRVPFLAGDSDLDQLTGIFEALGTPTEETWPGMSNLPDYVSFKLFPGTPLEHIFSAAGDDLLELLKGLFTFNPCTRTTASQALKMRYFSIRPGPTPGPQLPRPNSSTEALKEKENLLIGIKRKRDSIEQGTLKKKLVFj MTSKTKNIDDIPPEIKEEMIQLYHDLPGIENEYKLIDKIGEGTFSSVYKAKDITGKITKKFASHFWNYGSNYVALKKIYVTSSPQRIYNELNLLYIMTGSSRVAPLCDAKRVRDQVIAVLPYYPHEEFRTFYRDLPIKGIKKYIWELLRALKFVHSKGIIHRDIKPTNFLFNLELGRGVLVDFGLAEAQMDYKSMISSQNDYDNYANTNHDGGYSMRNHEQFCPCIMRNQYSPNSHNQTPPMVTIQNGKVVHLNNVNGVDLTKGYPKNETRRIKRANRAGTRGFRAPEVLMKCGAQSTKIDIWSVGVILLSLLGRRFPMFQSLDDADSLLELCTIFGWKELRKCAALHGLGFEASGLIWDKPNGYSNGLKEFVYDLLNKECTIGTFPEYSVAFETFGFLQQELHDRMSIEPQLPDPKTNMDAVDAYELKKYQEEIWSDHYWCFQVLEQCFEMDPQKRSSAEDLLKTPFFNELNENTYLLDGESTDEDDVVSSSEADLLDKDVLLISE nnLn MQSAVKNRQFVKEGPTKNVSINVNYDKLEQIGEGTYGVVYKALDKQTGKFVALKKVRMESSAEGVPSTAMREISLLKEINHENVVKLYDVIMSDKKLFLVFEFMDYDLKKVLELRRKEFGFGLPEPQIKSYLYQILNALAYCHIHRIIHRDLKPQNLLVNTAGGIIKLADFGLARAFSFPLRNYTHEVITLWYRAPEILLGAKVYTMAVDLWSLGCIFTEMMTLRPLFPGDSEIDQLFRIFRTLGTPTDVTWPGVDQLPDFKPLFPLWEARLIEEFLPELSDKNQQNVFYAMCTYNPANRMSAEKILEMDYFHSLRLASLPETP6mi MAPVYEGMASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLSQPATTTVSTSLPVPNPSLPYEQTIVFPGSTGHIVVTSASSTSVTGQVLGGPHNLMRRSTVSLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGS&|lu MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVFNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPFVTMTHLLDFPHSTHVKSCFQNMEICKRRVNMYDTVNQSKTPFITHVAPSTSTNLTMTFNNQLTTVHNQAPSSTSATISLANPEVSILNYPSTLYQPSAASMAAVAQRSMPLQTGTAQICARPDPFQQALIVCPPGFQGLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGLLAQQAWPSGTQQILLPPAWQQLTGVATHTSVQHATVIPETMAGTQQLADWRNTHAHGSHYNPIMQQPALLTGHVTLPAAQPLNVGVAHVMRQQPTSTTSSRKSKQHQSSVRNVSTCEVSSSQAISSPQRSKRVKENTPPRCAMVHSSPACSTSVTCGWGDVASSTTRERQRQTIVIPDTPSPTVSVITISSDTDEEEEQKHAPTSTVSKQRKNVISCVTVHDSPYSDSSSNTSPYSVQQRAGHNNANAFDTKGSLENHCTGNPRTIIVPPLKTQASEVLVECDSLVPVNTSHHSSSYKSKSSSNVTSTSGHSSGSSSGAITYRQQRPGPHFQQQQPLNLSQAQQHITTDRTGSHRRQQAYITPTMAQAPYSFPHNSPSHGTVHPHLAAAAAAAHLPTQPHLYTYTAPAALGSTGTVAHLVASQGSARHTVQHTAYPASIVHQVPVSMGPRVLPSPTIHPSQYPAQFAHQTYISASPASTVYTGYPLSPAKVNQYPYI Np MDYDFKMKTQIERTKVEDLFNYEGCKVGRGTYGHVYKAKWKETSDGKEYALKQIDGTGLSMSACREIALLRELKHQNVITLIRVFLSHNDRKVFLLIDYAEHDLWHIIKFHRAAKATKKQVVVPRGMVKSLLYQILDGIHYLHSNWVLHRDLKPANILVMGDGNERGRVKIADMGFARLFNAPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPQDKDWEDIKKMPEHHTLTKDFKRSTYSTCSLAKYMERHKIKPDSKAFHLLQKLLLMDPNKRITSEQAMQDQYFQEEPQPTQDVFAGCPIPYPKREFLTDDDQEDKSDNKRQQQQQQQQQQQQQQQQQQQQQQQQQQQQMNAEPNAKRVRLSGAGNQQDFHHQQQQQQQQQQQQQQQQQQMMFNQQQNFQRFNo MMSKHNSFPLDCDSPPKNLTVHSYQRSYQTISSLGNGSFGTVELAKFKFQKFDLLNMHEDKAGTLLYPLEDSKFNQSNLVAIKTMKKKLSLLSEYANVKEVKFILSIPSHPCLVQIFEMFIDDVNYQLHISMEALNQNLYQLIKSRRNIKFSPVTLKSILSQLLCAIKHIHKWNYFHRDVKPENILVIPTLHFYGSKASVPPYRKNDNFIVKLGDYGLARHVSNTKPYTAYVSTRWYRSPEILLRQKWYSRPIDIWAFGAVAVEIANFVPLFPGSNEFDQIWKILRILGSPYVPEPNTINANYVVPLGGYWNDAVYLANKLGLKLPAEPGMNIEDVVQHPDGNALQDVIQGCLKWDPLARADANELAKMPYFKETIKMMDSHFEGETLSVNATLNKLVGIPNSPSRKLMAPAKTQRNVSMLDEFPIYQDLDDGYENYFDEYIGIDQGEENSEGIDGYKLISHPWMSKVKDFIGTRESEKEPRSVGVNGTSGDKKKSNQVGGTKRSFTTFSMESEEIANL 9irO MTMAVPSRARVYADVNSQRPREYWDYESYVVDWGNQEDYQLVRKLGRGKYSEVFEAINITNNEKCVVKILKPVKKKKIKREIKILENLRGGTNIITLQAVVKDPVSRTPALIFEHVNNTDFKQLYQTLSDYDIRYYLYELLKALDYCHSMGIMHRDVKPHNVMIDHDHRKLRLIDWGLAEFYHPGQDYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEELFEYLDKYHIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDRLLRYDHYERYTAREAMDHPYFYPIVKEQGRMVSSNSPTPNALQGPISTTECq MSDYRMNRPKEQGTRGRATSFADPHVSRDSKPTAPRITRDKDGNKVTTVLATVGKPPDRQQEINYCEVKVIGNGSFGVVYQARLLETNDSVAIKKVLQDKRFKNRELQIMRRLDHCNIVRLQYFFYSSGDKKDELYLNLVLDFIPETVYRVIRHHSKAKQIIPLLYIKLYMYQLFRSLAYIHANGVCHRDIKPQNLLLDPSSGVLKLCDFGSAKVLVKGEPNVSYICSRYYRAPELIFGATDYTCDIDIWSAGCVFAEVLLGQPIFPGDSGVDQLVEIIKVLGTPTKEQIRQMNSNYTEFKFPQIKAHPWNRVFRPRTSPEAIDLVSRLLEYTPSNRITPMEACAHAMFNEIRQPGARMPNGREFPLSLTLHPKNLAIRPSLESILLPPHVSKASATPSSTSSTATSQDHAHSSTSGNHYSGGAGGTSSSLHKPGHNSSELNH __!t? MIDTLFFLFFLFFDSPLRRLLLLCAVLALRAPTAHSPILRSSIVTPTARAVSEVSGCTTIDPDFLVEISDSNQTRAMSKARVYTEVNVIRPKDYWDYESLIVQWGEQDDYEVVRKVGRGKYSEVFEGINVNSKEKCIIKILKPVKKKKIRREIKILQNLCGGPNIVKLLDVVRDQHSKTPSLIFEYVNSTDFKVLYPTLTDYDIRYYIYELLKALDFCHSQGIMHRDVKPHNVMIDHELRKLRLIDWGLAEFYHPGKEYNVRVASRYFKGPELLVDLQDYDYSLDMWSLGCMFAGMIFRKEPFFYGHDNQDQLVKIAKVLGTDELNAYLNKYQLELDPQLEALVGRHSRKPWSKFINADNQHLVSPEAIDFLDKLLRYDHQDRLTAKEAMAHAYFAQVRAAETSRMRSQxsm MDRMKKIKRQLSMTLRGGRGIDKTNGAPEQIGLDESGGGGGSDPGEAPTRAAPGELRSARGPLSSAPEIVHEDLKMGSDGESDQASATSSDEVQSPVRVRMRNHPPRKISTEDINKRLSLPADIRLPEGYLEKLTLNSPIFDKPLSRRLRRVSLSEIGFGKLETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYNYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFFLSLGERIHKLPDTTSIFALKEIQLQKEASLRSSSMPDSGRPAFRVVDTEF =*T~=h|qqXenopus.laevis.CSK2a1..sp.P28020.CSK21_XENLA.CaseiXenopus.laevis.CSK2a1..sp.P28020.CSK21_XENLA.Caseih{qqSchizosaccharomyces.pombe.CDK9..Probable.cyclin.deSchizosaccharomyces.pombe.CDK9..Probable.cyclin.dehzqqDanio.rerio.MAPK13..tr.E7F292.E7F292_DANRE.UncharaDanio.rerio.MAPK13..tr.E7F292.E7F292_DANRE.UncharahyqqLytechinus.variegatus.GSK3..tr.Q6IUG5.Q6IUG5_LYTVALytechinus.variegatus.GSK3..tr.Q6IUG5.Q6IUG5_LYTVAhxqqMicromonas.sp.RCC299.LF4..long.flagella.protein.LFMicromonas.sp.RCC299.LF4..long.flagella.protein.LFhwqqCandida.albicans.SSN3..Serine.threonine.protein.kiCandida.albicans.SSN3..Serine.threonine.protein.kihvqqMeleagris.gallopavo.MAPK13..tr.G1MQ62.G1MQ62_MELGAMeleagris.gallopavo.MAPK13..tr.G1MQ62.G1MQ62_MELGAhuqqHomo.sapiens.CDK17..sp.Q00537.CDK17_HUMAN.Cyclin.dHomo.sapiens.CDK17..sp.Q00537.CDK17_HUMAN.Cyclin.dhtqqArabidopsis.thaliana.CSK2a1..gi.30698301.ref.NP_20Arabidopsis.thaliana.CSK2a1..gi.30698301.ref.NP_20 nnwvk RAMNIARRRGFYRQELNRTVWELPRRYISLHPVGSGAYGSVCSAIDKKTGEKVAIKKLCRPFQTEIFAKRAYRELILLKQMQHENVIGLLDVFTSAPSYHGFQDFYLVMPYMRTDLQKIMGHEFSDEKIQYLVYQMLKGLKYIHSAGIVHRDLKPGNLAVNEDCQLKILDFGLARHADAEMTGYVVTRWYRAPEVILNWMHYNQTVDIWSIGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGHPGDDFVEKLEDKAAKSYIKSLPKMPKKDLSVLFPKANPQAVDLLDKMLQLDVEKRLTATEALAHPYFDQFRDIEEETEAQQAYDDSLEHEKLSIEEWKKHIYKEILSFSPIARKDSKKRSGMSLu# MKKFKRRLSLTLRGSQTIDESLSELAEQMTIEENSSKDNEPIVKNGRPPTSHSMHSFLHQYTGSFKKPPLRRPHSVIGGSLGSFMAMPRNGSRLDIVHENLKMGSDGESDQASGTSSDEVQSPTGVCLRNRIHRRISMEDLNKRLSLPADIRIPDGYLEKLQINSPPFDQPMSRRSRRASLSEIGFGKMETYIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIVHTDKSLTLVFEYLDKDLKQYMDDCGNIMSMHNVKLFLYQILRGLAYCHRRKVLHRDLKPQNLLINEKGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSSEYSTQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLLGTPSQETWPGISSNEEFKNYNFPKYKPQPLINHAPRLDSEGIELITKFLQYESKKRVSAEEAMKHVYFRSLGPRIHALPESVSIFSLKEIQLQKDPGFRNSSYPETGHGKNRRQSMLF hwM MSYSSASFRKLNNVGISQPSQTTTTTTSANQPQSQSQQQPLQQSQQQHLHMKPNPHIPHHQLPGTVGTRASIPQPALMASNSILTLGPFKHRKDLTRESVLSTYQIMGYIAAGTYGKVYKAKLKSNKLNKTDDDSGIDGINNKDIFSESMNDLHHDNSPSIMINTTTNITINNSLPQFFAIKKFKSDNHHHHINNNNNGGNHLSKGNNSIHQDEVLHYTGISQSAIREMSLCRELNNKNITKLVDIILENKSIYMVFEFCEHDLLQIIHYQSHPDFKPIPCPTIKSLIWQILNGVTFLHKNWILHRDLKPANIMVSSQGVVKIGDLGLARKFKSPLQSLYTGDKVVVTIWYRAPELLLGTRHYTPAVDLWAVGCILAELLSLRPIFKGEEAKIDLNNKKSVPFQKNQLQKIIEILGTPTTDIWNNLNKYPEYLSFTQHFNQNYPNNLSNWFKLINGGNNQNSEKCLELLSGLLKYDPELRLTADQALLHPYFLELPKVNENAFEGLNYKYPNRKIYTDDNDIMTTAANNNNNNNNNNNNNNNNNNNNNNNNNNNSGHQLSQQQNVQIQQVHQMQQQIHSQQLQSHGANSTYKRSGIDDLPGGIRKKRG $$&yI MSGSGRPRTTSFADANRGSTSSYGGLKVSRDKDSSKITSVTATEGPPPDRTKEISYTDTRVIGNGSFGVVYQARMVDTNDLVAIKKVLQDKRFKNRELQIMRRLDHHNIVKLKYFFYSSGEKKDEVFLNLVLEYVPETVYRVARHYSKAKQTISLIYVKLYMYQLFRSLAYIHSMGICHRDIKPQNLLLNPETAVLKLCDFGSAKVLVRGEPNVSYICSRYYRAPELIFGATDYTCDIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPSRDQIKEMNPNYTEFKFPQIKPHPWSKVFRTRTPADAIQLCSRLLEYTPKSRIKPLEACAHQFFSELRDPGIKLPNGRELPPLFNFTAGELASKPSLRTALIPPHVSQNSSSSTAPHDTPEPSTSATASSATGGSSSK.xY MGGAAMVRRSGDLGRYKHVLGVGAAATVTPNSPRIAQYRLVAKKGEGTFSEVLKAQCIKNGKYVAIKCMKNHFDSLDQVNNLREIQALRRLSPHGNIIKLLEVLYDQPTGRLALVFELMDMNIYELIRGRRHYLAEDRVKTYMYQLIKSMDHMHRNGIFHRDIKPENILIMDDCLKLADFGSCRGIYSKQPYTEYISTRWYRAPECLLTDGYYNYKMDMWGVGCVFFEIVSLFPLFPGTNELDQIQKIHNIIGTPSAELLGKMKQRSAHMDFNFPQKSGTGIEKLIPHAPPECVDLINKLLAYNPDDRLSARQALRHPYFREIREMEKRQYALMNPKADGTLSGSGGDDSRAGHHGSAATSSDARSDRTRRSRASASVASASVPSIAGKGIGDAGGGGGYEPSGGHRRLQVAGSHRSHAAASSVHSGYHAGASSYHGGSDASSIISAGGISLGGVSAARSGGYGGGGAADLGVQGVGSRNVKPGAREPVKLGGGYGGVAGSSYGGSYKSKPAARGSVRERMEPPSGVGGQKAPVSHRTDKYVSPYGQQRR //W{+ MKRSSSVSVEDEKSARRKLDVVPKLHFVGCSHLTDYHLMEKLGEGTFGEVYKSQRRKDGKVYALKRILMHTEKEGFPITAIREIKILKSIKHENIIPLSDMTVVRADKKHRRRGSIYMVTPYMDHDLSGLLENPSVKFTEPQIKCYMKQLFAGTKYLHDQLILHRDLKAANLLIDNHGILKIADFGLARVITEESYANKNPGLPPPNRREYTGCVVTRWYRSPELLLGERRYTTAIDMWSVGCIMAEMYKGRPILQGSSDLDQLDKIFRLCGSPTQATMPNWEKLPGCEGVRSFPSHPRTLETAFFTFGKEMTSLCGAILTLNPDERLSASMALEHEYFTTPPYPANPSELQSYSASHEYDKRRKREQRDANSHAFEQTANGKRQFRFMTRGPSDPWYGIRRPNYNSQPQYQRGSYNREGGNMDRSRNVNYQPKRQQNFKPLTSDLPQKNSEFSETNAMNQTSNHSHADGQRYYRPEQDRSQRLRNPSDYGRQGRQSSQSQQPAWNVSSRYQNNSKVQTTSRASENADTNKTQHNIKYIDSYVPEYSIARQSANQKTNEQHPSSTSLHQQSTSDLKSPSFHENSNVDDTPKrza MESRVEFSREEINSTVWEVPAKYVCLKQIGTGAYGSVCSSINNKTKEKVAIKKLHRPFQSEIFAKRAYRELRLLKHMKHENVIGLLDVFTPATRLDEFQDFYLVMPYMYTDLSKVKGLLTEDRIQFLVYQMLCGLKYIHGAGIIHRDLKPGNLAVNQDCELKILDFGLARHTDAEMTGYVVTRWYRAPEVILNWMHYTQTVDIWSVGCIMGEMFNGKTLFKGKDYMDQLTQIMKVAGTPGPEFVEKLESPEAKSYVRSLPHYPHRDFSTLFPRASKKAVELLEKMLVLDADARLTASGALAHSYFDGLRDPDDWPEPTAYDDSYDNATLPLEEWKRLSFKEVRSFVPFPRRDSKRRNTLTMS lD} MASQVLVYPPYVYQTQSSAFCSIKKLKVEPSSCLYNKRSYQRTDLNARSIGFAQPSNKNRAPFQTKNTSDKPRHQAAVSKTSPVTLNTNTGASGDLAAQAQQDPKEELTVGTPESGSDLLDAHQRCGLKRKSKDFENQNGTMQIVDELSILPAMLPNNAANQVTVVATTGTSKQSTASGDGDYQLMLHEVLC1| MSGPVPSRARVYTDVNTHRPRDYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQTRLTAREAMDHPYFYPIVKDQSRMGGSNMPSGSSTPVSSASMMSGISTVPTPSALGSLAGSPVISATNTLGTPVAAAAGATQ <*S}<hqqCaenorhabditis.briggsae.DYRK1..Dual.specificity.tyCaenorhabditis.briggsae.DYRK1..Dual.specificity.tyhqqHomo.sapiens.CSK2a3...sp.Q8NEV1.CSK23_HUMAN.CaseinHomo.sapiens.CSK2a3...sp.Q8NEV1.CSK23_HUMAN.CaseinhqqHomo.sapiens.CDK14..Cyclin.dependent.kinase.14.OS.Homo.sapiens.CDK14..Cyclin.dependent.kinase.14.OS.hqqHomo.sapiens.CDKL3..sp.Q8IVW4.CDKL3_HUMAN.Cyclin.dHomo.sapiens.CDKL3..sp.Q8IVW4.CDKL3_HUMAN.Cyclin.dhqqXenopus.laevis.MAPK14..sp.P47812.MK14_XENLA.MitogeXenopus.laevis.MAPK14..sp.P47812.MK14_XENLA.Mitoge099Aspergillus.niger.IME2Aspergillus.niger.IME2hqqMus.musculus.MAPK9..sp.Q9WTU6.MK09_MOUSE.Mitogen.aMus.musculus.MAPK9..sp.Q9WTU6.MK09_MOUSE.Mitogen.a6??Candida.dubliniensis.IME2Candida.dubliniensis.IME2h~qqMus.musculus.CDK11B.sp.P24788.CD11B_MOUSE.Cyclin.dMus.musculus.CDK11B.sp.P24788.CD11B_MOUSE.Cyclin.dh}qqXenopus.tropicalis.HIPK3..tr.F6SEG6.F6SEG6_XENTR.UXenopus.tropicalis.HIPK3..tr.F6SEG6.F6SEG6_XENTR.USVKNTYEVLDFLGRGTFGQVVKCWRRGTNEVVAVKILKNHPSYARQGQIEMGILARLSNENADEFNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIRAILQQVATALKKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASYVSKTVCSTYLQSRYYRAPEVILGLPFCEAIDMWSLGCVIAELFLGWPLYPGAQEYDQIRYISQTQGLPGDSLINAGTKTSRFFCREPDAPYPSWRLKTLEEHEAETGIKSKETRKYIFNNLDEIVHVNMMVDLDGSDLMAEKADRREFVALLKKMLMIDADKRISPADTLSQSFITMKHLLDFPHSNHVKSCFYIMDVCKARPNVGDTANHNKTSIVRPITSTNIGSMSAGFTKIGTIRGQALTTSGHSVIHHGIPLQAGSAPFGCNDAFQQTLILCPPAIQGMPPNHGKPTSYSVRVDNALPLVTQAPAIQPLQIRAGVLTQAWSNGTQPILVPAWQQMTTIAPTASSLASDTMAGPQRLGDWGKVIPHGNHYNSMIIQPIITNQMTLSAPQPISLGIAHVVWPQPAANKRNKLCQNRGSLTALLVEELMSHQVFSLPTINAIQDIVVHNPVVASPKIVSSENTRAEESSALPQDNHEEKEEEQSSSNNTQGPAPDTSIQQQQAIVIGDSPSPTVSVITINSDTDEDDPAQTLSLRECKRSLDCDTCQSALNVCSLSSPDSTLSTSSSGQSSPSPCKRRNSISDDEPESGCDTVNGSPSSDSSGHDSPFKNSFVRDSNQNTESRTPEKTDSKPAVCTVVVPPIRIENRQFNSHRVSNKDTVCYPVIKGRSAPGRINHPNSLGSRQQKLASAFQHQPPLNYSKVQHFGSGHQEWNGNYGHMRQQAYMQPTVASHPFTLQHGSPTHSALHAHLAGSTHIGGQPAILSYPPSASLSSAAPVAHLLASPCTSRPILQHPTYSLSHPSGIVHQVAVGINPRLLPSPTIHQTQFKPIFPSHSYITASPAYAGFPMSPTKLSQYPYM ~- MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKAHHRKDEKRKEKRRHRSHSAEGGKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKLREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREEYSDKGKVGHWSRSPLRPPRERFEMGDNRKPVKEEKVEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEEETGSNSEEASEQSAEEVSDEEMSEDEDRENENHILVVPESRFDRDSGDSEEGEEEVGEGTPQSSAPTEGDYVPDSPALSPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLSGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSDIDQINKIFKDLGTPSEKIWPGYNDLPAVKKMTFSEYPYNNLRKRFGALLSDQGFDLMNKFLTYYPGRRINAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF 99/[ MSDSKSDGQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQLGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEVMDWEERSKNGVKDQPSDAAVSSKATPSQSSSINDISSMSTEHTLASDTDSSLDASTGPLEGCR MSRHQSFPLDYDSPPKHLTVHSYHSKYQTINTLGNGSFGTVDLAKIKFFKFDLLNSHKNKSGTLLCPLEDSKCNTSNLVAIKTMKKKLPLLQEYSNVKEVKFILSVPSHPCLVQIYEMFIDDIQYQLHISMEALNQNLYQLIRSRRNIKFSPVTLKSILSQLLCAIRHIHKCNYFHRDVKPENILVIPTLHFYGSKAAIPPYRKNDNFIIKLGDYGLARHVSNIKPYTAYVSTRWYRSPEILLRQKWYSRPIDIWAFGAVAVETANFVPLFPGSNELDQIWKILKILGTPFVPEPKSINSSYIVPLGGYWTEALFLTNKLGIKLPDETGTTIEEIVQHPDSLALIEVIQSCLKWDPSARADATEIAKMQYFKESIAMMDTYFETDTVTMNTALNKLAGIPNSPSRKLLTPLKLQKNSTGICNTTGSVPVFQDSDDGYENYFGEYIAKQPERNSSGNESYKLFAQPWLLKVNEVLGTRESEMEPRRAGNGTSDLKKKQSKAAGTKRSFTTFSLDSEEVVNL - MTVCYDHHSLSRGAAPTSVASLEDRFEVLKEVGDGSFGSVAVARVRTAGSNVARRGTMVAIKTMKKTFESLAPCLELREVIFLRSLPPHPHLVPALDIFLDPLSRKLHICMEYMDGNLYQLMKARDHKPFDGKHVKSILYQILGGLDHIHAHHFFHRDIKPENILVSTSAPNDSAFSRYSNLVTPPSTPPTYTVKIADFGLARETHSKLPYTTYVSTRWYRAPEVLLRAGEYSAPVDMWAVGAMAVEIATLKPLFPGGNEVDQVWRVCEIMGSPGNWYSKSGNKLGGGEWREGSRLAQKLGFTFPKMAPHSMESILQAPQWPAALSQFVTWCLMWDPKNRPTSTQALNHEYFADAIDPLRPKSSTARLLGRKQSDKSFKSANRDASESSTLSYKSSWFRRSLIGRSESPVPPVESENSSKQSVAYSDLQVGKSKPAASKRATWANGAPMPILPSIRPVSPLSNAVTAQANSSLAHSGDSANASKASKKIGRQLSVNSHGNHYAEIHRQEAERALNGGGNVYSAVTPKESFFSHLRKRARRLSGRNQANSGTDDVEANAGCMPWSNRSSLALDSVNNVSESKQNSDLSELDKALQTVKYSLDSAALGNVPVQITSPIESTKRQSMPQGSIRSMGESPVSTSGTGGPISSRTRRAMQMSNNPIHRYETPEEEDELLDEVLHSASKAARRLAQTEVSSEVSSNYSRPAVGNDSSRPLPSPYPTPSPSAKCDGVCFGHSDATPCRRLPLAEEKTDANTSRQWPTPPYEDGDWAKPAPAKFLTGSATYR //X- MEMYETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQSVNKIAMREIKFLKQFHHENLVNLIEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIDYLHSNNIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYTDYVATRWYRAPELVLKDTSYGKPVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSKSPIFAGVVLPQVQHPKNARKKYPKLNGLLADIVHACLQIDPADRISSSDLLHHEYFTRDGFIEKFMPELKAKLLQEAKVNSLIKPKESSKENELRKDERKTVYTNTLLSSSVLGKEIEKEKKPKEIKVRVIKVKGGRGDISEPKKKEYEGGLGQQDANENVHPMSPDTKLVTIEPPNPINPSTNCNGLKENPHCGGSVTMPPINLTNSNLMAANLSSNLFHPSVRLTERAKKRRTSSQSIGQVMPNSRQEDPGPIQSQMEKGIFNERTGHSDQMANENKRKLNFSRSDRKEFHFPELPVTIQSKDTKGMEVKQIKMLKRESKKTESSKIPTLLNVDQNQEKQEGGDGHCEGKNLKRNRFFFWq_ MSSNQSYVFYRQELNKTLWEVPDRYQNLTPVGSGAYGSVCSSFDTRTALRIAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFSPAKSFEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSAGIIHRDLKPSNLAVNEDCELKILDFGLARHTDEEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPEPELLQKISSEAARNYIQSLPYMPKMNFEDVFLGANPQAVDLLEKMLVLDTDKRITAAEALAHSYFAQYHDPDDEPIAEPYDQSFESRELDIEEWKRLTYEEVTCFVPPPLDSEEMES  MSGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWRLGCMLASMIFRKEPFFHGRDNYDQLVRIAKFLGTEDLYGYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMGSSSMPGGSTPVSSANVMSGISSVPTPSPLGPLAGSPVIAAANPLGMPVPAATGAQQ]7 MCDLIEPQPAEKIGKMKKLRRTLSESFSRIALKKDDTTFDEICVTKMSTRNCQGMDSVIKPLDTIPEDKKVRVQRTQSTFDPFEKPANQVKRVHSENNACINFKTSSTGKESPKVRRHSSPSSPTSPKFGKADSYEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQEEEGTPFTAIREASLLKGLKHANIVLLHDIIHTKETLTLVFEYVHTDLCQYMDKHPGGLHPDNVKLFLFQLLRGLSYIHQRYILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTEYSTCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKPERFTLYSSKNLRQAWNKLSYVNHAEDLASKLLQCSPKNRLSAQAALSHEYFSDLPPRLWELTDMSSIFTVPNVRLQPEAGESMRAFGKNNSYGKSLSNSKH ll MNSGEKQDNLQAWGQQPSSSYSNTQQQHGQITGQIPLTITNQVEAHDNDFHMQDASNDELEKSKKIAEQPTEHPQQHHQQQPAVPRFPPQSRQPQAILRFPQPPITSINKANNSNSQNFFPQQEVLQSRPKKHRVSMTNAEAANTPGMPPEKLPAKKLSADSQRPLFRDSNVFQRSAGQFTNDNGPSSSSAIVGAPFDANSSSKPVHIQQFRNPNDAPVTKLTSDLIKTYKAINEKFQSFYLRKNVRRSTVGRHTSLDSSGKPKTGKEASSSDANLIETFSIHNAVPNTSSSGNQPHYDSHVNAPPLLDTNAPPTSTMVVPMRTETESQQQMRQKSSRGGPYNNGYDDQNYDYILKNGEIFDKRYVILSDTPVGKGSFGQVTKAYDTVTKEEVAIKIIKNKKTFFDQAQIEIHLLELTNAHDKDNKYNIVTLKGHFVHRAHLCLVFELLSYNLYDLLKNTNFRGVSLNLARKFAQQLGKTLLFLSSPELSIIHCDLKPENVLLVNAKRSQIRVIDFGSSCQTGHRIYQYIQSRFYRSPEVLLGIAYDTKIDMWSLGCILVEMHTGEPLFAGSSEVDQMMKIVEVLGMPPKEMLDIGPKTHKYFDKTEDGIYYCKKTRDGYRHTYKAPGARKLHEILGVTSGGPGGRRLGEPGHSVEDYSKFKDLIKRMLNFDPKQRILRTTLFPVSHTAYNQNLYHQQQIDQVPAVGSVYIEDNGMYRPVPTSSHPISVTSSFDDGDVIEIDPNRRRYSQQNYHNPNYQYSQQPQSSSQQQQQQYQQSQRAQLEKQQQLQQQQQQQQQQRQHLSHQPSQSVQQHSSSSSRSRPRQQDQAEWRTQLELEEAFKQRKAEEATAPRSLQYNPQQVVGVQLIKRVLISKLFQGSMSHGNVNAGSSRDMEKHDYPNNKL )JIsd)8AADebaryomyces.hansenii.SKY1Debaryomyces.hansenii.SKY16??Kluyveromyces.waltii.IME2Kluyveromyces.waltii.IME2hqqSaccharmomyces.cerevisiase.CK2a2..sp.P19454.CSK22_Saccharmomyces.cerevisiase.CK2a2..sp.P19454.CSK22_hqqHomo.sapiens.MAPK12..sp.P53778.MK12_HUMAN.Mitogen.Homo.sapiens.MAPK12..sp.P53778.MK12_HUMAN.Mitogen.h qqCaenorhabditis.elegans.GSK3..sp.Q9U2Q9.GSK3_CAEEL.Caenorhabditis.elegans.GSK3..sp.Q9U2Q9.GSK3_CAEEL.h qqCaenorhabditis.briggsae.CDK4..tr.Q8MUK2.Q8MUK2_CAECaenorhabditis.briggsae.CDK4..tr.Q8MUK2.Q8MUK2_CAEh qqCordyceps.militaris.GSK3..tr.G3JGQ8.G3JGQ8_CORMM.PCordyceps.militaris.GSK3..tr.G3JGQ8.G3JGQ8_CORMM.Ph qqHomo.sapiens.CDK5..sp.Q00535.CDK5_HUMAN.Cyclin.depHomo.sapiens.CDK5..sp.Q00535.CDK5_HUMAN.Cyclin.dep( 11Gallus.gallus.CDK1Gallus.gallus.CDK1hqqCaenorhabditis.elegans.MAPK8.sp.Q8WQG9.JNK1_CAEEL.Caenorhabditis.elegans.MAPK8.sp.Q8WQG9.JNK1_CAEEL.HQQSchizosaccharomyces.japonicus.IME2Schizosaccharomyces.japonicus.IME2 tt MPFRGKFWGTSKEKSVTTCTKLEDMYDVFQEIGDGTFGSVRLARRRNCPGELFAIKSMKTPLTKTSDSTRLREVRSLAKIPRHDNVVKVFELIVDAKKHLHMVMENLQYNLLQLITKQNLIPFSIDAVKDLVRQIFCGLEHIHLHGYFHRDMKPENILISEFPGVNSSRYVVKIADFGLARELRSSPPYTEYISTRWYRAPELLLRDPSYSSPVDVYAVGCMAFEIATLRPIFPGRDDLDQLYKMCEVLGSPKEWPELGDDVGGGPWPEAYELAKDLGFQLPTNMPLSFHELFSPPWNNTFASMLTAILKWDPKKRPTASECLAMPFLYVPPKSLYGLPNHSTTTAYLQKKTSRTSTRHRSSSLVESLSSEEFSEITLSSPRTNKNLFGNVSRKLVGGFKHSFKKSVSKPKADKSLHSSSVVNLSSTAYTDSSSSNTLLSANRPLSLAAPVARTGKLSEHKAAQNILFPVLPELRPTTPLNVKLSGLVLVSPTPSTASSSGGSIAQPRTPSSKRFTSERSSVDHISSPSHAERHCHSPRSPRSPSRQLFNEASTTYSNASTIASIKSMSATIYQPLPRPPTLSLTEVSISNSSENSSSKPSIKSEDLLNPDTFFTEGFHDSFDELSLASTLRIPKSAHGA %7 k  MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELHHPNIVCLQDVLMQDARLYLIFEFLSMDLKKYLDTIPSGQYLDRSRVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGVIKLADFGLARAFGIPVRVYTHEVVTLWYRSPEVLLGSALYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNDVWPDVESLQDYKNTFPKWKPGSLGTHVQNLDEDGLDLLSKMLIYDPAKRISGKMALNHPYFDDLDKSTLPANLIKKFW+ MEERLSTTSSYPSHPGRSVEEDHNTLLASSSISSIIRGTRGHLNNFIESVGNWLVPSSSGRDDDAVSLDSCQSVYSPVRHHINSGTGGGILMEPSSIHVPENYYSVTIGEAQMVVLKRYQNLRLIGSGAQGIVCSAFDTVRNEQVAIKKLSRPFQNVTHAKRAYRELKLMSLVNHKNIIGILNCFTPQKKLDEFNDLYIVMELMDANLCQVIQMDLDHERLSYLLYQMLCGIRHLHSAGIIHRDLKPSNIVVRSDCTLKILDFGLARTAIEAFMMTPYVVTRYYRAPEVILGMGYKENVDVWSIGCIFGELIRGRVLFPGGDHIDQWTRIIEQLGTPDRSFLERLQPTVRNYVENRPRYQATPFEVLFSDNMFPMTADSSRLTGAQARDLLSRMLVIDPERRISVDDALRHPYVNVWFDEIEVYAPPPLPYDHNMDVEQNVDSWREHIFRELTDYARTHDIYS -- ;  MSSQRPGAFNSLRMGEVIRERVQDGVTGETRELQYTQCKIVGNGSFGVVFQTKLSPSGEDAAIKRVLQDKRFKVCLSARSIFLLRRRKRRQYPNKPRQNRELQIMRIVRHPNIVQLKAFYYSNGERKDEVYLNLVQEFVPETVYRASRFFNKMKTTMPILEVKLYIYQLFRALAYIHSQGICHRDIKPQNLLLDPTSGILKLCDFGSAKILVENEPNVSYICSRYYRAPELIFGATNYTTKIDVWSTGCVMAELMLGQPLFPGESGIDQLVEIIKVLGTPTREQIRTMNPNYMEHKFPQIKPHPFNKVFRKADANAIDLITKLLEYTPTEREAAVNAMVHPFFDELRDPETKLPDSRHGTGQLRDLPELFNFTRHVPPHQRSVLAARGLDIDNFTPMPKQEMMAKLD, U  MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 0g D|"Z6qHomo.sapiens.CK2a..sp.P68400.CSK21_HUMAN.Casein.kib6qHomo.sapiens.CLK1..Dual.specificity.protein.kinase[6qHomo.sapiens.CLK2..Dual.specificity.protein.kinase6qHomo.sapiens.CLK3..Dual.specificity.protein.kinase7qHomo.sapiens.CLK4..Dual.specificity.protein.kinase6qHomo.sapiens.CSK2a1..sp.P68400.CSK21_HUMAN.Casein.f6qHomo.sapiens.CSK2a2..sp.P19784.CSK22_HUMAN.Casein.7qHomo.sapiens.CSK2a3...sp.Q8NEV1.CSK23_HUMAN.Casein7qHomo.sapiens.DYR1A..Dual.specificity.tyrosine.phos6qHomo.sapiens.DYR1B..Dual.specificity.tyrosine.phosi6qHomo.sapiens.DYRK2..Dual.specificity.tyrosine.phosD7qHomo.sapiens.DYRK3..Dual.specificity.tyrosine.phos26qHomo.sapiens.DYRK4..Dual.specificity.tyrosine.phos6qHomo.sapiens.GSK3a..sp.P49840.GSK3A_HUMAN.Glycogen`7qHomo.sapiens.GSK3b..sp.P49841.GSK3B_HUMAN.Glycogen 0g D|"Z6qHomo.sapiens.CK2a..sp.P68400.CSK21_HUMAN.Casein.kib6qHomo.sapiens.CLK1..Dual.specificity.protein.kinase[6qHomo.sapiens.CLK2..Dual.specificity.protein.kinase6qHomo.sapiens.CLK3..Dual.specificity.protein.kinase7qHomo.sapiens.CLK4..Dual.specificity.protein.kinase6qHomo.sapiens.CSK2a1..sp.P68400.CSK21_HUMAN.Casein.f6qHomo.sapiens.CSK2a2..sp.P19784.CSK22_HUMAN.Casein.7qHomo.sapiens.CSK2a3...sp.Q8NEV1.CSK23_HUMAN.Casein7qHomo.sapiens.DYR1A..Dual.specificity.tyrosine.phos6qHomo.sapiens.DYR1B..Dual.specificity.tyrosine.phosi6qHomo.sapiens.DYRK2..Dual.specificity.tyrosine.phosD7qHomo.sapiens.DYRK3..Dual.specificity.tyrosine.phos26qHomo.sapiens.DYRK4..Dual.specificity.tyrosine.phos6qHomo.sapiens.GSK3a..sp.P49840.GSK3A_HUMAN.Glycogen`7qHomo.sapiens.GSK3b..sp.P49841.GSK3B_HUMAN.Glycogen %%r a  MNKQLLSCSLKSGKQVTMVVASVATDGVDQQVEISYYDQKVIGNGSFGVVFLAKLSTTNEMVAIKKVLQDKRFKNRELQIMRKLNHPNIVKLKYFFYSSGEKKDELYLNLILEYVPETVYRVARHYSKQRQQIPMIYVKLYMYQLLRSLAYIHSIGICHRDIKPQNLLIDPESGVLKLCDFGSAKYLVRNEPNVSYICSRYYRAPELIFGATNYTNSIDVWSAGTVMAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIQSMNPNYKEFKFPQIKAHPWNKVFRVHTPAEAIDLISKIIEYTPTSRPTPQAACQHAFFDELRNPDARLPSGRPLPTLEMDGPMGTGEVSTTSGDVAGPSAa ?  MSENLYGEENRGEMVRLQKMMKNMNCGGPRPAALTLKDFKVGEALGKGAYGHVYRVRNMQDGKDYALKQIVMSASRDGVPQSVIREIAVMKRLTRQAHPNVVSLRTVLHTVDTSRNIIKIAMIMEICDWDLHTFLQNVPKVIPEKQAKHIIGQMMKGLDFLHSHAIIHRDLKPQNILVNRDQTVKLADFGLSKKYTNTSAFTTCVVTLWYRAPEVLLQSYYNSTVDMWSIGCIIYEIYNRVPLFPGPDEAQQLHEIFKKLGTPIGTDWPKQSVLTKDTFPHYTGISMTSDVTGMSAAALDFFKRCLIYDPARRMGSRAALGHEFLKLKPVSVKPRVLRQLRFNNL &&[3 MPLPPSTLNQKSNRVYSVARVYKNACEERPQEYWDYEQGVTIDWGKISNYEIINKIGRGKYSEVFSGRCIVNNQKCVIKVLKPVKMKKIYRELKILTNLTGGPNVVGLYDIVQDADSKIPALIFEEIKNVDFRTLYPTFKLPDIQYYFTQLLIALDYCHSMGIMHRDVKPQNVMIDPTERKLRLIDWGLAEFYHPGVDYNVRVASRYHKGPELLVNLNQYDYSLDLWSVGCMLAAIVFKKEPFFKGSSNPDQLVKIATVLGTKELLGYLGKYGLHLPSEYDNIMRDFTKKSWTHFITSETKLAVPEVVDLIDNLLRYDHQERLTAKEAMDHKFFKTKFEwk MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL nn MGYLGRKHSLKASTNAPPDVSNPPFYIPVKPIANRYALMQELGNGSFGTVTLAKLLSAQDGRKAENRNADHNAELLAATRQQYHNTLMDDANVPDVDQENYHNKQRGVLAIKTMMTRLPTLNDYTRVREVKFILSMPAHRNLVQIWELFIDDVNYQLHIVMECMEQNLYQLMRARRKRVFSLPSLKSILTQLITGIRHIHSHNFFHRDLKPENILISPSNHYFSKDWILNGNYSDNYVVKIADYGLARHVTNKSPYTAYVSTRWYRSPEILLRKGSYSRPLDIWAFGCVVVEVATFRPLFPGSDEMDQIWKILEVLGTPHTMSESAISGYQPHGGSWEKAEVLASRLNLKFPYVEGTSIESIVANPHLQELCEVVKECLTWDPKKRATVDEICAMPYFAETGGEQLGTEMLVQHQAAGHHVNDENESKFAEIHHHWASKVFDKKRAKNQNQNQQKLPLEPLELDSNSGHFKNSKGAHLSFKQFLNESASPDSELSSHASSVEIGKPEQDSKRDTSDVIGPPLSRDLGHELALSSSLQNAEDGNALEPPEIEESFVDYFVTNSAHYDHPSADAILESIEPSYIHYDQPTANQVRHHRCNILDDMSVDSSSSNRIPRSFAVPRISEECSTSVQENHDHSFSHTNSITF 9o NEEDLKDYVPGGYHTCYIGENYKSNKYTLVRKLGWGHFSTVWLAKDNDKHCHVAMKIVRSAKHYTETAIDEIKLLDKITTSDIHHPGHEHAIQLLDTFTHKGPNGVHVVMVFEVLGENLLGLIRRYKHRGIPVVFVKQIAKQLLSALDFLHRKCGVIHTDLKPENVLIEIGDVEQIVKMVEVETNEAKKQKKLQKSKYKSDNSLNATPDTSFQENAQAQPSTSTAASTKPTTNSPSLGRNGRRSRRQTLITGSQPLPSPLSTFNKSFSNVYARSSSTANTPSKTFFEGAQPTLINQTASSQIAMASSNTNIPNYDNQDTLNSSLSSMSISNAGRSNTTTDPLQIPSGFDSSMQQTESNENSLIINEDELISVKIADLGNACWTSHHFTDEIQTRQYRSPEVLLGYHWGSSADLWSFACLIFELLTGDYLFDPRDGKTYTKDDDHIAQIIELVGPFPRAMLKEGYYTRDFFNSRGELHRIQKLKPWSLKDVLMEKYKFSLADAVEIADFLQPMLTLQPELRADAGGMVNHSWLSDALGLENVVLERPVGGSGEDIPGWSKEV p/YhqqMus.musculus.CDKL3.sp.Q8BLF2.CDKL3_MOUSE.Cyclin.deMus.musculus.CDKL3.sp.Q8BLF2.CDKL3_MOUSE.Cyclin.dehqqXenopus.laevis.MAPK12..tr.Q7ZZX6.Q7ZZX6_XENLA.MapkXenopus.laevis.MAPK12..tr.Q7ZZX6.Q7ZZX6_XENLA.MapkhqqSaccharomyces.cerevisiae.MRK1.sp.P50873.MRK1_YEASTSaccharomyces.cerevisiae.MRK1.sp.P50873.MRK1_YEASThqqMus.musculus.CDK6..sp.Q64261.CDK6_MOUSE.Cyclin.depMus.musculus.CDK6..sp.Q64261.CDK6_MOUSE.Cyclin.dephqqHomo.sapiens.MAPK6..sp.Q16659.MK06_HUMAN.Mitogen.aHomo.sapiens.MAPK6..sp.Q16659.MK06_HUMAN.Mitogen.ahqqGallus.gallus.CSK2a2..sp.P21869.CSK22_CHICK.CaseinGallus.gallus.CSK2a2..sp.P21869.CSK22_CHICK.CaseinhqqXenopus.tropicalis.CDK6..tr.F6YRJ4.F6YRJ4_XENTR.UnXenopus.tropicalis.CDK6..tr.F6YRJ4.F6YRJ4_XENTR.UnLUUSchizosaccharomyces.japonicus.b.IME2Schizosaccharomyces.japonicus.b.IME2>GGSaccharomyces.cerevisiae.IME2Saccharomyces.cerevisiae.IME2 oo  MVEKRSRQSSSSGSEFSVPPDVDNPPLSIPLKTLSDRYQLIEKLGAGSFGCVTLAKAQFPLSNILGKQHDIRGTLMDQPKNGHQNYITKTQGVVAIKTMMTKLHTLQDYTRVREIKFILAIPANDHLIQIFEVFIDSENYQLHIVMECMEQNLYQMMKHRRRRVFSIPSLKSILSQILAGLKHIHEHNFFHRDLKPENILITPSTQYFEKEYMNQIGYQDNYVIKLADFGLARHVENKNPYTAYVSTRWYRSPEILLRSGYYSKPLDIWAFGCVAVEVTVFRALFPGANEIDQIWKILEVLGTPIKRSDFVNTNHITAPPPGGFWDDASNLVHKLNLKLPYVEGSSLDHLLSSSQLSDLSEVVKKCLRWDPNERATAQELCEMPFFENTVASQVDARGNVTNTEQALIFAGINPVATNTKPIYFNSSTKLPAETESNDIDISNNDHDSHAMCSPTLNQEKLTLVEFLNEFVEEDNDDHSIPDVGTDSTISDSIDETELSKEIRNNLALCQLPDEEVLDHSLSNIRQLTNDIEIINKDEADNMEQLFFDLEIPEKDEFQRKQPFNEHADIDEDIVLPYVNNSNYTHTDRSHHRGDNVLGDASLGDSFNSMPDFTPRNFLIPTLKKSREKFEPHLSNSNQHFGNVTF M MEKDSLADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPDPGVPSEIIKDMMLQLLRGLDFLHSHRVVHRDLKPQNILVTSNGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGNSDVDQLGKIFDVIGLPEEEEWPHDVAVPRNAFHFRQPQPIENVVPGIDEQGKDLLIKCLTFSPANRISAYSALSHPYFHDLQKGKDSVDSHRPSGQKGVDEGSAG# MDCNLYQLMKSRAGRQFSVPTVREMLRQILSGIEHIHRCGYMHRDIKPENILIKNKALNQGASCPYTLKIADFGLARPLHSSAPFTEYVSTRWYRAPELLLRTRRYDSAVDMYAFGCIAYELAMLRPLFPGRNELDQLNRMCKILGNPTRPNCNKVHEWQMAGMLASKLGFAFPDYLPYPIENLLPDEWHGAHSKMITELLAWNPNLRPSAKLCILRYFSNGNEIIESTISPSSPARYTSLSERTLRDSLDSKKSSSRKHSKTANWFRRNLHGLTHALKKSLHEGRSYHEGKHAEKHHFFSHKPSHNTSKTHSLSTPLKHNFGHSGTISTNTTNTTNTSFNQSKPGSIIQPKRQPMKLQTKDTQKCLADSRKSEDITDLSNTYWHQDDSLPKSNTVKLKPENCVKVTTEKTPLNCGDMKFQSTPQSFKSMKGLTTLKLDNSDVSTNGNSVAMTPKSMIPRLVRKSYSGKSNCSFANSVSNSATKSIYYTPGFPSNQETPIRNARIQSNASRSPSFRDAIAPSI fI MPGPAAGSRARVYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLRGGTNIINLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFDIRFYMYELLKALDYCHSMGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGQDNYDQLVRIAKVLGTDELYGYLKKYHIELDPHFNDILGQHSRKRWENFIHSENRHLVSPEVLDLLDKLLRYDHQQRLTAKEAMEHPYFYPVVKEQSQPSSENAVLSSGLTTAR ##Y/ MAEKFESLMNIHGFDLGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDPQSVKHALREIKIIRRLDHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGPLLEEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVVHEEDRQELLSVIPVYIRNDMTEPHKPLTQLLPGISREALDFLEQILTFSPMDRLTAEEALSHPYMSIYSFPMDEPISSHPFHIEDEVDDILLMDETHSHIYNWERYHDCQFSEHDWPVHNNFDIDEVQLDPRALSDVTDEEEVQVDPRKYLDGDREKYLEDPAFDTNYSTEPCWQYSDHHENKYCDLECSHTCNYKTRSSSYLDNLVWRESEVNHYYEPKLIIDLSNWKEQSKEKSDKKGKSKCERNGLVKAQIALEEASQQLAGKEREKNQGFDFDSFIAGTIQLSSQHEPTDVVDKLNDLNSSVSQLELKSLISKSVSQEKQEKGMANLAQLEALYQSSWDSQFVSGGEDCFFINQFCEVRKDEQVEKENTYTSYLDKFFSRKEDTEMLETEPVEDGKLGERGHEEGFLNNSGEFLFNKQLESIGIPQFHSPVGSPLKSIQATLTPSAMKSSPQIPHQTYSSILKHLN }w MTDVLRSLVRKISFNNSDNLQLKHKTSIQSNTALEKKKRKPDTIKKVSDVQVHHTVPNFNNSSEYINDIENLIISKLIDGGKEGIAVDHIEHANISDSKTDGKVANKHENISSKLSKEKVEKMINFDYRYIKTKERTIHKRVYKHDRKTDVDRKNHGGTIDISYPTTEVVGHGSFGVVVTTVIIETNQKVAIKKVLQDRRYKNRELETMKMLCHPNTVGLQYYFYEKDEEDEVYLNLVLDYMPQSLYQRLRHFVNLKMQMPRVEIKFYAYQLFKALNYLHNVPRICHRDIKPQNLLVDPTTFSFKICDFGSAKCLKPDQPNVSYICSRYYRAPELMFGATNYSNQVDVWSSACVIAELLLGKPLFSGESGIDQLVEIIKIMGIPTKDEISGMNPNYEDHVFPNIKPITLAEIFKAEDPDTLDLLTKTLKYHPCERLVPLQCLLSSYFDETKRCDTDTYVKAQNLRIFDFDVETELGHVPLVERPAIEERLKHFVSAPSSSLN MEKDSLSRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTSEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDIIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYGALNHPYFQDLERYKDNLNSHLPSNQSTSELNTA 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MEMYETLGKVGEGSYGTVMKCKHKDTGRIVAIKIFYEKPEKSVNKIATREIKFLKQFRHENLVNLIEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIEYLHNNNIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDVYTDYVATRWYRAPELVLKDTSYGKPVDIWALGCMIIEMATGHPFLPSSSDLDLLHKIVLKVGNLTPHLHNIFSKSPIFAGVVLPQVQHPKTARKKYPKLNGLLADIVHACLQIDPAERTSSTDLLRHDYFTRDGFIEKFIPELRAKLLQEAKVNSFIKPKENFKENEPVRDEKKSVFTNTLLYGNPSLYGKEVDRDKRAKELKVRVIKAKGGKGDVPDQKKPEYEGDHRQQGTADDTQPSSLDKKPSVLELTNPLNPSENSDGVKEDPHAGGCMIMPPINLTSSNLLAANLSSNLSHPNSRLTERTKKRRTSSQTIGQTLSNSRQEDTGPTQVQTEKGAFNERTGQNDQISSGNKRKLNFPKCDRKEFHFPELPFTVQAKEMKGMEVKQIKVLKRESKKTDSSKIPTLLSMDPNQEKQEGGDGDCEGKNLKRNRFFFSRsc MSTSPLPRKGYYTQEVNKTVWEVKERYRELLAVGSGAYGIVCSSLDTRTGTKVAIKKLYRPFQSELFAKRAYRELRLLKHMQHENVIGLLDVFTPDTNLDKFNDFYLVMPFMGTDLGKIMKHEKLSEDRIQFLVYQILRGLKYIHSAGIIHRDLKPGNLAVNEDCELKILDFGLARHTDSEMTGYVVTRWYRAPEVILNWMHYTQTVDIWSVGCIMAEMYTGRPLFKGNDHLNQLTEIMKITGTPTQDFVQKLQSTDAKNYIKSLPKVQKKDFGSLLRYANPLAVNILEKMLVLDAEKRITATEALAHAYFEQFHDIDDETEAEPYDDSFDNVNLPLEEWKRLTHEELTSFEPLVADSKETSV >d#>h$qqDrosophila.melanogaster.CK1b...gi.7292799.gb.AAF48Drosophila.melanogaster.CK1b...gi.7292799.gb.AAF48h#qqHomo.sapiens.MAPK11..sp.Q15759.MK11_HUMAN.Mitogen.Homo.sapiens.MAPK11..sp.Q15759.MK11_HUMAN.Mitogen.h"qqMus.musculus.MAPK10..sp.Q61831.MK10_MOUSE.Mitogen.Mus.musculus.MAPK10..sp.Q61831.MK10_MOUSE.Mitogen.h!qqHomo.sapiens.MAPK7..Mitogen.activated.protein.kinaHomo.sapiens.MAPK7..Mitogen.activated.protein.kina6 ??Kluyveromyces.lactis.IME2Kluyveromyces.lactis.IME2hqqMus.musculus.MAPK14..sp.P47811.MK14_MOUSE.Mitogen.Mus.musculus.MAPK14..sp.P47811.MK14_MOUSE.Mitogen.hqqDictyostelium.discoideum.CDK11..Cyclin.dependent.kDictyostelium.discoideum.CDK11..Cyclin.dependent.khqqXenopus.laevis.CDK4..sp.Q91727.CDK4_XENLA.Cyclin.dXenopus.laevis.CDK4..sp.Q91727.CDK4_XENLA.Cyclin.d.77Candida.albicans.IME2Candida.albicans.IME2hqqDanio.rerio.MAPK8.sp.Q9DGD9.MK08_DANRE.Mitogen.actDanio.rerio.MAPK8.sp.Q9DGD9.MK08_DANRE.Mitogen.act `t` 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(FCCFFFSALTPSPGRGSPMEAIQASFQKVEKIGEGTYGVVYKARNKRTGQLVALKKIRLDAESEGVPSTAIREISLLKELKHPNIVRLLDVIHSQKKLYMVFEYLNQDLKKYMDSCQAGELPLSLVKNYLFQLLQGVSFCHSHRVIHRDLKPQNLLINEAGAIKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLGCRYYSTPVDIWSIGCIFAEMMTRKALFPGDSEIDQLFQIFRTLGTPTEVTWPGVTQLPDYKGSFPRWPRKEMKDIVPNLDRDGRDLLTQLLLYDPSKRISAKAALNHQYFLCRNSGSPEQRPVLRRDYRC' 'MEKYEKLAKTGEGSYGVVFKCRNKTSGQVVAVKKFVESEDDPVVKKIALREIRMLKQLKHPNLVNLIEVFRRKRKMHLVFEYCDHTLLNELERNPNGVADGVIKSVLWQTLQALNFCHIHNCIHRDIKPENILITKQGIIKICDFGFAQILIPGDAYTDYVATRWYRAPELLVGDTQYGSSVDIWAIGCVFAELLTGQPLWPGKSDVDQLYLIIRTLGKLIPRHQSIFKSNGFFHGISIPEPEDMETLEEKFSDVHPVALNFMKGCLKMNPDDRLTCSQLLESSYFDSFQEAQIKRKARNEGRNRRRQQVLPLKS%&G &MDGYERLEKIGEGTYGVVYKARQATHGNRVVALKKIRLDAECEGVPSTAIREISILKELDHVNIVSLLDVLYCDRKLFMVFEFLDYDLKKYMDRHAPTGIPTDYLYQLLEGVAYCHAHRVLHRDLKPQNLLISSDGRIKLADFGLARAFGVPVRTYTHEVVTLWYRSPELLLGSQYYSTPVDIWSIGCIFAEMVTKRPLFPGDSEIDQLFRIFRTLGTPDESVWPGISSFPDYKSSFPKWPRQNLQRIVKSLDTLGINLLEQMLCYEPCKRITAINGMRHPFFSE <<@)} 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*MTVVHTLTPQGSSHGIGSGQALEDRFEVLKEIGDGSFGSVVLARVRSAGATVARRGTVIAIKTMKKTFESVGPCMELREVVFLRTLPAHPHLVPALDIFLDPFTKKLHIAMEYMEGNLYQLMKARDHKCLDNSSVKSILFQIMKGLEHIHAHHFFHRDIKPENILVSTSSHMDATNSFRRYSALMNPPPTPPTYTVKIADFGLARETHSKLPYTTYVSTRWYRAPEVLLRAGEYSAPVDIWAIGAMAVEIATLKPLFPGGNEVDQVWRVCEIMGSPGNWYNKAGARVGGGEWREGTRLAGKLGFSFPKMAPHSMDTILQTPQWPASLAHFVTWCLMWDPKNRPTSTQALAHDYFTDAVDPLRPKSSASRILGRKQSDISRGKDSATSTPTSSKPSWFRKSLIGRSESSTEVATVSTTQENAKVNIAPRPSPVQVAPEVPSPKPRPAVSKRTTWNNGPSNAAPMPILPTIRPITPLSDAVTAQASSRTPSYNDAYVNGTQRSAADENKATKKIGRQLSVASATNHYAEIHRQQAERALNGQTGLASPTSGTKESFFSHLRKRARRFSGRHQTPMSPAYDDVETQPHGVGCGPWGSNRSSMVIDSPPPAPVPKDTLESLEKTLRDPQPVAEVPPMPPAHRAPQHSTLKRHHSLPHHTPRSVDNPLMGARGSGPVSSRTRRQQAAQGVNQYDAPDEEDELLDEALTSTRKAIKRLEKDTKHLRQSASNLGLMNPYPTPSPSASGQNIFFADHGKEALTPQSLEPKKRSSEYKWPTPPYNDEGDWAASASASIWAAGSRI .+Y +MQKYDKMEKIGEGTYGTVFKGRNRDTMEIVALKRVRLDEDDEGVPSSALREICLLKELKHKNIVRLIDVLHSDKKLTLVFEHCDQDLKKYFDSLNGEIDMAVCRSFMLQLLRGLAFCHSHNVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVKCYSAEVVTLWYRPPDVLFGAKLYTTSIDMWSAGCILAELADAGRPLFPGSDVLDQLMKIFRVLGTPNEDSWPGVSHLSDYVALPSFPAITSWSQLVPRLNSKGRDLLQKLLICRPNQRISAEAAMQHPYFTDSSSSGH` N$7qHomo.sapiens.CK1..gi.68303575.ref.NP_001020276.1..p7qDictyostelium.discoideum.CDK10..Probable.cyclin.de1_?Candida.parapsilosis.IME2^^ ECaenorhabditis.briggsae.CDK1t6qDrosophila.melanogaster.CK1c...gi.7292798.gb.AAF48 6qGallus.gallus.CDKL1..tr.E1C5K5.E1C5K5_CHICK.Uncharp6qDanio.rerio.MAPK12..sp.O42376.MK12_DANRE.Mitogen.a@<6qHomo.sapiens.HIPK1..Homeodomain.interacting.protei7qHomo.sapiens.CDK15..Cyclin.dependent.kinase.15.OS.uH:L7qTaeniopygia.guttata.CDK3..tr.H0ZCU2.H0ZCU2_TAEGU.U(6qMus.musculus.CSK2a2..sp.O54833.CSK22_MOUSE.Casein.?6qLeishmania.infantum.GSK3..tr.A4HXQ3.A4HXQ3_LEIIN.G1:7qMus.musculus.CDK18..sp.Q04899.CDK18_MOUSE.Cyclin.d%7qOryzias.latipes.CLK2b.tr.H2M4E3.H2M4E3_ORYLA.Uncha7qMus.musculus.MAPK14..sp.P47811.MK14_MOUSE.Mitogen. 7qScheffersomyces.stipitis.MAPK3..tr.A3GF15.A3GF15_PP7qXenopus.tropicalis.CLK2..tr.F7C0E3.F7C0E3_XENTR.Un` N$7qHomo.sapiens.CK1..gi.68303575.ref.NP_001020276.1..q7qDictyostelium.discoideum.CDK10..Probable.cyclin.de1a?Candida.parapsilosis.IME2^` ECaenorhabditis.briggsae.CDK1t6qDrosophila.melanogaster.CK1c...gi.7292798.gb.AAF48 6qGallus.gallus.CDKL1..tr.E1C5K5.E1C5K5_CHICK.Uncharq6qDanio.rerio.MAPK12..sp.O42376.MK12_DANRE.Mitogen.a@=6qHomo.sapiens.HIPK1..Homeodomain.interacting.protei7qHomo.sapiens.CDK15..Cyclin.dependent.kinase.15.OS.uI:L7qTaeniopygia.guttata.CDK3..tr.H0ZCU2.H0ZCU2_TAEGU.U(6qMus.musculus.CSK2a2..sp.O54833.CSK22_MOUSE.Casein.?6qLeishmania.infantum.GSK3..tr.A4HXQ3.A4HXQ3_LEIIN.G1:7qMus.musculus.CDK18..sp.Q04899.CDK18_MOUSE.Cyclin.d%7qOryzias.latipes.CLK2b.tr.H2M4E3.H2M4E3_ORYLA.Uncha7qMus.musculus.MAPK14..sp.P47811.MK14_MOUSE.Mitogen.!7qScheffersomyces.stipitis.MAPK3..tr.A3GF15.A3GF15_PQ7qXenopus.tropicalis.CLK2..tr.F7C0E3.F7C0E3_XENTR.Un aa,3 ,MTSLHKQIIESHNNDITKLKSSMSTRAAARRSVCLSSMSYTLGADDVTPITSNTTPSNNNNNNNTTTTITTTTTTPTISPLKQSTTGSIIPKSILVTKSGSKEEPIVSSSKSSSNSSSINNNFNNLYSASTFSSSTKKVHERPSINPGFRKPREALLSGNSDSGIIKKPSSSSTSSSSSSSSTTSNIKAPIQISHSSNSGSSSSGGNNNNSDDNSGSSTIKHTAASLSKMKLSPSHTISDSPRSSTMKSRSVSISNGSLFSPTNTSVNNSNNNTSSNIKTPTKSSISENLDQNTPPPPSSSSTTKTPTATTTTTTTTTSSSSSTSTNTTPSKSSVDDVFARLANVSKPAIKSRSLSVSASLARVEQSPPTKDKGDKESSSSSSSSSSSFSSKFTKILRSSSKTPTPTSSNTTVQPSTTSLSASKISSRKDTKSLSSFSTTTTTTTLKSSSSSSSSSSSSSKSNIASSSSSSSNNLTNLLTQSQSISSTSTSTTTTPTSTSPTLASSMSVLSSPTSTTTTSTSTTSTTTTPTKSSCTIITPSIALKLYINDLTSAEQSEILDYPQIYFTGNTNKKTKFNSQLPNNGYDNDIGEYKVVERDHIAYRFEIVSILGQGSFCQVVKGYDYKTGEMVALKILRNQKRFHNQALTEIKILEYLKTNDPNSTASIVHLNNYFYFRNHLILTFELLSMNLYDFLKVNHFQGYNLNLVRRFGAQILTSLRFLSKRNIIHADLKPENILLKSPTKSGIKLIDFGSSCFENEQIFTYIQSRFYRSPEVILGTKYDKSIDIWSLGCILVEIFTGVPLFPGSDEPEQLACIMEVLGAPPKSVIDNSTRKDIFFEDDGTPKPVKNSTTGELYTIGTKSFKDSIRSGDEDFDNFILDCLKWEPSQRITAEQGLKHDWIIKVIAPTAPSTPS 7.k .MAVPNDMKSIMDIFQKLEKIGEGTYGVVYKAKNKQTGKVIALKKIRLDTDTEGVPSTAIREIALLRELTHPNIVQLLDVIQSQARLFLVFEYLNQDLKKYMDIAPKEGIKMNQIKSYTHQLLNGIAYCHAHRVLHRDLKPQNLLIDTEGKIKLADFGLARAFGLPMRSYTHEVVTLWYRAPEILLGTKMYSTAVDIWSIGCIFVEMMTRKALFPGDSEIDQLFKVFRVLGTPNEKVWPGVTDLKEFKSDFPKWRPQPFQTFLPMLDENGIDLLEKMLLYSPASRISAKNAMNHPYFDDLNHNM7-k -MAATRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGAAGGGLPVSTVREVALLRRLEAFEHPNVVRLMDVCATSRTDRDIKVTLVFEHIDQDLRTYLDKAPPPGLPVETIKDLMRQFLSGLDFLHANCIVHRDLKPENILVTSNGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPREVSLPRGAFAPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKEESDAE Zf%sZ@8IISchizosaccharomyces.pombe.CDK1Schizosaccharomyces.pombe.CDK1h7qqMus.musculus.HIPK3..sp.Q9ERH7.HIPK3_MOUSE.HomeodomMus.musculus.HIPK3..sp.Q9ERH7.HIPK3_MOUSE.Homeodomh6qqMus.musculus.MAPK1..sp.P63085.MK01_MOUSE.Mitogen.aMus.musculus.MAPK1..sp.P63085.MK01_MOUSE.Mitogen.aD5MMSchizosaccharomyces.pombe.b.IME2Schizosaccharomyces.pombe.b.IME2h4qqDanio.rerio.MAPK15..tr.Q0H1F6.Q0H1F6_DANRE.ExtraceDanio.rerio.MAPK15..tr.Q0H1F6.Q0H1F6_DANRE.Extraceh3qqSaccharomyces.cerevisiae.RIM11..Serine.threonine.pSaccharomyces.cerevisiae.RIM11..Serine.threonine.ph2qqHomo.sapiens.DYRK3..Dual.specificity.tyrosine.phosHomo.sapiens.DYRK3..Dual.specificity.tyrosine.phosh1qqMus.musculus.TTK..sp.P35761.TTK_MOUSE.Dual.specifiMus.musculus.TTK..sp.P35761.TTK_MOUSE.Dual.specifi,055Ashbya.gossypii.IME2Ashbya.gossypii.IME2h/qqGallus.gallus.CDK10..tr.F1NCQ0.F1NCQ0_CHICK.UncharGallus.gallus.CDK10..tr.F1NCQ0.F1NCQ0_CHICK.Unchar z/q /MADGDRAEAASAESELEPLRFQRLWGEGYFEVPASERLGKCRSVKEFEKLNRIGEGTYGIVYRAPDTVTDETVALKKVRMDNEKEGMPVSSLREITLLLELQHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENMQTPFSEAQVKCIILQVLKGLQYLHERYIIHRDLKVFNLLMTDKGCVKIADFGLARTYGMPPQPMTPKVVTLWYRAPELLLGVTTQTTSIDMWAVGCILAELLAHKPLLPGTSEIHQIDLIVQLLGTPNENIWPGFSKLPLVSQYTLRKQPYNNLKHKFPWLSEAGLRLLNFLFMYDPKKRATAKDSLDSSYFKEKPLPCEPELMPTFPHHRNKRAASTSTGTETQAKRAKP <0u 0MKYYSKKGHREQAEAMGVPPDVNNPPFYIPLKPVEGRYKLIQELGNGSFGSVTLAKAQFEISQINGKEGTLMDQSIIPTIREENWNNKNKGLVAIKTMMTRLPTLNDYTRVREIKFILQIPAHAHLVQIYELFIDDSLYQLHIVMECMEQNIYQLMKCRKRRVFSLPTLRSILSQILSGIRHIHAHNFYHRDIKPENILISPANRYYSKEWISAGHYPDNYVVKIADYGLARHVTNKSPYTAYVSTRWYRSPEILLRQGSYSRPLDIWAFGCVAVEVATFKPLFPGADEMDQIWKILELLGTPHPCHESKISGYVPHGGAWLQAEHLASRLNLKFPYVEGKDISWVMCNPQLESLCDVVRACLVWNPDDRATVEDLSQMPYFAGTIVQETKQPPLSTAQSALMFAGLLPSSGLQHRRLIFNDNANNHNSNNSNGSNNATTTTTTTMTTNMTAATTKKTTRTGGPVNRKRETNDENDVESLAHPIPIKRTLANLLSFNKEEPQLSFREFLKETSADKAKPNASNSNSGNCAANQLGHSNHNINNYLNRNNNSGTQHGPSYNNYGQNLNQQSGSSNHSGNGRNPTNNTHAVNTAITQTNTNKTNPTNNNTNNNNNTPTPTTTTTTTTTTPTPATTTTTITNHNGQHDDNDNDKSNFRNVGDGRAASDSTLSGPEELTKEISANIELYQEPPPLAEEQPLYDDIFGTTENIELDEDGDDDDPEDEDVSFILMYKNAVNQGGAGATQRENIEPLARNYIHESTHQNCHAIDEMSIDDASTDSHSQIPRDFIMEPTTIPQHDILPPAQVRHEPTPNHSFEDGLSF `1= 1MEAEELIGSSVTIDSIMSKMRDIKNKINEDCTDELSLSKICADHTETVNQIMRVGNTPENWLNFLLKLEKNSSPLNDDLLNKLIGRYSQAIEVLPPDKYGQNESFARIQVRLAELKAIQEPDDARDYFQMARENCKKFAFVHVSFAQFELSQGNLKKSEQLLHKAVETGAVPLQMLETAMRNLHLQKKQLLPEEDKKSVSASTVLSAQEPFSSSLGNVQNRSISCESRGQAGAARVLYGENLPPQDAEVRHQNPFKQTHAAKRSCPFGRVPVNLLNSPDFYVKTDSSAVTQLTTRLALSSVPLPYVTCLLHLQLLALAGLAKGSGPDRDAILPGSRPRGSDSYELRGLKPIQTIYLKDSLVSNEKSSELMSDLIALKSKTDSSLTKLEETKPEIAERRPMQWQSTRKPECVFQNPAAFAPLRHVPDVTPKADKESPPISVPKWLDPKSACETPSSSSLDDYMKCFKTPVVKNDFPPACPSSTPYSQLARLQQQQQQGLSTPLQSLQISGSSSINECISVNGRIYSILKQIGSGGSSKVFQVLNEKKQINAIKYVNLEDADSQTIESYRNEIAFLNKLQQHSDKIIRLYDYEITEQYIYMVMECGNIDLNSWLKKKKSINPWERKSYWKNMLEAVHIIHQHGIVHSDLKPANFVIVDGMLKLIDFGIANQMQPDTTSIVKDSQVGTVNYMAPEAIRDMSSSRENSKIRTKVSPRSDVWSLGCILYYMTYGRTPFQHIINQVSKLHAIINPAHEIEFPEISEKDLRDVLKCCLVRNPKERISIPELLTHPYVQIQPHPGSQMARGATDEMKYVLGQLVGLNSPNSILKTAKTLYERYNCGEGQDSSSSKTFDKKRERK **z3q 3MNIQSNNSPNLSNNIVSKQVYYAHPPPTIDPNDPVQISFPTTEVVGHGSFGVVFATVIQETNEKVAIKKVLQDKRFKNRELEIMKMLSHINIIDLKYFFYERDSQDEIYLNLILEYMPQSLYQRLRHFVHQRTPMSRLEIKYYMFQLFKSLNYLHHFANVCHRDIKPQNLLVDPETWSLKLCDFGSAKQLKPTEPNVSYICSRYYRAPELIFGATNYTNQIDIWSSGCVMAELLLGQPMFPGESGIDQLVEIIKILGTPSKQEICSMNPNYMEHKFPQIKPIPLSRVFKKEDDQTVEFLADVLKYDPLERFNALQCLCSPYFDELKLDDGKINQITTDLKLLEFDENVELGHLSPDELSSVKKKLYPKSKT2% 2MGGTARGPGRKDAGPPGAGLPPQQRRLGDGVYDTFMMIDETKCPPCSNVLCNPSEPPPPRRLNMTTEQFTGDHTQHFLDGGEMKVEQLFQEFGNRKSNTIQSDGISDSEKCSPTVSQGKSSDCLNTVKSNSSSKAPKVVPLTPEQALKQYKHHLTAYEKLEIINYPEIYFVGPNAKKRHGVIGGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVSGKRVVNPASAFQGLGSKLPPVVGIANKLKANLMSETNGSIPLCSVLPKLIS 49 4MNITEVEEHISSKYEIKRRLGKGAYGIVWKAADRKSGETVAVKKIFDAFRNRTDAHSSLTFREIMFLQEFGDHPNIIKLLNVIRAQNDKDIYLIFEFMDTDLHAVIKKGNLLKDIHKRYVMYQLLKATKYLHSGNVIHRDQKPSNILLDSDCFVKLCDFGLARSLYQIQEDAGNPALTEYVATRWYRAPEILLGSSRYTKGVDMWSIGCILAEMLLGKPLFPGTSTINQIEKIMNVIPHPSTEDVLAIRSEYGASVIQRMLLRPQVPLDEILPASVPPDALDLLQRLLLFNPDKRLSAEEALRHPYVSKFHNPSSEPSLLYDVILPVDDDVQLSVTQYRNKLYEMIVEKRASRQMQKQPHIRQKLEEKPAEVHVDGGLTRSSEADGSVKPPSHLRLVKRNQESAGVLPAEGANGPVAADPRGRSAPVGRTHSFSLTLAQPMNNPLIRKDEAIVSPVAGCHLCMLANARTIFLPVFHKKTAYFTARRLNSKGLVLALAHTHRCHIHRCHTRKRTTLKGRTLRAHTSRGPASPPSV SSn6Y 6MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS75k 5MSNESIYSVLDLTQVIFEDRYLVKQKLGDGSFGTVYLAQRKEKNGLYETVAVKKLKNSSKPKPKHELLKLRESLALRKISKHPCLIDLLETFMDPYRNIFLVMEFMDCNLFQLFKRRQGRLFTKETAFNILLQIISGIEHIHKHGFMHRDIKPENILVKRISPKPISSRYSIKLGDFGLARPSVSSDPLTEYVSTRWYRAPELLLRSGSYNHSVDLYAFGCIVFEIYSLKPLFPGRNETDQLNRVCEILGNPGIDELDTLHYWSQAKELAKRLGFMLPPTKPYPIQKLLPQNCPEGHAKMIPCLLAWNPDVRPTAKYCKEVFFPLPPSASKSNSVPQKISNPKVEQNLGFPISREDKKSTRRVGWLKKNLSEFVSSVKSVFPDSHGSQPHVKTEKPINAKESTGHLANPIASSNVPAISLKPGELHESVFFSENEQIDYLLTSIDYLPSYKPPSNGSNIAINAFNETVGDRIPSSKDILITEKIPFKKENEIRDSIVPSCSQPDESNKEGVASCLLLQKSGMEMTSVLEYSTPNPAEVQNICNDHAKFETSKSLHLSSPQNCTSGEGDYQLVQHEVLCSMKNTYEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTENADEYNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIRPVLQQVATALKKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGEQLLNVGTKSTRFFCRETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSLDDIVHVNTVMDLEGGDLLAEKADRREFVNLLKKMLLIDADLRITPIETLNHPFVNMKHLLDFPHSNHVKSCFHIMDICKSPSSCETNNHSKMSLLRPVASNGTAALAANFTKVGTLRSQALTTSAHSVVHHGIPLQAGTAQFGCGDAFHQTLIICPPAIQGIPAAHGKPTSYSIRVDNTVPLVTQAPAVQPLQIRPGVLSQQTWSGRTQQMLIPAWQQVTPMAPAAATLTSEGMAGSQRLGDWGKMIPHSNHYNSVMPPPLLTNQITLSAPQPISVGIAHVVWPQPATTKKNKLCQNRSNSLQNTNIPHSAFISPKIISGKEVEEVSCVDTQDNHTSEGEAGTCREASVRQDSSVSDKQRQTIIIADSPSPAVSVITISSDSDDEETSPRPSLRECKGSLDCEACQSTLNIDRMCSLSSPDSTLSTSSSGQSSPSPCKRPNSMSDDEQESGCETVDGSPTSDSSGHDSPFAENSFVEDAHQNTELGTCAGPEAKPAVGTAVEPPVGRESGLSVDEHMANTDSTCQPLRKGQPAPGKLHQPPALGARQQKPAAAFPQQHLNLSQVQHFGTGHQEWNGNFGHRRQQAYIPTSVTSNPFTLSHGSPNHTAVHAHLAGSTHLGGQPTLLPYPSSASLSSAAPVAHLLASPCTSRPMLQHPTYNISHPSGIVHQVPVGINPRLLPSPTIHQTQYKPIFPPHSYIAASPAYTGFPLSPTKLSQYPYM D18_ 8MENYQKVEKIGEGTYGVVYKARHKLSGRIVAMKKIRLEDESEGVPSTAIREISLLKEVNDENNRSNCVRLLDILHAESKLYLVFEFLDMDLKKYMDRISETGATSLDPRLVQKFTYQLVNGVNFCHSRRIIHRDLKPQNLLIDKEGNLKLADFGLARSFGVPLRNYTHEIVTLWYRAPEVLLGSRHYSTGVDIWSVGCIFAEMIRRSPLFPGDSEIDEIFKIFQVLGTPNEEVWPGVTLLQDYKSTFPRWKRMDLHKVVPNGEEDAIELLSAMLVYDPAHRISAKRALQQNYLRDFH07] 7MASQVLVYPPYVYQTQSSAFCSVKKLKVEPSGCVFQERTYPQIHVNGRNFGNSHPSTKGSAFQTKIPFTKPRGHSFSLQAGAIVVKDTAGATKVLAAQAQQAGVEAPRAVVWRNRLHFLEGPQRCGLKRKSEELENHSGAMQIVDELSILPAMLQTNMGNPVTVVTATTGSKg 0T~=0hBqqCarassius.auratus.CDK2..sp.P43450.CDK2_CARAU.CycliCarassius.auratus.CDK2..sp.P43450.CDK2_CARAU.CyclihAqqSaccharomyces.cerevisiae.SSN3..Meiotic.mRNA.stabilSaccharomyces.cerevisiae.SSN3..Meiotic.mRNA.stabil4@==Yarrowia.lipolytica.IME2Yarrowia.lipolytica.IME2h?qqHomo.sapiens.CDK3..sp.Q00526.CDK3_HUMAN.Cyclin.depHomo.sapiens.CDK3..sp.Q00526.CDK3_HUMAN.Cyclin.deph>qqMus.musculus.SGK71..sp.Q80YS9.SGK71_MOUSE.ProbableMus.musculus.SGK71..sp.Q80YS9.SGK71_MOUSE.Probableh=qqMus.musculus.CDK3..sp.Q80YP0.CDK3_MOUSE.Cyclin.depMus.musculus.CDK3..sp.Q80YP0.CDK3_MOUSE.Cyclin.deph<qqMus.musculus.MAPK8.sp.Q91Y86.MK08_MOUSE.Mitogen.acMus.musculus.MAPK8.sp.Q91Y86.MK08_MOUSE.Mitogen.ach;qqMus.musculus.CK1..gi.20544149.ref.NP_620690.1..casMus.musculus.CK1..gi.20544149.ref.NP_620690.1..cas>:GGSaccoglossus.kowalevskii.CDK1Saccoglossus.kowalevskii.CDK1h9qqOryzias.latipes.CLK2a..tr.H2LBC0.H2LBC0_ORYLA.UnchOryzias.latipes.CLK2a..tr.H2LBC0.H2LBC0_ORYLA.Unch : :MENFQKIEKIGEGTYGVVYKARDKLTGKMVALKKIRLDTESEGVPSTAIREISLLKELNHPNIVRLLDVVHSEKKLYLVFEYLNQDLKKYMDSSPPSGLPLPLVKSYLFQLLQGVAYCHSHRVLHRDLKPQNLLIDSEGAIKLADFGLARAFGVPVRTYTHEITRRALFPGDSEIDQLFRIFRTMGTPDEQTWPGVNKLPDFKSSFPKWPQQDLSKVVGSLDMDGLDLLRQMLTYEPNKRMSAKTALSHRYFRDVQVQIPEHLPK9' 9MPYTRRYSSSDRDSRTSYPDRYRDRGRRQRYRRSPTYSSSSDRERDRRGRGHRPNGSYGRTRSRSYDNRSMEHRPYDRRYCEGYRRLDPSRDQDRDREPHGTAESFYPREFSPNLYDYRRGREKERERSYQRKGSRRKHKRRRRKTRSYSQSSSKQRSNSRTRALSVRDDEEGHLICRSGDVLQERYEIVGTLGEGTFGRVMKCIDHRRGGVSVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKFLCVQMYDWFDYHGHMCLSFELLALSTFDFLKENNYLPYSIGQVRHMAYQICLAVKFLHDSKLTHTDLKPENILFVNSDFTMSYNVEKKREERTVKNTSVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSHPCDVWSIGCILFEYYLGFTLFQTHDNREHLAMMERILGPVPSRMIRKTRKQKYFYRGRLDWDESSSAGKYVRENCKPLRRYLLSEAEEHHQLFDLIESMLEYEPARRLTLADSLKHPFFENGGASDAAGSKNWDSNRDISR U< 9 >MLNPGALGVNLVVEELETETKFLIKQVECIDEHHANKALEELMPLLKLQHPNLSLYHEMFIMWNNEISSLFLCLVMDYYSQGTFQNIMENKRKLKAVVDTEWMHTMLSQVLDAIEYLHKLNIVHRNLKPSNIVLVNSGYCKLQDMSSQALMTHEAKWNVRAEEDPCQKSWMAPEALKFSFSTKSDIWSLGCIILDMATCSFLNDTEAMQLRKAIRHHPGSLKPILKTMEEKQIPGTDVYYLLLPFMLHINPSDRLAIKDVMQVTFMSNSFKSSSVALNMQRQKVPIFITDVLLEGNMANILDVMQNFSSRPEVQLRAINKLLTMPEDQLGLPWPTELLEEVISIIKQHGRILDILLSTCSLLLRVLGQALAKDPEAEIPRSSLIISFLMDTLRSHPNSERLVNVVYNVLAIISSQGQISEELEEEGLFQLAQENLEHFQEDRDICLSILSLLWSLLVDVVTVDKEPLEQLSGMVTWVLATHPEDVEIAEAGCAVLWLLSLLGCIKESQFEQVVVLLLRSIQLCPGRVLLVNNAFRGLASLAKVSELVAFRIVVLEEGSSGLHLIQDIYKLYKDDPEVVENLCMLLAHLTSYKEILPEMESGGIKDLVQVIRGRFTSSLELISYADEILQVLEANAQPGLQEDQLEPPAGQEAPLQGEPLFRP7=k =MDVFQKVEKIGEGTYGVVYKARNKVTGQLVALKKIRLDLEAEGVPSTAVREISLLKELKHPNIIKLLDVVHREKKLYMVFEFLTQDLKRHMDSSPTSELPLPVVKSYLAQLLEGVSFCHSHRVIHRDLKPQNLLLDGLGAIKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLGSKFYSTAVDISIGCIFAEMVTGKALFPGDSEIDQLFRIFRTLGTPSEATWPGVSQMPDYQSSFPKWSRKGLEEIVPSLGPEGKDLLLRLLQYDPSQRISAKTALAHPYFSPGHSLAPQQCTAGRSSR 9?o ?MDMFQKVEKIGEGTYGVVYKAKNRETGQLVALKKIRLDLEMEGVPSTAIREISLLKELKHPNIVRLLDVVHNERKLYLVFEFLSQDLKKYMDSTPGSELPLHLIKSYLFQLLQGVSFCHSHRVIHRDLKPQNLLINELGAIKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLGSKFYTTAVDIWSIGCIFAEMVTRKALFPGDSEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKGSFPKWTRKGLEEIVPNLEPEGRDLLMQLLQYDPSQRITAKTALAHPYFSSPEPSPAARQYVLQRFRH (@M @MPPTKTQTHPDIQPVTEDRRSLTVKSLDDRYVLLKNIGKGSFGHVSLARVRSKAAMENEDMRAGSMVAIKTMKKKLAAIDDYNLLREVEFIREVRPHRFLVNVHDMFVDSVNHHFHMSMEVMEMNLYNLMKAQEKVPFQPHAVRSMLWQIICGIDHIHRHNFFHRDIKPENILVSRYLPYHNENSSSPHSGFRIKIADFGLSRHIEDRDPYTAYVSTRWYRAPEILLRCEYYSAPVDIWAFGAMAAEVANLKPLFPGTNELDQFSLQVALLGTPGQNSLGGRWSRHPELCSKLNINIDAQTGQSSNSIMCNPEHASLTDVVLMCLTWDPDARCSARDIMYHRYFAQESSIEVPRTLKRSPLRITKQAAMNPHGDPPILMDPSLRHNNSNANNSAIVPTLASSLKQNQGLQMNKSHLSGVNGSTKRNSLSGAAAAAAMSMSLSLASKNSSVNSGGAGFLAGAAPAKKKFGHWANIFKRDSDVASSELERVGPNKENVPSIVPTQTPNRGAGGVGIVPKIPLPQLPPLETIAASIESLSIEARSTNTTLTERMTSGPPTGGTSDSEWSTTNASISESVGHDSGAGSSGAVDKGSTGTTNFEVEALMESTEARVTVKTLPQTPDSASSYDQMPPPPLPLPKVRVTAKPLNAIKPESPTQVQVSLSPQPCIKPPSPASSHYEPPACLDEHSDSQLTAYERSVRDSVLLMSFTLPPSSQESCTSLEGASESPSVNDSPLVDQFGGSSSDIRIETTSFLTPDLDKGNVWVRSEELECPVYPGLQTNSFRDRKIGAGAISSNNIEVE 2Ba BMESFQKVEKIGEGTYGVVYKAKNKVTGETVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLHDVIHTENKLYLVFEFLHQDLKRFMDSSTVTGISLPLVKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINAQGEIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMITRKALFPGDSEIDQLFRIFRTLGTPDESIWPGVTSMPDYKPSFPKWARQDLSKVVPPLDEDGRDLLGQMLIYDPNKRISAKNALVHRFFRDVTMPVPPLRL3Ac AMYNGKDRAQNSYQPMYQRPMQVQGQQQAQSFVGKKNTIGSVHGKAPMLMANNDVFTIGPYRARKDRMRVSVLEKYEVIGYIAAGTYGKVYKAKRQINSGTNSANGSSLNGTNAKIPQFDSTQPKSSSSMDMQANTNALRRNLLKDEGVTPGRIRTTREDVSPHYNSQKQTLIKKPLTVFYAIKKFKTEKDGVEQLHYTGISQSACREMALCRELHNKHLTTLVEIFLERKCVHMVYEYAEHDLLQIIHFHSHPEKRMIPPRMVRSIMWQLLDGVSYLHQNWVLHRDLKPANIMVTIDGCVKIGDLGLARKFHNMLQTLYTGDKVVVTIWYRAPELLLGARHYTPAVDLWSVGCIFAELIGLQPIFKGEEAKLDSKKTVPFQVNQLQRILEVLGTPDQKIWPYLEKYPEYDQITKFPKYRDNLATWYHSAGGRDKHALSLLYHLLNYDPIKRIDAFNALEHKYFTESDIPVSENVFEGLTYKYPARRIHTNDNDIMNLGSRTKNNTQASGITAGAAANALGGLGVNRRILAAAAAAAAAVSGNNASDEPSRKKNRR PP/g7qDanio.rerio.MAPK13..tr.E7F292.E7F292_DANRE.Unchara7qDanio.rerio.MAPK14a..sp.Q9DGE2.MK14A_DANRE.Mitogen6qDanio.rerio.MAPK14b..sp.Q9DGE1.MK14B_DANRE.MitogenQ7qDanio.rerio.MAPK15..tr.Q0H1F6.Q0H1F6_DANRE.Extrace47qDanio.rerio.MAPK8.sp.Q9DGD9.MK08_DANRE.Mitogen.act6qDanio.rerio.TTK..sp.Q8AYG3.TTK_DANRE.Dual.specificGADebaryomyces.hansenii.IME2pADebaryomyces.hansenii.SKY1"GDictyostelium.discoideum.CDK1 PP/g7qDanio.rerio.MAPK13..tr.E7F292.E7F292_DANRE.Unchara7qDanio.rerio.MAPK14a..sp.Q9DGE2.MK14A_DANRE.Mitogen6qDanio.rerio.MAPK14b..sp.Q9DGE1.MK14B_DANRE.MitogenQ7qDanio.rerio.MAPK15..tr.Q0H1F6.Q0H1F6_DANRE.Extrace47qDanio.rerio.MAPK8.sp.Q9DGD9.MK08_DANRE.Mitogen.act6qDanio.rerio.TTK..sp.Q8AYG3.TTK_DANRE.Dual.specificGADebaryomyces.hansenii.IME2pADebaryomyces.hansenii.SKY1"GDictyostelium.discoideum.CDK1 =*T=hIqqMus.musculus.CDK5..sp.P49615.CDK5_MOUSE.Cyclin.depMus.musculus.CDK5..sp.P49615.CDK5_MOUSE.Cyclin.dep>HGGScheffersomyces.stipitis.SKY1Scheffersomyces.stipitis.SKY1hGqqMus.musculus.NLK..sp.O54949.NLK_MOUSE.Serine.threoMus.musculus.NLK..sp.O54949.NLK_MOUSE.Serine.threohFqqCaenorhabditis.elegans.MBK1..Dual.specificity.tyroCaenorhabditis.elegans.MBK1..Dual.specificity.tyrohEqqSchizosaccharomyces.pombo.GSK3..Protein.kinase.gskSchizosaccharomyces.pombo.GSK3..Protein.kinase.gskhDqqNeurospora.crassa.GSK3..tr.Q9HE92.Q9HE92_NEUCS.GlyNeurospora.crassa.GSK3..tr.Q9HE92.Q9HE92_NEUCS.GlyhCqqKluyveromyces.lactis.CDC7.tr.Q6CUJ8.Q6CUJ8_KLULA.KKluyveromyces.lactis.CDC7.tr.Q6CUJ8.Q6CUJ8_KLULA.K D! DMASNRPAAFNTLRMGEVIREKVQDGVTGETREIQYTQCKIVGNGSFGVVFQTKLSPSNEDAAIKRVLQDKRFKNRELQIMRIVRHPNIVQLKAFYYSNGERKDEVYLNLVQEFVPETVYRASRFFNKMKTTMPILEVKLYTYQLFRALAYIHSQGICHRDIKPQNLLLDPTTGVLKLCDFGSAKILVENEPNVSYICSRYYRAPELIFGATNYTTKIDVWSTGCVMAELMLGQPLFPGESGIDQLVEIIKVLGTPTREQIRTMNPNYMEHKFPQIKPHPFNKVFKKADADAIDLIARLLEYTPTERLAAIDAMVHPFFDELRDPSTRLPDSRHNSGTVRDLPPLFDFTRHELSIAPQLNHKLVPSHMRPVLASKGLDIDNFTPMNKSEMMAKLDcCC CMDDIPAEIIQEMDDLYDKVPQLSSRYKLLDKIGEGTFSSVYKAQDLSNVSGRLYPDHFWDKNSKHVAIKRIYVTSSPNRIENELKLLELLSNSNNVAPLCDAIRYQDQVVVVLPWYPHEEFRHFYRDMPIKGIKKYMFELLSALKYVHSFGIIHRDVKPTNFLYNPILGRGVLVDFGLAEENEELYLPDLNYRVYVNDQGEKVCNCSSPYANNKKTSHLPLISIQNGQLNVRGANELSAAQSENLMKAELSKGYPKHETRRQRRANRAGTRGFRAPEVLMKCSFQTQKIDIWSVGVILLSFISRRFPIFQSMDDIDAFLEICCIFGIKPMQEVAKFHGLGLDMTKVPGFHSEGYPGGLQGFVRALLDKEVEEGTLPEYSIAFETLDYLTQFDKQLTPSLGPDDEEDIDDKIRSYKQAVWDDHFWCFDLLAKCFELNSYKRPSASDLLEHLWFKELNEDLLDRDQRREDHFTGVVE qq E EMNHGTKIPVDPFRIIKETARDGSTGEVKQLSYTSSKVVGSGSFGVVMQVHLIESDSKAAIKRVLQDKRFKNRELQIMRIMKHPNIVDLIAYYYTTGDNSDEVYLNLVLEFMPETIYRASRLYTRQKLSMPMLEVKLYIYQLLRSLAYIHASGICHRDIKPQNLLLDPENGILKLCDFGSAKILVAGEPNVSYICSRYYRAPELIFGATDYTHAIDIWSTGCVMAELMLGHPLFPGESGIDQLVEIIKILGTPSREQIKTMNPNYMEHRFPQIRPQPLSRVFSRSVPLDALDLLSKMLQYTPTDRLTAAEAMCHPFFDELRDPNTKLHNSRNPDASPRHLPELFNFSPFELSIRPDLNQKLIPSHARDALPVKLDDFVPIPIHRARID zFq FMNTADVPDNLQSWGQQPSSSYSNTQQHSQMTNLPPINHNNLCDTEPMNEDFQLQDVQADELQKQQKQQEQQHIQQQNAQRFIAQSRQPHSNILRFPQPPITSIKTNSHAFYPQQEVTQVRPKKHRVSMTNAEAALTPGMPPEKQAAKKRNIGQFSTDTVPAGIGMIGIPFESTSKPLQIQQFRNPQDAPVRKLTSDLIKTYKAINESFYLRKQVRRDRHKSQDAGKPKGSKDGSGASLTDTFSIHNAIPITSSDNHYQQDAHQNAPPLLDTNAPPTSTMVVPMRTETDLQQQQRQKSSRGGPYNNGYDDQNYDYILKNGEIFDKRYVILSDTPVGKGSFGQVTKAYDTLNKEEVAIKIIKNKKTFFDQAQIEIHLLELTNAHDKDNKYNIVTLKGHFVHRAHLCLVFELLSYNLYDLLKNTSFRGVSLNLARKFAQQLGKTLLFLSSPELSIIHCDLKPENVLLVNAKRSQIRVIDFGSSCQTGHRIYQYIQSRFYRSPEVLLGIAYDTKIDMWSLGCILVEMHTGEPLFAGSSEVDQMMKIVEVLGMPPKEMLDIGPKTHKYFDKTEDGIYYCKKTRDGYRHTYKAPGARKLHEILGVTSGGPGGRRLGEPGHSVEDYSKFKDLIKRMLQFDPKQRISPYYVVRHPFLKQKEERVPSQPPVSHSNLQQQQQLYIQQPSSQMSQVMESPSVGSVYVEDNGMYRQAPGSSANPISVTSSFDEGDAMEVDAGRRRFSAHQQNYHNPNYQYSQPQQQQQQQYQQTQRTQLEQQQKQAQLQQQLQQQQMQQQQQQQQQRQHMPQAQSSSQQHLQSRARPRQQDQNEWRNQFELDDTFQQKQRKVDDSVSNQISRNQFNPQQVSMTHGNVNANNREMEKLDYPNNKL G+ GMSLCGTRANAKMMAAYNGGTSAAAAGHHHHHHHHLPHLPPPHLHHHHHPQHHLHPGSAAAVHPVQQHTSSAAAAAAAAAAAAAMLNPGQQQPYFPSPAPGQAPGPAAAAPAQVQAAAAATVKAHHHQHSHHPQQQLDIEPDRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQPPHIDYFEEIYVVTELMQSDLHKIIVSPQPLSSDHVKVFLYQILRGLKYLHSAGILHRDIKPGNLLVNSNCVLKICDFGLARVEELDESRHMTQEVVTQYYRAPEILMGSRHYSNAIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPSLEAMRTACEGAKAHILRGPHKQPSLPVLYTLSSQATHEAVHLLCRMLVFDPSKRISAKDALAHPYLDEGRLRYHTCMCKCCFSTSTGRVYTSDFEPVTNPKFDDTFEKNLSSVRQVKEIIHQFILEQQKGNRVPLCINPQSAAFKSFISSTVAQPSEMPPSPLVWE ,IU IMQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPAMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP0H] HEEDLKDYVPGGYHTCYIGENYKNGKYTLVRKLGWGHFSTVWLARDNDKHSHVAMKIVRSAKHYTETAVDEIKLLDKVTTSDMHHPGHEHVIQLLDTFTHKGPNGVHVVMVFEVLGENLLGLIRRYKHRGIPIVFVKQIAKQLLSALDFLHRKCGVIHTDLKPENVLIEIGDVEQIVKIVEEEEFQKKLQKKLFKQAKKSSGNPTPTTSLQSTPQSSKVGDILSPIASSKSINHSPSLGRNGRRSRRQTLITGSQPLPSPLRTFNKSFTNVYGLANSTANTPVKTGFGGESVLESSISTAVPVTGMDSSNMDITLNSSLSSMSISQAANVDPVEIPSTSVEEQGIVDNGAANNDIINEDELISVKIADLGNACWTNHHFTDEIQTRQYRSPEVLLGYHWGSSSDLWSFACLVFELLTGDYLFDPRDGKTYTKDDDHIAQIIELIGPFPRAMLKEGYYTRDFFNSRGELHRIVKLKPWGLKEVLMEKYKFPMQDAMDVADFLLPMLTIQPEMRADAGGMVNHPWLSDALGLENVVLERPVGGSGEDIPGWSKELy-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YLWRTPSMANQNGRSLKEVIKCTAIYDVFS-V-V--QKVGDGTFGSVHLATRK---------------------------------------------------------G--------------------------S-----------------------------------------------------------------------------------------------------M-------------------------------------------------------------------------------KVVAIKSMKKKL---------------------M-------K-----I--SDAA-------------------------RLREVHSLL---HLS--E---------------H----D-----NIVN---IFDLYIDQ----------------------------------------------------------------S-FCLHIVMEFLEFN-LF-QzLINSR-R-------------------------DKPFSYNSVRDIMSQIFKGIGHIHA--NGFFHRDMKPENILVSPIE-------------------------------N----------------------------------------------------------------------------------------------------------------------------S-----------------------------------------------------------------------------------------------------------------------------------------D----------------------------V----------------------------------YKVKIADFGLAREI----N-S-----------------------------------------------------------------------------------------------------------------------------------------------------------------S-----P---------P-----Y----TEYVSTRWYRAPELLLRD---S----------Y-----------YS-CPVDIYAAGCMAFEIA------------------------------------------------T-L-QPIFPGMD------D-------------L---DQLYKI----------------------------------------------------------------------------------------------------------------------------CE-ILGSP-------D------------------------------------------------------D----ES------Q-------------K{-------------------------M--------GFGGGGTWKQA-EK-L--TKD----L----------------------------------------G---I------I---LP----K-S--------------------------A---P--LNLR--E---L--------------F-------S----------------P-----PW--NGAFASM-------LTEL-------LQWNPDARPSAQ--------------------------------------------------------------------------------------------------------------------------------------------------------------------ACL--E-L-DF--F---VAK-------------------------------------------------------------------------E--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------E---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KVQKPRKEKETKANQVGKVGETQVSLPTFSLQNIFTKVTLPYVEDKTGKRSSTLYQKFHKGITGFKRTFQKANKSKKSTKMSQTISTPMYRPPSPFFPILPQIRPSTPLNLKLRNYMLSTAEYNATNKSMPMFMETSQTEGPNQLRDKENTQFRRKSTNASTPSYFTSSARNSILSYFDAETSSPTTLNDRSATLRSSKFSGLSNDSSRSTAQTYSVLLEPSDCEKTLLWKKSSLKGDSNAQVTKRSLKNFKGEEADEEKNDSHQHLDSEKPSIFSSDILEHDFPDFCVTSLADTLGVPGLTLKSDSHVTSETIS}----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IQQDSTSTTLGGTSLGGTSLGGTSLGGTSLGGTSLGGTSLGGTSLGGSTTTSTTTPKSTNSKNKKKKQTSSNNNNNNNNNNNNNNENNRDNDAGSSNKSFMPLNNNEDEGTKDYKQGGYHPVRRNDVYGNRYQ-V-V--DKLGWGHFSTVWLCNDK---------------------------------------------------------D--------------------------T---------------------------------------------------P--------------ITTSSSSSSTTTTTTSSSSNGNGNGNGGNVI--G-Y-------------------------------------------------------------------------------KQVALKIVRSAR---------------------T----------------YSET-------------------------AEDEIKILN---AI---S---KY-N---A---QD----K-----CVAR---LLDHFTHRG-------------------------------------------------------------PNG-RHYCMVFELLGNN-LL-D~LIKHH-R-------------------------YRGMPITLVKTLMKQTLIALDYIHTK-CKIIHTDLKPENVLLEKSF--------------------------------------------------------------------------------------------------------------------------DFFTSNDYIWSEKYGYFKNRTSSSNKQSQQQQQPQQQQSQQNINDYSDDSDDSHSDYSDSEDELKNKGNKKSSNRDRDNNKNKNIKKDDNKSSVNEINNISKENTDNKDLNSSEENKKEEEQQQNKKEEPTTTTTTATATATTTTTTGTEEFKFVNGISYKFKKNNELFNENH----------------------------Y----------------------------------PRAQLVDLGNACWT----D-------------------------------------------------------------------------------------------------------------------------------------------------------------------------K---------H-----F----TDDIQTRQYRAPEAIVKA--------------K-----------WG-TPVDIWSAACMAFELA------------------------------------------------T-G-DHLFKPKSGKGFEKS-------------D---DHLALM----------------------------------------------------------------------------------------------------------------------------IE-LLGKP-------P------------------------------------------------------R----FI------F-------------A-------------------------------------------GG-DE-S--RVY----F-----TH---------------------------KGDLRKIPDLS------D---QW-----------------------------------------PLF--S---V--------LTEKYKF-------S----------------I-----QE--AKDFEAF-------LLPM-------LNYLPEKRATAK--------------------------------------------------------------------------------------------------------------------------------------------------------------------DCL--N-H-TW--L---KDV-------------------------------------------------------------------------P-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PFLN C  ------------------M------K---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------K----------------------------------------------------------------------------------------------------------------------------------------------x D ------------------M------S---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------D----------------------------------------------------------------------------------------------------------------------------------------------|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MESFQ-K-V--EKIGEGTYGVVYKAKNK---------------------------------------------------------V--------------------------T-----------------------------------------------------------------------------------------------------G-------------------------------------------------------------------------------ETVALKKIRLDT---------------------E-------T---E-G--VPST-------------------------AIREISLLK---EL---N---------------H----P-----NIVK---LRDVIHT-----------------------------------------------------------------E-NKLYLVFEFLHQD-LK-RFMDST-S-------------------------VSGISLPLVKSYLFQLLQGLAFCHS--HRVLHRDLKPQNLLINA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Q----------------------------------GEIKLADFGLARAF----G-V---P-------------------------------------------------------------------------------------------------------------------------------------------------------------V-----R---------T-----Y----THEVVTLWYRAPEILLGC---K----------Y-----------YS-TAVDIWSLGCIFAEMI------------------------------------------------T-R-RALFPGDS------E-------------I---DQLFRI----------------------------------------------------------------------------------------------------------------------------FR-TLGTP-------D------------------------------------------------------E----SI------W-------------P-------------------------------------------GV-TS-M--PDY----K--------------------------------------------P------S---FP----K-W--------------------------A---R--QDLS--K---V--------------V-------P----------------P------L--DEDGRDL-------LGQM-------LTYDPNKRISAK--------------------------------------------------------------------------------------------------------------------------------------------------------------------NAL--V-H-RF--F---RDV-------------------------------------------------------------------------T--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------P----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VPPLRL D -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AAPAPPQMGIENIPAVLSHGGRFIQYNIFGNIFEVTAKYKPP-I--MPIGKGAYGIVCSAHNS---------------------------------------------------------E--------------------------T-----------------------------------------------------------------------------------------------------N-------------------------------------------------------------------------------EHVAVKKIANAF---------------------D-------N---K-I--DAKR-------------------------TLREIKLLR---HM---D---------------H----E-----NVVA---IRDIVPPPQ------------------------------------------------------R------EVF-NDVYIAYELMDTD-LH-QIIRSN----------------------------QALSEEHCQYFLYQILRGLKYIHS--ANVLHRDLKPSNLLLNA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N----------------------------------CDLKICDFGLARVT----S-E-----------------------------------------------------------------------------------------------------------------------------------------------------------------T-----D---------F-----M----TEYVVTRWYRAPELLLNS---S----------D-----------YT-AAIDVWSVGCIFMELM------------------------------------------------D-R-KPLFPGRD------H-------------V---HQLRLL----------------------------------------------------------------------------------------------------------------------------ME-LIGTP-------S------------------------------------------------------E----DD------L-------------G-------------------------------------------FL-NE--NAKRY----I--------------------------------------------R------Q---LP----P-Y--------------------------R---R--QSFQ--E---K--------------F-------P----------------H------V--HPEAIDL-------VEKM-------LTFDPRKRITVE--------------------------------------------------------------------------------------------------------------------------------------------------------------------DAL--A-H-PY--L---TSL-------------------------------------------------------------------------H--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------D-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------I-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SDEPVCMTPFSFDFEQHALTEEQMKELIYREALAFNPEYQQ D ------------------M------E---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GGGAPPADTVMSD----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MQKYE-K-L--EKIGEGTYGTVFKAKNR---------------------------------------------------------D--------------------------T-----------------------------------------------------------------------------------------------------H-------------------------------------------------------------------------------EIVALKRVRLDD---------------------D-------D---E-G--VPSS-------------------------ALREICLLK---EL---K---------------H----K-----NIVR---LHDVLHS-----------------------------------------------------------------D-KKLTLVFEFCDQD-LK-KYFDSC-N--------------------------GDLDPEIVKSFMYQLLKGLAFCHS--RNVLHRDLKPQNLLINR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N----------------------------------GELKLADFGLARAF----G-I---P-------------------------------------------------------------------------------------------------------------------------------------------------------------V-----R---------C-----Y----SAEVVTLWYRPPDVLFGA---K----------L-----------YS-TSIDMWSAGCIFAELA------------------------------------------------NAG-RPLFPGND------V-------------D---DQLKRI----------------------------------------------------------------------------------------------------------------------------FR-LLGTP-------T------------------------------------------------------E----EQ------W-------------P-------------------------------------------AM-TK-L--PDY----K---------------------------------------------------P---YP----M-Y--------------------------PA--T--MSLV--N---V--------------V-------P----------------K------L--NATGRDL-------LQNL-------LKCNPVQRICAD--------------------------------------------------------------------------------------------------------------------------------------------------------------------EAL--Q-H-PY--F---ADF-------------------------------------------------------------------------C--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------P-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------P D -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RNSSKVGRYE-K-L--EKIGEGTYGTVFRGRDR---------------------------------------------------------D--------------------------------------------------------------------------------------------------------------------------------G-------------------------------------------------------------------------------SEVALKRIKLDD---------------------D-------E---E-G--VPSS-------------------------ALREICLLR---EL---R---------------H----K-----NVVR---LLDVLHT-----------------------------------------------------------------D-KKLTLVFEYCSVD-LK-RYFEIK----------------------------GKLHAPEVSALFYQLLKGLSYCHA--KSVLHRDLKPQNLLIHE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVLKLADFGLARAV----G-L---P-------------------------------------------------------------------------------------------------------------------------------------------------------------V-----R---------Q-----Y----SNEVVTLWYRPPDVLLGA---R----------V-----------YT-FTVDSWSAGCIFAEIA------------------------------------------------NSG-TPLFPGQD------I-------------E---DQLRII----------------------------------------------------------------------------------------------------------------------------FR-LIGTP-------N------------------------------------------------------D----NE------W-------------P-------------------------------------------TM-RR-L--PDY----R---------------------------------------------------P---FP----R-F--------------------------PA--E--TNWS--E---Q--------------V-------P----------------T------L--SETGIDL-------LKKM-------LMPNPQSRLTAD--------------------------------------------------------------------------------------------------------------------------------------------------------------------QAL--M-H-QY--F---TML-------------------------------------------------------------------------N--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NSRTLL D ------------------M------E---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SKMLPQRSNLHDKTPPDVNKPPPTIPLKSLENDYK-M-I--SRLGDGGFGIVRLAKYRHD------------------K-----S----------NLLQSAKRGTLTDVGDGSNVN--------------------------L-----------------------------------------------------------------------------------------------------S-------------------------------------------------------------------------------PLVAIKTMNARL---------------------P-------K-----L--EHYT-------------------------RVKEVQFIQ---AMP--A---------------H----I-----NLLH---IYEVFIDT---------------------------------------------------------------SQ-YCLHFSMECMDQT-LY-GLMRSR-G-------------------------GKRFTASTVRSILWQLLSAISHIHD--HGYFHRDIKPQNILISSMS-------------------------------Q---------------------------------------------------------------------------------------------------------------YYGGIDSVPPGSRD-----------------------------------------------------------------------------------------------------------------------------------------Q----------------------------K----------------------------------YMVKLADYGLARHV----E-N-----------------------------------------------------------------------------------------------------------------------------------------------------------------C-----K---------D-----F----TTYISTRWYRAPEMLLRR---K----------W-----------HS-TPVDIWAFGTVAAEVA------------------------------------------------K-V-TPLFPGAN------E-------------I---DQIWRI----------------------------------------------------------------------------------------------------------------------------FK-VLGNP-------A------------------------------------------------------P----PK------N-------------I------------------------------Q-ARPFPVGGYWVEG-QL-L--AGK----C----------------------------------------G---Y------S---FP----E-G--------------------------T---G--IPID--E---F--------------I-------P----------------H-----S---YPFLCDM-------IRIC-------LRWNPETRPIAS--------------------------------------------------------------------------------------------------------------------------------------------------------------------ELY--D-Q-SY--F---MYT-------------------------------------------------------------------------P-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EKKAMETSLFKRSGNVSLLSATAKESVDHSNISPIETYDFYKVPPDLEADMDNYGYMDSGNNKENLGPYDIEVDESQIACQSPRTDHTNNLEIDEAMNPLNPNQLKGASSEGTFSFSGSCVSLAQLMG 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------------------M------V----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AKNYVGLSLLTNALEQVIVLFMFSHTAMGITEMWKP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MHKYR-L-V--AKKGEGTFSEVLKAQCI---------------------------------------------------------K--------------------------N-----------------------------------------------------------------------------------------------------G-------------------------------------------------------------------------------KYVAIKCMKNHF---------------------D-------S-----L--DQVN-------------------------NLREIQALR---RLS--P---------------H----A-----NIIK---LLEVLYDQ---------------------------------------------------------------PT-GRLALVFELMDMN-IY-ELIRGR-R--------------------------HYVAEERIKNYMYQLMKSMDHMHR--NGIFHRDIKPENILIMD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DCLKLADFGSCRGI----Y-S-----------------------------------------------------------------------------------------------------------------------------------------------------------------K-----Q---------P-----Y----TEYISTRWYRAPECLLTD---G----------Y-----------YN-YKMDMWGVGCVFFEIV------------------------------------------------S-L-FPLFPGTN------E-------------L---DQITKI----------------------------------------------------------------------------------------------------------------------------HN-ILGTP-------P------------------------------------------------------P----DL------L-------------A-------------------------------------------KM-KK-R--SAH----M----------------------------------------D---F------N---FP----P-K--------------------------E---G--SGVA--K---L--------------I-------P----------------H------V--NPECVDL-------IVKL-------LMYNPDERLSAR--------------------------------------------------------------------------------------------------------------------------------------------------------------------QAL--R-H-PY--F---RDL-------------------------------------------------------------------------R--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------E-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EKRQKALLAPDVSNHFTAMEADKARQQQTVSSTGSDHEHPTSAGGDGGAGTGAVGTHDGSAAAAAAAAALPSISGARGHAGPEGGHDNDMGGMDASGGGGGGGYGRLPGLAAQSSMASVDGDEASLPPIANLSLGKANMTGSTVGGAAHASTRRSTLNTYYEPGAGGGGGTGGAGGGGGGAGPGPAGYGKVAKAAAVGGAGSVAGGGGVVGGAGVGGGGAVGSGTVGRRQSVGVVVGKYGSVNKQASQGHGGGGPG----------------------------------------------VAGAAGMAVTGGHAGGGVGGGGGGAVGVGGVGVNKYKANVGKTNSKYISPYSLRQLAGQNAGQG D ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MRILKESRPEIIVGGKYR-V-I--RKIGSGSFGDIYLGMSI---------------------------------------------------------Q--------------------------S-----------------------------------------------------------------------------------------------------G-------------------------------------------------------------------------------EEVAIKMESAHA---------------------R-----------------HPQ-------------------------LLYEAKLYR---IL---S---G-----------G----V-----GFPR---IRHHGKE-----------------------------------------------------------------K-NFNTLVMDLLGPS-LE-DLFNFC-T--------------------------RHFTIKTVLMLVDQMIGRLEYIHL--KCFIHRDIKPDNFLMGIGR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H----------------------------C----------------------------------NKLFLIDFGLAKKF----R-D-----------------------------------------------------------------------------------------------------------------------------------------------------------------P-----H---------T----------RHHI---VYREDKNLTGT---A----------RYASINAHLGIEQS-RRDDMESLGYVMMYFN------------------------------------------------R-G-VLPWQGMK------A-------------NTKQQKYEKI----------------------------------------------------------------------------------------------------------------------------SEKKMSTP-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IEVLCKGSPAEFSMYLNYCRSLRFEEQPDYMYLRQLFRILFRTL--N-H-QYDYIYDWT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLKQKTHQGQPNPAILLEQLDKDKEKQNGKPLIAD 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------------------M------D---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------K-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VQSPLTATNSGLAVNNNTMNSQMPNRSNVRLVNGTLPPSLHVSSNLNHNTGNSSASYSGSQSRDDSTIVGLHYK-I-G--KKIGEGSFGVLFEGTNM---------------------------------------------------------I--------------------------N-----------------------------------------------------------------------------------------------------G-------------------------------------------------------------------------------LPVAIKFEPRKT---------------------E-----------------APQ-------------------------LKDEYRTYK---IL---A---G-----------T----P-----GIPQ---EYYFGQE-----------------------------------------------------------------G-LHNILVIDLLGPS-LE-DLFDWC-G--------------------------RRFSVKTVVQVAVQMITLIEDLHA--HDLIYRDIKPDNFLIGRPG-------------------------------Q----------------------------------------------------------------------------------------------------------------------------P-----------------------------------------------------------------------------------------------------------------------------------------D----------------------------A----------------------------------NKVHLIDFGMAKQY----R-D-----------------------------------------------------------------------------------------------------------------------------------------------------------------P-----K---------T----------KQHI---PYREKKSLSGT---A----------RYMSINTHLGREQS-RRDDMEAMGHVFFYFL------------------------------------------------R-G-QLPWQGLK------A-------------PNNKQKYEK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IGEKKRLTNVYDLA-------QGLPIQFGRYLEIVRNLSFEETPDYEGYRMLLLSVLDDLGETADGQYDWMKLNGGRGWDLSINKKPNLHGYGHPNPPNEKSKRHRSKNHQYSSPDHHHHYNQQQQQQQAQAQAQAQAQAKVQQQQLQQAQAQQQANRYQLQPDDSHYDEEREASKLDPTSYEAYQQQTQQKYAQQQQKQMQQKSKQFANT--G-A-NGQTNKYPY--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NAQPTANDEQNAKNAAQDRNSNKSSKGFFSKLGCC 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------------------M------S---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Q---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DFKVKLSSERERVEDLFE-YEG--CKVGRGTYGHVYKAKRK---------------------------------------------------------D--------------------------G---------------------------------------------------K-----------------------------------------------D-D-------------------------------------------------------------------------------KDYALKQIEGT------------------------------------G--ISMS-------------------------ACREIALLR---EL---K---------------H----P-----NVIS---LQKVFLSH---------------------------------------------------------------AD-RKVWLLFDYAEHD-LW-HIIKFH-R------------------ASKANKKPVQLPRGMVKSLLYQILDGIHYLHA--NWVLHRDLKPANILVMGEG------------------------------------------------------------------------------------------------------------------------------------------------------------P-----------------------------------------------------------------------------------------------------------------------------------------E----------------------------R----------------------------------GRVKIADMGFARLF----N-S---P-------------------------------------------------------------------------------------------------------------------------------------------------------------L-----K---------P--LADL----DPVVVTFWYRAPELLLGA---R----------H-----------YT-KAIDIWAIGCIFAELL------------------------------------------------T-S-EPIFHCRQ------ED--I--KTSNPYHH---DQLDRI----------------------------------------------------------------------------------------------------------------------------FN-VMGFP-------A------------------------------------------------------D----KD------W-------------E-------------------------------------------DI-KK-M--PEH----S---------------------------------TLMKDFRR---N--TYTNC---SL----------------------------------------IKYM--E---K--------------H------KV----------------K------P--DSKAFHL-------LQKL-------LTMDPIKRITSE--------------------------------------------------------------------------------------------------------------------------------------------------------------------QAM--Q-D-PY--F---LED-------------------------------------------------------------------------P--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------P-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TSDVFAGCQIPYPKREFLTEEEPDDKGDKKNQQQQQGNNHTNGTGHPGNQDSSHTQGPPLKKVRVVPPTTTSGGLIMTSDYQRSNPHAAYPNPGPSTSQPQSSMGYSATSQQPPQYSHQTHRY 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------------------M------D---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EIPFSSLNLKEFRFEDRYY-V-K--HKLGDGSFGTVYLAKCK---------------------------------------------------------G--------------------------K---------------------------------------------------Q-----------------------------------------------G-H-------------------------------------------------------------------------------DQVVL----------------------------------------------------------------------------------R---QIS--K---------------H----P-----SLID---LLETFMDP----------------------------------------------------------------N-RNIYLVMECMEAN-LY-QILKRR-Q-------------------------GKPFTKYTACHILNQIVRGIEHIHT--HGFMHRDVKPENILVKKVT-------------------------------D-------------------------------------------------------------------------------------------------------------------------RPVF-----------------------------------------------------------------------------------------------------------------------------------------S----------------------------R----------------------------------YSVKIADFGLARSS----T-S-----------------------------------------------------------------------------------------------------------------------------------------------------------------D-----D---------S-----L----TEYVSTRWYRAPELLLRA---K----------N-----------YG-KAVDMYAFGCITFEVF------------------------------------------------T-L-KPLFPGRN------E-------------T---DQLNRI----------------------------------------------------------------------------------------------------------------------------CE-ILGNP-------L------------------------------------------------------L----NV------K-------------D-------------------------K--L----------HYWPTA-KE-L--AVK----L----------------------------------------G---F------S---FS----A-T--------------------------R---P--YPLR--K---L--------------L-------P----------------A-----NC--DDMYTEM-------IAQL-------LAWDPFIRPSAV--------------------------------------------------------------------------------------------------------------------------------------------------------------------SCK----E-KY--F---PKP-------------------------------------------------------------------------P--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ESPNGQQGTKLGSTKVNNIGSSKNDATVKPNNEKRQEKRVSWFKKNLNSLTNAVKMALPEAPPPHLPRKSVKLVSDEKDSQMCNFLMSETMNSNESPAKIKQPETISCELVESRLLPVYEQQSSHLMSKTDQSILQVNPEISIESLPAEPKKCVNHVPNRDENKACEEVNWSRATFFHDNKLYKPPISLNLKTDSCLKLPSDYDTAVGTPKDAMGQGLKIIGINHSLIPRPVRRNHGAPDFQASRSISCQAYPNFMVYNPSSPVRINRSTSEGFSKG D  ------------------M------S---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------K-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SPRQVSFNVSDHYQ-I-L--EIVGEGAYGIVCSAIHK---------------------------------------------------------P--------------------------S-----------------------------------------------------------------------------------------------------Q-------------------------------------------------------------------------------QKVAIKKIEP-F---------------------E-------R---S-M--LCLR-------------------------TLRELKLLK---HF---N---------------H----E-----NIIS---ILAIQRPIN------------------------------------------------------------YESF-NEIYLIQELMETD-LH-RVIRTQ-----------------------------NLSDDHIQYFIYQTLRALKAMHS--ANVLHRDLKPSNLLLNS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N----------------------------------CDLKICDFGLARSI----A-S-----------------------------------------------------------------------------------------------------------------------------------------------------------------QED-NYG---------F-----M----TEYVATRWYRAPEIMLTF---Q----------E-----------YT-TAIDVWSVGCILAEML------------------------------------------------S-G-RPLFPGRD------Y-------------H---NQLWLI----------------------------------------------------------------------------------------------------------------------------ME-VLGTP-------N------------------------------------------------------M----ED------Y-------------Y-------------------------------------------NI-KS-KRAREY----I--------------------------------------------R------S---LP----F-C--------------------------K---K--IPFS--E---L--------------F-------ANTNNNTSTSNTGGRT-N------I--NPLALDL-------LEKL-------LIFNPAKRITVE--------------------------------------------------------------------------------------------------------------------------------------------------------------------DAL--K-H-PY--L---QLY-------------------------------------------------------------------------H--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------D-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------P----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DEPISDKIPEDFFDFDKMKDQLTIEDLKKLLYEEIMKPL 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------------------M------N-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IDQHHQLQQQHQQQMLQQQAQAQAQAQAQAQQQQQAAAAAAAANAAATTSS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TVMSKARVYTDVNVIRPKDYWDYESLNVQWGEQDDYE-V-V--RKVGRGKYSEVFEGINM---------------------------------------------------------N--------------------------N-----------------------------------------------------------------------------------------------------N-------------------------------------------------------------------------------EKCIIKILKPVK---------------------K------------------KK-------------------------IRREIKILQ---NL---C---G-----------G----P-----NIVK---LLDVVRDQ---------------------------------------------------------------HS-KTPSLIFEYVNST-DF-KVLY------------------------------PTLTDYDIRYYIYELLKALDFCHS--QGIMHRDVKPHNVMIDHE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L----------------------------------RKLRLIDWGLAEFY----H-P-----------------------------------------------------------------------------------------------------------------------------------------------------------------G-----K---------E-----Y----NVRVASRYFKGPELLVDL---Q----------D-----------YD-YSLDMWSLGCMFAGMIF-----------------------------------------------R-K-EPFFYGHD------N-------------Q---DQLVKI----------------------------------------------------------------------------------------------------------------------------AK-VLGTD-------E------------------------------------------------------L----NA------Y-------------L-------------------------------------------NK-YQLELDTQ-------------------------------------------------------------LEALVGR-H--------------------------S---R--KPWS--K---F--------------I-------N-----------ADNRHL------V--SPEAIDY-------LDKL-------LRYDHQDRLTAK--------------------------------------------------------------------------------------------------------------------------------------------------------------------EAM--A-H-PY--F---AQV-------------------------------------------------------------------------R--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ESSRMRTQ D ------------------M------H----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LIFFFSYFLRRYLLLLCAILILRAPLAHSLIPPLTCVNTGTVESDVTGIRFDRCLDTDSLAKISLS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IPNIGNVMNKFE-I-L--GVVGEGAYGVVLKCRHK---------------------------------------------------------E--------------------------T-----------------------------------------------------------------------------------------------------H-------------------------------------------------------------------------------EIVAIKKFKDSE---------------------E-------N---E-E--VKET-------------------------TLRELKMLR---TL---K---------------Q----E-----NIVE---LKEAFRR-----------------------------------------------------------------R-GKLYLVFEYVEKN-ML-ELLEEM-P--------------------------NGVPPEKVKSYIYQLIKAIHWCHK--NDIVHRDIKPENLLISH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N----------------------------------DVLKLCDFGFARNL----S-EG--S-------------------------------------------------------------------------------------------------------------------------------------------------------------N-----A---------N-----Y----TEYVATRWYRSPELLLGA--------------P-----------YG-KAVDMWSVGCILGELS------------------------------------------------D-G-QPLFPGES------E-------------I---DQLFTI----------------------------------------------------------------------------------------------------------------------------QK-VLGPL-------P------------------------------------------------------A----EQ------M-------------K-------------------------------------------LF-YS-N--PRF----H----------------------------------------G---L------R---FP----A-V--------------------------N--HP--QSLE--R---R--------------Y------LG----------------I------L--SGVLLDL-------MKNL-------LKLDPADRYLTE--------------------------------------------------------------------------------------------------------------------------------------------------------------------QCL--N-H-PS--F---QTQ-------------------------------------------------------------------------R-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LLDRCGSSPSRSAKRKPYHVDSNTLSNRNQASKSSALQSHHRSNSKDIQTLGIGGPREEGLPANESFLNGNLSGAAHSPMHAKKSSNQPGSGNKDLANNNMPHLLSPKETKAKTEFDFNVDPKSSDGPGTKYLKSNTRSQQNRHSFMETSQSKTGTLQPGDKHSRHSYIDTIPQSSKSPSYRTKSKSHGVLTDSKSVGNLSEARAQAAEPNSSRYFPSSCMDLNSPTSPTAPRHSDNRTLLSPSGRNNRSEGTLDTRRPSTRHSKTMEELKLPDHMDGSHSHSLSAPHESFSYGLGYTSPFSSQQRPHRHSMYVSRDRVRSKGSEGGLSVGQGMAARANSLQLLSPQQSDQIPSETNLTRPPVKDSSRDVTAAFHSRRKSEGG---------------------------------------------------------------------------------------------------AYHDPHTEDGASTKENRILYNEAVPRRVGSFYRVPSPRPDSTYIENNVSNRASVLPADSSTVANHSKRQTTFDTWKSPENLNSHSEQLKEKEKQGFFRAIKKKKKKSQTMPGTDGQDLLALQKAIHSSNHQSSRQKDWHPEKMTEIQPHSQPLKSL----------------------------------------------RKLLHLSSNHPIPAEPRFQPLPSQPAKPAFSEVRIHPMSQSSSSGSSNARQEPQPKSRPTLQIP E ------------------M------K-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SDYYSQRVGDTVFTVQKRYT-N-L--TNIGSGAQGVVCSAFDT---------------------------------------------------------V--------------------------T-----------------------------------------------------------------------------------------------------Q-------------------------------------------------------------------------------EKIAIKKLVKPF---------------------Q-------N---E-T--YAKR-------------------------AFRELRLMK---MV---D---------------H----K-----NIIG---LKNLFTPAK------------------------------------------------------S-----LDDF-QDVYIVMELMDAN-LC-RVIGI------------------------------ELDHDRMSYLLYQLLCGIKHLHS--AGIIHRDLKPSNIVVKE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------D----------------------------------CSLKILDFGLARTA----D-Q-----------------------------------------------------------------------------------------------------------------------------------------------------------------T-----F---------N-----M----TPYVVTRYYRAPEVIVGM--------------K-----------YK-ENVDIWSVGCIFAEMI------------------------------------------------R-G-DILLPGKD------Y-------------I---DQWNKV----------------------------------------------------------------------------------------------------------------------------TQ-VLGTP-------P------------------------------------------------------S----VF------F-------------K-------------------------------------------QL-SS--SVRLY----C--------------------------------------------E------S---QP----R-Y--------------------------A---G--KSWK--D---L--------------F-------P---DDVFPNDTPEDK-A------K--TRHGRDL-------LSKM-------LQIDPQNRITVE--------------------------------------------------------------------------------------------------------------------------------------------------------------------QAL--A-H-PY--V---SIW-------------------------------------------------------------------------Y--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------D-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------P--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AEVHAPPPKRYDHALDEQSIPLDQWKTRIYEEVKTYNS D ------------------M------S---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------S-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LSARRRELADHAGSGRRSGPSPTARSGPHLSALRAQPARAAHLSGRGTYVRRDTAGGGPGQARPLGPPGTSLLGRGARRSGEGWCPGAFESGARAARPPSRVEPRLATAASREGAGLPRAEVAAGSGRGARSGEWGLAAAGAWETMHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYE-I-V--GNLGEGTFGKVVECLDH---------------------------------------------------------AR-------------------------G-----------------------------------------------------------------------------------------------------K-------------------------------------------------------------------------------SQVALKIIRNVG---------------------K----------------YREA-------------------------ARLEINVLK---KI---K---EK-D---K--ENK----F-----LCVL---MSDWFNF-----------------------------------------------------------------H-GHMCIAFELLGKN-TF-EFLKEN-N-------------------------FQPYPLPHVRHMAYQLCHALRFLHE--NQLTHTDLKPENILFVNSE-------------------------------F--------------------------------------------------------------------------------------------------------------ETLYNEHKSCEEKSV-----------------------------------------------------------------------------------------------------------------------------------------K----------------------------N----------------------------------TSIRVADFGSATFD----H-------------------------------------------------------------------------------------------------------------------------------------------------------------------------E---------H-----H----TTIVATRHYRPPEVILEL--------------G-----------WA-QPCDVWSIGCILFEYY------------------------------------------------R-G-FTLFQTHE------N-------------R---EHLVMM----------------------------------------------------------------------------------------------------------------------------EK-ILGPI-------P------------------------------------------------------S----HM------I-------------H-------------------------------------------RT-RK-Q--KYF----Y---------------------------KGGLVWDENSSDGR---Y------V---KE----N--------------------------------C--KPLK--S---Y--------------M----LQDS----------------L------E--HVQLFDL-------MRRM-------LEFDPAQRITLA--------------------------------------------------------------------------------------------------------------------------------------------------------------------EAL--L-H-PF--F---AGL-------------------------------------------------------------------------T--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------P----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EERSFHTSRN-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PSR D ------------------M------P---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------V----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEDFQ-K-I--EKIGEGTYGVVYKGRNK---------------------------------------------------------L--------------------------T-----------------------------------------------------------------------------------------------------G-------------------------------------------------------------------------------QIVAMKKIRLES---------------------E-------D---E-G--IPST-------------------------AIREISLLK---EL---K---------------H----P-----NIVS---LEDVLME-----------------------------------------------------------------E-NRLYLIFEFLSMD-LK-KYMDTL-P------------------P------EKMMDSDLVKSYMYQITAALLFCHK--RRVLHRDLKPQNLLINK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------E----------------------------------GLIKVADFGLGRSF----N-I---P-------------------------------------------------------------------------------------------------------------------------------------------------------------V-----R---------N-----Y----THEIVTLWYRAPEVLLGS---P----------R-----------YA-CPVDIWSIGCIFAEMT------------------------------------------------T-R-KPLFQGDS------E-------------I---DQLFRM----------------------------------------------------------------------------------------------------------------------------FR-ILKTP-------T------------------------------------------------------E----EI------W-------------P-------------------------------------------GV-TS-L--PDY----K--------------------------------------------P------T---FP----C-W--------------------------T---Q--NNLT--S---Q--------------V-------K----------------N------L--DSAGLDL-------LQKC-------LIYDPVHRISAK--------------------------------------------------------------------------------------------------------------------------------------------------------------------KIL--E-H-KY--F----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- D ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HSKRTYCPDWDERDWDYGTWRSSSSHKRKKRSHSSAREQKRCRYDHSKTTDSYYLESRSINEKAYHSRRYVDEYRNDYMGYEPGHPYGEPGSRYQMHSSKSSGRSGRSSYKSKHRSRHHTSQHHSHGKSHRRKRSRSVEDDEEGHLICQSGDVLSARYE-I-V--DTLGEGAFGKVVECIDH---------------------------------------------------------KV-------------------------G-----------------------------------------------------------------------------------------------------G-------------------------------------------------------------------------------RRVAVKIVKNVD---------------------R----------------YCEA-------------------------AQSEIQVLE---HL---N---TT-D---P--HST----F-----RCVQ---MLEWFEH-----------------------------------------------------------------R-GHICIVFELLGLS-TY-DFIKEN-S-------------------------FLPFRMDHIRKMAYQICKSVNFLHS--NKLTHTDLKPENILFVKSD-------------------------------Y--------------------------------------------------------------------------------------------------------------TEAYNPKMKRDERTI-----------------------------------------------------------------------------------------------------------------------------------------V----------------------------N----------------------------------PDIKVVDFGSATYD----D-------------------------------------------------------------------------------------------------------------------------------------------------------------------------E---------H-----H----STLVSTRHYRAPEVILAL--------------G-----------WS-QPCDVWSIGCILIEYY------------------------------------------------L-G-FTVFPTHD------S-------------R---EHLAMM----------------------------------------------------------------------------------------------------------------------------ER-ILGPL-------P------------------------------------------------------K----HM------I-------------Q-------------------------------------------KT-RK-R--RYF----H---------------------------HDRLDWDEHSSAGR---Y------V---SR----R--------------------------------C--KPLK--E---F--------------M----LSQD----------------A------E--HELLFDL-------IGKM-------LEYDPAKRITLK--------------------------------------------------------------------------------------------------------------------------------------------------------------------EAL--K-H-PF--F---YPL-------------------------------------------------------------------------K--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------K----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HT D ------------------M------R-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYE-I-V--STLGEGTFGRVVQCVDH---------------------------------------------------------RR-------------------------G-----------------------------------------------------------------------------------------------------G-------------------------------------------------------------------------------ARVALKIIKNVE---------------------K----------------YKEA-------------------------ARLEINVLE---KI---N---EK-D---P--DNK----N-----LCVQ---MFDWFDY-----------------------------------------------------------------H-GHMCISFELLGLS-TF-DFLKDN-N-------------------------YLPYPIHQVRHMAFQLCQAVKFLHD--NKLTHTDLKPENILFVNSD-------------------------------Y--------------------------------------------------------------------------------------------------------------ELTYNLEKKRDERSV-----------------------------------------------------------------------------------------------------------------------------------------K----------------------------S----------------------------------TAVRVVDFGSATFD----H-------------------------------------------------------------------------------------------------------------------------------------------------------------------------E---------H-----H----STIVSTRHYRAPEVILEL--------------G-----------WS-QPCDVWSIGCIIFEYY------------------------------------------------V-G-FTLFQTHD------N-------------R---EHLAMM----------------------------------------------------------------------------------------------------------------------------ER-ILGPI-------P------------------------------------------------------S----RM------I-------------R-------------------------------------------KT-RK-Q--KYF----Y---------------------------RGRLDWDENTSAGR---Y------V---RE----N--------------------------------C--KPLR--R---Y--------------L----TSEA----------------E------E--HHQLFDL-------IESM-------LEYEPAKRLTLG--------------------------------------------------------------------------------------------------------------------------------------------------------------------EAL--Q-H-PF--F---ARL-------------------------------------------------------------------------R--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EPPNKLWDSSRD-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ISR D ------------------M------P------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ASELKASEIPFHPSIKTQDPKAEEKSPKKQKVTLTAAEALKLFKNQLSPYEQSEILGYAELWFLGLEAKKLDTAPEKFSKTSFDDEHGFYLKVLHDHIAYRYE-V-L--ETIGKGSFGQVAKCLDH---------------------------------------------------------K--------------------------N-----------------------------------------------------------------------------------------------------N-------------------------------------------------------------------------------ELVALKIIRNKK---------------------R----------------FHQQ-------------------------ALMELKILE---AL---R---KK-D---K--DNT----Y-----NVVH---MKDFFYF-----------------------------------------------------------------R-NHFCITFELLGIN-LY-ELMKNN-N-------------------------FQGFSLSIVRRFTLSVLKCLQMLSV--EKIIHCDLKPENIVLYQKG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Q----------------------------------ASVKVIDFGSSCYE----H-------------------------------------------------------------------------------------------------------------------------------------------------------------------------Q---------K-----V----YTYIQSRFYRSPEVILGH--------------P-----------YD-VAIDMWSLGCITAELY------------------------------------------------T-G-YPLFPGEN------E-------------V---EQLACI----------------------------------------------------------------------------------------------------------------------------ME-VLGLP-------P------------------------------------------------------A----GF------I-------------Q-------------------------------------------TA-SR-R--QTF----F------D----SKGFP----------------KNITNNRGK---K------R---YP----D--------------------------------S--KDLT--M---V--------------L-------K----------------T------Y--DTSFLDF-------LRRC-------LVWEPSLRMTPD--------------------------------------------------------------------------------------------------------------------------------------------------------------------QAL--K-H-AW--I---HQS-------------------------------------------------------------------------R--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LKPQPRPQTLRKSNSFFPSETRKDKVQGCHHSSRKADEITKETTEKTKDSPTKHVQHSGDQQDCLQHGADTVQLPQLVDAPKKSEAAVGAEVSMTSPGQSKNFSLKNT---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NVLPPIV D ------------------M------P---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QLQVFSPPSVSSSAFCSAKKLKIEPSGWDVSGQSSNDKYYTHSKTLPATQGQANSSHQVANFNIPAYDQGLLLPAPAVEHIVVTAADSSGSAATSTFQSSQTLTHRSNVSLLEPYQKCGLKRKSEEVDSNGSVQIIEEHPPLMLQNRTVVGAAATTTTVTTKSSSSSGEGDYQLVQHEI--LCSMTNSYE-V-L--EFLGRGTFGQVAKCWKR---------------------------------------------------------S--------------------------T-----------------------------------------------------------------------------------------------------K-------------------------------------------------------------------------------EIVAIKILKNHP---------------------S----------------YARQ-------------------------GQIEVSILS---RL---S---SE-N---A---DE----Y-----NFVR---SYECFQH-----------------------------------------------------------------K-NHTCLVFEMLEQN-LY-DFLKQN-K-------------------------FSPLPLKYIRPILQQVATALMKLKS--LGLIHADLKPENIMLVDPV------------------------------------------------------------------------------------------------------------------------------------------------------------R-----------------------------------------------------------------------------------------------------------------------------------------Q----------------------------P----------------------------------YRVKVIDFGSASHV----S-K-----------------------------------------------------------------------------------------------------------------------------------------------------------------------A---------V-----C----STYLQSRYYRAPEIILGL--------------P-----------FC-EAIDMWSLGCVIAELF------------------------------------------------L-G-WPLYPGAS------E-------------Y---DQIRYI----------------------------------------------------------------------------------------------------------------------------SQ-TQGLP-------A------------------------------------------------------E----YL------L-------------S-------------------------------------------AG-TK-T--TRF----F------NRDPNLGYPLWRLKTPEEHELETGIKSKEARKYIFNCLDDMAQVNMSTDLE-------------------------------------------GTDM---L--------------A-------E----------------K-----AD--RREYIDL-------LKKM-------LTIDADKRITPL--------------------------------------------------------------------------------------------------------------------------------------------------------------------KTL--N-H-QF--V---TMT----------------------------------------------------------------------------------------------------------------------------------------------HLLDFPHSNHVKSCFQNMEICKRRVHMYDTVSQIKSPFTTHVAPNTSTNLTMSFSNQLNTVHNQASVLASSSTAAAATLSLANSDVSLLNYQSALYPSSAAPVPGVAQQGVSLQPGTTQICTQTDPFQQTFIVCPPAFQTGLQATTKHSGFPVRMDNAVPIVPQAPAAQ--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLQIQSGVLTQGSCTPLMVATLHPQVATITPQYAVPFTLSCAAGRPALVEQTAAVLQAWPGGTQQILLPSTWQQLPGVALHNSVQPTAMIPEAMGSGQQLADWRNAHSHGNQYSTIMQQPSLLTNHVTLATAQPLNVGVAHVVRQQQSSSLPSKKNKQSAPVSSKSSLDVLPSQVYSLVGSSPLRTTSSYNSLVPVQDQHQPIIIPDTPSPPVSVITIRSDTDEEEDNKYKPSSSGLKPRSNVISYVTVNDSPDSDSSLSSPYSTDTLSALRGNSGSVLEGPGRVVADGTGTRTIIVPPLKTQLGDCTVATQASGLLSNKTKPVASVSGQSSGCCITPTGYRAQRGGTSAAQPLNLSQNQQSSAAPTSQERSSNPAPRRQQAFVAPLSQAPYTFQHGSPLHSTGHPHLAPAPAHLPSQAHLYTYAAPTSAAALGSTSSIAHLFSPQGSSRHAAAYTTHPSTLVHQVPVSVGPSLLTSASVAPAQYQHQFATQSYIGSSRGSTIYTGYPLSPTKISQYSYL 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------------------M------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------S----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MERYE-K-L--GKVGEGSYGVVFKCRNR---------------------------------------------------------E--------------------------T-----------------------------------------------------------------------------------------------------G-------------------------------------------------------------------------------QIVAIKKFLESE---------------------E-------D---P-V--IRKI-------------------------ALREVRMLK---QL---K---------------H----P-----NLVN---LLEVFRR-----------------------------------------------------------------K-RKLHLVFEYCDHT-VL-HELDKH-P--------------------------RGVPEQLVRSITWQTLQAVNFCHK--HNCIHRDVKPENILITK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H----------------------------------SVIKLCDFGFARML----T-G---P-------------------------------------------------------------------------------------------------------------------------------------------------------------G-----D---------Y-----Y----TDYVATRWYRSPELLVGD---T----------Q-----------YG-PPVDVWAIGCVFAELL------------------------------------------------S-G-VPLWPGKS------D-------------V---DQLYLI----------------------------------------------------------------------------------------------------------------------------RR-TLGDL-------I------------------------------------------------------P----RH------Q-------------Q-------------------------------------------VF-ST-N--QFF----S----------------------------------------G---V------T---IP----D-P--------------------------ES--M--EPLE--M---K--------------F-------P----------------S------I--SYPALAL-------MKGC-------LHMDPAERQTCE--------------------------------------------------------------------------------------------------------------------------------------------------------------------QLL--Q-H-PY--F---DSV-------------------------------------------------------------------------R--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------E---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A---------------------------------------------------GDVGKEHEKAARRPAKLTRKHVPGFQYLPQLSSSNVLPALDSKKYFCKTRKSNYHFPNI D ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FICIPMSDSFQ-K-I--EKIGEGTYGVVYKAKER---------------------------------------------------------K--------------------------T-----------------------------------------------------------------------------------------------------G-------------------------------------------------------------------------------KIVALKKIRLEN---------------------E-------S---E-G--IPPT-------------------------TIREILLLK---NL---K---------------H----P-----TIVS---LDDVIYN-----------------------------------------------------------------I-NKMYLVFEYIDMD-LR-QYLDNL-Y------------------R-----EEKLMDLNILKKMVYQLITAIHFCHS--KNIFHRDLKPQNLLIDT-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y----------------------------------GNLKLADFGLARLA----S-I---P-------------------------------------------------------------------------------------------------------------------------------------------------------------L-----R---------T-----Y----TTEVVTLWYRPPDLLLGS---K----------H-----------YD-SSVDVWSAACIIAEMI------------------------------------------------L-L-RPLFSGDS------E-------------I---EQLLKI----------------------------------------------------------------------------------------------------------------------------FK-ILGTP-------S------------------------------------------------------N----VN------W-------------K-------------------------------------------NV-ES-L--PNY----Q--------------------------------------------A------S---FP----K-Y--------------------------K---A--IPLG--E---I--------------L-------T-----------------------I--DEDLINL-------LENM-------FIYDPIIRISAQ--------------------------------------------------------------------------------------------------------------------------------------------------------------------QAL--N-H-KF--F---EDF-------------------------------------------------------------------------V--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FNN D 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----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------@F------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IRKKGFYKQDVNKTAWELPKTYV-S-P--THVGSGAYGSVCSAIDK---------------------------------------------------------R--------------------------S-----------------------------------------------------------------------------------------------------G-------------------------------------------------------------------------------EKVAIKKLSRPF---------------------Q-------S---E-I--FAKR-------------------------AYRELLLLK---HM---Q---------------H----E-----NVIG---LLDVFTPAS------------------------------------------------------S-----LRNF-YDFYLVMPFMQTD-LQ-KGIMGM------------------------------EFSEEKIQYLVYQMLKGLKYIHS--AGVVHRDLKPGNLAVNE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------D----------------------------------CELKILDFGLARHA----D-A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------E-----M----TGYVVTRWYRAPEVILSW---M----------H-----------YN-QTVDIWSVGCIMAEML------------------------------------------------T-G-KTLFKGKD------Y-------------L---DQLTQI----------------------------------------------------------------------------------------------------------------------------LK-VTGVP-------G------------------------------------------------------T----EF------V-------------QH-------------------------------------------KL-ND-KAAKSY----I--------------------------------------------Q------S---LP----Q-T--------------------------P---R--KDFT--Q---L--------------F-------P----------------R------A--SPQAADL-------LEKM-------LELDVDKRLTAA--------------------------------------------------------------------------------------------------------------------------------------------------------------------QAL--T-H-PF--F---EPF-------------------------------------------------------------------------R--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------D-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------P----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------E---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVNFSPIARKDSRRRSGMKL D* (------------------M------S---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L----------------------------------------------------------------------------------------------------------------------------------------------EK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LCGARANAKMMAAYNGGTSAAAAGHHHHHHHHLPHLPPPHLHHHHHPQHHLHPGSAAAVHPVQQHTSSAAAAAAAAAAAAAMLNPGQQQPYFPSPAPGQAPGPAAAAPAQVQAAAAATVKAHHHQHSHHPQQQLDIE-P-D--RPIGYGAFGVVWSVTDP---------------------------------------------------------R--------------------------D-----------------------------------------------------------------------------------------------------G-------------------------------------------------------------------------------KRVALKKMPNVF---------------------Q-------N---L-V--SCKR-------------------------VFRELKMLC---FF---K---------------H----D-----NVLS---ALDILQPPH------------------------------------------------------------IDYF-EEIYVVTELMQSD-LH-KLIIVSP----------------------------QPLSSDHVKVFLYQILRGLKYLHS--AGILHRDIKPGNLLVNS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N----------------------------------CVLKICDFGLARVE----E-L---D------------------------------------------------------------------------------------------------------------------------------------------------------------ES-----R---------H-----M----TQEVVTQYYRAPEILMGS---R----------H-----------YS-NAIDIWSVGCIFAELL------------------------------------------------G-R-RILFQAQS------P-------------I---QQLDLI----------------------------------------------------------------------------------------------------------------------------TD-LLGTP-------S------------------------------------------------------L----EA------M-------------RM-------------------------------------------TA-CE-G--AKA----H----------------------------------------I---L------R---GP----H-K--------------------------Q---PSLPVLY--T---L--------------S-------S----------------Q------A--THEAVHL-------LCRM-------LVFDPSKRISAK--------------------------------------------------------------------------------------------------------------------------------------------------------------------DAL--A-H-PY--L---DEG-------------------------------------------------------------------------R-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LRYHTCMCKCCFSTSTGRVYTSDFEPVTNPKF----------------------------------------------DDTFEKNLSSVRQVKEIIHQFILEQQKGNRVPLCINPQSAAFKSFISSTVAQPSEMPPSPLVWE D+ )------------------M------S--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------JP------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDNFV-K-I--EKIGEGTYGVVYKAKDK---------------------------------------------------------L--------------------------T-----------------------------------------------------------------------------------------------------G-------------------------------------------------------------------------------KLVALKKIRLET---------------------E-------S---E-G--VPST-------------------------AIREISLLR---EL---T---------------H----P-----NIVQ---LFDVVDG-----------------------------------------------------------------D-NHLYLVFEFLQQD-LK-KQLLDSV-K--------------------------GGLDQALVKSYLYQLLKAISFCHL--HCILHRDLKPQNLLIDR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------E----------------------------------GHIKLADFGLARTF----G-V---P-------------------------------------------------------------------------------------------------------------------------------------------------------------V-----R---------T-----Y----THEIVTLWYRAPEILLGT---K----------L-----------YS-NAVDVWSLGCIFAEMA------------------------------------------------T-R-RALFPGDS------E-------------I---DQLFRI----------------------------------------------------------------------------------------------------------------------------FR-TLGTP-------D------------------------------------------------------E----NI------W-------------PR-------------------------------------------GV-SQ-L--RDY----T--------------------------------------------S------M---FP----R-W--------------------------E---P--RPLD--E---V--------------V-------P----------------S------F--DSDAKDL-------LLKL-------LTYDPNQRITAK--------------------------------------------------------------------------------------------------------------------------------------------------------------------KGL--S-H-PY--F---TGV-------------------------------------------------------------------------T--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VPP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLPKKT D, *----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------OU-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KVLALQARKKRTKAKKDKAQRKSETQHRGSAPHSESDLPEQEEEILGSDDDEQEDPNDYCKGGYHLVKIGDLFNGRYH-V-I--RKLGWGHFSTVWLSWDI---------------------------------------------------------Q--------------------------G-----------------------------------------------------------------------------------------------------K-------------------------------------------------------------------------------KFVAMKVVKSAE---------------------H----------------YTET-------------------------ALDEIRLLK---SV---R---NS-D---PNDPNR----E-----MVVQ---LLDDFKISG-------------------------------------------------------------VNG-THICMVFEVLGHH-LL-KVWIIKS-N-------------------------YQGLPLPCVKKIIQQVLQGLDYLHTK-CRIIHTDIKPENILLSVNE-------------------------------QYIRRLAAEATEWQRSGAPPPSGSAVSTAPQPKPADKMSKNKKKKLKKKQKRQAELLEKRMQEIEEMEKESGPGQKRPNKQEESESPVERPLKENPPNKMTQEKLEESSTIGQDQTLMERDTEGGAAEINCNGVIEVINYTQNSNNETLRHKEDLHNANDCDVQNLNQESSFLSSQNGDSSTSQETDSCTPITSEVSDTMVCQSSSTVGQSFSEQHISQLQESIRAEIPCEDEQEQEHNGPLDNKGKSTAGNFLVNPLEPKNAE----------------------------K----------------------------------LKVKIADLGNACWV----H-------------------------------------------------------------------------------------------------------------------------------------------------------------------------K---------H-----F----TEDIQTRQYRSLEVLIGS--------------G-----------YN-TPADIWSTACMAFELA------------------------------------------------T-G-DYLFEPHSGEEYTRD-------------E---DHIALI----------------------------------------------------------------------------------------------------------------------------IE-LLGKV-------P------------------------------------------------------R----KL------I-------------VW-------------------------------------------AG-KY-S--KEF----F------T---------------------------KKGDLKHITKL------K---PW-----------------------------------------GLF--E---V--------LVEKYEW-------S----------------Q-----EE--AAGFTDF-------LLPM-------LELIPEKRATAA--------------------------------------------------------------------------------------------------------------------------------------------------------------------ECL--R-H-PW--L---N------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------S D- +------------------M------E---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------R----------------------------------------------------------------------------------------------------------------------------------------------TZ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KVMEKYQ-V-L--GLIGEGSYGVVSRCRNK---------------------------------------------------------E--------------------------S-----------------------------------------------------------------------------------------------------G-------------------------------------------------------------------------------QVVAVKKFLESE---------------------D-------N---A-A--VRKI-------------------------AVREIKLLK---QL---R---------------H----E-----NLVS---LLEVYKK-----------------------------------------------------------------K-KRWYLVFEFVDHT-VL-D[DLEAF-P--------------------------NGLDYSRVRKYLFQILRGIAFCHS--QNIIHRDIKPENILVSQ-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------S----------------------------------GVVKLCDFGFARTL----A-A---S-------------------------------------------------------------------------------------------------------------------------------------------------------------G-----E---------A-----Y----TDYVATRWYRAPELLVGD---T----------K-----------YG-RAVDVWAIGCLVTEML------------------------------------------------T-G-EPLFPGDS------D-------------I---DQLYHI----------------------------------------------------------------------------------------------------------------------------TK-CLGNL-------I------------------------------------------------------P----RH------Q-------------E\-------------------------------------------LF-CK-N--PLF----A----------------------------------------G---M------R---LP----E-V--------------------------KE--A--ESLD--R---R--------------Y-------P----------------K------L--SASVLDL-------AKKC-------LQIDPDKRPSCA--------------------------------------------------------------------------------------------------------------------------------------------------------------------ELL--Q-S-DF--F---NKD-------------------------------------------------------------------------G------------------------------------------------FAERFAQELKLRIHKEARDHQSQKKSKINRKDKDDAVEERKMLGVQDFNTDPKSRDAKVFKVKCSKADGEKAERSSDLSSLYDSAINPFKICSQTNLKDSSSNLHYIKNADIVIPPINQNVSPTMSSMVPVPGNCNYRVDERSKNYLKPFLKQMKHSPAGHYSVSLTSVSNEKNILQANKKKREFSKTD---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------V----------------------------------------------HLPELNHLPELKGVEGWHPRYLKKENKTVSESRVPSLAAIDLHNTSLASQQKTTNNGTRGGPRR D. ,------------------M---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y_-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SKRDSNFSVFEIGDSTFTVLKRYQ-N-L--KPIGSGAQGIVCAAFDA---------------------------------------------------------V--------------------------L-----------------------------------------------------------------------------------------------------E-------------------------------------------------------------------------------RHVAIKKLSRPF---------------------Q-------N---Q-T--HAKR-------------------------AYRELVLMK---CV---N---------------H----K-----NIIG---LLNVFTPQK------------------------------------------------------S-----LEEF-QDLYIVMELMDAN-LC-Q`VIQM------------------------------ELDHERMSYLLYQMLCGIKHLHS--AGIIHRDLKPSNIVVKS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------D----------------------------------CTLKILDFGLARTA----G-T-----------------------------------------------------------------------------------------------------------------------------------------------------------------S-----F---------M-----M----TPYVVTRYYRAPEVILGM--------------G-----------YK-ENVDIWSVGCILGEMI------------------------------------------------K-G-GVLFPGTD------H-------------I---DQWNKV----------------------------------------------------------------------------------------------------------------------------IE-QLGTP-------C------------------------------------------------------T----EF------M-------------Ka-------------------------------------------KL-QP--TVRTY----V--------------------------------------------E------N---RP----K-Y--------------------------A---G--YSFE--K---L--------------F-------P---DVLFPADSEHNK-L------K--ASQARDL-------LSKM-------LVIDASKRISVD--------------------------------------------------------------------------------------------------------------------------------------------------------------------DAL--Q-H-PY--I---NVW-------------------------------------------------------------------------Y--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------D-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------P---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LEAEAPPPKIPDKQ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LDEREHTIEEWKELIYKEVLD----------------------------------------------WEERAKNGVIRGQPAPLGAAVTDGSQAHTSSSSGDASSMSTDPTLPSDTDSSLETSAGTLGCCR D/ -------------------M------S---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------R----------------------------------------------------------------------------------------------------------------------------------------------^d---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DLSPPDSPEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFD-I-I--GIIGEGTYGQVYKAKDK---------------------------------------------------------D--------------------------T-----------------------------------------------------------------------------------------------------G-------------------------------------------------------------------------------ELVALKKVRLDN---------------------E-------K---E-G--FPIT-------------------------AIREIKILR---QL---I---------------H----R-----SVVN---MKEIVTDKQ----------------------------------------------------DAL---DFKKDK-GAFYLVFEYMDHD-LM-GeLLESG-L--------------------------VHFSEDHIKSFMKQLMEGLEYCHK--KNFLHRDIKCSNILLNN-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------S----------------------------------GQIKLADFGLARLY----N-S---E------------------------------------------------------------------------------------------------------------------------------------------------------------ES-----R---------P-----Y----TNKVITLWYRPPELLLGE---E----------R-----------YT-PAIDVWSCGCILGELF------------------------------------------------T-K-KPIFQANL------E-------------L---AQLELI----------------------------------------------------------------------------------------------------------------------------SR-LCGSP-------C------------------------------------------------------P----AV------W-------------Pf-------------------------------------------DV-IK-L--PYF----N----------------------------------------T---M----------KP----KKQ--------------------------Y---R--RRLR--E---E--------------F-------S----------------F------I--PSAALDL-------LDHM-------LTLDPSKRCTAE--------------------------------------------------------------------------------------------------------------------------------------------------------------------QTL--Q-S-DF--L---KDV-------------------------------------------------------------------------E------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNIHSNPEMQQQLEALNQSISALTEATSQQQDSETMAPEESLKEAPSAPVILPSAEQTTLEASSTPADMQNILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAACPPHILPPEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPHEHQALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERNSGPALTESLVQTLVKNRTFSGSLSHLGESSSYQGTGSV-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QFPGDQDLRF------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ARVPLALHPVVGQPFLKAEGS----------------------------------------------SNSVVHAETKLQNYGELGPGTTGASSSGAGLHWGGPTQSSAYGKLYRGPTRVPPRGGRGRGVPY D0 .------------------M------PNSERHGGKKDGSGGASGTLQPSSGGGSSNSRERHRLVSKHKRHKSKHSKDMGLVTPEAASLGTVIKPLVEYDDISSDSDTFSDDMAFKLDRRENDERRGSDRSDRLHKHRHHQHRRSRDLLKAKQTEKEKSQEVSSKSGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLHKEKTRKERELKSGHKDRSKSHRKRETPKSYKTVDSPKRRSRSPHRKWSDSSKQDDSPSGASYGQDYDLSPSRSHTSSNYDSYKKSPGSTSRRQSVSPPYKEPSAYQSSTRSPSPYSRRQRSVSPYSRRRSSSYERSGSYSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSRSPAYSRHSSSHSKKKRSSSRSRHSSISPVRLPLNSSLGAELSRKKKERAAAAAAAKMDGKESKGSPVFLPRKENSSVEAKDSGLESKKLPRSVKLEKSAPDTELVNVTHLNTEVKNSSDTGKVKLDENSEKHLVKDLKAQGTRDSKPIALKEEIVTPKETETSEKETPPPLPTIASPPPPLPTTTPPPQTPPLPPLPPIPALPQQPPLPPSQPAFSQVPASSTSTLPPSTHSKTSAVSSQANSQPPVQVSVKTQVSVTAAIPHLKTSTLPPLPLPPLLPGDDDMDSPKETLPSKPVKKEKEQRTRHLLTDLPLPPELPGG----------------------------------------------------------------------------------------------------------------------------------------------ci------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MKNYK-A-I--GKIGEGTFSEVMKMQSL---------------------------------------------------------R--------------------------D-----------------------------------------------------------------------------------------------------G-------------------------------------------------------------------------------NYYACKQMKQHF---------------------E-------S-----I--EQVN-------------------------SLREIQALR---RLN--P---------------H----P-----NILA---LHEVVFDR---------------------------------------------------------------KS-GSLALICELMDMN-IY-EjLIRGR-R--------------------------HPLSEKKIMLYMYQLCKSLDHMHR--NGIFHRDVKPENILVKQ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DVLKLGDFGSCRSV----Y-S-----------------------------------------------------------------------------------------------------------------------------------------------------------------K-----Q---------P-----Y----TEYISTRWYRAPECLLTD---G----------F-----------YT-YKMDLWSAGCVFYEIA------------------------------------------------S-L-QPLFPGVN------E-------------L---DQISKI----------------------------------------------------------------------------------------------------------------------------HD-VIGTP-------C------------------------------------------------------Q----KT------L-------------Tk-------------------------------------------KF-KQ-S---RA----M----------------------------------------S---F------D---FP----F-K--------------------------K---G--SGIP--L---L--------------T-------A----------------N------L--SPQCLSL-------LHAM-------VAYDPDERIAAH--------------------------------------------------------------------------------------------------------------------------------------------------------------------QAL--Q-H-PY--F---QVQ-------------------------------------------------------------------------R--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ETQTLAKHRRAFCPKFSMVPESSSHNWSFSQEGRKQKQSLRHEEGHARRQGPTSLMELPKLRLSG----------------------------------------------MTKLSSCSSPALRSVLGTGANGKVPVLRPLKCAAVNKKTDTQKDIKPHLKHYHLPTINRKGGEY D1 /----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------hn----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QAKRIRSPGVWLSEFSWVESRKRQKRDDSNSSVRENKSRRRQQPLKTHEGHYLETHSLNQQRIESKDRRAREASLEMGYGEDNRAAATRDRDREREKDKEWHHYSKSSGRSGKSGRSSRRGRRRSPSHQRSSYSRSHHRRSRKRSRSVEDDDEGHLIYHRRDMLRARYE-I-V--STLGEGAFGKVVECIDH---------------------------------------------------------SK-------------------------I-----------------------------------------------------------------------------------------------------G-------------------------------------------------------------------------------SRVALKIIKNID---------------------R----------------YREA-------------------------AMAEVEVLE---QM---N---SL-D---C--DRR----Y-----GCVR---MLDWFDH-----------------------------------------------------------------H-GHVCISFELLGLS-TY-DoYLKEN-N-------------------------FQPFPIEHIRIMAYQIIRAVRFLHK--NKLTHTDLKPENILFVDSE-------------------------------Y--------------------------------------------------------------------------------------------------------------DIEYNAKMKRDERTL-----------------------------------------------------------------------------------------------------------------------------------------K----------------------------N----------------------------------PDVKVVDFGNATYE----H-------------------------------------------------------------------------------------------------------------------------------------------------------------------------N---------H-----H----TSVVSTRHYRAPEVILDL--------------G-----------WD-HACDVWSLGCILIEYY------------------------------------------------L-G-STLFQTHD------S-------------K---EHLAMM----------------------------------------------------------------------------------------------------------------------------ER-VLGPI-------P------------------------------------------------------V----HL------L-------------Qp-------------------------------------------KT-KK-R--RYV----H---------------------------RYQLDWDALSSSGR---Y------V---RK----H--------------------------------C--KPLK--Q---Y--------------M----MVQS----------------L------D--HDQLFDL-------IQKM-------LEYDPAKRLSLD--------------------------------------------------------------------------------------------------------------------------------------------------------------------QAL--R-H-PF--F---TCL-------------------------------------------------------------------------R--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------K-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TRK E2 ------------------M------R--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ms---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IRKNDMNYTLDDFT-K-L--EKIGEGTYGVVYKGRNR---------------------------------------------------------R--------------------------T-----------------------------------------------------------------------------------------------------Q-------------------------------------------------------------------------------AMVAMKKIRLES---------------------E-------D---E-G--VPST-------------------------AVREISLLK---EL---Q---------------H----P-----NVVG---LEAVIMQ-----------------------------------------------------------------E-NRLYLIFEFLSYD-LK-RtYMDTL-S------------------K------EEYLPSETLKSYTFQILQAMCFCHQ--RRVIHRDLKPQNLLVDE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------K----------------------------------GAIKLADFGLARAI----G-I---P-------------------------------------------------------------------------------------------------------------------------------------------------------------I-----R---------V-----Y----THEVVTLWYRAPEILMGA---Q----------R-----------YS-MGVDMWSIGCIFAEMA------------------------------------------------T-K-KPLFQGDS------E-------------I---DELFRI----------------------------------------------------------------------------------------------------------------------------FR-ILGTP-------T------------------------------------------------------E----LE------W-------------Nu-------------------------------------------GV-ES-L--PDY----K--------------------------------------------A------T---FP----K-W--------------------------R---E--NFLR--D---K--------------FYDKKSGNY----------------L------M--DEDAFSL-------LEGL-------LIYDPALRISSK--------------------------------------------------------------------------------------------------------------------------------------------------------------------KAL--H-H-PY--F---NDI-------------------------------------------------------------------------D--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------T---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SKLPAGNYRGE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LQLE D3 t------------------M------T---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A----------------------------------------------------------------------------------------------------------------------------------------------rx-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NAADAADERSRKEMDRFQ-V-E--RMAGQGTFGTVQLGKEK---------------------------------------------------------S--------------------------T-----------------------------------------------------------------------------------------------------G-------------------------------------------------------------------------------MSVAIKKVIQDP---------------------R-------------------F-------------------------RNRELQIMQDLAVL---H---------------H----P-----NIVQ---LQSYFYTLG------------------------------------------------------E----RDRRD-IYLNVVMEYVPDT-LH-RyCCRNY-Y------------------R-----RQVAPPPILIKVFLFQLIRSIGCLHLPSVNVCHRDIKPHNVLVNEA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------D----------------------------------GTLKLCDFGSAKKL----S-P-----------------------------------------------------------------------------------------------------------------------------------------------------------------S-----E---------P-----N----VAYICSRYYRAPELIFGN---Q----------H-----------YT-TSVDIWSVGCIFAEMM------------------------------------------------L-G-EPIFRGDN------S-------------A---GQLHEI----------------------------------------------------------------------------------------------------------------------------VR-VLGCP-------S------------------------------------------------------R----EV------L-------------Rz-------------------------------------------KL-N-----PSH----T----------------------------------------D---V------D---LY----N-S--------------------------K---G--IPWS--S---V--------------F-------C-------------DHSL-----KD--AKEAYDL-------LSAL-------LQYLPEDRMKPY--------------------------------------------------------------------------------------------------------------------------------------------------------------------EAL--C-H-PY--F---DEL-------------------------------------------------------------------------H--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------D-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------S----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TKLPNNKDLPEDLFRFLPSEIEVMSEAQKAKLVRK D4 1------------------M------S---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L----------------------------------------------------------------------------------------------------------------------------------------------w}-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MRILKESRPEIIVGGKYR-V-I--RKIGSGSFGDIYLGMSI---------------------------------------------------------Q--------------------------S-----------------------------------------------------------------------------------------------------G-------------------------------------------------------------------------------EEVAIKMESAHA---------------------R-----------------HPQ-------------------------LLYEAKLYR---IL---S---G-----------G----V-----GFPR---IRHHGKE-----------------------------------------------------------------K-NFNTLVMDLLGPS-LE-D~LFNFC-T--------------------------RHFTIKTVLMLVDQMIGRLEYIHL--KCFIHRDIKPDNFLMGIGR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H----------------------------C----------------------------------NKLFLIDFGLAKKF----R-D-----------------------------------------------------------------------------------------------------------------------------------------------------------------P-----H---------T----------RHHI---VYREDKNLTGT---A----------RYASINAHLGIEQS-RRDDMESLGYVMMYFN------------------------------------------------R-G-VLPWQGMK------A-------------NTKQQKYEKI----------------------------------------------------------------------------------------------------------------------------SEKKMSTP-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IEVLCKGSPAEFSMYLNYCRSLRFEEQPDYMYLRQLFRILFRTL--N-H-QYDYIYDWT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLKQKTHQGQPNPAILLEQLDKDKEKQNGKPLIAD D5 2------------------M------D---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------K----------------------------------------------------------------------------------------------------------------------------------------------|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MNRYT-T-M--RQLGDGTYGSVLMGKSN---------------------------------------------------------E--------------------------S-----------------------------------------------------------------------------------------------------G-------------------------------------------------------------------------------ELVAIKRMKRKF---------------------Y-------S-----W--DECM-------------------------NLREVKSLK---KL---N---------------H----A-----NVIK---LKEVIRE-----------------------------------------------------------------N-DHLYFIFEYMKEN-LY-QLMKDR-N--------------------------KLFPESVIRNIMYQILQGLAFIHK--HGFFHRDMKPENLLCMG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------P----------------------------------ELVKIADFGLAREL----R-S-----------------------------------------------------------------------------------------------------------------------------------------------------------------Q-----P---------P-----Y----TDYVSTRWYRAPEVLLRS---S----------V-----------YS-SPIDVWAVGSIMAELY------------------------------------------------M-L-RPLFPGTS------E-------------V---DEIFKI----------------------------------------------------------------------------------------------------------------------------CQ-VLGTP-------K------------------------------------------------------K----SD------W-------------P-------------------------------------------EG-YQ-L--ASS----M----------------------------------------N---F------R---FP----Q-C--------------------------V---P--INLK--T---L--------------I-------P----------------N------A--SNEAIQL-------MTEM-------LNWDPKKRPTAS--------------------------------------------------------------------------------------------------------------------------------------------------------------------QAL--K-H-PY--F---QVG-------------------------------------------------------------------------Q------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VLGPSSNHLESKQSLNKQLQPLESKPSLVEVEPKPLPDIIDQVVGQPQPKTSQQPLQPIQPPQNLSVQQPPKQQSQEKPPQTLFPSIVKNMPTKPNGTLSHKSGRRRWGQTIFKSGDSWEELEDYDFGASHSKKPSMGVFKEKRKKDSPFRLPEPVPSGSNHSTGENKSLPAVTSLKSDSELSTAPTSKQYYLKQSRYLPGVNPKKVSLIASGKEINPHTWSNQLFPKSLGPVGAELAFKRSNAGNLGSYATYNQSGYIPSFLKKEVQSAG----------------------------------------------QRIHLAPLNATASEYTWNTKTGRGQFSGRTYNPTAKNLNIVNRAQPIPSVHGRTDWVAKYGGHR E6 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RAMSKARVYTEVNVIRPKDYWDYESLIVQWGEQDDYE-V-V--RKVGRGKYSEVFEGINV---------------------------------------------------------N--------------------------S-----------------------------------------------------------------------------------------------------K-------------------------------------------------------------------------------EKCIIKILKPVK---------------------K------------------KK-------------------------IRREIKILQ---NL---C---G-----------G----P-----NIVK---LLDVVRDQ---------------------------------------------------------------HS-KTPSLIFEYVNST-DF-KVLY------------------------------PTLTDYDIRYYIYELLKALDFCHS--QGIMHRDVKPHNVMIDHE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L----------------------------------RKLRLIDWGLAEFY----H-P-----------------------------------------------------------------------------------------------------------------------------------------------------------------G-----K---------E-----Y----NVRVASRYFKGPELLVDL---Q----------D-----------YD-YSLDMWSLGCMFAGMIF-----------------------------------------------R-K-EPFFYGHD------N-------------Q---DQLVKI----------------------------------------------------------------------------------------------------------------------------AK-VLGTD-------E------------------------------------------------------L----NA------Y-------------L-------------------------------------------NK-YQLELDPQ-------------------------------------------------------------LEALVGR-H--------------------------S---R--KPWS--K---F--------------I-------N-----------ADNQHL------V--SPEAIDF-------LDKL-------LRYDHQDRLTAK--------------------------------------------------------------------------------------------------------------------------------------------------------------------EAM--A-H-AY--F---AQV-------------------------------------------------------------------------R--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ETSRMRSQ D7 5------------------M------I----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DTLFFLFFLFFDSPLRRLLLLCAVLALRAPTAHSPILRSSIVTPTARAVSEVSGCTTIDPDFLVEISDSNQT---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LCGTSSNANMMAAYNGGTSTAAGGHHHHHHHHLAHLPPPHLHHHHHLHPQHHLHPGSAAAVHPVQQHVSSSSASTSSSAAAAAAAAAAAAAMLNPGQAQSYFPSPAPGQAPGPAAAVAPAQVQAAAVKAHHHQHSHHAQQLDIE-P-D--RPIGYGAFGVVWSVTDP---------------------------------------------------------R--------------------------D-----------------------------------------------------------------------------------------------------G-------------------------------------------------------------------------------KRVALKKMPNVF---------------------Q-------N---L-V--SCKR-------------------------VFRELKMLC---FF---K---------------H----D-----NVLS---ALDILQPPH------------------------------------------------------------IDYF-EEIYVVTELMQSD-LH-KIIVSP----------------------------QPLSSDHVKVFLYQILRGLKYLHS--AGILHRDIKPGNLLVNS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N----------------------------------CVLKICDFGLARVE----E-L---D------------------------------------------------------------------------------------------------------------------------------------------------------------ES-----R---------H-----M----TQEVVTQYYRAPEILMGS---R----------H-----------YT-NAIDVWSVGCIFAELL------------------------------------------------G-R-RILFQAQS------P-------------I---QQLDLI----------------------------------------------------------------------------------------------------------------------------TD-LLGTP-------S------------------------------------------------------L----EA------M-------------R-------------------------------------------TA-CE-G--AKA----H----------------------------------------I---L------R---GP----H-K--------------------------Q---PSLPVLY--T---L--------------S-------S----------------Q------A--THEAVHL-------LCRM-------LVFDPSKRISAK--------------------------------------------------------------------------------------------------------------------------------------------------------------------DAL--A-H-PY--L---DEG-------------------------------------------------------------------------R-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LRYHTCMCKCCFSTSSGRVYTSDFEPITNPKF----------------------------------------------DDTFEKNLSSVRQVKEIIHQFILEQQKGNRVPLCINPQSAAFKSFISSTVAQPSEMPPSPLVWE D8 6------------------M------S--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TKTQTHPDIQPVTEDRRSLTVKSLDDRYV-L-L--KNIGKGSFGHVSLARVRSK------------------A-----------------------------AMENEDMR--------------------------A-----------------------------------------------------------------------------------------------------G-------------------------------------------------------------------------------SMVAIKTMKKKL---------------------A-------A-----I--DDYN-------------------------LLREVEFIR---EVR--P---------------H----R-----FLVN---VHDMFVDS---------------------------------------------------------------VN-HHFHMSMEVMEMN-LY-NLMKAQ-E-------------------------KVPFQPHAVRSMLWQIICGIDHIHR--HNFFHRDIKPENILVSRYL--------------------------------------------------------------------------------------------------------------------------------------------------PYHNENSSSPH-----------------------------------------------------------------------------------------------------------------------------------------S----------------------------G----------------------------------FRIKIADFGLSRHI----E-D-----------------------------------------------------------------------------------------------------------------------------------------------------------------R-----D---------P-----Y----TAYVSTRWYRAPEILLRC---E----------Y-----------YS-APVDIWAFGAMAAEVA------------------------------------------------N-L-KPLFPGTN------E-------------L---DQFSLQ----------------------------------------------------------------------------------------------------------------------------VA-LLGTP-------G------------------------------------------------------Q----NS------L-------------G---------------------------------------GRWSRH-PE-L--CSK----L----------------------------------------N---I------N---ID----A-Q--------------------------T---G--QSSN--S---I--------------M-------C----------------N-----PE--HASLTDV-------VLMC-------LTWDPDARCSAR--------------------------------------------------------------------------------------------------------------------------------------------------------------------DIM--Y-H-RY--F---AQE-------------------------------------------------------------------------S-------------------------------------------------------------------------------------------------------------------------------------------------------------SIEVPRTLKRSPLRITKQAAMNPHGDPPILMDPSLRHNNSNANNSAIVPTLASSLKQNQGLQMNKSHLSGVNGSTKRNSL--------------------------------------------------------------------------------------------------------------------------------SGAAAAAAMSMSLSLASKNSSVNSGGAGFLAGAAPAKKKFGHWANIFKRDSDVASSELERVGPNKENVPSIVPTQTPNRGAGGVGIVPKIPLPQLPPLETIAASIESLSIEARSTNTTLTERMTSGPPTGGTSDSEWSTTNASISESVGHDSGAGSSGAVDKGSTGTTNFEVEALMESTEARVTVKTLPQTPDSASSYDQMPPPPLPLPKVRVTAKPLNAIKPESPTQVQVSLSPQPCIK----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PPSPASSHYEPPACLDEHSDSQLTAYERSVRDSVLLMSFTLPPSSQESCTSLEGASESPSVNDSPLVDQFGGSSSDIRIETTSFLTPDLDKGNVWVRSEELECPVYPGLQTNSFRDRKIGAGAISSNNIEVE E9 @------------------M------P---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------P----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QVLVYPPYVYQTQSSAFCSVKKLKVEPSSCVFQERNYPRTYVNGRNFGNSHPPTKGSAFQTKIPFNRPRGHNFSLQTSAVVLKNTAGATKVIAAQAQQAHVQAPQIGAWRNRLHFLEGPQRCGLKRKSEELDNHSSAMQIVDELSILPAMLQTNMGNPVTVVTATTGSKQNCTTGEGDYQLVQHEV--LCSMKNTYE-V-L--DFLGRGTFGQVVKCWKR---------------------------------------------------------G--------------------------T-----------------------------------------------------------------------------------------------------N-------------------------------------------------------------------------------EIVAIKILKNHP---------------------S----------------YARQ-------------------------GQIEVSILA---RL---S---TE-N---A---DE----Y-----NFVR---AYECFQH-----------------------------------------------------------------R-NHTCLVFEMLEQN-LY-DFLKQN-K-------------------------FSPLPLKVIRPILQQVATALKKLKS--LGLIHADLKPENIMLVDPV------------------------------------------------------------------------------------------------------------------------------------------------------------R-----------------------------------------------------------------------------------------------------------------------------------------Q----------------------------P----------------------------------YRVKVIDFGSASHV----S-K-----------------------------------------------------------------------------------------------------------------------------------------------------------------------T---------V-----C----STYLQSRYYRAPEIILGL--------------P-----------FC-EAIDMWSLGCVIAELF------------------------------------------------L-G-WPLYPGAL------E-------------Y---DQIRYI----------------------------------------------------------------------------------------------------------------------------SQ-TQGLP-------G------------------------------------------------------E----QL------L-------------N-------------------------------------------VG-TK-S--TRF----F------CKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSLDDVAHVNTVMDLE-------------------------------------------GSDL---L--------------A-------E----------------K-----AD--RREFVSL-------LKKM-------LLIDADLRITPA--------------------------------------------------------------------------------------------------------------------------------------------------------------------ETL--N-H-PF--V---NMK-------------------------------------------------------------------------H-----------------------------------------------------------------------LLDFPHSNHVKSCFHIMDICKSHLNSCDTNNHNKTSLLRPVASSSTATLTANFTKIGTLRSQALTTSAHSVVHHGIPLQAGTAQFGCGDAFQQTLIICPPAIQGIPATHGKPTSYSIRVDNTVPLVTQAPAVQPLQIRPGVLSQTWSGRTQQMLVPAWQQVTPLAP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ATTTLTSESVAGSHRLGDWGKMISCSNHYNSVMPQPLLTNQITLSAPQPVSVGIAHVVWPQPATTKKNKQCQNRGILVKLMEWEPGREEINAFSWSNSLQNTNIPHSAFISPKIINGKDVEEVSCIETQDNQNSEGEARNCCETSIRQDSDSSVSDKQRQTIIIADSPSPAVSVITISSDTDEEETSQRHSLRECKGSLDCEACQSTLNIDRMCSLSSPDSTLSTSSSGQSSPSPCKRPNSMSDEEQESSCDTVDGSPTSDSSGHDSPFAESTFVEDTHENTELVSSADTETKPAVCSVVVPPVELENGLNADEHMANTDSICQPLIKGRSAPGRLNQPSAVGTRQQKLTSAFQQQHLNFSQVQHFGSGHQEWNGNFGHRRQQAYIPTSVTSNPFTLSHGSPNHTAVHAHLAGNTHLGGQPTLLPYPSSATLSSAAPVAHLLASPCTSRPMLQHPTYNISHPSGIVHQVPVGLNPRLLPSPTIHQTQYKPIFPPHSYIAASPAYTGFPLSPTKLSQYPYM D: 8------------------M------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------S-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVGEGTPQSSALTEGDYVPDSPALLPIELKQELPKYLPALQGCRSVEEFQ-C-L--NRIEEGTYGVVYRAKDK---------------------------------------------------------K--------------------------T-----------------------------------------------------------------------------------------------------D-------------------------------------------------------------------------------EIVALKRLKMEK---------------------E-------K---E-G--FPIT-------------------------SLREINTIL---KA---Q---------------H----P-----NIVT---VREIVVGS---------------------------------------------------------------NM-DKIYIVMNYVEHD-LK-SLMETM-K--------------------------QPFLPGEVKTLMIQLLRGVKHLHD--NWILHRDLKTSNLLLSH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A----------------------------------GILKVGDFGLAREY----G-S---P-------------------------------------------------------------------------------------------------------------------------------------------------------------L-----K---------A-----Y----TPVVVTQWYRAPELLLGA---K----------E-----------YS-TAVDMWSVGCIFGELL------------------------------------------------T-Q-KPLFPGNS------E-------------I---DQINKV----------------------------------------------------------------------------------------------------------------------------FK-ELGTP-------S------------------------------------------------------E----KI------W-------------P-------------------------------------------GY-SE-L--PVV----K----------------------------------------K---M------T---FS----E-H--------------------------P---Y--NNLR--K---R--------------F-------G----------------A-----LL--SDQGFDL-------MNKF-------LTYFPGRRISAE--------------------------------------------------------------------------------------------------------------------------------------------------------------------DGL--K-H-EY--F---RET-------------------------------------------------------------------------P--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------P------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ID----------------------------------------------PSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF D; 9------------------M------G-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKWKHARVKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPGEARPAPAQKPAQLKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IPDIGNVMNKFE-V-L--GIVGEGAYGVVLKCRHK---------------------------------------------------------E--------------------------T-----------------------------------------------------------------------------------------------------K-------------------------------------------------------------------------------ELVAIKKFKDSE---------------------E-------N---E-E--VKET-------------------------TLRELKMLR---TL---K---------------Q----D-----NIVE---LKEAFRR-----------------------------------------------------------------R-GKLYLVFEYVEKN-ML-ELLEEL-P--------------------------NGALPDKVRSYIFQLIKAIHWCHK--NEIVHRDIKPENLLISA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N----------------------------------DILKLCDFGFARNL----S-EG--S-------------------------------------------------------------------------------------------------------------------------------------------------------------D-----A---------N-----Y----TEYVATRWYRSPELLLGA--------------P-----------YG-KAVDMWSVGCILGELS------------------------------------------------D-G-QPLFPGES------E-------------I---DQLFTI----------------------------------------------------------------------------------------------------------------------------QK-VLGPL-------P------------------------------------------------------P----EQ------M-------------K-------------------------------------------LF-YS-N--PRF----A----------------------------------------G---L------R---FP----S-V--------------------------S--HP--QTLD--R---R--------------Y------LG----------------I------I--NGLMLDL-------MKNL-------LCLNPTERFLTE--------------------------------------------------------------------------------------------------------------------------------------------------------------------QCL--N-H-PV--F---QGL-------------------------------------------------------------------------R--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PEQPAVPSPTPPRSSKRKPYHGDNTIPSRSHGSKSSSHRRANSKDCSSLPRHEDLHRSTDSFLNGTNMPTSSTLSPTLHPKSYQAQTLSRSASSNKDLANNNLPHLLSPKDAKGKTEFDFNLGPKVGVASVGMDTSTGKYLKSSKQGRHSSFLEGKTSTLQSGDKHSRHNYMESSHGSMPSTSSSKSSSSFLSLSKSHGALNDAKSVSNLAETRLHLDDPMAGSGSGSRYFPSSCLDLNAAPGSPRGERHAGTERQGHSPSGRGSNRLEGGTLDSRRSSGRKKTPDEPKPTDTLDPSRAAGGHAHNLPSPHESYPYGLGYTSPFSSQQRPHRHSMYVRRERHRPHGQENNLVVGQGVPTRASSLQLLSPQLQHRTLPRHNTSSSREELTPELSRNDQSPKEKPHSRPLIKDSTRDNTATFHTQRPKNEAGMYHDAHMEDGTSSKENRIIYSDSMPRRVGSFYRVPSPRPDNTFLETTGQSRVQAVAAENPTMTNHSKRQTNFDPWNNSEAMVMNPPEVPKQKEKQGFFRAIKKKKKKSQPTDGNAGRNPSIKKSLFPL---------------------------------------------------------------------------------------------------FNSKNSLKHNSSVKVLPVVPQPMVPSETQQDQLVLQRPVKSSSHHSSRHRNRDRERERDMERDRERERDRNRDRDRERDRDNTWPPEKQPEVQPQNQPLKSLRKLLHLSSPATSNQPPPPDRSAELRFQPLPNPPSKANLNEVRGHPAGSVTPNTK----------------------------------------------SRKPHNYPLPGQIESSWHVSALNRAEGAPYPDQLANKGGQNGIGFTRAARTRMPNLNDLKETAL D< :------------------M------K-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCRSVEEFQ-C-L--NRIEEGTYGVVYRAKDK---------------------------------------------------------K--------------------------T-----------------------------------------------------------------------------------------------------D-------------------------------------------------------------------------------EIVALKRLKMEK---------------------E-------K---E-G--FPIT-------------------------SLREINTIL---KA---Q---------------H----P-----NIVT---VREIVVGS---------------------------------------------------------------NM-DKIYIVMNYVEHD-LK-SLMETM-K--------------------------QPFLPGEVKTLMIQLLRGVKHLHD--NWILHRDLKTSNLLLSH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A----------------------------------GILKVGDFGLAREY----G-S---P-------------------------------------------------------------------------------------------------------------------------------------------------------------L-----K---------A-----Y----TPVVVTLWYRAPELLLGA---K----------E-----------YS-TAVDMWSVGCIFGELL------------------------------------------------T-Q-KPLFPGKS------E-------------I---DQINKV----------------------------------------------------------------------------------------------------------------------------FK-DLGTP-------S------------------------------------------------------E----KI------W-------------P-------------------------------------------GY-SE-L--PAV----K----------------------------------------K---M------T---FS----E-H--------------------------P---Y--NNLR--K---R--------------F-------G----------------A-----LL--SDQGFDL-------MNKF-------LTYFPGRRISAE--------------------------------------------------------------------------------------------------------------------------------------------------------------------DGL--K-H-EY--F---RET-------------------------------------------------------------------------P--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------P------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ID----------------------------------------------PSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF D= <------------------M------G-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKRRHRSHSAEGGKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPGEARPARAQKPAQLKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LGRKHSLKASTNAPPDVSNPPFYIPVKPIANRYA-L-M--QELGNGSFGTVTLAKLLSAQDGRKAENRNADHNAELLA-----A-----TRQQYHNTLMDDANVPDVDQENYHNK--------------------------Q-----------------------------------------------------------------------------------------------------R-------------------------------------------------------------------------------GVLAIKTMMTRL---------------------P-------T-----L--NDYT-------------------------RVREVKFIL---SMP--A---------------H----R-----NLVQ---IWELFIDD---------------------------------------------------------------VN-YQLHIVMECMEQN-LY-QLMRAR-R-------------------------KRVFSLPSLKSILTQLITGIRHIHS--HNFFHRDLKPENILISPSN-------------------------------H----------------------------------------------------------------------------------------------------------------YFSKDWILNGNYS-----------------------------------------------------------------------------------------------------------------------------------------D----------------------------N----------------------------------YVVKIADYGLARHV----T-N-----------------------------------------------------------------------------------------------------------------------------------------------------------------K-----S---------P-----Y----TAYVSTRWYRSPEILLRK---G----------S-----------YS-RPLDIWAFGCVVVEVA------------------------------------------------T-F-RPLFPGSD------E-------------M---DQIWKI----------------------------------------------------------------------------------------------------------------------------LE-VLGTP-------H------------------------------------------------------T----MS------E-------------S-------------------------A--I---SGYQPHGGSWEKA-EV-L--ASR----L----------------------------------------N---L------K---FP----Y-V--------------------------E---G--TSIE--S---I--------------V-------A----------------N-----PH--LQELCEV-------VKEC-------LTWDPKKRATVD--------------------------------------------------------------------------------------------------------------------------------------------------------------------EIC--A-M-PY--F---AET-------------------------------------------------------------------------G-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GEQLGTEMLVQHQAAGHHVNDENESKFAEIHHHWASKVFDKKRAKNQNQNQQKLPLEPLELDSNSGHFKNSKGAHLSFKQFLNESASPDSELSSHASSVEIGKPEQDSKRDT----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SDVIGPPLSRDLGHELALSSSLQNAEDGNALEPPEIEESFVDYFVTNSAHYDHPSADAILESIEPSYIHYDQPTANQVRHHRCNILDDMSVDSSSSNRIPRSFAVPRISEECSTSVQENHDHSFSHTNSITF E> ------------------M------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DMNLSSGGTNSHLDHSVVNAMDISRNSESEGELSNESVDMIMNNATGDPTIDMCDEGHSDDEFGEQGQHFDQAQFERMLSQRHYK-V-V--RERGEGTFSKVLEAKNL---------------------------------------------------------K--------------------------T-----------------------------------------------------------------------------------------------------N-------------------------------------------------------------------------------QRVAIKCMKSKF---------------------K-------D-----R--DRVN-------------------------RLREIQALK---ILS--P---------------H----D-----NVIS---LLEVVYDP---------------------------------------------------------------KN-GNLALVFELMDMN-IY-ELIKRR-K--------------------------KYFPEHQLKSYMYQVLKSIDHMHR--HNIFHRDVKPENILVMKITTPPSIPTSSSMTQPNQILSTNFLYYYYLNGTA-----------------------------------------------------------------------------------------------------------PTSASPSSSRSETPTDSF-----------------------------------------------------------------------------------------------------------------------------------------S----------------------------Y----------------------------------PTLKLADFGSCQGT----K-G-----------------------------------------------------------------------------------------------------------------------------------------------------------------K-----R---------P-----Y----TEYISTRWYRAPECLLTD---G----------F-----------YD-QKMDMWSIGCVFYELI------------------------------------------------T-F-EPLFPGEN------E-------------L---DQIHLI----------------------------------------------------------------------------------------------------------------------------HK-VVGTP-------S------------------------------------------------------E----DI------L-------------N-------------------------------------------KF-RK-H-ASRY----L---------------------------------------SN---G------K---FP----K-R--------------------------A---G--KGLK--A---M--------------I-------P----------------N------V--SKDCLDL-------LQKL-------LIYNPEERITAS--------------------------------------------------------------------------------------------------------------------------------------------------------------------KAL--R-H-PY--F---KEL-------------------------------------------------------------------------Y--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DQSFGGGQSIPSPSPLMNNISTNATNSPSSTQGPGLQQAPLIHHNIQNQAQNHNNNSNMVVLPTIYGTKQKPTNKKPVQNQQGITSYGKNMSNSNLNTSNQSNASGTGGSLNQFFSSMKRNTNMKTVNL----------------------------------------------SPYMNDHPPVSSSMTYQTTTTYNNFQSNKAPPIFQNNVHASLSNSNKNEPIEKQQKKYSLHYMI D? =------------------M------T---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------D---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KRCRQSSSSGSEFSIPPDVDNPPLSIPLKTLSDRYQ-L-I--EKLGAGSFGCVTLAKAQFS------------------L-----SNILGR---QQQDLRGTLMDQPKNGHQNYITK--------------------------T-----------------------------------------------------------------------------------------------------Q-------------------------------------------------------------------------------GVVAIKTMMTKL---------------------H-------T-----L--QDYT-------------------------RVREIKFIL---AIP--A---------------N----D-----HLIQ---IFEVFIDS---------------------------------------------------------------EN-YQLHIVMECMEQN-LY-QMMKHR-R-------------------------RRVFSIPSLKSILSQILAGLRHIHQ--ENFFHRDLKPENILITPST-------------------------------Q----------------------------------------------------------------------------------------------------------------YFEKEYMNQIGYQ-----------------------------------------------------------------------------------------------------------------------------------------D----------------------------N----------------------------------YVIKLADFGLARHV----E-N-----------------------------------------------------------------------------------------------------------------------------------------------------------------K-----N---------P-----Y----TAYVSTRWYRSPEILLRS---G----------Y-----------YS-KPLDIWAFGCVAVEVT------------------------------------------------V-F-RALFPGAN------E-------------I---DQIWKI----------------------------------------------------------------------------------------------------------------------------LE-VLGTP-------I------------------------------------------------------K----NS------D------------FA-------------------------N---TNHIITPPPGGFWDDA-SK-L--VHK----L----------------------------------------N---L------K---LP----D-V--------------------------E---G--SSLD--H---L--------------L-------S----------------S-----SQ--LSDLSDV-------VKKC-------LRWDPNERATAQ--------------------------------------------------------------------------------------------------------------------------------------------------------------------ELC--E-M-PF--F---ENT-------------------------------------------------------------------------V--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SQVETKTDVTNTEQALIFAGINPLAAKNTKPLCFNSSDKLPVETESHGFDINQNDNNSQTVCSPTLNQEKLTLVEFLNEFVEEDNDDHSIPDVDTDSTISDSIDETDLSKEIRNNLALCQLPD----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EEVLDHSLSNIRQLTNDIEIINKDEADNMEQLFFDLEIPEQDEFHKKQPFNEHEDFDEDIVLPFVNDSNYTHTEKPYHKGSNFLGDASLGDSFNSMPDFTPRNFLIPTLEKSQEKFETHLSNQNQHFGNVTF D@ >------------------M------V---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------E--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AAGSRARVYAEVNSLRSREYWDYEAHVPSWGNQDDYQ-L-V--RKLGRGKYSEVFEAINI---------------------------------------------------------T--------------------------N-----------------------------------------------------------------------------------------------------N-------------------------------------------------------------------------------ERVVVKILKPVK---------------------K------------------KK-------------------------IKREVKILE---NL---R---G-----------G----T-----NIIK---LIDTVKDP---------------------------------------------------------------VS-KTPALVFEYINNT-DF-KQLY------------------------------QILTDFDIRFYMYELLKALDYCHS--KGIMHRDVKPHNVMIDHQ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Q----------------------------------KKLRLIDWGLAEFY----H-P-----------------------------------------------------------------------------------------------------------------------------------------------------------------A-----Q---------E-----Y----NVRVASRYFKGPELLVDY---Q----------M-----------YD-YSLDMWSLGCMLASMIF-----------------------------------------------R-K-EPFFHGQD------N-------------Y---DQLVRI----------------------------------------------------------------------------------------------------------------------------AK-VLGTD-------E------------------------------------------------------L----YG------Y-------------L-------------------------------------------KK-YHIDLDPH-------------------------------------------------------------FNDILGQ-H--------------------------S---R--KRWE--N---F--------------I-------H-----------SENRHL------V--SPEALDL-------LDKL-------LRYDHQQRLTAK--------------------------------------------------------------------------------------------------------------------------------------------------------------------EAM--E-H-PY--F---YPV-------------------------------------------------------------------------V--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------K--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EQSQPCAENTVL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SSGLTAAR DA ?------------------M------P--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RSRPGYFRQEINKTIWEVPDRYK-D-L--KQVGTGAYGTVCYALDR---------------------------------------------------------R--------------------------T-----------------------------------------------------------------------------------------------------G-------------------------------------------------------------------------------AKVAIKKLHRPF---------------------Q-------S---D-L--FAKR-------------------------AYRELRLLK---HM---K---------------H----D-----NVIG---LVDVFTADL------------------------------------------------------S-----LDRF-HDFYLVMPFMGTD-LG-KLMKME-----------------------------RLSEERVQYLVYQMLKGLKYIHA--AGIIHRDLKPGNLAINE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------E----------------------------------CELKILDFGLARQT----D-S---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------E-----M----TGYVVTRWYRAPEVILSW---M----------H-----------YT-QTVDIWSVGCIMAEML------------------------------------------------L-G-KPLFKGHD------H-------------L---DQLMEI----------------------------------------------------------------------------------------------------------------------------MK-VTGTP-------S------------------------------------------------------K----EF------T-------------A-------------------------------------------KL-QS-EDARNY----V--------------------------------------------T------K---LP----R-F--------------------------R---K--KDLR--I---L--------------L-------P----------------N------V--NPQAIKV-------LDGM-------LLLDPESRITAA--------------------------------------------------------------------------------------------------------------------------------------------------------------------EAL--A-F-PF--F---SEF-------------------------------------------------------------------------R--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------E-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------P----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------E------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EETEAPPYDHSLDEADQSLEQWKRLTFTEILTFQPAPAVAESKETAL DB @------------------M------T---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDKYN-I-E--ALIGEGTYGVVSRATVK---------------------------------------------------------A--------------------------T-----------------------------------------------------------------------------------------------------G-------------------------------------------------------------------------------QIVAIKKIRKIL---------------------I-QNQ--TD---D-G--INFS-------------------------AIREIKILQ---EL---K---------------H----D-----NVVN---LLDIFAH-----------------------------------------------------------------K-SNVYLVFELMQWD-LQ-EVIEDK-S--------------------------IILKPADIKSYMKMLLQGIEACHR--NWVLHRDLKPNNLLMSI-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N----------------------------------GDLKLADFGLARQY----G-S---P-------------------------------------------------------------------------------------------------------------------------------------------------------------N-----K---------V-----F----SPQAVTIFYRAPELLFGA---K----------S-----------YG-PSVDIWSIGCIFAELM------------------------------------------------L-R-TPYLPGTG------E-------------I---DQLRKI----------------------------------------------------------------------------------------------------------------------------CS-ALGTP-------N------------------------------------------------------E----SN------W-------------P-------------------------------------------GV-TC-L--PNY----I---------------------------------------------------K---FT----D-H--------------------------P---A--TPFK--Q---L--------------F-------T----------------A------A--SDEAIDL-------ISKM-------LLFNPSNRISAA--------------------------------------------------------------------------------------------------------------------------------------------------------------------DAL--N-H-PY--F---TSG-------------------------------------------------------------------------V--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------K----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HTNPADLPVPFAKKASLLQQRQ-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VLAQVQQQLLQKQQQQQQQQQQQIQSQPEPIQVDNVEQTQQAQQV DC A-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VPPGHGPFSGFPGPQEHTQVLPDVRLLPRRLPLAFRDAASAPLRKLSVDLIKTYKHINEVYYAKKKRRAQQAPPQDSSTKKEKKVLNHGYDDDNHDYIVRSGERWLERYE-I-D--SLIGKGSFGQVVKAYDH---------------------------------------------------------Q--------------------------T-----------------------------------------------------------------------------------------------------Q-------------------------------------------------------------------------------ELVAIKIIKNKK---------------------A----------------FLNQ-------------------------AQIELRLLE---LM---N---QH-D---T--EMK----Y-----YIVH---LKRHFMF-----------------------------------------------------------------R-NHLCLVFELLSYN-LY-DLLRNT-H-------------------------FRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPK-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------R----------------------------------SAIKIVDFGSSCQL----G-------------------------------------------------------------------------------------------------------------------------------------------------------------------------Q---------R-----I----YQYIQSRFYRSPEVLLGT--------------P-----------YD-LAIDMWSLGCILVEMH------------------------------------------------T-G-EPLFSGSN------E-------------V---DQMSRI----------------------------------------------------------------------------------------------------------------------------VE-VLGIP-------P------------------------------------------------------A----PM------L-------------E-------------------------------------------QA-PK-A--RKY----F------E----------------RLPGGGWTLRRTKELRKD---Y------Q---GP----G--------------------------------T--RRLQ--E---VLGVQTGGPGGRRAGE----PGHS--------------P-A------D--YLRFQDL-------VLRM-------LEYEPAARISPL--------------------------------------------------------------------------------------------------------------------------------------------------------------------GAL--Q-H-GF--F---RRT-------------------------------------------------------------------------A--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------D--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EATNTGPAGSSASTSPAPLDTCPSSSTASSISSSGGSSGSSNDNRAYRYSNRYCGGPGPPITDCEMNSPQVLPSQPLRPWAGGDVPHKTHQAPISASTLPGTGAQLPPLPRCLGRPPSPTSPPPPELMDVSLVGSPPDCSPPPPAPAPQHPAASALRTRMTGGRPPLPPPDDPATLGPRLGLHGVP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QSTAASS DD C------------------M------A--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TRKPSAAAPAAYPTGRGGDSAVRQLQASPGLGAGATRSGVGTGPPSPIALPPLRASNAAAAAHTIGGSKHTMNDHLHVGSHAHGQIQVQQLFEDNSNKRTVLTTQPNGLTTVGKTGLPVVPERQLDSIHRRQGSSTSLKSMEGMGKVKATPMTPEQAMKQYMQKLTAFEHHEIFSYPEIYFLGLNAKKRQGMTGGPNNGGYDDDQGSYVQVPHDHVAYRYE-V-L--KVIGKGSFGQVVKAYDH---------------------------------------------------------K--------------------------V-----------------------------------------------------------------------------------------------------H-------------------------------------------------------------------------------QHVALKMVRNEK---------------------R----------------FHRQ-------------------------AAEEIRILE---HL---R---KQ-D---K--DNT----M-----NVIH---MLENFTF-----------------------------------------------------------------R-NHICMTFELLSMN-LY-ELIKKN-K-------------------------FQGFSLPLVRKFAHSILQCLDALHK--NRIIHCDLKPENILLKQQG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------R----------------------------------SGIKVIDFGSSCYE----H-------------------------------------------------------------------------------------------------------------------------------------------------------------------------Q---------R-----V----YTYIQSRFYRAPEVILGA--------------R-----------YG-MPIDMWSLGCILAELL------------------------------------------------T-G-YPLLPGED------E-------------G---DQLACM----------------------------------------------------------------------------------------------------------------------------IE-LLGMP-------S------------------------------------------------------Q----KL------L-------------D-------------------------------------------AS-KR-A--KNF----V------S----SKGYPRYCTVTTLSDGSVVLNGGRSRRGKL---R------G---PP----E--------------------------------S--REWG--N---A--------------L-------K--------------G-C------D--DPLFLDF-------LKQC-------LEWDPAVRMTPG--------------------------------------------------------------------------------------------------------------------------------------------------------------------QAL--R-H-PW--L---RRR-------------------------------------------------------------------------L----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PKPPTGEKTSVKRITESTGAITSISKLPPPSSSASKLRTNLAQMTDANGNIQQRT---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VLPKLVS DE D------------------M------L-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AEVDRHVAQRYL-I-K--RRLGKGAYGIVWKAMDR---------------------------------------------------------R--------------------------T-----------------------------------------------------------------------------------------------------G-------------------------------------------------------------------------------EVVAIKKIFDAF---------------------R-------D---Q-I--DAQR-------------------------TFREIMLLK---EFG--G---------------H----P-----NIIR---LLDVIPAK---------------------------------------------------------------ND-RDIYLVFESMDTD-LN-AVIQKG----------------------------RLLKDIHKRCIFYQLLRATKFIHS--GRVIHRDQKPANVLLDS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A----------------------------------CRVKLCDFGLARSL----G-D---L-----------------------------------------------------------------------------------------------------------------------------------------------P---------EGPGG-----Q---------A-----L----TEYVATRWYRAPEVLLSS---R----------W-----------YT-PGVDMWSLGCILGEML------------------------------------------------R-G-QPLFPGTS------T-------------F---HQLELI----------------------------------------------------------------------------------------------------------------------------LK-TIPLP-------S------------------------------------------------------M----EE------L-------------Q-------------------------------------------DL-GS-----DYSALIL--------------------------------------------Q------N---LG----S-R--------------------------P---Q--QTLD--A---L--------------L-------P----------------P-----DT--PPEALDL-------LKRL-------LAFAPDKRLSAE--------------------------------------------------------------------------------------------------------------------------------------------------------------------QAL--Q-H-PY--V---QRF-------------------------------------------------------------------------H--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------C-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------P-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DREWARESDVRLPVHEGD---------------------------------------------------------------------------------------------------QLSAPEYRKRLYQIILEQSGNSRSPREEGLGVVASRAELRASPARTQSLKSGVLPQVPAETPARKRGPKPPRSPGHDPEHVEVRRQSSDPLFQLPPPGRGERPPGATGQPPSAPSGVKTQVRAMAPSLTSQAEAQAANQALIRSDPARGGGPRAVG----------------------------------------------ARRVPSRLPREAPEPRPGRRMFGISVSQGAQGAARAALGGYSQAYGTVCRSALGRLPLLPGPRA DF F------------------M------C---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A----------------------------------------------------------------------------------------------------------------------------------------------TMILQKAFEMNAKPRHVLEAAVRNLKTGKRQLLSHEDKENLSVSALDHTQGSRRSDGTCELKPSNTFLHSDQKFSPQEENGPVWRTGSQHRRTAMAERVPMVPLSIPENETSDSDCAQKAEAPFTHSSGFSRQTSGSSVRSAFSLCSSKKGTPDGDSYSLNIKPPVISPDYLREDIEEGHTITALLNRAEKRETARTEETTDINQIISTNSTEGCQAFLKNLEKRADPHSDAAFLSKLLDCYSKVFARFPLAEHCKTESYARMLVRYAELKGIEDPEDAADDFSIARSHCKAFAFVHIAHAQFELSRGNSRKSVSILQKALSSNARPIELLQTAIRNLKSGKTLLLPAEHQESSEAENVEAQNGMKREENPVKAPEDHQKPFSKETSSEWKIPALITKHTSPEDRKAPVEPVSSSSSHHAVRTPAPLRLNPSLSCQTPNYRQPNPNSFVTPVVKQRPVIVSVPATAQKMCPTALPCTPQSGVSYIQPPTQTPSSAFSNESITIKGKQFF-I-F--KMIGRGGSSKVYQVFDH---------------------------------------------------------K--------------------------------------------------------------------------------------------------------------------------------K-------------------------------------------------------------------------------HVYAVKYVNLEE---------------------A-------D---A-Q--AVES-------------------------YKNEIEHLN---HL---Q---Q-----------Y---SD-----QIIK---LYDYEIT-----------------------------------------------------------------S-SYIYMLMECGHLD-LN-TWLRNR-K---------------------------TVKPLDRKAYWRNMLEAVHTIHK--HGIVHSDLKPANFLIVD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GSLKLIDFGIANQI----Q-P-----------------------------------------------------------------------------------------------------------------------------------------------------------------D-----VT------SIM-----K----DSQVGTLNYMPPEAIKDT---SSN---GKPGSK-----------IS-AKGDVWSLGCILYCMT------------------------------------------------Y-G-KTPFQN--------I-------------T---NQISKI----------------------------------------------------------------------------------------------------------------------------HA-IIDPS-------H------------------------------------------------------E----I-------------------------------------------------------------------------------------------------------------------------------------D---FP----D-I------------------------------------------------------------------------------------------P--EKDLLDV-------LKKC-------LVRNPRERISIA--------------------------------------------------------------------------------------------------------------------------------------------------------------------ELL--D-H-PY--L---QLQ-------------------------------------------------------------------------P--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Q-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------P----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------APEPAETSSSDFKRILNELVALQSPNSIARAASNLAMMCNSGRKLDVSECVKSSSQTLWK DG G------------------M------D---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EEESTERQMQIAMLCQKLAMMKQLFNEDDTDYINQAISSNSPDTCRTFLSNLEKKGNPQADPSLLSKLMDSYTRVFSSMPLGKYSQNESYAKMLVRFAELKAIQDVNDAQTSFDIARSHCKDFAFVHVAYAQFELLQGNMKKC---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LLRLPALTRTETSMDTNKARKRSLTTFPILKARKKQSFTSVKVESKPLGHLQKPSSKNKKLRVNRCPQKIPSNTAFPFVDTKGKRNTVNFPQIGNKVPSKGPMQYQENQIHNQVLSSELKTSEIPFNINTKAQDTKPHPELQKKHKVPLTVAEALKFFKNQLSPYEQSEILGYSELWFLGLEAKKLNVVPEKFSKTSFDDEHGSYMKVLHDHIAYRYE-V-L--EMIGKGSFGQVAKCLDH---------------------------------------------------------K--------------------------N-----------------------------------------------------------------------------------------------------N-------------------------------------------------------------------------------ELVALKIIRNKK---------------------R----------------FHHQ-------------------------ALVELKILE---AL---R---RK-D---K--DNN----H-----NVVH---MKDFFYF-----------------------------------------------------------------R-NHLCITFELLGIN-LY-ELMKNN-S-------------------------FHGFNLSIVRRFTFSILKCLHMLYV--EKIIHCDLKPENIVLYQRG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Q----------------------------------VTVKVIDFGSSCYE----H-------------------------------------------------------------------------------------------------------------------------------------------------------------------------Q---------K-----V----YTYIQSRFYRSPEVILGH--------------P-----------YN-MAIDMWSLGCIMAELY------------------------------------------------T-G-YPLFPGEN------E-------------V---EQLACI----------------------------------------------------------------------------------------------------------------------------ME-VLGLP-------P------------------------------------------------------A----HF------T-------------Q-------------------------------------------TA-SR-R--QVF----F------D----SKGLP----------------KNINNNRGG---K------R---YP----D--------------------------------S--KDLT--M---V--------------V-------K----------------T------Y--DSSFLDF-------LRRC-------LVWEPSLRMTPE--------------------------------------------------------------------------------------------------------------------------------------------------------------------QAL--K-H-AW--I---HEP-------------------------------------------------------------------------R--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------K-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FKPRPKPQILRKPGASISSEISTEKAEEQQASKGKKDEATKETTDKLKDEAEKHLENSGKQQSSVEHTADTIQLPHLTEASGKSETVAGSEMSAEQQSTSSPKST---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NILPPIV DH H------------------M------Q------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AVPSRARVYADVNSQRPREYWDYESYVVDWGNQEDYQ-L-V--RKLGRGKYSEVFEAINI---------------------------------------------------------T--------------------------N-----------------------------------------------------------------------------------------------------N-------------------------------------------------------------------------------EKCVVKILKPVK---------------------K------------------KK-------------------------IKREIKILE---NL---R---G-----------G----T-----NIIT---LQAVVKDP---------------------------------------------------------------VS-RTPALIFEHVNNT-DF-KQLY------------------------------QTLSDYDIRYYLYELLKALDYCHS--MGIMHRDVKPHNVMIDHD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H----------------------------------RKLRLIDWGLAEFY----H-P-----------------------------------------------------------------------------------------------------------------------------------------------------------------G-----Q---------D-----Y----NVRVASRYFKGPELLVDY---Q----------M-----------YD-YSLDMWSLGCMLASMIF-----------------------------------------------R-K-EPFFHGHD------N-------------Y---DQLVRI----------------------------------------------------------------------------------------------------------------------------AK-VLGTE-------E------------------------------------------------------L----FE------Y-------------L-------------------------------------------DK-YHIELDPR-------------------------------------------------------------FNDILGR-H--------------------------S---R--KRWE--R---F--------------V-------H-----------SENQHL------V--SPEALDF-------LDRL-------LRYDHYERYTAR--------------------------------------------------------------------------------------------------------------------------------------------------------------------EAM--D-H-PY--F---YPI-------------------------------------------------------------------------V--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------K----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EQGRMVSSNSPTPNAL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QGPISTTE 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I------------------M------T---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------V----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MQKYD-K-M--EKIGEGTYGTVFKGRNR---------------------------------------------------------D--------------------------T-----------------------------------------------------------------------------------------------------M-------------------------------------------------------------------------------EIVALKRVRLDE---------------------D-------D---E-G--VPSS-------------------------ALREICLLK---EL---K---------------H----K-----NIVR---LIDVLHS-----------------------------------------------------------------D-KKLTLVFEHCDQD-LK-KYFDSL-N--------------------------GEIDMAVCRSFMLQLLRGLAFCHS--HNVLHRDLKPQNLLINK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N----------------------------------GELKLADFGLARAF----G-I---P-------------------------------------------------------------------------------------------------------------------------------------------------------------V-----K---------C-----Y----SAEVVTLWYRPPDVLFGA---K----------L-----------YT-TSIDMWSAGCILAELA------------------------------------------------DAG-RPLFPGSD------V-------------L---DQLMKI----------------------------------------------------------------------------------------------------------------------------FR-VLGTP-------N------------------------------------------------------E----DS------W-------------P-------------------------------------------GV-SH-L--SDY----V---------------------------------------------------A---LP----S-F--------------------------PA--I--TSWS--Q---L--------------V-------P----------------R------L--NSKGRDL-------LQKL-------LICRPNQRISAE--------------------------------------------------------------------------------------------------------------------------------------------------------------------AAM--Q-H-PY--F---TDS-------------------------------------------------------------------------S--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------S---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SGH EK 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DL J------------------M------E---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------E-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TEDEFCGCLFPDPEIPGSSSSSGCSSSSTELYDLAAAHAALISRQQQILSQAIPIIPEHQLAAVAAHHQHHQQLHPSVQYQLVAAATHHNHHQPQAAQPHYSAVVPRSDVIQQPPHFALHHHLQNLVQQQQQQQAHHHHQQLVGEMALVSHTHPAAVGSTTCYEKNQQKQQQVQQIPTQPQVAHVSSNAILAAAQPFYPPPVQDSQ-P-D--RPIGYGAFGVVWSVTDP---------------------------------------------------------R--------------------------S-----------------------------------------------------------------------------------------------------G-------------------------------------------------------------------------------KRVALKKMPNVF---------------------Q-------N---L-A--SCKR-------------------------VFREIKMLS---SF---R---------------H----D-----NVLS---LLDILQPAN------------------------------------------------------------PSFF-QELYVLTELMQSD-LH-KIIVSP----------------------------QALTPDHVKVFVYQILRGLKYLHT--ANILHRDIKPGNLLVNS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N----------------------------------CILKICDFGLARTW----D-Q---R------------------------------------------------------------------------------------------------------------------------------------------------------------DR-----L---------N-----M----THEVVTQYYRAPELLMGA---R----------R-----------YT-GAVDIWSVGCIFAELL------------------------------------------------Q-R-KILFQAAG------P-------------I---EQLQMI----------------------------------------------------------------------------------------------------------------------------ID-LLGTP-------S------------------------------------------------------Q----EA------M-------------K-------------------------------------------YA-CE-G--AKN----H---------------------------------------VL---R------A---GL------R--------------------------A---PDTQRLY--K---I--------------A-----SPD----------------D------K--NHEAVDL-------LQKL-------LHFDPDKRISVE--------------------------------------------------------------------------------------------------------------------------------------------------------------------EAL--Q-H-RY--L---EEG-------------------------------------------------------------------------R--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RFHSCMCSCCYTKPNMPSRLFAQDLDPRHESPFD----------------------------------------------PKWEKDMSRLSMFELREKMYQFVMDRPALYGVALCINPQSAAYKNFASSSVAQASELPPSPQAW 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K------------------M------V-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SWGRGKDAYYLYISREQEEDDDDSLSFYSSQKD----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MNRYT-T-M--KQLGDGTYGSVLMGKSN---------------------------------------------------------E--------------------------S-----------------------------------------------------------------------------------------------------G-------------------------------------------------------------------------------ELVAIKRMKRKF---------------------Y-------S-----W--DECM-------------------------NLREVKSLK---KL---N---------------H----A-----NVIK---LKEVIRE-----------------------------------------------------------------N-DHLYFVFEYMKEN-LY-QLMKDR-N--------------------------KLFPESVIRNIMYQILQGLAFIHK--HGFFHRDMKPENLLCMG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------P----------------------------------ELVKIADFGLAREL----R-S-----------------------------------------------------------------------------------------------------------------------------------------------------------------Q-----P---------P-----Y----TDYVSTRWYRAPEVLLRS---S----------V-----------YS-SPIDVWAVGSIMAELY------------------------------------------------T-F-RPLFPGTS------E-------------V---DEIFKI----------------------------------------------------------------------------------------------------------------------------CQ-VLGTP-------K------------------------------------------------------K----SD------W-------------P-------------------------------------------EG-YQ-L--ASS----M----------------------------------------N---F------R---FP----Q-C--------------------------I---P--INLK--T---L--------------I-------P----------------N------A--SSEAIQL-------MTEM-------LNWDPKKRPTAS--------------------------------------------------------------------------------------------------------------------------------------------------------------------QAL--K-H-PY--F---QVG-------------------------------------------------------------------------Q-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VLGSSAHHLDTKQTLHKQLQPLEPKPSSSERDPKPLPNILDQPAGQPQPKQGHQPLQTIQPPQNTVTHPPPKQQGHQKPPQTMFPSIIKTIPVNSVSTLGHKGARRRWGQTVFKSGDSCDDIEDDLGASHSKKPSMEACKEKKKESPFRFPDSGLPVSNHFKGENRNLHASVSLKSDPNLSTASTAKQYYLKQSRYLPGVNPKNVSLVAGGKDINSHSWNNQLFPKSLGSMGADLSFKRSNAAGNLGSYTTYNQTGYMPSFLKKEVGSAG----------------------------------------------QRIQLAPLGASASDYTWSTKTGRGQFSGRTYNPTAKNLNIVNRTQPVPSVHGRTDWVAKYGGHR DN L----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MENFQ-K-V--EKIGEGTYGVVYKARNK---------------------------------------------------------L--------------------------T-----------------------------------------------------------------------------------------------------G-------------------------------------------------------------------------------EVVALKKIRLDT---------------------E-------T---E-G--VPST-------------------------AIREISLLK---EL---N---------------H----P-----NIVK---LLDVIHT-----------------------------------------------------------------E-NKLYLVFEFLHQD-LK-KFMDAS-A-------------------------LTGIPLPLIKSYLFQLLQGLAFCHS--HRVLHRDLKPQNLLINT-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------E----------------------------------GAIKLADFGLARAF----G-V---P-------------------------------------------------------------------------------------------------------------------------------------------------------------V-----R---------T-----Y----THEVVTLWYRAPEILLGC---K----------Y-----------YS-TAVDIWSLGCIFAEMV------------------------------------------------T-R-RALFPGDS------E-------------I---DQLFRI----------------------------------------------------------------------------------------------------------------------------FR-TLGTP-------D------------------------------------------------------E----VV------W-------------P-------------------------------------------GV-TS-M--PDY----K--------------------------------------------P------S---FP----K-W--------------------------A---R--QDFS--K---V--------------V-------P----------------P------L--DEDGRSL-------LSQM-------LHYDPNKRISAK--------------------------------------------------------------------------------------------------------------------------------------------------------------------AAL--A-H-PF--F---QDV-------------------------------------------------------------------------T--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------K-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------P----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VPHLRL DO M-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HFLYNCSEPTLDVKIAFCQGFGNQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQ-N-L--KPIGSGAQGIVCAAYDA---------------------------------------------------------V--------------------------L-----------------------------------------------------------------------------------------------------D-------------------------------------------------------------------------------RNVAIKKLSRPF---------------------Q-------N---Q-T--HAKR-------------------------AYRELVLMK---CV---N---------------H----K-----NIIS---LLNVFTPQK------------------------------------------------------S-----LEEF-QDVYLVMELMDAN-LC-QVIQM------------------------------ELDHERMSYLLYQMLCGIKHLHS--AGIIHRDLKPSNIVVKS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------D----------------------------------CTLKILDFGLARTA----G-T-----------------------------------------------------------------------------------------------------------------------------------------------------------------S-----F---------M-----M----TPYVVTRYYRAPEVILGM--------------G-----------YK-ENVDIWSVGCIMGEMV------------------------------------------------R-H-KILFPGRD------Y-------------I---DQWNKV----------------------------------------------------------------------------------------------------------------------------IE-QLGTP-------C------------------------------------------------------P----EF------M-------------K-------------------------------------------KL-QP--TVRNY----V--------------------------------------------E------N---RP----K-Y--------------------------A---G--LTFP--K---L--------------F-------P---DSLFPADSEHNK-L------K--ASQARDL-------LSKM-------LVIDPAKRISVD--------------------------------------------------------------------------------------------------------------------------------------------------------------------EAL--Q-H-PY--I---NVW-------------------------------------------------------------------------Y--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------D-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------P---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SEVEAPPPQIYDKQ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LDEREHTIEEWKELIYKEVMN----------------------------------------------FEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR DP N------------------M------S---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------R---------------------------------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VGVAPTSGLREASGHGAAGVDRLPEEMNDMKIRDDREMEATVVDGNGTETGHIIVTTIGGRNGQPKQTISYM-A-E--RVVGHGSFGVVFQAKCL---------------------------------------------------------E--------------------------T-----------------------------------------------------------------------------------------------------G-------------------------------------------------------------------------------ETVAIKKVLQDK---------------------R-------------------Y-------------------------KNRELQTMR---LL---D---------------H----P-----NVVC---LKHCFFSTT------------------------------------------------------------EKDE-LYLNLVLEYVPET-VN-R 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-------------------------------------------CM-N-----PNY----T----------------------------------------E---F------K---FP----Q-I--------------------------K---A--HPWH--K---I--------------F-------H----------------K-----RM--PPEAVDL-------VSRL-------LQYSPNLRCTAL--------------------------------------------------------------------------------------------------------------------------------------------------------------------DAL--T-H-PF--F---DEL-------------------------------------------------------------------------R--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------D-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------P----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SRLPNGRFLPPLFNFKSHELKGVPAEILVKLVPEHARKQCPFLGL DQ O------------------M------T---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------S------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SHEYSLKGTSHSAMTLEDRFE-V-I--KEVGDGSFGSVVLARTR---------------------------------------------------------T--------------------------A---------------------------------------------------G------------------------------------------SNVARR-G-------------------------------------------------------------------------------TMVAIKTMKKTF---------------------E-------S-----F--APCL-------------------------ELREVIFLR---TLP--H---------------H----T-----HIVP---ALDIFLDP---------------------------------------------------------------LS-KKLHICMEYMDGN-LY-QLMKAR-D-------------------------HKYLEAKHVKSILYQIMSGLDHIHA--HNFFHRDIKPENILVSTSA------------------------------PN-----------------------------------------------------------------------------------------------------------DSSAFSRYSNLVTPPSTP-----------------------------------------------------------------------------------------------------------------------------------------P----------------------------T----------------------------------YTVKIADFGLARET----H-S-----------------------------------------------------------------------------------------------------------------------------------------------------------------K-----S---------P-----Y----TTYVSTRWYRAPEVLLRA---G----------E-----------YS-APVDIWAVGAMAVEIA------------------------------------------------T-L-KPLFPGVN------E-------------V---DQVWRI----------------------------------------------------------------------------------------------------------------------------CE-IMGSP-------G------------------------------------------------------N----WY------T-------------K-------------------------S-------GAKVGGGEWREG-TK-L--AQK----L----------------------------------------G---F------T---FP----K-M--------------------------A---P--HSMS--S---I--------------L-------Q----------------G----PHW--PQSLANF-------VTWC-------LMWDPRNRPTST--------------------------------------------------------------------------------------------------------------------------------------------------------------------QAL--N-H-EY--F---ADA-------------------------------------------------------------------------V--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------D-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------P---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LRPKSSASRLLGRKMSEKSFKPAPTKETTELPALSSKPSWFRRSLVLRTDSPTPLLEPETAVRPPAISYNTVPEVQASKGRSIKRATWANGAPMPILPSIRPVSPLSNAVTAQANSSVAHNGDQTLAVPVEDIGKSKKIGRQLSVNSHGNHYADIHRQEAERALNGLSGGANTSTQKEGFFSHLRKRARRLSGRNQVAAVAPTSNYDIEANAGCSPWPNRSSVVLDSGVIDTKTGDFTELDKTLQNVKYGLSSAANPPPQITSIPNQSPSKRQSVPQVPMRSMTESPTPSVGGPIYGRTRRALQMTSHPVHRYETPEEEDELLDEVLHSADRAARHLAQHYDSESASLYKEDHRLAHLVNDSTRTLNPYPTPSPSAKRDGVSFGDIDNTPVRQRDVTKIPEDTSSRQWPTPPYGEQEWASSVANSILSGSTYR DR P------------------M------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------I---------------------------------------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KARPTFYRQELNKTIWEVPERYQ-N-L--SPVGSGAYGSVMSAFDG---------------------------------------------------------K--------------------------A-----------------------------------------------------------------------------------------------------G-------------------------------------------------------------------------------LRVAVKKLSRPF---------------------Q-------S---I-I--HAKR-------------------------TYRELRLLK---HM---K---------------H----E-----NVIG---LLDVFSPAT------------------------------------------------------S-----LEGF-NDVYLVTHLMGAD-LN-NIVKCQ-----------------------------KLTDDHVQFLIYQILRALKYIHS--ADIIHRDLKPSNLAVNE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------D----------------------------------CELKILDFGLARLT----D-D---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------E-----M----TGYVATRWYRAPEIMLNW---M----------H-----------YN-MTVDIWSVGCIMAELL------------------------------------------------T-G-RTLFPGTD------H-------------I---NQLQQI----------------------------------------------------------------------------------------------------------------------------MR-LTGTP-------P------------------------------------------------------A----SL------I-------------S-------------------------------------------RM-PS-HEARNY----I--------------------------------------------S------S---LP----H-M--------------------------P---K--RNFA--D---V--------------F-------I----------------G------A--NPLAVDL-------LEKM-------LVLDTDKRITAS--------------------------------------------------------------------------------------------------------------------------------------------------------------------QAL--A-H-PY--F---AQY-------------------------------------------------------------------------H--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------D-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------P----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------D---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DEPEADPYDQSFESRDLEIEEWKSKIYIQNRN DS Q------------------M------S---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Q---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KGDCIASVYGYDLGGRFV-D-F--QPLGFGVNGLVLSAVDS---------------------------------------------------------R--------------------------A-----------------------------------------------------------------------------------------------------C-------------------------------------------------------------------------------RKVAVKKIALSD---------------------A-------------R--SMKH-------------------------ALREIKIIR---RL---D---------------H----D-----NIVK---VYEVLGPKG------------------------------------------------------TDLQGELFKF-SVAYIVQEYMETD-LA-RLLEQG-----------------------------TLAEEHAKLFMYQLLRGLKYIHS--ANVLHRDLKPANIFISTE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------D----------------------------------LVLKIGDFGLARIV----D-Q-----------------------------------------------------------------------------------------------------------------------------------------------------------------H-----YSH-----KGY-----L----SEGLVTKWYRSPRLLLSP---N----------N-----------YT-KAIDMWAAGCILAEML------------------------------------------------T-G-RMLFAGAH------E-------------L---EQMQLI----------------------------------------------------------------------------------------------------------------------------LE-TIPVI-------R------------------------------------------------------E----ED------K-------------D-------------------------------------------ELLRV-M--PSF----V----------------------------------------S---S------T---WE---------------------------------V---K--RPLR--K---L--------------L-------P----------------E------V--NSEAIDF-------LEKI-------LTFNPMDRLTAE--------------------------------------------------------------------------------------------------------------------------------------------------------------------MGL--Q-H-PY--M---SPY-------------------------------------------------------------------------S--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------C-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------P-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EDEPTSQHPFRIEDEIDDIVLMAANQSQLSNWDTCSSRYPVSLSSDLEWRPDRCQDASEVQRDPRAGSAPLAEDVQVDPRKDSHSSSERFLEQSHSSMERAFEADYGRSCDYKVGSPSYLDKLLWRDNKPHHYSEPKLILDLSHWKQAAGAPPTATGLADTGAREDEPASLFLEIAQWVKSTQGGPEHASPPADDPERRLSASPPGRPAPVDGGASPQFDLDVFISRALKLCTKPEDLPDNKLGDLNGACIPEHPGDLVQTEAFSKERW DT R------------------M------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------E----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MNRYI-T-L--TQLGDGTYGTVVLGQRK---------------------------------------------------------D--------------------------T-----------------------------------------------------------------------------------------------------G-------------------------------------------------------------------------------EKVAIKRMKRKY---------------------Y-------S-----W--EEAM-------------------------NLREVKSLK---KL---S---------------H----P-----NIVK---LKEVIRE-----------------------------------------------------------------N-DTLYFVFEYMKEN-LY-QMIKDR-D--------------------------THLPEPELKSILFQVLTGLAFMHR--HGFFHRDLKPENLLCSG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------P----------------------------------DLIKIADFGLAREI----R-S-----------------------------------------------------------------------------------------------------------------------------------------------------------------R-----P---------P-----F----TDYVSTRWYRAPEVLLHS---T----------N-----------YG-STIDLWAMGCIMAELY------------------------------------------------T-F-RPLFPGSS------E-------------V---DQLFKI----------------------------------------------------------------------------------------------------------------------------CS-VLGTP-------D------------------------------------------------------K----DD------W-------------P-------------------------------------------DG-YR-L--ASM----I----------------------------------------H---F------R---YP----D-C--------------------------I---K--VPLS--S---V--------------V-------S----------------R------C--SQNGLDL-------LEDM-------LAYDPDKRPTAQ--------------------------------------------------------------------------------------------------------------------------------------------------------------------QSL--K-Y-PY--F---HAL-------------------------------------------------------------------------K--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------R-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------I----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SPTAATKANVRLNSKYAASNGHPVQSVSNNVLPVQEKLQAVTELLHQTNNNMNSHSNLGKNNNLAPKNGGVPRKYQPKLSFLTTSEMGAGSHADSSSLVGGATVDGVPVPQHQNGGESINDIYLNRNISQLFGLPAGPQHQQQQQVHHPNVSFSTTSSRNAGAIYVNGSHLSYDTANMNAKNNAKFVVGASNGGYYVPVARPSLLGPDAKVYNVFSKVSASQAPPSLIVRQPQLQPEVAPAPMRLSGRSRAAAAVQDPKMGALKSDDLDLILGSKLKTSAKRQRNAKANILLEDLFGQLSMDSDSDGKYPHTVPPTQQAKSGKTSTGGHGAGARERDLFGESYLPRPGLRKK----------------------------------------------ATQSSLEVNNGSHADSLAPNAQKEKPAVASSFPWDESNRTEDEKLTAWMVAENGNLILDNHQQA DU S----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------"---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DDRFAEDEIIQQRRKRRLEILKKYQQTGNGHSDLSIPEKKLKEDVDQVSTTKPIEAVPKMKTNASKIEINKEGSNSNTKLDVTNSTTSDSPSIKSSVQIEDTEDDMFADSPSPSVKRQNTGKGISTLTRSFADMQDNWDDIEGYYKVVLMEELDSRYI-V-Q--SNLGKGMFSTVVSALDR---------------------------------------------------------N--------------------------R-----------------------------------------------------------------------------------------------------N-------------------------------------------------------------------------------QTFAIKIIRNNE---------------------V----------------MYKE-------------------------GLKEVSILE---RL---Q---AA-D---R--EGK----Q-----HIIH---YERHFMH-----------------------------------------------------------------K-NHLCMVFEMLSLN-LR-D#ILKKF-G------------------R------NVGLSIKAVRLYAYQMFMALDLLKQ--CNVIHSDIKPDNMLVNEK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------R----------------------------------NILKICDLGSASDA----S-E-----------------------------------------------------------------------------------------------------------------------------------------------------------------------N---------E-----I----TPYLVSRFYRAPEIILGF--------------P-----------YS-CPIDTWSVGCSLYELY------------------------------------------------T-G-QILFPGRT------N-------------N---QMLRYM----------------------------------------------------------------------------------------------------------------------------ME-CKGKF-------S------------------------------------------------------H----KM------L-------------K$-------------------------------------------RS-QF-L--NDH----F--------------------------DADFNFIQIDHDPIT---N------Q---ET----R--------------------------------K--PVKF--S---KPTKDIRSRLKEVPTS----TDEE--------------F-I------I--RQELMDL-------LEKC-------LELNPEKRVPPE--------------------------------------------------------------------------------------------------------------------------------------------------------------------VAL--K-H-PF--F---IK-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------K DV T------------------M------S--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------!'---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SPGRRAKSRSLERKRREPERRRLSSPRTRPRDDILGRCERSKDASPINRWSPTRRRSRSPIRRRSRSPLRRSRSPRRRSRSPRRRDRSRRSRSRLRRRSRSRGGHRRRSRSKVKEDKFKGSLSEGMKVEQESSSDDNLEDFDVEEEDEEALIEQRRIQRQAIVQKYKYLAEDSNISVPSEPSSPQSSTRSRSPSPDDILERVAADVKEYERENVDTFEASVKAKHNLMTVEQNNGSSQKKILAPDMFTESDDMFAAYFDSARLRAAGIGKDFKENPNLRDNWTDAEGYYRVNIGEVLDKRYN-V-Y--GYTGQGVFSNVVRARDN--------------------------------------------------------AR--------------------------A-----------------------------------------------------------------------------------------------------N-------------------------------------------------------------------------------QEVAVKIIRNNE---------------------L----------------MQKT-------------------------GLKELEFLK---KL---N---DA-D---P--DDK----F-----HCLR---LFRHFYH-----------------------------------------------------------------K-QHLCLVFEPLSMN-LR-E(VLKKY-G------------------K------DVGLHIKAVRSYSQQLFLALKLLKR--CNILHADIKPDNILVNES------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------K----------------------------------TILKLCDFGSASHV----A-D-----------------------------------------------------------------------------------------------------------------------------------------------------------------------N---------D-----I----TPYLVSRFYRAPEIIIGK--------------S-----------YD-YGIDMWSVGCTLYELY------------------------------------------------T-G-KILFPGKT------N-------------N---HMLKLA----------------------------------------------------------------------------------------------------------------------------MD-LKGKM-------P------------------------------------------------------N----KM------I-------------R)-------------------------------------------KG-VF-K--DQH----F--------------------------DQNLNFMYIEVDKVT---E------R---EK----V--------------------------------T--VMST--I---NPTKDLLADLIGCQRL----PEDQ--------------R-K------K--VHQLKDL-------LDQI-------LMLDPAKRISIN--------------------------------------------------------------------------------------------------------------------------------------------------------------------QAL--Q-H-AF--I---QEK----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------I DW U------------------M------A----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ATEPPSLREQAEMDDADNSEKSVNEENGEVSEDQSQNKHSRHKKKKHKHRSKHKKHKHSSEEDRDKKHKHKHKHKKHKRKEVIEASDKEGLSPAKRTKLDDLALLEDLEKQRALIKAELDNELMEGKVQSGMGLILQGYESGSEEEGEIHEKARNGNRSSTRSSSTRGKLEITDNKNSAKKRSKSRSKERTRHRSDKRKSKGAGEMLREKANRSKSKERRKSKSPSKRSKSQDQARKSKSPPLRRRSQEKVGKARSPAEEKMKSEEKGKIKDRKKSPIVNERSRDRSKKSKSPVDLRDKSKDRRSRSKERKSKRSEIDKEKKPIKSPSKDASSGKENRSPSRRPGRSPKRRSLSPKLRDKSRRSRSPLLNDRRSKQSKSPSRTL----------------------------------------------------------------------------------------------------------------------------------------------&,---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DPSPPDSPEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFD-I-I--GIIGEGTYGQVYKAKDK---------------------------------------------------------D--------------------------T-----------------------------------------------------------------------------------------------------G-------------------------------------------------------------------------------ELVALKKVRLDN---------------------E-------K---E-G--FPIT-------------------------AIREIKILR---QL---V---------------H----Q-----SVVN---MKEIVTDKQ----------------------------------------------------DAL---DFKKDK-GAFYLVFEYMDHD-LM-G-LLESG-L--------------------------VHFSEDHIKSFMKQLMEGLDYCHK--KNFLHRDIKCSNILLNN-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------S----------------------------------GQIKLADFGLARLY----N-S---E------------------------------------------------------------------------------------------------------------------------------------------------------------ES-----R---------P-----Y----TNKVITLWYRPPELLLGE---E----------R-----------YT-PAIDVWSCGCILGELF------------------------------------------------T-K-KPIFQANL------E-------------L---AQLELI----------------------------------------------------------------------------------------------------------------------------SR-LCGSP-------C------------------------------------------------------P----AV------W-------------P.-------------------------------------------DV-IK-L--PYF----N----------------------------------------T---M----------KP----KKQ--------------------------Y---R--RRLR--E---E--------------F-------S----------------F------I--PSAALDL-------LDHM-------LTLDPSKRCTAE--------------------------------------------------------------------------------------------------------------------------------------------------------------------QTL--Q-S-DF--L---KDV-------------------------------------------------------------------------E--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LSKMAPPDLPHWQDCHELWSKKRRRQRQSGIVIEDPPPSKASRKETTSGTTAEPVKNNSPAPPQPAPVKAEPGPGDAVGLGDITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNIHSNPEMQQQLEALNQSISALTEASSQQQDSESIAPEESLKEVPSVPVVLPPAEQTTPEASNTPADMQNVLAVLLSQLMKTQEPAGNLEENTNDKNSGPQGPRRTPTMPQEEAAACPPHILPPEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPHEHQALRPMEYSTRSHPNRTYGNTDGPETGFSSADTDERSSGPALTESLVQTPVKNRTFSGSVSHLGESNSYQGTG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SVQFPGDQDL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RFTRVPLALHSVVGQPFLKSE----------------------------------------------GNSNSVVHAETKLQNYGELGPGTTGANSSGTTLQWGGPAQSYGKPYRGAARVLPRGGRGRGVPY DX V------------------M------P----NSERHGGKKDGSGGASGTSQPSSGGGSSNSRERHRLVSKHKRHKSKHSKDVGLVTPEAASLGTIIKPLVEYDDISSDSDTFSDDTAFKSDRRENEERRGTDRSDRLHRHRHHQHRRSRDLLKTKQTEKEKNQEVSKSGSMKDRVSGSSKRSVEGSDDYGKAQLSKSGSKESRSSKMHKEKTRKERELKSGYKDRSKSHRKRETPKSYKTVASPKRRSRSPHRKWSDSSKQDDSPSGASYGQDYDLSPPRSHTSSNYDSYKKSPGSTSRRQSISPPYKEPSAYQSSTRSPSPYSRRQRSVSPYSRRRSSSYERSGSYSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSRSPAYSRHSSSHSKKKRSGSRSRHSSISPVRLPLNSSLGAELSRKKKERAAAAAAAKMDGKESKSSPIILPKKEKLEVKESGLESKKLPRSIKSEKSTPDTELVTVAHSNPEVKHCLDTGKVRLDENLQKHPAKDLKAQGTKDVKPVAPKEVIVTSKETETSEKETLPPLPTITSPPPLPATTPPPQTPPLPPLPPLPAIPLQPPLPPPQPPFSQVPVSSTSILPSSPHPRTSTLSSQTNSQPPVQVSMKTQVSITAAIPHLKTSTLPPLPLPPLLPGDDDMDSPKETLPSKPAKKEKEQRTRHLLTDLPLPPELPGG----------------------------------------------------------------------------------------------------------------------------------------------+1-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HNQSSNQNGGGSGGGGGGGGSSTFSPIVLTSTYRLDVQEKYT-F-S--YEIGSGTYGMVYKADDK---------------------------------------------------------K--------------------------R---------------------------------------------------------------------------------------------------P-N-------------------------------------------------------------------------------NKVAVKKFRSTK---------------------E-------G---E-G--LSLT-------------------------AYREIGLLK---EL---S---------------N----E-----NIVK---LLDVCLNP---------------------------------------------------------------KD-KLLYLIFDYAEFD-LF-G2IIKYH-R------------------E-----NGSHFSDATIKSLIWQVLNGIHYLHS--NWVIHRDLKPSNILVMGEG------------------------------------------------------------------------------------------------------------------------------------------------------------K-----------------------------------------------------------------------------------------------------------------------------------------E----------------------------C----------------------------------GTVKIGDFGLARIF----Q-S---P-------------------------------------------------------------------------------------------------------------------------------------------------------------L-----K---------P--LN-E----NGVVVTIWYRSPELLLGS---K----------H-----------YT-RAVDIWAIGCIFAELI------------------------------------------------T-T-KPLFPGKE------KD-P---KIPSLFQD---DQVEKI----------------------------------------------------------------------------------------------------------------------------IR-VLGKP-------T------------------------------------------------------L----DM------W-------------P3-------------------------------------------DI-KH-L--PEW----K----------------------------------------R---L--SSMEA---FP----------------------------------------NSLA--K---C--------------V------GI----------------D------E--NSQAYDL-------LSKM-------ILYDPSKRITAS--------------------------------------------------------------------------------------------------------------------------------------------------------------------EAL--D-H-PY--F---KEL-------------------------------------------------------------------------P--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------P--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LPNAFSKPIPYPPRLPINKKKREFDD DY W------------------M------N---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------T----------------------------------------------------------------------------------------------------------------------------------------------06----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VDLESDQIRLKCIRKEGFFTVPPEHRLGRCRSVKEFE-K-L--NRIGEGTYGIVYRARDT---------------------------------------------------------Q--------------------------T-----------------------------------------------------------------------------------------------------D-------------------------------------------------------------------------------EIVALKKVRMDK---------------------E-------K---D-G--IPIS-------------------------SLREITLLL---RL---R---------------H----P-----NIVE---LKEVVVGN---------------------------------------------------------------HL-ESIFLVMGYCEQD-LA-S7LLENM-P--------------------------TPFSEAQVKCIMLQVLRGLQYLHR--NFIIHRDLKVSNLLMTD-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------K----------------------------------GCVKTADFGLARAY----G-V---P-------------------------------------------------------------------------------------------------------------------------------------------------------------V-----K---------P-----M----TPKVVTLWYRAPELLLGT---T----------T-----------QT-TSIDMWAVGCILAELL------------------------------------------------A-H-KPLLPGTS------E-------------I---HQIDLI----------------------------------------------------------------------------------------------------------------------------VQ-LLGTP-------S------------------------------------------------------E----NI------W-------------P8-------------------------------------------GF-SK-L--PLA----G----------------------------------------Q---Y------S---LR----K-Q--------------------------P---Y--NNLK--H---K--------------F-------P----------------W------L--SEAGLRL-------LNFL-------FMYDPKKRATSG--------------------------------------------------------------------------------------------------------------------------------------------------------------------DCL--E-S-SY--F---KEK-------------------------------------------------------------------------P--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------P---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CEPELMPTFPHHRNKRAAPAAAEGQSKRCRP DZ X------------------M------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------E----------------------------------------------------------------------------------------------------------------------------------------------5;-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELANYK-R-L--EKVGEGTYGVVYKALDL---------------------------------------------------------R--------------------------P---------------------------------------------------G-----------------------------------------------QGQ-------------------------------------------------------------------------------RVVALKKIRLES---------------------E-------D---E-G--VPST-------------------------AIREISLLK---EL---K---------------D----D-----NIVR---LYDIVHS-----------------------------------------------------------------DAHKLYLVFEFLDLD-LK-R